iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Dre-028629

Ensembl Protein ID

ENSDARP00000141791.1

UniProt Accession

Q1L8W0; Q4JEX7; ZBT18_DANRE

Genbank Protein ID

AAT68457.1; CAK04546.1

Protein Name

Zinc finger and BTB domain-containing protein 18; Zinc finger protein 238

Genbank Nucleotide ID

AY562553; CR589882

Gene Name

zbtb18; znf238; si:ch211-221n23.1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000028228.8	ENSDART00000169895.1	ENSDARP00000141791.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB	6.30e-11	43.4	24	89

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_Other: BTB

   S: 1    aDvilvvggeeffahkivLaasSsvFyalflmeleesksklmveik.d.vqpevfrallkFlYtgklde 67
           +D ++ vg+ +f+ah++vLa++S +F+   + +l+++   + v+++ d v + +f  ll+F+Y gkl+ 
   Q: 24   CDSTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKR---DIVHLNsDiVTAPAFALLLEFMYEGKLQF 89
           788999********************98777777765...6*****99******************985 PP

Organism

Danio rerio

Functional Description
(View)

Transcriptional repressor that plays a role in various developmental processes. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes (By similarity).

Protein Sequence
(Fasta)

MEFPDHSRHL LQCLSEQRHQ GFLCDSTVLV GDAQFRAHRA VLASCSMYFH LFYKDQLDKR 60
DIVHLNSDIV TAPAFALLLE FMYEGKLQFK SLPVEDVLAA ASYLHMYDIV KVCKKKLKQK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGAAAAATAT TTGAAGATTA TAAACACTAG GGCTTACTTT TGAAACATGT TACTTTTTAT 60
TTTATTCAAT TGTAAATAAT TTCGGCGCTC GGCTAATATC GTCTGTCTGT TTCTCATTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000210--BTB/POZ_dom
IPR004039--Rubredoxin-type_fold
IPR011333--SKP1/BTB/POZ
IPR013087--Znf_C2H2_type

PROSITE

PS50097--BTB
PS00028--ZINC_FINGER_C2H2_1
PS50157--ZINC_FINGER_C2H2_2

Pfam

PF00651--BTB

SMART

SM00225--BTB
SM00355--ZnF_C2H2

Gene Ontology

GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0046872--F:metal ion binding
GO:0006355--P:regulation of transcription, DNA-templated
GO:0006351--P:transcription, DNA-templated

KEGG

dre:100003157

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002255	Ailuropoda melanoleuca	69.67	0.00e+00	652.00
IUUC-Apl-004085	Anas platyrhynchos	71.69	0.00e+00	687.00
IUUC-Aca-005205	Anolis carolinensis	71.40	0.00e+00	689.00
IUUC-Ame-011717	Astyanax mexicanus	90.91	0.00e+00	921.00
IUUC-Bta-013254	Bos taurus	72.48	0.00e+00	704.00
IUUC-Cja-019019	Callithrix jacchus	72.48	0.00e+00	697.00
IUUC-Cfa-020089	Canis familiaris	68.09	2.00e-161	562.00
IUUC-Cpo-022313	Cavia porcellus	68.89	0.00e+00	645.00
IUUC-Csa-023163	Chlorocebus sabaeus	67.58	6.00e-96	344.00
IUUC-Dno-029978	Dasypus novemcinctus	69.91	0.00e+00	667.00
IUUC-Dor-031076	Dipodomys ordii	70.64	0.00e+00	655.00
IUUC-Eca-034186	Equus caballus	72.32	0.00e+00	701.00
IUUC-Eeu-035053	Erinaceus europaeus	72.48	0.00e+00	705.00
IUUC-Fca-036534	Felis catus	81.16	1.00e-95	343.00
IUUC-Fal-036841	Ficedula albicollis	71.82	0.00e+00	689.00
IUUC-Gmo-039206	Gadus morhua	89.47	7.00e-102	364.00
IUUC-Gga-040558	Gallus gallus	71.74	0.00e+00	689.00
IUUC-Gac-042192	Gasterosteus aculeatus	70.89	0.00e+00	702.00
IUUC-Ggo-045056	Gorilla gorilla	72.48	0.00e+00	706.00
IUUC-Hsa-046837	Homo sapiens	72.48	0.00e+00	706.00
IUUC-Itr-048183	Ictidomys tridecemlineatus	72.29	0.00e+00	701.00
IUUC-Lch-050214	Latimeria chalumnae	71.59	0.00e+00	681.00
IUUC-Loc-051869	Lepisosteus oculatus	79.52	0.00e+00	755.00
IUUC-Laf-053454	Loxodonta africana	71.74	0.00e+00	702.00
IUUC-Mcc-055511	Macaca mulatta	68.26	3.00e-150	524.00
IUUC-Meu-056846	Macropus eugenii	71.93	0.00e+00	702.00
IUUC-Mga-059766	Meleagris gallopavo	69.91	0.00e+00	656.00
IUUC-Mmr-061689	Microcebus murinus	72.11	0.00e+00	701.00
IUUC-Mdo-062846	Monodelphis domestica	71.93	0.00e+00	703.00
IUUC-Mmu-063612	Mus musculus	72.29	0.00e+00	704.00
IUUC-Mpu-066244	Mustela putorius furo	74.18	4.00e-112	398.00
IUUC-Mlu-067913	Myotis lucifugus	71.79	0.00e+00	684.00
IUUC-Nle-068967	Nomascus leucogenys	72.29	0.00e+00	694.00
IUUC-Ont-072037	Oreochromis niloticus	69.46	0.00e+00	654.00
IUUC-Ocu-073991	Oryctolagus cuniculus	72.29	0.00e+00	699.00
IUUC-Ola-086871	Oryzias latipes	71.74	0.00e+00	705.00
IUUC-Oga-089062	Otolemur garnettii	71.93	0.00e+00	701.00
IUUC-Oar-089345	Ovis aries	64.65	3.00e-156	545.00
IUUC-Ptr-091144	Pan troglodytes	72.48	0.00e+00	706.00
IUUC-Pan-091848	Papio anubis	72.48	0.00e+00	706.00
IUUC-Pfo-097013	Poecilia formosa	70.68	0.00e+00	708.00
IUUC-Pab-097678	Pongo abelii	72.29	0.00e+00	717.00
IUUC-Pva-102751	Pteropus vampyrus	72.29	0.00e+00	704.00
IUUC-Rno-105901	Rattus norvegicus	72.29	0.00e+00	704.00
IUUC-Sha-106850	Sarcophilus harrisii	71.93	0.00e+00	703.00
IUUC-Sar-112964	Sorex araneus	72.48	0.00e+00	704.00
IUUC-Ssc-115395	Sus scrofa	72.29	0.00e+00	703.00
IUUC-Tgu-117216	Taeniopygia guttata	71.82	0.00e+00	688.00
IUUC-Tsy-118841	Tarsius syrichta	72.16	0.00e+00	704.00
IUUC-Tni-120035	Tetraodon nigroviridis	72.64	0.00e+00	701.00
IUUC-Ttr-128943	Tursiops truncatus	72.20	1.00e-120	426.00
IUUC-Xtr-131820	Xenopus tropicalis	68.99	0.00e+00	654.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence