iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-006732

UUCD1 version

UUC-ArT-01708

Ensembl Protein ID

AT2G32780.1

UniProt Accession

Q9FPT5; O48839; UBP1_ARATH

Genbank Protein ID

AAC04485.1; AEC08739.1; AAG42749.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 1; Deubiquitinating enzyme 1; Ubiquitin thioesterase 1; Ubiquitin-specific-processing protease 1

Genbank Nucleotide ID

AC003974; CP002685; AF302658

Gene Name

UBP1; At2g32780; F24L7.8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT2G32780	AT2G32780.1	AT2G32780.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
Protein-protein Interaction
HINT
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.50e-79	267.8	203	1082

Active Site

Position(s)	Description	Evidence
211	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
1029	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw...kskkkavsprellkalkkeaeefsgyeqqDaqE 94
           Gl NlgNtC++NSv+Q L+++ +lre +l+   e+l+       +g+l++sl++lf+e     +  ++ ++pr+l+ ++++ a++f+gy+q+D++E
   Q: 203  GLVNLGNTCFFNSVMQNLLSLDQLREHFLK---EDLS------VSGPLVSSLKELFAESNseaSVFRNEINPRDLFFSVCSQAPQFRGYQQHDSHE 289
           9*****************************...5554......4689************866677788**************************** PP
   S: 95   flaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke..... 185
           +l++lld+l+ e ++     ++++        sd ++++ + ++++li+ +F+g+++s++ clec++ s+ +epf+dlslpvp+ +   k+     
   Q: 290  LLRCLLDGLSIEESS----LRKKL------GVSD-SNDSSTYQKPTLIDSVFGGEISSTVSCLECGHFSKVYEPFMDLSLPVPSMKLPPKKqqils 374
           **********99922....22223......2333.4578889999**************************************9997766689999 PP
   S: 186  ................................................................................................ 185
                                                                                                           
   Q: 375  qakevlkngavskdsevvsakpasdhnstvplfpsdhkiqsrpetsdnetdlvllsdvsdtapsteakgvnqilvgstetlmhdndrtgktvpdke 470
           ************************************************************************************************ PP
   S: 186  ................................................................................................ 185
                                                                                                           
   Q: 471  dvratqsneetsasgisavideaqvcgcpdleqssssanqgadeelalmvadsqvlympykdhlfyddymvaeasssfvsgdhepkkdyfdfssfl 566
           ************************************************************************************************ PP
   S: 186  ................................................................................................ 185
                                                                                                           
   Q: 567  depeiregpvfrplsksevyeagfkadcsddktvsagkgeasssfissdheqnidyvdfssffdepeiserpffrplsksevseagfkadcsddkt 662
           ************************************************************************************************ PP
   S: 186  ................................................................................................ 185
                                                                                                           
   Q: 663  vsagkgeasssfvssdheqnidyvdfssffdepeiserpffrplsksevseagfmavsgndktvragkgetfssfmsgdnernidyveftnrifdd 758
           ************************************************************************************************ PP
   S: 186  .........................................slqdcLesftkeeelegenkyycekck............................ 212
                                                    s++ cL++ftk e l ++n+++ce+c                             
   Q: 759  rgtserpvfgppskakvseagfvavssdsdpavldesdspvSVDRCLAQFTKHEILSEDNAWHCENCSknlklqrlrekrrtkeglsnrwvnenga 854
           ************************************************************************************************ PP
   S: 213  ...............................................................................................k 213
                                                                                                           
   Q: 855  ssafdecrdsslnqscidlengykaappitklpnckeeesaiddgfvgeentkqapitsvtetpllggetissqpasdnecenwedlavdseeviV 950
           ************************************************************************999999999999999999999998 PP
   S: 214  kqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn........ 301
           k++a+kk+ ++k P+vL++hLkRfs + + ++ +k++ +v+f + +dls+++ +++++++ +  Y+L + v H G +s GHYv+y++         
   Q: 951  KRDARKKVLINKAPPVLTIHLKRFSQDAR-GRVSKLSGHVDFQEFIDLSKYMDTRCSEED-EPVYRLAGLVEHLGAMSRGHYVSYIRGghkerrds 1044
           899*********************87776.7888*********99*********998875.99*************************77766665 PP
   S: 302  ..ekgk.....WllfdDskVtevkeeevleetgstaYvlfYkr 337
             +  +     W++ +Ds+V++ + eevl+   s+aY+lfY+r
   Q: 1045 dtK--EpnssiWYHASDSQVRPASLEEVLR---SEAYILFYER 1082
           541..155678*******************...********98 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Is involved in resistance to the arginine analog canavanine (CAN).

Protein Sequence
(Fasta)

MRFAATVSEK QSEQSVEVTE EFAVTMTEKR SCVHFDKYVD LDKLLKIIKS YQQIKCGECN 60
ERVHVKRGSR WGASNRRDWY SSSDQNCARN AIWLCLECGY YVCGDVGLPT EAQSHVMGHN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGGTTTG CTGCAACGGT CTCCGAGAAG CAATCTGAGC AAAGCGTGGA AGTAACTGAG 60
GAGTTTGCTG TGACAATGAC AGAAAAAAGA TCTTGTGTCC ATTTTGATAA ATATGTTGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT2G32780

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001931	Ailuropoda melanoleuca	33.84	8.00e-34	138.00
IUUC-Apl-003512	Anas platyrhynchos	30.53	5.00e-35	142.00
IUUC-Aca-004284	Anolis carolinensis	29.92	3.00e-33	136.00
IUUC-Aly-006422	Arabidopsis lyrata	78.13	0.00e+00	1510.00
IUUC-Bta-013362	Bos taurus	34.55	3.00e-36	146.00
IUUC-Bol-015941	Brassica oleracea	45.93	7.00e-172	597.00
IUUC-Bra-016751	Brassica rapa	43.47	2.00e-140	493.00
IUUC-Cja-019177	Callithrix jacchus	31.36	2.00e-34	140.00
IUUC-Cfa-020051	Canis familiaris	34.35	5.00e-34	139.00
IUUC-Cpo-021886	Cavia porcellus	33.63	2.00e-36	147.00
IUUC-Csa-024103	Chlorocebus sabaeus	33.63	1.00e-34	140.00
IUUC-Csv-026075	Ciona savignyi	36.30	4.00e-22	99.00
IUUC-Dre-028106	Danio rerio	27.11	7.00e-31	128.00
IUUC-Dno-029409	Dasypus novemcinctus	32.15	1.00e-34	140.00
IUUC-Dor-030438	Dipodomys ordii	30.12	6.00e-25	108.00
IUUC-Ete-032736	Echinops telfairi	26.08	3.00e-23	103.00
IUUC-Eca-033479	Equus caballus	33.93	1.00e-34	141.00
IUUC-Fca-036320	Felis catus	34.15	2.00e-34	140.00
IUUC-Fal-037199	Ficedula albicollis	30.26	6.00e-35	142.00
IUUC-Gmo-039480	Gadus morhua	31.86	1.00e-31	130.00
IUUC-Gga-040527	Gallus gallus	30.86	2.00e-32	133.00
IUUC-Gac-042406	Gasterosteus aculeatus	30.91	1.00e-29	124.00
IUUC-Ggo-045598	Gorilla gorilla	33.03	1.00e-33	137.00
IUUC-Hsa-046598	Homo sapiens	33.03	1.00e-33	138.00
IUUC-Itr-047951	Ictidomys tridecemlineatus	32.83	1.00e-34	141.00
IUUC-Lch-050536	Latimeria chalumnae	30.40	1.00e-33	137.00
IUUC-Lpe-050703	Leersia perrieri	37.83	9.00e-48	185.00
IUUC-Loc-051814	Lepisosteus oculatus	30.25	1.00e-30	127.00
IUUC-Laf-053988	Loxodonta africana	33.02	4.00e-36	145.00
IUUC-Mcc-054661	Macaca mulatta	33.33	3.00e-34	139.00
IUUC-Meu-055967	Macropus eugenii	26.75	6.00e-25	108.00
IUUC-Mga-059551	Meleagris gallopavo	31.38	1.00e-33	137.00
IUUC-Mmr-061747	Microcebus murinus	33.74	2.00e-33	137.00
IUUC-Mdo-062220	Monodelphis domestica	30.08	5.00e-34	139.00
IUUC-Mmu-063582	Mus musculus	30.97	1.00e-33	137.00
IUUC-Mpu-066339	Mustela putorius furo	33.63	3.00e-34	139.00
IUUC-Mlu-067511	Myotis lucifugus	30.73	2.00e-34	140.00
IUUC-Nle-069252	Nomascus leucogenys	33.33	3.00e-34	139.00
IUUC-Opr-070969	Ochotona princeps	30.45	4.00e-32	132.00
IUUC-Ont-072121	Oreochromis niloticus	29.52	4.00e-28	119.00
IUUC-Ocu-074704	Oryctolagus cuniculus	33.63	6.00e-34	139.00
IUUC-Oba-075094	Oryza barthii	39.70	1.00e-50	194.00
IUUC-Obr-076743	Oryza brachyantha	38.95	4.00e-47	182.00
IUUC-Ogl-077739	Oryza glaberrima	39.70	5.00e-51	195.00
IUUC-Ogu-078851	Oryza glumaepatula	39.70	9.00e-51	195.00
IUUC-Oin-079402	Oryza indica	39.70	9.00e-51	195.00
IUUC-Olo-080431	Oryza longistaminata	39.70	8.00e-51	195.00
IUUC-Ome-081580	Oryza meridionalis	39.70	8.00e-51	195.00
IUUC-Oni-082644	Oryza nivara	39.70	9.00e-51	195.00
IUUC-Opu-083452	Oryza punctata	39.33	2.00e-50	193.00
IUUC-Oru-084546	Oryza rufipogon	39.70	1.00e-50	194.00
IUUC-Osa-085858	Oryza sativa	39.70	9.00e-51	194.00
IUUC-Ola-086795	Oryzias latipes	30.92	3.00e-31	129.00
IUUC-Oga-088713	Otolemur garnettii	33.03	6.00e-34	138.00
IUUC-Oar-089887	Ovis aries	33.84	6.00e-35	142.00
IUUC-Ptr-091670	Pan troglodytes	32.73	3.00e-33	136.00
IUUC-Pan-092293	Papio anubis	33.33	3.00e-34	139.00
IUUC-Psi-093101	Pelodiscus sinensis	32.05	5.00e-34	139.00
IUUC-Pfo-097202	Poecilia formosa	29.23	5.00e-31	129.00
IUUC-Pab-098539	Pongo abelii	28.97	5.00e-34	139.00
IUUC-Pca-100610	Procavia capensis	31.25	2.00e-26	114.00
IUUC-Rno-105237	Rattus norvegicus	30.10	5.00e-33	135.00
IUUC-Sha-107022	Sarcophilus harrisii	30.45	1.00e-33	137.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	32.90	2.00e-17	84.00
IUUC-Sar-113530	Sorex araneus	34.23	6.00e-35	142.00
IUUC-Sbi-113785	Sorghum bicolor	39.86	5.00e-43	169.00
IUUC-Ssc-116091	Sus scrofa	30.53	2.00e-34	140.00
IUUC-Tgu-116907	Taeniopygia guttata	30.71	2.00e-35	143.00
IUUC-Tru-118640	Takifugu rubripes	29.38	4.00e-35	142.00
IUUC-Tsy-118869	Tarsius syrichta	30.71	2.00e-27	117.00
IUUC-Tni-120015	Tetraodon nigroviridis	28.61	2.00e-30	127.00
IUUC-Tbe-128041	Tupaia belangeri	34.58	1.00e-26	114.00
IUUC-Ttr-128271	Tursiops truncatus	31.89	1.00e-35	144.00
IUUC-Vpa-130674	Vicugna pacos	33.64	2.00e-34	140.00
IUUC-Xtr-131869	Xenopus tropicalis	29.56	1.00e-34	141.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence