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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045872
UUCD1 version UUC-HoS-00165
Ensembl Protein ID ENSP00000364742.3
UniProt Accession Q6P3S6; B3KP30; Q5TEU8; Q86XI0; Q8N3N4; Q8N5F8; Q9BRM0; Q9P2L4; FBX42_HUMAN
Genbank Protein ID BAG51542.1; CAH73774.1; CAH73774.1; CAI22560.1; CAI22560.1; CAI22561.1; AAH06174.1; AAH32439.1; AAH43410.1; AAH63864.1; BAA92570.1; CAD38731.1
Protein Name F-box only protein 42; Just one F-box and Kelch domain-containing protein
Genbank Nucleotide ID AK055598; AL358794; AL109627; AL109627; AL358794; AL109627; BC006174; BC032439; BC043410; BC063864; AB037753; AL833874
Gene Name FBXO42; FBX42; JFK; KIAA1332
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000037637.10 ENST00000375592.7 ENSP00000364742.3
ENSG00000037637.10 ENST00000456164.5 ENSP00000415663.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbGWAS CentralOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDPhospho.ELMUniProtPHOSIDA
BioGRIDmUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/SCF/F-box F-box 21127074; 19509332
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/SCF/F-box 0.00015 23.5 32 83
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/SCF/F-box
   S: 88   paptptpeegpdaglldrlpeeilveilkll.dkeellraarvcrrwqelas 138
           p p    ee  ++ ++++lpee+l  il++l + +e  +aa+vc++w++l++
   Q: 32   PHPVLEAEETRHNRSMSELPEEVLEYILSFLsPYQEHKTAALVCKQWYRLIK 83
           77888899***********************67777************8876 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.
 Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Specifically recognizes p53/TP53, promoting its ubiquitination and degradation.
Protein Sequence
(Fasta)
MASSSDSEDD SFMAVDQEET VLEGTMDQDE EPHPVLEAEE TRHNRSMSEL PEEVLEYILS 60
FLSPYQEHKT AALVCKQWYR LIKGVAHQCY HGFMKAVQEG NIQWESRTYP YPGTPITQRF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045872|E3,F-box|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AGCAGCAGCT GCGGCGGCGG CGGCGTTTGA GTGGAGGAAG ATGGCGGCTC CGGGCGGCTC 60
GGGGTCCCGC CAGCTGTGAG GAGCCCCGAG CACGGCTGTC GCGGCCTGAG GCAGAGCGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045872|E3,F-box|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR001810--F-box_dom
IPR015916--Gal_Oxidase_b-propeller
IPR011498--Kelch_2
PROSITE

PS50181--FBOX
Pfam

PF12937--F-box-like
PF07646--Kelch_2
SMART

SM00256--FBOX
KEGG hsa:54455
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000275 Aegilops tauschii 25.29 2.00e-08 54.30
IUUC-Aml-001864 Ailuropoda melanoleuca 97.77 0.00e+00 1335.00
IUUC-Atr-002804 Amborella trichopoda 27.91 6.00e-10 59.30
IUUC-Apl-003557 Anas platyrhynchos 82.62 0.00e+00 699.00
IUUC-Aca-005180 Anolis carolinensis 95.11 6.00e-133 466.00
IUUC-Aly-006384 Arabidopsis lyrata 26.53 3.00e-09 57.40
IUUC-Ago-007713 Ashbya gossypii 28.47 1.00e-19 92.80
IUUC-Ame-010855 Astyanax mexicanus 81.91 0.00e+00 660.00
IUUC-Bgr-012290 Blumeria graminis 29.25 7.00e-15 75.50
IUUC-Bta-013486 Bos taurus 95.12 0.00e+00 1303.00
IUUC-Bdi-014314 Brachypodium distachyon 26.44 4.00e-10 60.10
IUUC-Cel-018449 Caenorhabditis elegans 31.25 1.00e-17 84.70
IUUC-Cja-019262 Callithrix jacchus 98.47 0.00e+00 1339.00
IUUC-Cfa-020940 Canis familiaris 97.07 0.00e+00 1328.00
IUUC-Cpo-021395 Cavia porcellus 95.28 0.00e+00 1290.00
IUUC-Csa-023124 Chlorocebus sabaeus 98.88 0.00e+00 1341.00
IUUC-Cho-024551 Choloepus hoffmanni 96.37 0.00e+00 1159.00
IUUC-Dre-028731 Danio rerio 48.95 7.00e-59 220.00
IUUC-Dno-029539 Dasypus novemcinctus 96.41 0.00e+00 991.00
IUUC-Dor-030876 Dipodomys ordii 95.85 0.00e+00 702.00
IUUC-Dme-031647 Drosophila melanogaster 41.23 2.00e-70 260.00
IUUC-Eca-033693 Equus caballus 96.23 0.00e+00 1309.00
IUUC-Eeu-035050 Erinaceus europaeus 87.24 0.00e+00 1139.00
IUUC-Fca-036529 Felis catus 97.07 0.00e+00 1335.00
IUUC-Fal-037072 Ficedula albicollis 82.03 0.00e+00 1144.00
IUUC-Gmo-038565 Gadus morhua 82.75 2.00e-174 605.00
IUUC-Gga-040374 Gallus gallus 89.68 0.00e+00 1149.00
IUUC-Gac-041540 Gasterosteus aculeatus 66.02 0.00e+00 844.00
IUUC-Gma-043308 Glycine max 27.49 6.00e-10 59.30
IUUC-Ggo-044616 Gorilla gorilla 99.58 0.00e+00 1354.00
IUUC-Hvu-047513 Hordeum vulgare 26.44 4.00e-09 56.60
IUUC-Itr-048509 Ictidomys tridecemlineatus 98.46 0.00e+00 1080.00
IUUC-Lch-049856 Latimeria chalumnae 84.63 0.00e+00 1195.00
IUUC-Lpe-051405 Leersia perrieri 25.00 1.00e-09 58.20
IUUC-Loc-052085 Lepisosteus oculatus 66.72 0.00e+00 703.00
IUUC-Laf-054501 Loxodonta africana 97.49 0.00e+00 1328.00
IUUC-Mcc-054911 Macaca mulatta 99.16 0.00e+00 1345.00
IUUC-Meu-056603 Macropus eugenii 95.17 0.00e+00 798.00
IUUC-Mpo-057339 Magnaporthe poae 34.69 3.60e-02 34.70
IUUC-Mtr-058566 Medicago truncatula 28.07 1.00e-10 62.00
IUUC-Mga-060021 Meleagris gallopavo 95.00 0.00e+00 816.00
IUUC-Mdo-062483 Monodelphis domestica 92.80 0.00e+00 836.00
IUUC-Mmu-064113 Mus musculus 95.40 0.00e+00 1271.00
IUUC-Mac-065674 Musa acuminata 23.81 7.00e-06 45.80
IUUC-Mpu-066030 Mustela putorius furo 97.21 0.00e+00 1335.00
IUUC-Mlu-067493 Myotis lucifugus 97.49 0.00e+00 1330.00
IUUC-Nle-070165 Nomascus leucogenys 99.30 0.00e+00 1352.00
IUUC-Opr-071213 Ochotona princeps 94.85 0.00e+00 1302.00
IUUC-Ont-072365 Oreochromis niloticus 81.62 0.00e+00 675.00
IUUC-Oan-073729 Ornithorhynchus anatinus 92.77 0.00e+00 976.00
IUUC-Ocu-074656 Oryctolagus cuniculus 95.40 0.00e+00 1312.00
IUUC-Obr-076287 Oryza brachyantha 25.49 5.00e-10 59.30
IUUC-Ogl-077276 Oryza glaberrima 25.49 6.00e-10 58.90
IUUC-Oin-079279 Oryza indica 25.49 4.00e-10 59.70
IUUC-Olo-080732 Oryza longistaminata 26.01 1.00e-08 55.10
IUUC-Ome-081307 Oryza meridionalis 25.49 6.00e-10 59.70
IUUC-Oni-082839 Oryza nivara 25.49 6.00e-10 59.30
IUUC-Opu-083251 Oryza punctata 25.49 5.00e-10 59.70
IUUC-Oru-084639 Oryza rufipogon 25.49 7.00e-10 59.30
IUUC-Ola-086831 Oryzias latipes 80.24 0.00e+00 667.00
IUUC-Oga-087947 Otolemur garnettii 98.05 0.00e+00 1342.00
IUUC-Oar-089465 Ovis aries 93.86 0.00e+00 1248.00
IUUC-Ptr-090532 Pan troglodytes 99.86 0.00e+00 1357.00
IUUC-Pan-092678 Papio anubis 98.88 0.00e+00 1342.00
IUUC-Psi-093738 Pelodiscus sinensis 91.91 0.00e+00 1262.00
IUUC-Pma-094684 Petromyzon marinus 70.09 8.00e-40 157.00
IUUC-Pfo-097406 Poecilia formosa 65.34 0.00e+00 834.00
IUUC-Pab-097535 Pongo abelii 99.58 0.00e+00 1356.00
IUUC-Pop-099147 Populus trichocarpa 24.42 2.00e-10 60.50
IUUC-Pca-100629 Procavia capensis 84.52 0.00e+00 1099.00
IUUC-Ppe-101531 Prunus persica 28.33 1.00e-10 61.20
IUUC-Pva-102996 Pteropus vampyrus 96.23 0.00e+00 1300.00
IUUC-Ptt-103897 Puccinia triticina 34.78 1.90e-01 31.20
IUUC-Rno-105811 Rattus norvegicus 95.82 0.00e+00 1268.00
IUUC-Sha-107432 Sarcophilus harrisii 94.00 0.00e+00 1276.00
IUUC-Smo-108794 Selaginella moellendorffii 26.74 9.00e-09 55.50
IUUC-Sit-109972 Setaria italica 25.87 7.00e-10 59.30
IUUC-Sly-111708 Solanum lycopersicum 27.33 1.00e-09 58.50
IUUC-Sar-113343 Sorex araneus 97.40 0.00e+00 707.00
IUUC-Ssc-116340 Sus scrofa 97.77 0.00e+00 1337.00
IUUC-Tgu-117084 Taeniopygia guttata 85.65 0.00e+00 1134.00
IUUC-Tru-117610 Takifugu rubripes 65.39 0.00e+00 858.00
IUUC-Tsy-119147 Tarsius syrichta 86.47 0.00e+00 1147.00
IUUC-Tni-120076 Tetraodon nigroviridis 65.65 0.00e+00 857.00
IUUC-Tae-123716 Triticum aestivum 27.40 1.00e-10 61.60
IUUC-Tur-126133 Triticum urartu 27.40 1.00e-10 61.60
IUUC-Tbe-127544 Tupaia belangeri 97.21 0.00e+00 1293.00
IUUC-Ttr-129038 Tursiops truncatus 96.93 0.00e+00 1323.00
IUUC-Vpa-130757 Vicugna pacos 86.05 0.00e+00 1123.00
IUUC-Xtr-132341 Xenopus tropicalis 76.04 0.00e+00 1013.00
IUUC-Xma-133928 Xiphophorus maculatus 66.25 0.00e+00 842.00
IUUC-Yli-134330 Yarrowia lipolytica 21.74 1.00e-09 58.50
Created Date 25-Jun-2017

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