• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063565
Ensembl Protein ID ENSMUSP00000099404.1
UniProt Accession Q62077; Q6P1G1; PLCG1_MOUSE
Genbank Protein ID AAH65091.1; CAA64639.1
Protein Name 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1; Phosphoinositide phospholipase C-gamma-1; Phospholipase C-gamma-1
Genbank Nucleotide ID BC065091; X95346
Gene Name Plcg1; Plcg-1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000016933.17 ENSMUST00000151590.7 ENSMUSP00000133771.1
ENSMUSG00000016933.17 ENSMUST00000103115.7 ENSMUSP00000099404.1
ENSMUSG00000016933.17 ENSMUST00000109462.7 ENSMUSP00000105088.1
ENSMUSG00000016933.17 ENSMUST00000143997.1 ENSMUSP00000115181.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemicroRNATRANSFACRepTar
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Mentha
Drug and target
GRAC
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
Phospho.ELMUniProtPHOSIDA
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 5.40e-12 46.6 792 849
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 2    skekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGl.fPenFvekl 62
           +k  v++l+dy+aq +deLt++k  +++ +  e+qd+gW++g  +  gk+ l fP+n+ve++
   Q: 792  FKCAVKALFDYKAQREDELTFTKSAIIQNV--EKQDGGWWRG--DYGGKKQLwFPSNYVEEM 849
           56789************************9..9*********..676666655******985 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
 Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.
Protein Sequence
(Fasta)
MAGVATPCAN GCGPGAPSEA EVLHLCRSLE VGTVMTLFYS KKSQRPERKT FQVKLETRQI 60
TWSRGADKIE GSIDIREIKE IRPGKTSRDF DRYQEDPAFR PDQSHCFVIL YGMEFRLKTL 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063565|UBD,SH3|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GGAGGCCAGG CTGGCGCGGC TCCCTCCGCC CGGCAGCCTT GCCAGGTAAC CGGGTTCGGC 60
GGGAGGGCTG GGGGTCGCGC AGCCCCCTCG CTCCCTGGGA GGCGTGCACA CTGCCGCGGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063565|UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0007--Acetylation
KW-0106--Calcium
KW-0966--Cell projection
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0442--Lipid degradation
KW-0443--Lipid metabolism
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0807--Transducer
KW-0832--Ubl conjugation
Interpro

IPR000008--C2_dom
IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001192--PI-PLC_fam
IPR016279--PLC-gamma
IPR028380--PLC-gamma1
IPR017946--PLC-like_Pdiesterase_TIM-brl
IPR000909--PLipase_C_PInositol-sp_X_dom
IPR001711--PLipase_C_Pinositol-sp_Y
IPR000980--SH2
IPR001452--SH3_domain
PROSITE

PS50004--C2
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS50003--PH_DOMAIN
PS50007--PIPLC_X_DOMAIN
PS50008--PIPLC_Y_DOMAIN
PS50001--SH2
PS50002--SH3
Pfam

PF00168--C2
PF00388--PI-PLC-X
PF00387--PI-PLC-Y
PF00017--SH2
PF00018--SH3_1
PRINTS

PR00390--PHPHLIPASEC
PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
SMART

SM00239--C2
SM00233--PH
SM00148--PLCXc
SM00149--PLCYc
SM00252--SH2
SM00326--SH3
Gene Ontology

GO:0042995--C:cell projection
GO:0005911--C:cell-cell junction
GO:0008180--C:COP9 signalosome
GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0030027--C:lamellipodium
GO:0005886--C:plasma membrane
GO:0001726--C:ruffle
GO:0005509--F:calcium ion binding
GO:0035254--F:glutamate receptor binding
GO:0005168--F:neurotrophin TRKA receptor binding
GO:0004435--F:phosphatidylinositol phospholipase C activity
GO:0019901--F:protein kinase binding
GO:0030971--F:receptor tyrosine kinase binding
GO:0004871--F:signal transducer activity
GO:0019722--P:calcium-mediated signaling
GO:0016477--P:cell migration
GO:0071364--P:cellular response to epidermal growth factor stimulus
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0001701--P:in utero embryonic development
GO:0009395--P:phospholipid catabolic process
GO:0045766--P:positive regulation of angiogenesis
GO:0043536--P:positive regulation of blood vessel endothelial cell migration
GO:0010634--P:positive regulation of epithelial cell migration
GO:0051281--P:positive regulation of release of sequestered calcium ion into cytosol
GO:0002223--P:stimulatory C-type lectin receptor signaling pathway
GO:0050852--P:T cell receptor signaling pathway
KEGG mmu:18803
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001452 Ailuropoda melanoleuca 96.57 0.00e+00 2554.00
IUUC-Apl-003541 Anas platyrhynchos 69.81 0.00e+00 1763.00
IUUC-Aca-005291 Anolis carolinensis 86.02 0.00e+00 2238.00
IUUC-Ame-011004 Astyanax mexicanus 69.74 0.00e+00 1800.00
IUUC-Bta-012660 Bos taurus 96.67 0.00e+00 2415.00
IUUC-Cja-019206 Callithrix jacchus 96.39 0.00e+00 2540.00
IUUC-Cfa-020257 Canis familiaris 97.26 0.00e+00 2425.00
IUUC-Cpo-022391 Cavia porcellus 91.20 0.00e+00 2385.00
IUUC-Csa-024170 Chlorocebus sabaeus 96.91 0.00e+00 1887.00
IUUC-Cin-025520 Ciona intestinalis 47.70 0.00e+00 1111.00
IUUC-Dre-027944 Danio rerio 71.90 0.00e+00 1881.00
IUUC-Dno-029440 Dasypus novemcinctus 96.56 0.00e+00 2316.00
IUUC-Dor-031001 Dipodomys ordii 96.48 0.00e+00 2554.00
IUUC-Eca-033809 Equus caballus 97.34 0.00e+00 2434.00
IUUC-Fca-036510 Felis catus 96.60 0.00e+00 2415.00
IUUC-Fal-037541 Ficedula albicollis 88.00 0.00e+00 2100.00
IUUC-Gmo-038630 Gadus morhua 65.68 0.00e+00 1454.00
IUUC-Gga-040142 Gallus gallus 88.56 0.00e+00 2298.00
IUUC-Ggo-045063 Gorilla gorilla 96.95 0.00e+00 2569.00
IUUC-Hsa-046428 Homo sapiens 96.87 0.00e+00 2567.00
IUUC-Itr-048245 Ictidomys tridecemlineatus 97.18 0.00e+00 2506.00
IUUC-Lch-049766 Latimeria chalumnae 79.39 0.00e+00 1965.00
IUUC-Loc-052285 Lepisosteus oculatus 76.75 0.00e+00 2031.00
IUUC-Laf-053365 Loxodonta africana 95.77 0.00e+00 2394.00
IUUC-Mcc-054871 Macaca mulatta 96.53 0.00e+00 2542.00
IUUC-Meu-056724 Macropus eugenii 88.81 0.00e+00 2173.00
IUUC-Mga-059329 Meleagris gallopavo 87.57 0.00e+00 2174.00
IUUC-Mmr-061110 Microcebus murinus 96.08 0.00e+00 2542.00
IUUC-Mdo-062448 Monodelphis domestica 93.34 0.00e+00 2489.00
IUUC-Mpu-066683 Mustela putorius furo 96.95 0.00e+00 2565.00
IUUC-Mlu-067779 Myotis lucifugus 96.68 0.00e+00 2414.00
IUUC-Nle-069219 Nomascus leucogenys 96.40 0.00e+00 2108.00
IUUC-Opr-070766 Ochotona princeps 93.11 0.00e+00 1427.00
IUUC-Ont-072524 Oreochromis niloticus 73.64 0.00e+00 1959.00
IUUC-Oan-073214 Ornithorhynchus anatinus 91.30 2.00e-46 177.00
IUUC-Ocu-074361 Oryctolagus cuniculus 94.76 0.00e+00 2490.00
IUUC-Ola-086820 Oryzias latipes 72.90 0.00e+00 1966.00
IUUC-Oga-088172 Otolemur garnettii 96.87 0.00e+00 2568.00
IUUC-Oar-090306 Ovis aries 94.20 0.00e+00 2346.00
IUUC-Ptr-090682 Pan troglodytes 96.87 0.00e+00 2568.00
IUUC-Pan-092835 Papio anubis 97.12 0.00e+00 1812.00
IUUC-Psi-093344 Pelodiscus sinensis 86.51 0.00e+00 2281.00
IUUC-Pfo-096984 Poecilia formosa 71.48 0.00e+00 1915.00
IUUC-Pab-097871 Pongo abelii 96.78 0.00e+00 2493.00
IUUC-Pca-100772 Procavia capensis 89.98 0.00e+00 2348.00
IUUC-Pva-102790 Pteropus vampyrus 97.13 0.00e+00 2525.00
IUUC-Rno-105974 Rattus norvegicus 99.29 0.00e+00 2627.00
IUUC-Sar-112995 Sorex araneus 95.12 0.00e+00 2451.00
IUUC-Ssc-115360 Sus scrofa 96.62 0.00e+00 2551.00
IUUC-Tgu-116585 Taeniopygia guttata 85.74 0.00e+00 2185.00
IUUC-Tru-117742 Takifugu rubripes 73.48 0.00e+00 1976.00
IUUC-Tsy-119259 Tarsius syrichta 97.14 0.00e+00 856.00
IUUC-Tni-120833 Tetraodon nigroviridis 67.65 0.00e+00 1714.00
IUUC-Tbe-127504 Tupaia belangeri 81.99 0.00e+00 1383.00
IUUC-Ttr-128650 Tursiops truncatus 96.55 0.00e+00 1322.00
IUUC-Xtr-132862 Xenopus tropicalis 77.94 0.00e+00 2001.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved