iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Cel-018711

Ensembl Protein ID

C01G5.8a

UniProt Accession

P90740; FAN1_CAEEL

Genbank Protein ID

CCD62449.1

Protein Name

Fanconi-associated nuclease 1 homolog

Genbank Nucleotide ID

FO080264

Gene Name

fan-1; C01G5.8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
WBGene00015310	C01G5.8a	C01G5.8a

Annotation

mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Protein Expression/Proteomics

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/ZnF/UBZ	29.94	2.00e-63	241.00	IUUC-Hsa-046520

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Caenorhabditis elegans

Functional Description
(View)

Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.

Protein Sequence
(Fasta)

MKKAKKEKKE KIIKPDGPIN FNRSIMAAFE KQSRGKICPL CETKFSLASY KSHMNTCNVA 60
DDDEEIEVIA TYTRDEAILM RAGPEIILGD ASFSDKSENP TKRRKTDERE VPSEDDIVPE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGAAAATTGT TTTCTATTTT TTAAAATCGT TTTATTTAAT TGTATTTTTC CTATATTAAC 60
GCGATGAAAA AGGCTAAAAA AGAGAAGAAA GAAAAGATTA TCAAACCGGA CGGCCCAATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0378--Hydrolase
KW-0460--Magnesium
KW-0464--Manganese
KW-0479--Metal-binding
KW-0540--Nuclease
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR033315--Fan1-like
IPR014883--VRR_NUC

Pfam

PF08774--VRR_NUC

SMART

SM00990--VRR_NUC

Gene Ontology

GO:0005634--C:nucleus
GO:0008409--F:5'-3' exonuclease activity
GO:0017108--F:5'-flap endonuclease activity
GO:0070336--F:flap-structured DNA binding
GO:0046872--F:metal ion binding
GO:0004528--F:phosphodiesterase I activity
GO:0006281--P:DNA repair
GO:0036297--P:interstrand cross-link repair

KEGG

cel:CELE_C01G5.8

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000306	Aegilops tauschii	27.25	2.00e-33	135.00
IUUC-Aml-001380	Ailuropoda melanoleuca	31.34	4.00e-68	251.00
IUUC-Atr-002873	Amborella trichopoda	24.48	6.00e-37	148.00
IUUC-Apl-003430	Anas platyrhynchos	29.97	1.00e-64	240.00
IUUC-Aca-005376	Anolis carolinensis	29.10	6.00e-68	251.00
IUUC-Aly-005463	Arabidopsis lyrata	25.49	9.00e-38	150.00
IUUC-Ath-007392	Arabidopsis thaliana	25.07	2.00e-39	156.00
IUUC-Acl-008285	Aspergillus clavatus	23.88	3.00e-27	115.00
IUUC-Afl-008680	Aspergillus flavus	24.93	7.00e-30	124.00
IUUC-Afu-008795	Aspergillus fumigatus	24.20	8.00e-23	101.00
IUUC-Ani-009329	Aspergillus nidulans	22.36	3.00e-21	95.90
IUUC-Ang-009526	Aspergillus niger	21.58	3.00e-14	72.40
IUUC-Aor-009880	Aspergillus oryzae	25.29	4.00e-30	125.00
IUUC-Ate-010269	Aspergillus terreus	24.03	2.00e-30	126.00
IUUC-Ame-011630	Astyanax mexicanus	29.88	5.00e-48	185.00
IUUC-Bgr-012168	Blumeria graminis	22.41	1.00e-06	47.40
IUUC-Bta-013504	Bos taurus	30.63	3.00e-63	235.00
IUUC-Bci-013838	Botrytis cinerea	23.37	3.00e-26	112.00
IUUC-Bdi-014522	Brachypodium distachyon	26.83	7.00e-35	141.00
IUUC-Bol-016153	Brassica oleracea	25.77	1.00e-37	150.00
IUUC-Bra-017548	Brassica rapa	24.45	6.00e-31	128.00
IUUC-Cja-018810	Callithrix jacchus	29.46	2.00e-55	209.00
IUUC-Cfa-020147	Canis familiaris	31.24	1.00e-67	250.00
IUUC-Cpo-021787	Cavia porcellus	30.27	6.00e-67	248.00
IUUC-Csa-023730	Chlorocebus sabaeus	30.44	6.00e-66	244.00
IUUC-Cho-024754	Choloepus hoffmanni	49.37	4.00e-19	89.00
IUUC-Cin-025459	Ciona intestinalis	39.13	7.00e-20	88.60
IUUC-Cgl-026724	Colletotrichum gloeosporioides	22.32	1.00e-15	77.00
IUUC-Cne-026815	Cryptococcus neoformans	34.13	4.00e-21	95.90
IUUC-Cme-027208	Cyanidioschyzon merolae	24.66	6.00e-16	78.20
IUUC-Dre-027725	Danio rerio	31.31	1.00e-74	273.00
IUUC-Dno-029713	Dasypus novemcinctus	30.16	3.00e-69	255.00
IUUC-Dse-031534	Dothistroma septosporum	23.41	1.00e-25	110.00
IUUC-Ete-033004	Echinops telfairi	27.27	3.00e-20	92.80
IUUC-Eca-034119	Equus caballus	31.08	2.00e-68	253.00
IUUC-Eeu-034618	Erinaceus europaeus	34.78	3.00e-46	179.00
IUUC-Fca-035411	Felis catus	30.48	3.00e-67	249.00
IUUC-Fal-037505	Ficedula albicollis	30.42	2.00e-66	246.00
IUUC-Fox-038070	Fusarium oxysporum	23.30	6.00e-27	114.00
IUUC-Fso-038376	Fusarium solani	23.13	7.00e-29	121.00
IUUC-Gmo-039093	Gadus morhua	31.52	1.00e-76	280.00
IUUC-Ggr-040081	Gaeumannomyces graminis	23.28	5.00e-26	112.00
IUUC-Gac-041973	Gasterosteus aculeatus	31.04	3.00e-73	268.00
IUUC-Gma-043421	Glycine max	27.90	4.00e-44	171.00
IUUC-Ggo-044431	Gorilla gorilla	30.11	8.00e-68	251.00
IUUC-Hsa-046520	Homo sapiens	29.94	6.00e-67	248.00
IUUC-Hvu-047632	Hordeum vulgare	25.97	6.00e-38	151.00
IUUC-Itr-048263	Ictidomys tridecemlineatus	30.60	9.00e-66	244.00
IUUC-Lch-049799	Latimeria chalumnae	32.78	1.00e-77	283.00
IUUC-Lpe-051149	Leersia perrieri	26.44	7.00e-43	167.00
IUUC-Loc-051964	Lepisosteus oculatus	30.51	3.00e-69	256.00
IUUC-Lma-053161	Leptosphaeria maculans	21.43	2.00e-27	116.00
IUUC-Laf-054446	Loxodonta africana	32.24	7.00e-73	267.00
IUUC-Mcc-055087	Macaca mulatta	30.51	4.00e-67	248.00
IUUC-Meu-055930	Macropus eugenii	29.55	1.00e-33	137.00
IUUC-Mor-056966	Magnaporthe oryzae	26.11	1.00e-27	117.00
IUUC-Mpo-057393	Magnaporthe poae	24.25	7.00e-26	110.00
IUUC-Mtr-058315	Medicago truncatula	26.66	2.00e-41	163.00
IUUC-Mla-058859	Melampsora laricipopulina	30.03	4.00e-20	92.40
IUUC-Mga-059870	Meleagris gallopavo	29.79	1.00e-58	220.00
IUUC-Mvi-060226	Microbotryum violaceum	25.82	9.00e-26	111.00
IUUC-Mmr-060892	Microcebus murinus	30.11	1.00e-66	246.00
IUUC-Mdo-062896	Monodelphis domestica	31.65	4.00e-68	251.00
IUUC-Mmu-064276	Mus musculus	31.13	2.00e-74	272.00
IUUC-Mac-064503	Musa acuminata	24.44	1.00e-27	117.00
IUUC-Mpu-066820	Mustela putorius furo	31.22	3.00e-66	246.00
IUUC-Mlu-068131	Myotis lucifugus	30.45	4.00e-65	241.00
IUUC-Nfi-068480	Neosartorya fischeri	24.60	1.00e-25	110.00
IUUC-Ncr-068646	Neurospora crassa	23.03	5.00e-27	115.00
IUUC-Nle-069545	Nomascus leucogenys	29.25	7.00e-62	231.00
IUUC-Opr-070722	Ochotona princeps	30.54	1.00e-56	213.00
IUUC-Ont-072561	Oreochromis niloticus	30.73	5.00e-72	265.00
IUUC-Oan-072811	Ornithorhynchus anatinus	31.62	1.00e-67	250.00
IUUC-Ocu-073884	Oryctolagus cuniculus	29.96	1.00e-73	270.00
IUUC-Oba-075112	Oryza barthii	24.59	2.00e-29	123.00
IUUC-Obr-076057	Oryza brachyantha	26.07	1.00e-40	160.00
IUUC-Ogl-077002	Oryza glaberrima	25.48	3.00e-36	145.00
IUUC-Ogu-078683	Oryza glumaepatula	26.99	6.00e-29	121.00
IUUC-Oin-079952	Oryza indica	28.25	1.00e-27	117.00
IUUC-Olo-080278	Oryza longistaminata	26.77	2.00e-28	119.00
IUUC-Ome-081094	Oryza meridionalis	27.43	2.00e-30	126.00
IUUC-Oni-083059	Oryza nivara	24.33	1.00e-28	120.00
IUUC-Opu-084144	Oryza punctata	25.08	2.00e-34	139.00
IUUC-Oru-084897	Oryza rufipogon	25.04	6.00e-29	121.00
IUUC-Osa-085924	Oryza sativa	25.04	7.00e-35	141.00
IUUC-Oga-088979	Otolemur garnettii	30.33	4.00e-62	232.00
IUUC-Oar-090362	Ovis aries	30.85	4.00e-70	258.00
IUUC-Ptr-090823	Pan troglodytes	29.94	7.00e-67	248.00
IUUC-Pan-092863	Papio anubis	30.74	6.00e-67	248.00
IUUC-Psi-093006	Pelodiscus sinensis	30.29	2.00e-63	236.00
IUUC-Pma-094523	Petromyzon marinus	31.21	4.00e-51	194.00
IUUC-Pno-094770	Phaeosphaeria nodorum	22.40	2.00e-22	100.00
IUUC-Ppa-095372	Physcomitrella patens	24.93	3.00e-43	169.00
IUUC-Pfo-096875	Poecilia formosa	31.55	9.00e-73	267.00
IUUC-Pab-097665	Pongo abelii	30.08	7.00e-67	247.00
IUUC-Pop-099082	Populus trichocarpa	26.09	1.00e-39	157.00
IUUC-Pca-100138	Procavia capensis	34.18	4.00e-19	89.40
IUUC-Ppe-101167	Prunus persica	22.40	1.00e-08	53.90
IUUC-Pva-103199	Pteropus vampyrus	23.71	2.00e-17	82.40
IUUC-Pgr-103480	Puccinia graminis	26.37	1.00e-26	114.00
IUUC-Ptt-103783	Puccinia triticina	25.92	3.00e-25	109.00
IUUC-Pte-104357	Pyrenophora teres	22.50	3.00e-20	92.80
IUUC-Pyt-104788	Pyrenophora triticirepentis	27.03	3.00e-24	105.00
IUUC-Rno-104958	Rattus norvegicus	30.61	5.00e-74	271.00
IUUC-Sha-106828	Sarcophilus harrisii	31.27	5.00e-72	265.00
IUUC-Sja-107731	Schizosaccharomyces japonicus	23.98	1.00e-25	110.00
IUUC-Spo-108086	Schizosaccharomyces pombe	24.03	3.00e-22	99.00
IUUC-Ssl-108610	Sclerotinia sclerotiorum	23.21	8.00e-27	114.00
IUUC-Smo-108690	Selaginella moellendorffii	26.52	3.00e-41	162.00
IUUC-Sit-110385	Setaria italica	29.58	2.00e-30	126.00
IUUC-Sly-111187	Solanum lycopersicum	26.57	2.00e-41	163.00
IUUC-Stu-112673	Solanum tuberosum	32.74	3.00e-15	73.20
IUUC-Sar-113548	Sorex araneus	27.81	1.00e-26	113.00
IUUC-Sbi-114131	Sorghum bicolor	28.33	3.00e-33	135.00
IUUC-Sre-114921	Sporisorium reilianum	27.75	3.00e-16	79.30
IUUC-Ssc-115484	Sus scrofa	30.63	4.00e-69	255.00
IUUC-Tgu-116749	Taeniopygia guttata	30.48	2.00e-68	252.00
IUUC-Tru-118772	Takifugu rubripes	30.62	4.00e-64	238.00
IUUC-Tsy-119359	Tarsius syrichta	28.18	2.00e-48	186.00
IUUC-Tni-120878	Tetraodon nigroviridis	30.76	3.00e-67	248.00
IUUC-Tca-120912	Theobroma cacao	27.38	4.00e-44	172.00
IUUC-Tre-122171	Trichoderma reesei	22.92	4.00e-28	119.00
IUUC-Tvi-122483	Trichoderma virens	23.89	2.00e-30	126.00
IUUC-Tae-125125	Triticum aestivum	25.96	2.00e-40	159.00
IUUC-Tur-126497	Triticum urartu	25.68	1.00e-39	157.00
IUUC-Tbe-127473	Tupaia belangeri	25.19	6.00e-15	74.30
IUUC-Ttr-128458	Tursiops truncatus	27.71	3.00e-50	192.00
IUUC-Uma-129558	Ustilago maydis	29.13	1.00e-17	84.30
IUUC-Vda-129683	Verticillium dahliae	24.17	3.00e-23	102.00
IUUC-Vpa-130201	Vicugna pacos	31.97	2.00e-06	47.40
IUUC-Vvi-131226	Vitis vinifera	29.65	1.00e-36	146.00
IUUC-Xtr-132517	Xenopus tropicalis	27.93	1.00e-54	206.00
IUUC-Xma-133763	Xiphophorus maculatus	31.25	8.00e-71	260.00
IUUC-Zma-135455	Zea mays	26.70	5.00e-41	162.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence