iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-050026

Ensembl Protein ID

ENSLACP00000016451.2

UniProt Accession

H3B3I0; H3B3I0_LATCH

Genbank Protein ID

ENSLACP00000016451

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AFYH01051028

Gene Name

SMURF2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000014496.2	ENSLACT00000016565.2	ENSLACP00000016451.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.60e-130	434.9	421	753

Active Site

Position(s)	Description	Evidence
722	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+++f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 421  PKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 508
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e+vdp+l++sl +i+en   d++   ld tf+v+++ +ge+ ++eLkp+G++ipV +eNk+eYv+l+v+
   Q: 509  GFTLPFYKQLLGKPITLDDMESVDPDLHNSLVWILEN---DTTGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVSEENKKEYVRLYVN 593
           ***********************************99...88887.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfnevip++ll+ F+e+elel+icG  +idv+d+k++t+ k+ +t+ds+ ++wFw+++e f++e r+++LqFv
   Q: 594  WRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGQIDVNDWKANTRLKH-CTPDSNIVKWFWKAVEFFDEERRARLLQFV 681
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ das+++lP+++TCfn++++P+Y+++e+l+ekLl+Aieet gF +
   Q: 682  TGSSRVPLQGFKALQgaagPRLFTIHQiDASPNNLPKAHTCFNRIDIPPYENYEKLYEKLLTAIEETCGFAV 753
           **********************************************************************76 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MSNQGVRRNG PVKLRLTVLC AKNLVKKDFF RLPDPFAKVV VDGSGQCHST DTVKNTLDPK 60
WNQHYDLYIG KSDSITISVW NHKKIHKKQG AGFLGCVRLL SNAINRLKDT GYQRLDLCKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTCCAACC AAGGAGTGCG GAGGAATGGG CCCGTAAAGC TGCGACTGAC AGGTAAAAAC 60
AAAAAAACAA CAAAAAAGGA GGGTTTTAAA GGGAAATGTG CGGCCGGTAT CCCATGTGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

KEGG

lcm:102353199

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001305	Ailuropoda melanoleuca	95.28	0.00e+00	1451.00
IUUC-Apl-003513	Anas platyrhynchos	96.21	0.00e+00	1469.00
IUUC-Aca-005358	Anolis carolinensis	96.68	0.00e+00	1494.00
IUUC-Ame-011320	Astyanax mexicanus	88.38	0.00e+00	1403.00
IUUC-Bta-013399	Bos taurus	95.66	0.00e+00	1451.00
IUUC-Cja-019355	Callithrix jacchus	95.42	0.00e+00	1451.00
IUUC-Cfa-020568	Canis familiaris	71.50	0.00e+00	1107.00
IUUC-Cpo-022200	Cavia porcellus	95.67	0.00e+00	1454.00
IUUC-Csa-024145	Chlorocebus sabaeus	74.48	0.00e+00	1152.00
IUUC-Cho-024804	Choloepus hoffmanni	96.76	0.00e+00	632.00
IUUC-Cin-025126	Ciona intestinalis	65.27	0.00e+00	976.00
IUUC-Csv-026339	Ciona savignyi	64.54	0.00e+00	1006.00
IUUC-Dre-027650	Danio rerio	90.72	0.00e+00	1448.00
IUUC-Dno-029534	Dasypus novemcinctus	95.49	0.00e+00	1476.00
IUUC-Dme-031740	Drosophila melanogaster	71.65	2.00e-172	599.00
IUUC-Ete-032715	Echinops telfairi	90.76	0.00e+00	1358.00
IUUC-Eca-033580	Equus caballus	95.67	0.00e+00	1453.00
IUUC-Eeu-034945	Erinaceus europaeus	94.03	0.00e+00	1348.00
IUUC-Fca-035905	Felis catus	73.94	0.00e+00	1119.00
IUUC-Fal-037275	Ficedula albicollis	96.37	0.00e+00	1461.00
IUUC-Gmo-039234	Gadus morhua	86.47	0.00e+00	760.00
IUUC-Gga-041060	Gallus gallus	93.50	0.00e+00	1426.00
IUUC-Gac-041295	Gasterosteus aculeatus	92.11	0.00e+00	1417.00
IUUC-Ggo-045408	Gorilla gorilla	67.39	0.00e+00	1016.00
IUUC-Hsa-046726	Homo sapiens	95.62	0.00e+00	1477.00
IUUC-Itr-048317	Ictidomys tridecemlineatus	72.24	0.00e+00	1112.00
IUUC-Loc-051760	Lepisosteus oculatus	88.52	0.00e+00	1395.00
IUUC-Laf-053753	Loxodonta africana	95.53	0.00e+00	1451.00
IUUC-Mcc-054815	Macaca mulatta	95.36	0.00e+00	1472.00
IUUC-Meu-056436	Macropus eugenii	73.61	0.00e+00	1070.00
IUUC-Mpo-057442	Magnaporthe poae	38.02	6.00e-146	511.00
IUUC-Mga-059723	Meleagris gallopavo	74.45	0.00e+00	1150.00
IUUC-Mmr-060806	Microcebus murinus	95.40	0.00e+00	1451.00
IUUC-Mdo-062805	Monodelphis domestica	94.30	0.00e+00	1459.00
IUUC-Mmu-064034	Mus musculus	95.09	0.00e+00	1470.00
IUUC-Mpu-066762	Mustela putorius furo	95.28	0.00e+00	1450.00
IUUC-Mlu-066981	Myotis lucifugus	95.53	0.00e+00	1449.00
IUUC-Nle-069804	Nomascus leucogenys	95.73	0.00e+00	1470.00
IUUC-Opr-070591	Ochotona princeps	90.08	0.00e+00	1348.00
IUUC-Ont-072243	Oreochromis niloticus	89.18	0.00e+00	1431.00
IUUC-Oan-072699	Ornithorhynchus anatinus	92.34	0.00e+00	1473.00
IUUC-Ocu-074913	Oryctolagus cuniculus	95.49	0.00e+00	1476.00
IUUC-Ola-086597	Oryzias latipes	85.70	0.00e+00	1298.00
IUUC-Oga-089116	Otolemur garnettii	92.28	0.00e+00	1392.00
IUUC-Oar-089366	Ovis aries	95.40	0.00e+00	1452.00
IUUC-Ptr-091382	Pan troglodytes	95.62	0.00e+00	1477.00
IUUC-Pan-092479	Papio anubis	71.89	0.00e+00	1113.00
IUUC-Psi-093298	Pelodiscus sinensis	96.75	0.00e+00	1447.00
IUUC-Pma-094354	Petromyzon marinus	73.13	0.00e+00	1134.00
IUUC-Pfo-096071	Poecilia formosa	90.53	0.00e+00	1441.00
IUUC-Pab-098682	Pongo abelii	95.62	0.00e+00	1476.00
IUUC-Pca-100516	Procavia capensis	87.50	4.00e-179	621.00
IUUC-Pva-102754	Pteropus vampyrus	94.43	0.00e+00	1413.00
IUUC-Rno-105600	Rattus norvegicus	95.02	0.00e+00	1246.00
IUUC-Sha-107144	Sarcophilus harrisii	94.32	0.00e+00	1324.00
IUUC-Sar-113122	Sorex araneus	84.38	0.00e+00	1234.00
IUUC-Ssc-116413	Sus scrofa	73.99	0.00e+00	1101.00
IUUC-Tgu-117112	Taeniopygia guttata	96.55	0.00e+00	1489.00
IUUC-Tru-118497	Takifugu rubripes	90.26	0.00e+00	1383.00
IUUC-Tsy-119455	Tarsius syrichta	69.53	0.00e+00	1035.00
IUUC-Tni-120781	Tetraodon nigroviridis	90.54	0.00e+00	1190.00
IUUC-Tme-126897	Tuber melanosporum	39.15	6.00e-152	531.00
IUUC-Tbe-127371	Tupaia belangeri	85.78	0.00e+00	1184.00
IUUC-Ttr-129305	Tursiops truncatus	88.90	0.00e+00	1250.00
IUUC-Vpa-130591	Vicugna pacos	85.46	0.00e+00	1255.00
IUUC-Xtr-132979	Xenopus tropicalis	77.41	0.00e+00	1106.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence