iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Gga-041023

Ensembl Protein ID

ENSGALP00000046116.1

UniProt Accession

Q5ZMW5; Q98935; RHG26_CHICK

Genbank Protein ID

CAG30928.1; AAB07998.1

Protein Name

Rho GTPase-activating protein 26; GTPase regulator associated with focal adhesion kinase; Rho-type GTPase-activating protein 26

Genbank Nucleotide ID

AJ719269; U36309

Gene Name

ARHGAP26; GRAF

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000033938.2	ENSGALT00000070058.2	ENSGALP00000046116.1
ENSGALG00000033938.2	ENSGALT00000049656.1	ENSGALP00000058378.1
ENSGALG00000033938.2	ENSGALT00000065201.1	ENSGALP00000049807.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.70e-12	47.5	705	758

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           +k ++ly  +a++d eL++++G v + + + +q+ gWl+g  +l+gk Gl+Pen+ve
   Q: 705  RKARALYACKAEHDSELSFTAGTVFDNV-HPSQEPGWLEG--TLNGKTGLIPENYVE 758
           5789************************.***********..8*************8 PP

Organism

Gallus gallus

Functional Description
(View)

GTPase-activating protein for RHOA and CDC42.

Protein Sequence
(Fasta)

MGLPALEFSE CCLDSPQFRE RLRSHEAELE KTNKFIKELI KDGKSLIAAL KNLSSAKRKF 60
ADSLNEFKFR CIGDAETDDE ICIAKSLQEF ATVLRNLEDE RMRMIENASE VLITPLEKFR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCGGGGGA GGCGGCGCCG CGCCCGGCGC GAGCCCTGCC CGGGCGGCGG CCCCAGAGCG 60
GCGGCAGCAG CGCCCCCGGC GCTCCCGCAC GGCTCGGCAC GGCCCGGCCC GCTCTGGGGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0965--Cell junction
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0343--GTPase activation
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR027267--AH/BAR-dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR030061--RHG26
IPR008936--Rho_GTPase_activation_prot
IPR000198--RhoGAP_dom
IPR001452--SH3_domain

PROSITE

PS50003--PH_DOMAIN
PS50238--RHOGAP
PS50002--SH3

Pfam

PF00169--PH
PF00620--RhoGAP
PF14604--SH3_9

SMART

SM00233--PH
SM00324--RhoGAP
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005856--C:cytoskeleton
GO:0005925--C:focal adhesion
GO:0005096--F:GTPase activator activity
GO:0005543--F:phospholipid binding
GO:0030036--P:actin cytoskeleton organization
GO:0051056--P:regulation of small GTPase mediated signal transduction
GO:0007165--P:signal transduction

KEGG

gga:396113

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001613	Ailuropoda melanoleuca	93.92	0.00e+00	1158.00
IUUC-Apl-003321	Anas platyrhynchos	95.42	0.00e+00	1079.00
IUUC-Aca-004570	Anolis carolinensis	92.64	0.00e+00	1315.00
IUUC-Ame-011422	Astyanax mexicanus	76.14	0.00e+00	963.00
IUUC-Bta-013262	Bos taurus	93.75	0.00e+00	1062.00
IUUC-Cel-018542	Caenorhabditis elegans	43.74	2.00e-127	449.00
IUUC-Cja-019208	Callithrix jacchus	93.67	0.00e+00	1144.00
IUUC-Cfa-020928	Canis familiaris	92.76	0.00e+00	1261.00
IUUC-Cpo-021338	Cavia porcellus	90.41	0.00e+00	1142.00
IUUC-Csa-023570	Chlorocebus sabaeus	93.67	0.00e+00	1143.00
IUUC-Dno-029143	Dasypus novemcinctus	91.63	0.00e+00	1147.00
IUUC-Dor-030697	Dipodomys ordii	92.86	0.00e+00	1134.00
IUUC-Dme-032147	Drosophila melanogaster	43.62	2.00e-136	479.00
IUUC-Ete-032645	Echinops telfairi	84.66	0.00e+00	1004.00
IUUC-Eca-033791	Equus caballus	93.43	0.00e+00	1151.00
IUUC-Eeu-035202	Erinaceus europaeus	73.57	6.00e-120	424.00
IUUC-Fca-036131	Felis catus	93.93	0.00e+00	1127.00
IUUC-Fal-037129	Ficedula albicollis	96.45	0.00e+00	1311.00
IUUC-Ggo-044863	Gorilla gorilla	93.37	0.00e+00	1138.00
IUUC-Hsa-046471	Homo sapiens	93.83	0.00e+00	1145.00
IUUC-Itr-049060	Ictidomys tridecemlineatus	93.18	0.00e+00	1168.00
IUUC-Lch-050300	Latimeria chalumnae	81.67	0.00e+00	947.00
IUUC-Loc-052782	Lepisosteus oculatus	78.79	0.00e+00	1175.00
IUUC-Laf-053585	Loxodonta africana	93.28	0.00e+00	1129.00
IUUC-Mcc-055458	Macaca mulatta	93.68	0.00e+00	1146.00
IUUC-Meu-056107	Macropus eugenii	75.34	0.00e+00	921.00
IUUC-Mga-059914	Meleagris gallopavo	97.06	0.00e+00	1221.00
IUUC-Mmr-060728	Microcebus murinus	93.44	0.00e+00	1043.00
IUUC-Mdo-062387	Monodelphis domestica	91.32	0.00e+00	1181.00
IUUC-Mmu-063756	Mus musculus	92.21	0.00e+00	1132.00
IUUC-Nle-069043	Nomascus leucogenys	88.75	0.00e+00	844.00
IUUC-Opr-071168	Ochotona princeps	78.08	0.00e+00	925.00
IUUC-Ont-072338	Oreochromis niloticus	78.53	0.00e+00	905.00
IUUC-Oan-073441	Ornithorhynchus anatinus	91.93	0.00e+00	1059.00
IUUC-Ocu-073915	Oryctolagus cuniculus	90.45	0.00e+00	1164.00
IUUC-Ola-086319	Oryzias latipes	74.16	0.00e+00	944.00
IUUC-Oar-089349	Ovis aries	91.95	0.00e+00	1151.00
IUUC-Ptr-091027	Pan troglodytes	93.67	0.00e+00	1141.00
IUUC-Pan-092791	Papio anubis	93.67	0.00e+00	1144.00
IUUC-Psi-093144	Pelodiscus sinensis	95.13	0.00e+00	1367.00
IUUC-Pab-097783	Pongo abelii	93.51	0.00e+00	1142.00
IUUC-Pva-102980	Pteropus vampyrus	93.76	0.00e+00	1192.00
IUUC-Rno-105142	Rattus norvegicus	91.32	0.00e+00	1248.00
IUUC-Sha-107213	Sarcophilus harrisii	92.13	0.00e+00	1197.00
IUUC-Tru-117767	Takifugu rubripes	76.61	0.00e+00	999.00
IUUC-Tsy-119150	Tarsius syrichta	88.16	0.00e+00	1110.00
IUUC-Tni-119893	Tetraodon nigroviridis	74.96	0.00e+00	799.00
IUUC-Ttr-129028	Tursiops truncatus	79.70	0.00e+00	864.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence