iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000005352.3	ENSMMUT00000007534.3	ENSMMUP00000007079.3
ENSMMUG00000005352.3	ENSMMUT00000058555.1	ENSMMUP00000053050.1
ENSMMUG00000005352.3	ENSMMUT00000063087.1	ENSMMUP00000055285.1
ENSMMUG00000005352.3	ENSMMUT00000071808.1	ENSMMUP00000043968.1
ENSMMUG00000005352.3	ENSMMUT00000065293.1	ENSMMUP00000047756.1
ENSMMUG00000005352.3	ENSMMUT00000070682.1	ENSMMUP00000053929.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.20e-79	269.0	123	421

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeq 89
           Gl+NlgNtC++N+++QcL+ +p+l+++ll+ ++ ++++     + + ++l+ +q+ + +   ++ +a++p ++++ lkk+a++f+  +q
   Q: 123  GLHNLGNTCFLNATIQCLTYTPPLANYLLSkEHARSCH-----QGSFCMLCVMQNHIVQAFANSGNAIKPVSFIRDLKKIARHFRFGNQ 206
           9*****************************33333333.....456788899999999999**************************** PP
   S: 90   qDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpg 178
           +Da+Efl++ +d++++++                  l+  a+ + +++ ++l++++F+g l+s++kc  c++vs +++p ld+ l++++
   Q: 207  EDAHEFLRYTIDAMQKAC------------------LNGCAKLDRQTQATTLVHQIFGGYLRSRVKCSMCKSVSDTYDPYLDVALEIRQ 277
           ******************..................344556788999***************************************** PP
   S: 179  keetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts 267
                  ++  +Le f+k++ l gen+y c kckkk+ a+k++++++ ++vL+l LkRf    ++ s  ki+k v +p+ L+++p++++
   Q: 278  AA-----NIVRALELFVKADVLSGENAYMCAKCKKKVPASKRFTIHRTSNVLTLSLKRF----ANFSGGKITKDVGYPEFLNIRPYMSQ 357
           **.....9***************************************************....668899******************** PP
   S: 268  peekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYk 336
           ++ +   ++ Y L+av+vHsG s++ GHY++yvk ++g+W++++Ds V++++ + vl+   ++aYvlfY 
   Q: 358  NNGD---PVMYGLYAVLVHSGySCHAGHYYCYVKASNGQWYQMNDSLVHSSNVKVVLN---QQAYVLFYL 421
           6654...9**************************************************...********6 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MPIVDKLKEA LKPGRKDSAD DGELGKLLAS SAKKVLLQKI EFEPASKSFS YQLESLKSKY 60
VLLNPKTEGA SRRKSGDDPP ARRQGSEHTY ESCGDGVPAP QKVLFPMERL SLRWERVFRV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTAGTTTATG CCCATCCTGT GCTTCTCTGA GTTTCTGAGG TCAGGCCAGA AACCAACACT 60
CTCTCCACCT GCCCAGGGGA ATGGGGAGGA AGCCAGCGAA GTTGCCTCAG ATCAAGCGGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0016607--C:nuclear speck
GO:0005730--C:nucleolus
GO:0003723--F:RNA binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1903955--P:positive regulation of protein targeting to mitochondrion
GO:0016579--P:protein deubiquitination
GO:1903146--P:regulation of mitophagy
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000401	Aegilops tauschii	39.20	2.00e-69	257.00
IUUC-Aml-002092	Ailuropoda melanoleuca	73.80	0.00e+00	1357.00
IUUC-Atr-003102	Amborella trichopoda	46.41	3.00e-84	306.00
IUUC-Aca-005360	Anolis carolinensis	79.56	0.00e+00	870.00
IUUC-Aly-006389	Arabidopsis lyrata	37.38	8.00e-77	281.00
IUUC-Ath-006710	Arabidopsis thaliana	38.48	7.00e-77	282.00
IUUC-Ago-007836	Ashbya gossypii	27.22	2.00e-30	127.00
IUUC-Ame-011358	Astyanax mexicanus	68.41	1.00e-157	551.00
IUUC-Bta-013047	Bos taurus	72.04	0.00e+00	1291.00
IUUC-Bdi-014036	Brachypodium distachyon	44.62	9.00e-84	305.00
IUUC-Bol-015996	Brassica oleracea	43.95	4.00e-81	296.00
IUUC-Bra-016634	Brassica rapa	44.27	3.00e-82	300.00
IUUC-Cja-019203	Callithrix jacchus	88.53	0.00e+00	1683.00
IUUC-Cfa-020586	Canis familiaris	73.71	0.00e+00	1334.00
IUUC-Cpo-021804	Cavia porcellus	70.42	0.00e+00	1277.00
IUUC-Cre-022988	Chlamydomonas reinhardtii	47.98	2.00e-52	199.00
IUUC-Csa-023137	Chlorocebus sabaeus	98.58	0.00e+00	1957.00
IUUC-Cin-025230	Ciona intestinalis	53.03	3.00e-98	351.00
IUUC-Cne-027049	Cryptococcus neoformans	34.17	8.00e-39	155.00
IUUC-Cme-027339	Cyanidioschyzon merolae	37.77	2.00e-62	233.00
IUUC-Dre-028587	Danio rerio	73.76	0.00e+00	804.00
IUUC-Dno-029149	Dasypus novemcinctus	68.49	0.00e+00	1260.00
IUUC-Dor-030836	Dipodomys ordii	70.28	0.00e+00	1000.00
IUUC-Dme-032119	Drosophila melanogaster	34.17	2.00e-70	261.00
IUUC-Ete-032567	Echinops telfairi	70.54	0.00e+00	887.00
IUUC-Eca-033600	Equus caballus	76.25	0.00e+00	1405.00
IUUC-Eeu-035206	Erinaceus europaeus	58.84	3.00e-137	483.00
IUUC-Fca-036392	Felis catus	59.55	0.00e+00	642.00
IUUC-Fal-036852	Ficedula albicollis	67.66	2.00e-160	559.00
IUUC-Gmo-039033	Gadus morhua	71.63	0.00e+00	800.00
IUUC-Gga-040664	Gallus gallus	76.80	0.00e+00	765.00
IUUC-Gac-042176	Gasterosteus aculeatus	61.13	0.00e+00	796.00
IUUC-Gma-044075	Glycine max	48.21	9.00e-85	308.00
IUUC-Ggo-045437	Gorilla gorilla	95.28	0.00e+00	1851.00
IUUC-Hsa-046863	Homo sapiens	94.75	0.00e+00	1840.00
IUUC-Hvu-047620	Hordeum vulgare	39.88	6.00e-68	252.00
IUUC-Itr-048655	Ictidomys tridecemlineatus	72.76	0.00e+00	1335.00
IUUC-Lch-050120	Latimeria chalumnae	59.77	0.00e+00	748.00
IUUC-Lpe-051574	Leersia perrieri	35.56	4.00e-79	289.00
IUUC-Loc-052796	Lepisosteus oculatus	75.83	0.00e+00	778.00
IUUC-Laf-054243	Loxodonta africana	71.35	0.00e+00	1313.00
IUUC-Meu-056697	Macropus eugenii	68.18	0.00e+00	1265.00
IUUC-Mtr-058537	Medicago truncatula	40.49	4.00e-86	312.00
IUUC-Mla-059049	Melampsora laricipopulina	42.81	7.00e-60	225.00
IUUC-Mga-059359	Meleagris gallopavo	80.23	3.00e-160	558.00
IUUC-Mvi-060547	Microbotryum violaceum	44.62	3.00e-78	286.00
IUUC-Mmr-060966	Microcebus murinus	77.08	0.00e+00	1390.00
IUUC-Mdo-062733	Monodelphis domestica	64.98	0.00e+00	1203.00
IUUC-Mmu-064331	Mus musculus	70.72	0.00e+00	1323.00
IUUC-Mac-065039	Musa acuminata	40.35	9.00e-89	321.00
IUUC-Mpu-065759	Mustela putorius furo	72.65	0.00e+00	1264.00
IUUC-Mlu-067371	Myotis lucifugus	66.43	0.00e+00	1179.00
IUUC-Nle-070087	Nomascus leucogenys	94.12	0.00e+00	1815.00
IUUC-Opr-070729	Ochotona princeps	67.69	0.00e+00	1008.00
IUUC-Ont-071346	Oreochromis niloticus	75.67	0.00e+00	800.00
IUUC-Oan-072931	Ornithorhynchus anatinus	70.68	0.00e+00	865.00
IUUC-Ocu-074823	Oryctolagus cuniculus	65.49	0.00e+00	1114.00
IUUC-Oba-075866	Oryza barthii	44.13	2.00e-82	300.00
IUUC-Obr-076408	Oryza brachyantha	36.04	9.00e-83	301.00
IUUC-Ogl-077239	Oryza glaberrima	44.30	4.00e-83	303.00
IUUC-Ogu-078064	Oryza glumaepatula	44.30	3.00e-83	303.00
IUUC-Oin-079471	Oryza indica	44.94	3.00e-83	303.00
IUUC-Olo-080231	Oryza longistaminata	43.04	2.00e-75	277.00
IUUC-Ome-081746	Oryza meridionalis	44.24	2.00e-82	300.00
IUUC-Oni-082339	Oryza nivara	40.16	3.00e-83	303.00
IUUC-Opu-083194	Oryza punctata	40.05	1.00e-83	305.00
IUUC-Oru-085083	Oryza rufipogon	44.30	4.00e-83	303.00
IUUC-Osa-085395	Oryza sativa	44.94	3.00e-83	303.00
IUUC-Ola-087255	Oryzias latipes	71.71	0.00e+00	813.00
IUUC-Olu-087773	Ostreococcus lucimarinus	44.44	3.00e-71	261.00
IUUC-Oga-088818	Otolemur garnettii	78.62	0.00e+00	1259.00
IUUC-Oar-089410	Ovis aries	70.00	0.00e+00	1261.00
IUUC-Ptr-090680	Pan troglodytes	95.66	0.00e+00	1595.00
IUUC-Pan-092482	Papio anubis	98.75	0.00e+00	1950.00
IUUC-Pma-094651	Petromyzon marinus	37.50	7.00e-49	187.00
IUUC-Ppa-095853	Physcomitrella patens	47.13	2.00e-91	330.00
IUUC-Pfo-096807	Poecilia formosa	71.96	0.00e+00	817.00
IUUC-Pab-098724	Pongo abelii	95.37	0.00e+00	1890.00
IUUC-Pop-099693	Populus trichocarpa	41.35	1.00e-82	301.00
IUUC-Pca-100117	Procavia capensis	78.01	2.00e-155	543.00
IUUC-Ppe-101678	Prunus persica	40.15	1.00e-81	297.00
IUUC-Pva-102883	Pteropus vampyrus	62.57	0.00e+00	1008.00
IUUC-Pgr-103270	Puccinia graminis	46.25	9.00e-70	258.00
IUUC-Ptt-103887	Puccinia triticina	45.62	2.00e-69	257.00
IUUC-Rno-105340	Rattus norvegicus	73.22	0.00e+00	1113.00
IUUC-Sha-107019	Sarcophilus harrisii	66.32	0.00e+00	1225.00
IUUC-Sja-107805	Schizosaccharomyces japonicus	42.61	2.00e-76	279.00
IUUC-Spo-108119	Schizosaccharomyces pombe	41.52	6.00e-84	304.00
IUUC-Smo-108763	Selaginella moellendorffii	47.40	1.00e-79	289.00
IUUC-Sit-110536	Setaria italica	40.86	7.00e-79	289.00
IUUC-Sly-111722	Solanum lycopersicum	39.81	6.00e-80	292.00
IUUC-Stu-112912	Solanum tuberosum	39.66	3.00e-81	296.00
IUUC-Sbi-114477	Sorghum bicolor	44.62	9.00e-85	308.00
IUUC-Sre-114924	Sporisorium reilianum	40.65	2.00e-66	247.00
IUUC-Ssc-116022	Sus scrofa	84.17	0.00e+00	882.00
IUUC-Tgu-116976	Taeniopygia guttata	70.53	8.00e-160	556.00
IUUC-Tru-118391	Takifugu rubripes	63.33	0.00e+00	818.00
IUUC-Tsy-119253	Tarsius syrichta	66.74	0.00e+00	946.00
IUUC-Tni-120064	Tetraodon nigroviridis	76.92	0.00e+00	786.00
IUUC-Tca-120936	Theobroma cacao	37.97	8.00e-85	308.00
IUUC-Tae-125259	Triticum aestivum	47.00	8.00e-87	315.00
IUUC-Tur-126014	Triticum urartu	46.41	6.00e-83	302.00
IUUC-Tbe-127377	Tupaia belangeri	64.22	0.00e+00	825.00
IUUC-Ttr-129259	Tursiops truncatus	65.28	0.00e+00	1079.00
IUUC-Uma-129416	Ustilago maydis	43.20	1.00e-68	254.00
IUUC-Vpa-130568	Vicugna pacos	67.52	7.00e-45	176.00
IUUC-Vvi-131535	Vitis vinifera	45.63	1.00e-83	304.00
IUUC-Xtr-132944	Xenopus tropicalis	77.49	0.00e+00	679.00
IUUC-Xma-133735	Xiphophorus maculatus	74.40	0.00e+00	819.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence