iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	8.30e-06	26.2	6	89
E3 activity/RING/RING	1.60e-09	38.5	10	60

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggk...........tcPvtrqpl.....teedlvPnltlrrliqawcee 71
           +e+ CpI + ++ dP vlp+ +t+ r+++e  l+ +g+           +cP +r+ +       e+l  n +lr++i+++ +e
   Q: 6    DELTCPICYSIFDDPRVLPCSHTFCRNCLENVLQASGNfyiwrplriplKCPNCRSIIeiastGIESLPVNFALRAIIEKYQQE 89
           7899*****************************999999**************9998743321234555688999999999776 PP

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefr..........CPlCr 46
           C+iC++ f+d p+vlpC H+f+++Cl+++     ++s++f+          CP Cr
   Q: 10   CPICYSIFDD-PRVLPCSHTFCRNCLENV----LQASGNFYiwrplriplkCPNCR 60
           **********.***************999....667777766667777777****8 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MHNFEDELTC PICYSIFDDP RVLPCSHTFC RNCLENVLQA SGNFYIWRPL RIPLKCPNCR 60
SIIEIASTGI ESLPVNFALR AIIEKYQQED HPDVVTCPEH YRQPLNVYCL LDKKLVCGHC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCGCACCAA GCTGCTTGGG AGCCATCGCT GTGTGCATCG TCGCCCGCCT CGCGGTGAGT 60
AAGCCGGCTC TGCCCGGGAG GCGGTTCGGG GCCTCTCGTT TCCCGAGTGC CGGCTGTCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00643--zf-B_box
PF13445--zf-RING_UBOX

SMART

SM00184--RING

Gene Ontology

GO:0005813--C:centrosome
GO:0005929--C:cilium
GO:0005783--C:endoplasmic reticulum
GO:0016021--C:integral component of membrane
GO:0030992--C:intraciliary transport particle B
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0060271--P:cilium assembly
GO:0045087--P:innate immune response
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046597--P:negative regulation of viral entry into host cell

KEGG

rno:365813

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002249	Ailuropoda melanoleuca	88.06	0.00e+00	741.00
IUUC-Apl-003996	Anas platyrhynchos	67.00	3.00e-122	431.00
IUUC-Aca-005141	Anolis carolinensis	57.04	5.00e-133	467.00
IUUC-Ame-011353	Astyanax mexicanus	52.61	5.00e-100	358.00
IUUC-Bta-013440	Bos taurus	88.12	0.00e+00	667.00
IUUC-Cfa-021168	Canis familiaris	88.53	0.00e+00	747.00
IUUC-Cpo-021702	Cavia porcellus	76.12	1.00e-176	612.00
IUUC-Csa-024141	Chlorocebus sabaeus	85.32	0.00e+00	654.00
IUUC-Dre-028408	Danio rerio	47.12	1.00e-89	323.00
IUUC-Dno-029180	Dasypus novemcinctus	85.82	0.00e+00	714.00
IUUC-Ete-033028	Echinops telfairi	87.42	4.00e-168	585.00
IUUC-Eca-034357	Equus caballus	87.56	0.00e+00	702.00
IUUC-Fca-036287	Felis catus	89.05	0.00e+00	743.00
IUUC-Gga-040739	Gallus gallus	57.14	2.00e-135	475.00
IUUC-Ggo-045307	Gorilla gorilla	83.58	0.00e+00	680.00
IUUC-Hsa-045690	Homo sapiens	84.08	0.00e+00	681.00
IUUC-Itr-048230	Ictidomys tridecemlineatus	91.54	0.00e+00	765.00
IUUC-Laf-054522	Loxodonta africana	85.57	0.00e+00	723.00
IUUC-Mcc-055145	Macaca mulatta	85.82	0.00e+00	693.00
IUUC-Meu-056214	Macropus eugenii	46.29	2.00e-59	222.00
IUUC-Mmr-061197	Microcebus murinus	90.55	0.00e+00	760.00
IUUC-Mdo-062631	Monodelphis domestica	60.84	3.00e-136	478.00
IUUC-Mmu-064217	Mus musculus	95.77	0.00e+00	753.00
IUUC-Mpu-065691	Mustela putorius furo	89.80	0.00e+00	753.00
IUUC-Mlu-067742	Myotis lucifugus	85.54	0.00e+00	687.00
IUUC-Nle-069722	Nomascus leucogenys	85.07	0.00e+00	714.00
IUUC-Oan-073382	Ornithorhynchus anatinus	58.96	2.00e-135	475.00
IUUC-Oar-089206	Ovis aries	87.06	0.00e+00	735.00
IUUC-Pan-092189	Papio anubis	86.07	0.00e+00	696.00
IUUC-Psi-093523	Pelodiscus sinensis	59.85	2.00e-139	488.00
IUUC-Pma-094162	Petromyzon marinus	34.06	1.00e-49	189.00
IUUC-Pfo-096032	Poecilia formosa	45.66	1.00e-87	317.00
IUUC-Pva-103089	Pteropus vampyrus	88.53	0.00e+00	709.00
IUUC-Pgr-103338	Puccinia graminis	37.10	4.00e-06	44.70
IUUC-Ssc-115809	Sus scrofa	85.82	0.00e+00	692.00
IUUC-Tru-118402	Takifugu rubripes	42.94	6.00e-92	330.00
IUUC-Tni-119737	Tetraodon nigroviridis	45.02	1.00e-86	312.00
IUUC-Ttr-128921	Tursiops truncatus	87.53	0.00e+00	711.00
IUUC-Vpa-130397	Vicugna pacos	88.56	0.00e+00	744.00
IUUC-Xtr-132752	Xenopus tropicalis	45.94	2.00e-85	309.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence