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Tag Content
UUCD2 ID IUUC-Cfa-020607
UUCD1 version UUC-CaF-00985
Ensembl Protein ID ENSCAFP00000025021.3
UniProt Accession E2QZQ0; E2QZQ0_CANLF
Genbank Protein ID ENSCAFP00000025021
Protein Name Ubiquitinyl hydrolase 1
Genbank Nucleotide ID AAEX03016201
Gene Name USP3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCAFG00000016993.3 ENSCAFT00000026918.3 ENSCAFP00000025021.3
Status Unreviewed
Classification
Family E-Value Score Start End
DUB/USP 2.70e-100 336.2 159 510
UBD/ZnF/ZnF_UBP 2.30e-27 95.3 27 104
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   DUB/USP
   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalk 78
           tGl+NlgNtC+mN++LQ+Lsni+++ ++++e             +++ + +++ +++ +l+++++k + +lw+++++a+sp++l+ +++
   Q: 159  TGLRNLGNTCFMNAILQSLSNIEQFCCYFKElpavelrngktAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVW 247
           7******************************888888777765555555555688889******************************* PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           k+ ++f+gy+qqDa+Ef+++lld+l+ el+   n    ++  +++s+ls  +++   +  +++++ +F+g l++++ cl c+++s +++
   Q: 248  KIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSAILQENSTLS-ASNKCCINGASTVVTAIFGGILQNEVNCLICGTESRKFD 335
           *****************************77444444444444444444.45688899999**************************** PP
   S: 168  pfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           pfldlsl++p++  +k +         sl+dcL+sft  eel++ + y c kckkkq+++kk++++klP+vL+lhLkRf+++   + r+
   Q: 336  PFLDLSLDIPSQFRNKRSknqengpvcSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTA--YLRN 422
           **********66655444667899999****************************************************7755..799* PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           k++++vefpl+ Ld++ ++ +pe++  e++ Y+L avvvH+G +++sGHY+ay+ + +g+W++f+Ds+Vt ++e++v++   ++aY+lf
   Q: 423  KVDTYVEFPLRgLDMKCYLLEPENSGPEHCLYDLAAVVVHHGsGVGSGHYTAYATH-EGRWFHFNDSTVTLTDEDTVVK---AKAYILF 507
           ********************************************************.9*********************...******* PP
   S: 335  Ykr 337
           Y +
   Q: 508  YVE 510
           *76 PP
   

   UBD/ZnF/ZnF_UBP
   S: 1    kkcsvcdktenlWlcLtcgsvgCGRyvegHalkHyeetqhpl................vlslstlsvycYacddyvhr 62
           ++csvc++++++W+cLtc+sv+CGRyv+gHa+kHye++q+pl                ++++s++s+ycY+cdd+v++
   Q: 27   WCCSVCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQVPLtnhkksekqdkpqhtvCMDCSSYSTYCYRCDDFVVN 104
           9***************************************************************************85 PP
   
Organism Canis familiaris
Protein Sequence
(Fasta)
MECPHLSSSV CIAPDSAKFP NGSPSSWCCS VCRSNKSPWV CLTCSSVHCG RYVNGHAKKH 60
YEDAQVPLTN HKKSEKQDKP QHTVCMDCSS YSTYCYRCDD FVVNDTKLGL VQKVREHLQN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cfa-020607|DUB,USP;UBD,ZnF_UBP|Canis familiaris
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTGGGACCTC GCGCTCAGCA AACCCAAGTT ACAACTGTTT CACTTGGACC TCCACTGGTG 60
AGTGAGGTCT GAAAGTCCAA CCACGTGCTC CAGGTAACGC AGATGGTGAG TCACAGAGTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cfa-020607|DUB,USP;UBD,ZnF_UBP|Canis familiaris
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP
PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP
Pfam

PF00443--UCH
PF02148--zf-UBP
SMART

SM00290--ZnF_UBP
Gene Ontology

GO:0070938--C:contractile ring
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016578--P:histone deubiquitination
GO:0000278--P:mitotic cell cycle
GO:0031647--P:regulation of protein stability
GO:0006511--P:ubiquitin-dependent protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001537 Ailuropoda melanoleuca 99.42 0.00e+00 969.00
IUUC-Apl-003358 Anas platyrhynchos 95.71 0.00e+00 898.00
IUUC-Aca-004454 Anolis carolinensis 91.99 0.00e+00 825.00
IUUC-Ame-011544 Astyanax mexicanus 76.98 0.00e+00 738.00
IUUC-Bta-012738 Bos taurus 97.89 0.00e+00 937.00
IUUC-Cel-018186 Caenorhabditis elegans 37.08 3.00e-55 209.00
IUUC-Cja-018893 Callithrix jacchus 98.08 0.00e+00 949.00
IUUC-Cpo-021828 Cavia porcellus 96.15 0.00e+00 921.00
IUUC-Csa-023884 Chlorocebus sabaeus 98.82 0.00e+00 779.00
IUUC-Cho-024863 Choloepus hoffmanni 88.65 0.00e+00 817.00
IUUC-Dre-028452 Danio rerio 73.66 0.00e+00 748.00
IUUC-Dno-029531 Dasypus novemcinctus 97.35 0.00e+00 871.00
IUUC-Dor-030913 Dipodomys ordii 88.92 8.00e-177 613.00
IUUC-Ete-032611 Echinops telfairi 91.92 0.00e+00 879.00
IUUC-Eca-033622 Equus caballus 98.98 0.00e+00 882.00
IUUC-Eeu-035268 Erinaceus europaeus 92.84 0.00e+00 800.00
IUUC-Fca-035801 Felis catus 98.57 0.00e+00 913.00
IUUC-Fal-036749 Ficedula albicollis 94.70 0.00e+00 850.00
IUUC-Gmo-039598 Gadus morhua 76.91 0.00e+00 768.00
IUUC-Gga-040883 Gallus gallus 95.92 0.00e+00 863.00
IUUC-Gac-042235 Gasterosteus aculeatus 76.20 0.00e+00 745.00
IUUC-Ggo-044767 Gorilla gorilla 92.67 0.00e+00 838.00
IUUC-Hsa-046581 Homo sapiens 98.46 0.00e+00 975.00
IUUC-Itr-047898 Ictidomys tridecemlineatus 98.46 0.00e+00 942.00
IUUC-Lch-049732 Latimeria chalumnae 91.35 0.00e+00 918.00
IUUC-Loc-052371 Lepisosteus oculatus 89.81 0.00e+00 908.00
IUUC-Laf-054565 Loxodonta africana 98.27 0.00e+00 939.00
IUUC-Mcc-055522 Macaca mulatta 98.65 0.00e+00 979.00
IUUC-Meu-056754 Macropus eugenii 86.03 4.00e-177 614.00
IUUC-Mga-060095 Meleagris gallopavo 94.66 0.00e+00 638.00
IUUC-Mmr-060839 Microcebus murinus 98.46 0.00e+00 940.00
IUUC-Mdo-062339 Monodelphis domestica 97.47 0.00e+00 758.00
IUUC-Mmu-063638 Mus musculus 96.35 0.00e+00 905.00
IUUC-Mpu-066647 Mustela putorius furo 99.77 0.00e+00 773.00
IUUC-Mlu-067921 Myotis lucifugus 97.35 0.00e+00 893.00
IUUC-Nle-069752 Nomascus leucogenys 98.65 0.00e+00 978.00
IUUC-Opr-070636 Ochotona princeps 82.88 0.00e+00 729.00
IUUC-Ont-071638 Oreochromis niloticus 77.05 0.00e+00 701.00
IUUC-Oan-073417 Ornithorhynchus anatinus 90.38 0.00e+00 890.00
IUUC-Ocu-074620 Oryctolagus cuniculus 96.54 0.00e+00 925.00
IUUC-Ola-087281 Oryzias latipes 79.03 0.00e+00 630.00
IUUC-Olu-087697 Ostreococcus lucimarinus 40.00 2.00e-48 186.00
IUUC-Oga-088448 Otolemur garnettii 97.88 0.00e+00 969.00
IUUC-Oar-090132 Ovis aries 97.69 0.00e+00 939.00
IUUC-Ptr-090696 Pan troglodytes 98.37 0.00e+00 914.00
IUUC-Pan-092124 Papio anubis 98.27 0.00e+00 974.00
IUUC-Psi-093801 Pelodiscus sinensis 96.55 0.00e+00 751.00
IUUC-Pma-094472 Petromyzon marinus 72.81 8.00e-96 342.00
IUUC-Pfo-096330 Poecilia formosa 78.50 0.00e+00 782.00
IUUC-Pab-098191 Pongo abelii 98.85 0.00e+00 979.00
IUUC-Pca-100341 Procavia capensis 96.63 0.00e+00 727.00
IUUC-Pva-103177 Pteropus vampyrus 98.65 0.00e+00 932.00
IUUC-Rno-105048 Rattus norvegicus 95.40 0.00e+00 892.00
IUUC-Sha-107429 Sarcophilus harrisii 95.98 0.00e+00 868.00
IUUC-Sar-113024 Sorex araneus 96.38 0.00e+00 818.00
IUUC-Ssc-115749 Sus scrofa 96.80 6.00e-152 529.00
IUUC-Tgu-117277 Taeniopygia guttata 94.90 0.00e+00 887.00
IUUC-Tru-117844 Takifugu rubripes 78.89 0.00e+00 781.00
IUUC-Tsy-119456 Tarsius syrichta 95.71 0.00e+00 869.00
IUUC-Tni-120251 Tetraodon nigroviridis 74.71 0.00e+00 792.00
IUUC-Tbe-127423 Tupaia belangeri 91.92 0.00e+00 853.00
IUUC-Ttr-128401 Tursiops truncatus 91.41 0.00e+00 794.00
IUUC-Vpa-130549 Vicugna pacos 87.43 5.00e-163 566.00
IUUC-Xtr-131892 Xenopus tropicalis 83.18 0.00e+00 800.00
Created Date 25-Jun-2017

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