iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tru-118062

UUCD1 version

UUC-TaR-00119

Ensembl Protein ID

ENSTRUP00000005720.1

UniProt Accession

H2RZZ9; H2RZZ9_TAKRU

Protein Name

E3 ubiquitin-protein ligase

Gene Name

wwp1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000002473.1	ENSTRUT00000005753.1	ENSTRUP00000005718.1
ENSTRUG00000002473.1	ENSTRUT00000005754.1	ENSTRUP00000005719.1
ENSTRUG00000002473.1	ENSTRUT00000005755.1	ENSTRUP00000005720.1
ENSTRUG00000002473.1	ENSTRUT00000005756.1	ENSTRUP00000005721.1
ENSTRUG00000002473.1	ENSTRUT00000005757.1	ENSTRUP00000005722.1
ENSTRUG00000002473.1	ENSTRUT00000005758.1	ENSTRUP00000005723.1
ENSTRUG00000002473.1	ENSTRUT00000005759.1	ENSTRUP00000005724.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-133	446.5	591	923

Active Site

Position(s)	Description	Evidence
892	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl+v f+gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl++F f+Gr++++al++++++d+
   Q: 591  PYDLRRRLYVIFRGEEGLDYGGLAREWFFLLSHEVLNPMYCLFEYAGKSNYCLQINPASTI-NPDHLSYFCFIGRFIAMALFHSKFIDT 678
           6799*******************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            +s +fyk++l+kkl l+dle++dpe+y+sl +i++n   +iee+gl++ fsv+ eilg++++++Lkp+G+n+ Vt+eNkeeY++l++e
   Q: 679  GFSLPFYKRMLNKKLILKDLESIDPEFYNSLIWIRDN---NIEECGLEMYFSVDMEILGKITSHDLKPDGANVLVTEENKEEYISLMAE 764
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +g++ q++af +Gfnev+pl++l++F+e+ele+++cG++e+d++d++++t y++ yt++s++i+wFw+ ++e+++e r +++qFv
   Q: 765  WRFSRGVEGQTKAFLDGFNEVVPLQWLQYFDEKELEVMLCGMQEVDLQDWQRNTVYRH-YTRNSKQIIWFWQLVKEVDNEVRLRLMQFV 852
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlPlgGfael+    p++f+i+k ++d++lP+s+TCfn+L+LP+Y+s e+lkekLl+Aieet+gF++
   Q: 853  TGTCRLPLGGFAELMgsngPQKFCIEKVGKDTWLPRSHTCFNRLDLPPYKSFEQLKEKLLFAIEETEGFGQ 923
           *********************************************************************96 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MATASPRAES GQNHRGTSQL HAVVSCAKIK RKKSLFGTAV YVEVTAEGES RRTAKSHSSS 60
SPKWEERLTL NVTCHTQLDF KVWSHHTLKA DALLGKASLD LARVLEQHER KLENVKEVLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTGTCTGCTC CTGCAGCCTC CGTCCAGCTA CAACCAGCTG TAGTTTCAGG TCAGTCTGGG 60
GGAGTTCCTC ACGATGAACA CCACCCTTGA AGAACAGCCC CCCCCCCCAC TGCTAATAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001213	Ailuropoda melanoleuca	71.81	0.00e+00	1328.00
IUUC-Apl-003310	Anas platyrhynchos	72.87	0.00e+00	1357.00
IUUC-Aca-005388	Anolis carolinensis	70.90	0.00e+00	1301.00
IUUC-Bta-012857	Bos taurus	72.41	0.00e+00	1313.00
IUUC-Cel-018299	Caenorhabditis elegans	67.24	0.00e+00	840.00
IUUC-Cja-019448	Callithrix jacchus	71.37	0.00e+00	1341.00
IUUC-Cfa-020728	Canis familiaris	71.78	0.00e+00	1338.00
IUUC-Cpo-021635	Cavia porcellus	70.32	0.00e+00	1320.00
IUUC-Csa-023805	Chlorocebus sabaeus	90.20	0.00e+00	1128.00
IUUC-Cin-025212	Ciona intestinalis	73.23	0.00e+00	912.00
IUUC-Csv-026256	Ciona savignyi	72.66	0.00e+00	909.00
IUUC-Dre-028245	Danio rerio	95.92	0.00e+00	1209.00
IUUC-Dno-029618	Dasypus novemcinctus	71.65	0.00e+00	1334.00
IUUC-Dme-032041	Drosophila melanogaster	69.51	0.00e+00	902.00
IUUC-Ete-032779	Echinops telfairi	89.44	0.00e+00	1063.00
IUUC-Eca-033313	Equus caballus	71.23	0.00e+00	1321.00
IUUC-Eeu-035259	Erinaceus europaeus	64.55	0.00e+00	1163.00
IUUC-Fca-035420	Felis catus	71.56	0.00e+00	1338.00
IUUC-Fal-037335	Ficedula albicollis	71.75	0.00e+00	1352.00
IUUC-Gmo-039172	Gadus morhua	90.65	0.00e+00	1097.00
IUUC-Gga-040246	Gallus gallus	72.81	0.00e+00	1345.00
IUUC-Gac-042211	Gasterosteus aculeatus	98.11	0.00e+00	1233.00
IUUC-Ggo-045001	Gorilla gorilla	71.87	0.00e+00	1192.00
IUUC-Hsa-046544	Homo sapiens	71.01	0.00e+00	1334.00
IUUC-Itr-048860	Ictidomys tridecemlineatus	71.86	0.00e+00	1306.00
IUUC-Lch-050398	Latimeria chalumnae	93.16	0.00e+00	1174.00
IUUC-Loc-052116	Lepisosteus oculatus	95.95	0.00e+00	1216.00
IUUC-Laf-053551	Loxodonta africana	91.84	0.00e+00	1140.00
IUUC-Mga-059986	Meleagris gallopavo	72.58	0.00e+00	1348.00
IUUC-Mmr-060945	Microcebus murinus	68.49	0.00e+00	1270.00
IUUC-Mdo-063024	Monodelphis domestica	70.97	0.00e+00	1283.00
IUUC-Mmu-063202	Mus musculus	71.64	0.00e+00	1320.00
IUUC-Mpu-065773	Mustela putorius furo	71.87	0.00e+00	1333.00
IUUC-Nle-069188	Nomascus leucogenys	71.22	0.00e+00	1342.00
IUUC-Opr-070965	Ochotona princeps	90.34	0.00e+00	1120.00
IUUC-Ont-072226	Oreochromis niloticus	81.29	0.00e+00	1550.00
IUUC-Oan-073497	Ornithorhynchus anatinus	72.52	0.00e+00	1343.00
IUUC-Ocu-073891	Oryctolagus cuniculus	67.93	0.00e+00	1221.00
IUUC-Ola-087438	Oryzias latipes	96.60	0.00e+00	1229.00
IUUC-Oga-087922	Otolemur garnettii	71.88	0.00e+00	1336.00
IUUC-Oar-089317	Ovis aries	92.02	0.00e+00	1134.00
IUUC-Ptr-090484	Pan troglodytes	70.90	0.00e+00	1333.00
IUUC-Pan-092117	Papio anubis	70.80	0.00e+00	1333.00
IUUC-Psi-093338	Pelodiscus sinensis	73.31	0.00e+00	1368.00
IUUC-Pma-094279	Petromyzon marinus	70.83	0.00e+00	837.00
IUUC-Pfo-096171	Poecilia formosa	97.45	0.00e+00	1239.00
IUUC-Pab-098654	Pongo abelii	87.83	0.00e+00	1093.00
IUUC-Pva-102811	Pteropus vampyrus	68.05	0.00e+00	1213.00
IUUC-Rno-106125	Rattus norvegicus	71.99	0.00e+00	1315.00
IUUC-Sha-107243	Sarcophilus harrisii	73.12	0.00e+00	1342.00
IUUC-Ssc-115368	Sus scrofa	71.76	0.00e+00	1315.00
IUUC-Tgu-117079	Taeniopygia guttata	71.74	0.00e+00	1345.00
IUUC-Tsy-119507	Tarsius syrichta	66.88	0.00e+00	1219.00
IUUC-Tni-120151	Tetraodon nigroviridis	99.66	0.00e+00	1252.00
IUUC-Ttr-129260	Tursiops truncatus	62.33	0.00e+00	1072.00
IUUC-Xtr-132877	Xenopus tropicalis	64.09	0.00e+00	1134.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence