iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Cpo-021982

Ensembl Protein ID

ENSCPOP00000006781.2

UniProt Accession

H0VAA8; H0VAA8_CAVPO

Genbank Protein ID

ENSCPOP00000006781

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

AAKN02027842

Gene Name

WHSC1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCPOG00000007513.3	ENSCPOT00000007586.2	ENSCPOP00000006781.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	5.50e-15	55.3	835	875

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC +gg+    l++Ce C  +fHp+Cl++     +p+ + w+C++Cr
   Q: 835  WCFVCSKGGS----LLCCEACPAAFHPDCLNID----MPDGS-WFCNDCR 875
           8*********....*******************....9***8.******8 PP

Organism

Cavia porcellus

Protein Sequence
(Fasta)

MEFSIKKGPL SVQKVVKCIK MKQAPEILGS TNGKTQNCEV NRDCSVFLSK AQLSNSLQEG 60
VMQKFNGHDA LPFIPAEKLK DLTSCVFNGE PGAPDAKLCF ESQEAKGIGT PPNTTPIKNG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAATTTA GCATCAAAAA AGGTCCTCTT TCTGTGCAGA AAGTTGTAAA GTGCATAAAG 60
ATGAAGCAGG CACCAGAAAT CCTTGGCAGT ACCAATGGAA AGACTCAGAA CTGTGAAGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006560--AWS_dom
IPR009071--HMG_box_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51215--AWS
PS50118--HMG_BOX_2
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2
PS50089--ZF_RING_2

Pfam

PF00505--HMG_box
PF00855--PWWP
PF00856--SET

SMART

SM00570--AWS
SM00398--HMG
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00184--RING
SM00317--SET

Gene Ontology

GO:0005634--C:nucleus
GO:0003682--F:chromatin binding
GO:0018024--F:histone-lysine N-methyltransferase activity
GO:0043565--F:sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0003289--P:atrial septum primum morphogenesis
GO:0003290--P:atrial septum secundum morphogenesis
GO:0060348--P:bone development
GO:0010452--P:histone H3-K36 methylation
GO:0034770--P:histone H4-K20 methylation
GO:0003149--P:membranous septum morphogenesis
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0048298--P:positive regulation of isotype switching to IgA isotypes
GO:2001032--P:regulation of double-strand break repair via nonhomologous end joining
GO:0070201--P:regulation of establishment of protein localization

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002181	Ailuropoda melanoleuca	89.22	0.00e+00	2360.00
IUUC-Apl-003677	Anas platyrhynchos	79.33	0.00e+00	2110.00
IUUC-Aca-004278	Anolis carolinensis	75.08	0.00e+00	1413.00
IUUC-Ame-011932	Astyanax mexicanus	70.30	0.00e+00	1031.00
IUUC-Bta-012522	Bos taurus	84.11	0.00e+00	2199.00
IUUC-Cja-018908	Callithrix jacchus	89.48	0.00e+00	2311.00
IUUC-Cfa-020894	Canis familiaris	88.56	0.00e+00	2409.00
IUUC-Csa-023807	Chlorocebus sabaeus	90.23	0.00e+00	2343.00
IUUC-Cho-024405	Choloepus hoffmanni	71.07	0.00e+00	716.00
IUUC-Csv-026298	Ciona savignyi	40.00	2.00e-58	219.00
IUUC-Dre-027492	Danio rerio	71.76	0.00e+00	1065.00
IUUC-Dno-030020	Dasypus novemcinctus	85.24	0.00e+00	2025.00
IUUC-Dor-031103	Dipodomys ordii	83.19	0.00e+00	2137.00
IUUC-Ete-032488	Echinops telfairi	80.47	0.00e+00	2093.00
IUUC-Eca-034066	Equus caballus	89.55	0.00e+00	2425.00
IUUC-Eeu-035199	Erinaceus europaeus	70.21	0.00e+00	749.00
IUUC-Fca-035434	Felis catus	84.53	0.00e+00	1956.00
IUUC-Fal-037113	Ficedula albicollis	77.36	0.00e+00	2121.00
IUUC-Gmo-039686	Gadus morhua	70.97	0.00e+00	1016.00
IUUC-Gga-040273	Gallus gallus	78.02	0.00e+00	2103.00
IUUC-Gac-042123	Gasterosteus aculeatus	50.60	0.00e+00	1235.00
IUUC-Ggo-044643	Gorilla gorilla	89.84	0.00e+00	2363.00
IUUC-Hsa-046380	Homo sapiens	89.90	0.00e+00	2329.00
IUUC-Itr-048658	Ictidomys tridecemlineatus	91.66	0.00e+00	1439.00
IUUC-Lch-050217	Latimeria chalumnae	66.69	0.00e+00	1727.00
IUUC-Loc-052766	Lepisosteus oculatus	68.76	0.00e+00	1139.00
IUUC-Laf-053780	Loxodonta africana	87.51	0.00e+00	2389.00
IUUC-Mcc-054928	Macaca mulatta	90.23	0.00e+00	2375.00
IUUC-Meu-056184	Macropus eugenii	74.46	0.00e+00	784.00
IUUC-Mga-059576	Meleagris gallopavo	78.88	0.00e+00	2102.00
IUUC-Mmr-061045	Microcebus murinus	89.69	0.00e+00	2413.00
IUUC-Mdo-062576	Monodelphis domestica	81.86	0.00e+00	2199.00
IUUC-Mmu-063640	Mus musculus	89.04	0.00e+00	2352.00
IUUC-Mac-065303	Musa acuminata	28.04	4.00e-11	63.20
IUUC-Mpu-066512	Mustela putorius furo	89.24	0.00e+00	2362.00
IUUC-Mlu-067280	Myotis lucifugus	79.37	0.00e+00	1098.00
IUUC-Nle-069896	Nomascus leucogenys	90.21	0.00e+00	2258.00
IUUC-Ont-072197	Oreochromis niloticus	73.89	0.00e+00	1040.00
IUUC-Oan-072724	Ornithorhynchus anatinus	80.16	0.00e+00	1386.00
IUUC-Ocu-074758	Oryctolagus cuniculus	88.10	0.00e+00	2296.00
IUUC-Ogl-077641	Oryza glaberrima	29.65	1.00e-10	60.50
IUUC-Ogu-078898	Oryza glumaepatula	29.65	2.00e-10	60.10
IUUC-Oin-079557	Oryza indica	29.65	2.00e-10	60.10
IUUC-Olo-080702	Oryza longistaminata	41.94	2.00e-45	177.00
IUUC-Opu-083371	Oryza punctata	42.31	5.00e-47	182.00
IUUC-Osa-085353	Oryza sativa	29.65	1.00e-10	60.50
IUUC-Oga-088702	Otolemur garnettii	89.97	0.00e+00	2096.00
IUUC-Oar-089736	Ovis aries	78.63	0.00e+00	1929.00
IUUC-Ptr-091055	Pan troglodytes	89.83	0.00e+00	2326.00
IUUC-Pan-092752	Papio anubis	94.48	0.00e+00	1407.00
IUUC-Psi-093620	Pelodiscus sinensis	79.97	0.00e+00	2137.00
IUUC-Pfo-097464	Poecilia formosa	51.50	0.00e+00	1206.00
IUUC-Pab-098051	Pongo abelii	89.68	0.00e+00	2360.00
IUUC-Pop-099927	Populus trichocarpa	28.96	1.00e-11	65.50
IUUC-Pca-100273	Procavia capensis	86.77	0.00e+00	2320.00
IUUC-Pva-102473	Pteropus vampyrus	78.95	0.00e+00	1949.00
IUUC-Rno-105056	Rattus norvegicus	88.44	0.00e+00	2352.00
IUUC-Sha-107494	Sarcophilus harrisii	82.77	0.00e+00	2188.00
IUUC-Sar-113310	Sorex araneus	89.82	0.00e+00	1874.00
IUUC-Sbi-114581	Sorghum bicolor	33.33	4.00e-10	58.50
IUUC-Ssc-116344	Sus scrofa	83.06	0.00e+00	2209.00
IUUC-Tgu-116786	Taeniopygia guttata	79.46	0.00e+00	2121.00
IUUC-Tru-117638	Takifugu rubripes	50.44	0.00e+00	1234.00
IUUC-Tsy-118937	Tarsius syrichta	93.10	0.00e+00	1519.00
IUUC-Tni-120452	Tetraodon nigroviridis	68.65	0.00e+00	1045.00
IUUC-Tae-125237	Triticum aestivum	30.82	7.00e-07	47.80
IUUC-Tbe-127291	Tupaia belangeri	84.97	0.00e+00	1499.00
IUUC-Ttr-129017	Tursiops truncatus	81.17	0.00e+00	1720.00
IUUC-Xtr-132673	Xenopus tropicalis	66.62	0.00e+00	1764.00
IUUC-Xma-133695	Xiphophorus maculatus	72.99	0.00e+00	1015.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence