iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-107243

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AEFK01064587

Gene Name

WWP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000004236.1	ENSSHAT00000004875.1	ENSSHAP00000004827.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.30e-132	440.7	592	925

Active Site

Position(s)	Description	Evidence
894	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGv.treflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           ++dl++rl+v f+gEegld+gG+ +re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++g+++d
   Q: 592  PYDLRRRLYVIFRGEEGLDYGGLaSREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHGKFID 679
           6799******************7469**********************************98.89************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvv 178
           + +s +fyk++l+kkl+++dle++d e+y+sl +i++n   +iee+gl++ fsv+ eilg++++++Lk gG+ni Vt+eNkeeY+ l++
   Q: 680  TGFSLPFYKRMLSKKLTIKDLESIDTEFYNSLIWIRDN---NIEECGLEMYFSVDMEILGKVTSHDLKLGGSNILVTEENKEEYIGLMA 765
           ************************************99...9*********************************************** PP
   S: 179  eyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqF 267
           e+r+ +g++ q++af +Gfnev+pl++l++F+e+ele+++cG++e+d+ d++++t y++ yt++s++i+wFw+ ++e ++e r +++qF
   Q: 766  EWRFSRGVQDQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLADWQRNTVYRH-YTRNSKQIIWFWQYVKETDNEVRMRLMQF 853
           *********************************************************99.***************************** PP
   S: 268  vTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           vTg++rlPlgGfael+    p++f+i+k +++++lP+s+TCfn+L+LP+Y+s+e+lkekLl+Aieet+gF++
   Q: 854  VTGTCRLPLGGFAELMgsngPQKFCIEKVGKETWLPRSHTCFNRLDLPPYKSYEQLKEKLLFAIEETEGFGQ 925
           **********************************************************************96 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

MATASPRSDT SNNHNGRSQL QVTVSSAKLK RKKNWFGTAI YAELSVDGEI KKTAKSSSSS 60
NPKWDEQLTV NVTPQTTLEF RVWSHHTLKA DALLGRATVD LRQALEIHNR KLERVKEQLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTAAAACTG AATACTAGGA AATGGCCACA GCTTCACCAC GGTCTGATAC TAGTAATAAC 60
CATAATGGAA GATCACAGCT TCAGGTGACT GGTAAGTTAA TTATTTATAA TTATTTGATT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0070062--C:extracellular exosome
GO:0061630--F:ubiquitin protein ligase activity
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	85.34	0.00e+00	1555.00
IUUC-Apl-003310	Anas platyrhynchos	84.44	0.00e+00	1535.00
IUUC-Aca-005388	Anolis carolinensis	81.07	0.00e+00	1443.00
IUUC-Bta-012857	Bos taurus	84.81	0.00e+00	1518.00
IUUC-Cja-019448	Callithrix jacchus	85.45	0.00e+00	1566.00
IUUC-Cfa-020728	Canis familiaris	86.10	0.00e+00	1559.00
IUUC-Cpo-021635	Cavia porcellus	82.06	0.00e+00	1514.00
IUUC-Csa-023805	Chlorocebus sabaeus	86.94	0.00e+00	1185.00
IUUC-Cho-024943	Choloepus hoffmanni	74.53	0.00e+00	1031.00
IUUC-Cin-025212	Ciona intestinalis	73.07	0.00e+00	900.00
IUUC-Csv-026256	Ciona savignyi	72.29	0.00e+00	894.00
IUUC-Dre-028245	Danio rerio	91.00	0.00e+00	1150.00
IUUC-Dno-029618	Dasypus novemcinctus	85.13	0.00e+00	1551.00
IUUC-Dor-030665	Dipodomys ordii	70.77	0.00e+00	1009.00
IUUC-Dme-032041	Drosophila melanogaster	69.33	0.00e+00	882.00
IUUC-Ete-032779	Echinops telfairi	91.08	0.00e+00	1068.00
IUUC-Eca-033313	Equus caballus	84.27	0.00e+00	1526.00
IUUC-Eeu-035259	Erinaceus europaeus	77.69	0.00e+00	1379.00
IUUC-Fca-035420	Felis catus	85.13	0.00e+00	1553.00
IUUC-Fal-037335	Ficedula albicollis	82.81	0.00e+00	1530.00
IUUC-Gmo-039172	Gadus morhua	86.34	0.00e+00	1045.00
IUUC-Gga-040246	Gallus gallus	83.44	0.00e+00	1520.00
IUUC-Gac-042211	Gasterosteus aculeatus	91.34	0.00e+00	1161.00
IUUC-Ggo-045001	Gorilla gorilla	84.46	0.00e+00	1371.00
IUUC-Hsa-046544	Homo sapiens	85.02	0.00e+00	1563.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	84.69	0.00e+00	1511.00
IUUC-Lch-050398	Latimeria chalumnae	92.21	0.00e+00	1160.00
IUUC-Loc-052116	Lepisosteus oculatus	93.21	0.00e+00	1173.00
IUUC-Laf-053551	Loxodonta africana	84.48	0.00e+00	1531.00
IUUC-Meu-056455	Macropus eugenii	75.29	0.00e+00	916.00
IUUC-Mga-059986	Meleagris gallopavo	83.12	0.00e+00	1529.00
IUUC-Mmr-060945	Microcebus murinus	83.19	0.00e+00	1508.00
IUUC-Mdo-063024	Monodelphis domestica	91.90	0.00e+00	1630.00
IUUC-Mmu-063202	Mus musculus	83.60	0.00e+00	1487.00
IUUC-Mpu-065773	Mustela putorius furo	85.91	0.00e+00	1548.00
IUUC-Mlu-067373	Myotis lucifugus	68.42	0.00e+00	768.00
IUUC-Nle-069188	Nomascus leucogenys	85.45	0.00e+00	1568.00
IUUC-Opr-070965	Ochotona princeps	82.00	0.00e+00	1465.00
IUUC-Ont-072226	Oreochromis niloticus	90.53	0.00e+00	1170.00
IUUC-Oan-073497	Ornithorhynchus anatinus	88.27	0.00e+00	1571.00
IUUC-Ocu-073891	Oryctolagus cuniculus	81.90	0.00e+00	1449.00
IUUC-Ola-087438	Oryzias latipes	89.16	0.00e+00	1159.00
IUUC-Oga-087922	Otolemur garnettii	85.16	0.00e+00	1536.00
IUUC-Oar-089317	Ovis aries	84.19	0.00e+00	1504.00
IUUC-Ptr-090484	Pan troglodytes	85.02	0.00e+00	1562.00
IUUC-Pan-092117	Papio anubis	85.13	0.00e+00	1565.00
IUUC-Psi-093338	Pelodiscus sinensis	84.33	0.00e+00	1535.00
IUUC-Pma-094279	Petromyzon marinus	72.81	0.00e+00	833.00
IUUC-Pfo-096171	Poecilia formosa	90.71	0.00e+00	1165.00
IUUC-Pab-098654	Pongo abelii	84.62	0.00e+00	1149.00
IUUC-Pva-102811	Pteropus vampyrus	75.75	0.00e+00	1333.00
IUUC-Rno-106125	Rattus norvegicus	83.60	0.00e+00	1501.00
IUUC-Ssc-115368	Sus scrofa	84.73	0.00e+00	1521.00
IUUC-Tgu-117079	Taeniopygia guttata	82.92	0.00e+00	1515.00
IUUC-Tru-118062	Takifugu rubripes	73.02	0.00e+00	1350.00
IUUC-Tsy-119507	Tarsius syrichta	79.74	0.00e+00	1434.00
IUUC-Tni-120151	Tetraodon nigroviridis	90.65	0.00e+00	1156.00
IUUC-Ttr-129260	Tursiops truncatus	76.08	0.00e+00	1307.00
IUUC-Xtr-132877	Xenopus tropicalis	69.27	0.00e+00	1198.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence