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Tag Content
UUCD2 ID IUUC-Bta-013221
UUCD1 version UUC-BoT-00493
Ensembl Protein ID ENSBTAP00000041274.3
UniProt Accession F1MLS5; F1MLS5_BOVIN
Genbank Protein ID ENSBTAP00000041274
Protein Name Uncharacterized protein
Genbank Nucleotide ID DAAA02058311
Gene Name SMURF1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSBTAG00000007118.5 ENSBTAT00000043725.3 ENSBTAP00000041274.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 5.40e-128 427.2 437 769
Active Site
Position(s) Description Evidence
738 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 437  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 524
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt+eNk+eYv+l+v+
   Q: 525  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 609
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ + +ds++++wFw+++e f++e r+++LqFv
   Q: 610  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLDDWKSNTRLKH-CGADSNVVRWFWQAVETFDEERRARLLQFV 697
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+    prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 698  TGSTRVPLQGFKALQgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 769
           ***************************99999**************************************76 PP
   
Organism Bos taurus
Protein Sequence
(Fasta)
CDPGSFKNTL INSPILFLVL CAKNLAKKDF FRLPDPFAKI VVDGSGQCHS TDTVKNTLDP 60
KWNQHYDLYV GKTDSITISV WNHKKIHKKQ GAGFLGCVRL LSNAISRLKD TGYQRLDLCK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Bta-013221|E3,HECT|Bos taurus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TGTGATCCTG GCAGTTTCAA GAACACATTG ATAAATTCAC CCATGTATGT TTAAGAAAAA 60
TTTTTAAGTT TAAACCATTT TGCATTTGTT ACAGTTGATT TCTAACTGAA GGAGAAAACA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Bta-013221|E3,HECT|Bos taurus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001459 Ailuropoda melanoleuca 92.33 0.00e+00 1387.00
IUUC-Apl-004155 Anas platyrhynchos 87.67 0.00e+00 1360.00
IUUC-Aca-005238 Anolis carolinensis 89.46 0.00e+00 1362.00
IUUC-Ame-010901 Astyanax mexicanus 83.18 0.00e+00 1290.00
IUUC-Cja-018985 Callithrix jacchus 88.22 0.00e+00 1384.00
IUUC-Cfa-020568 Canis familiaris 89.27 0.00e+00 1377.00
IUUC-Cpo-022531 Cavia porcellus 87.72 0.00e+00 1376.00
IUUC-Csa-024145 Chlorocebus sabaeus 91.29 0.00e+00 1402.00
IUUC-Cho-024963 Choloepus hoffmanni 72.69 0.00e+00 878.00
IUUC-Dre-028341 Danio rerio 83.72 0.00e+00 1300.00
IUUC-Dno-029705 Dasypus novemcinctus 88.65 0.00e+00 1365.00
IUUC-Dor-030314 Dipodomys ordii 98.17 1.00e-128 453.00
IUUC-Eca-034125 Equus caballus 89.37 0.00e+00 1377.00
IUUC-Fca-035905 Felis catus 92.07 0.00e+00 1390.00
IUUC-Fal-037336 Ficedula albicollis 90.87 0.00e+00 1373.00
IUUC-Gmo-039486 Gadus morhua 80.30 0.00e+00 851.00
IUUC-Gga-040218 Gallus gallus 88.39 0.00e+00 1368.00
IUUC-Gac-041707 Gasterosteus aculeatus 78.08 0.00e+00 1201.00
IUUC-Ggo-045408 Gorilla gorilla 83.21 0.00e+00 1278.00
IUUC-Hsa-045878 Homo sapiens 88.10 0.00e+00 1383.00
IUUC-Itr-048317 Ictidomys tridecemlineatus 89.62 0.00e+00 1379.00
IUUC-Loc-052628 Lepisosteus oculatus 82.39 0.00e+00 1305.00
IUUC-Laf-053644 Loxodonta africana 92.15 0.00e+00 1370.00
IUUC-Mcc-055479 Macaca mulatta 83.16 0.00e+00 1236.00
IUUC-Mga-059723 Meleagris gallopavo 90.16 0.00e+00 1369.00
IUUC-Mdo-063005 Monodelphis domestica 90.03 0.00e+00 1389.00
IUUC-Mmu-063634 Mus musculus 90.54 0.00e+00 1385.00
IUUC-Mpu-065898 Mustela putorius furo 91.61 0.00e+00 1398.00
IUUC-Mlu-067584 Myotis lucifugus 89.29 0.00e+00 1383.00
IUUC-Nle-069033 Nomascus leucogenys 89.50 0.00e+00 1379.00
IUUC-Ont-072265 Oreochromis niloticus 76.93 0.00e+00 1211.00
IUUC-Oan-073621 Ornithorhynchus anatinus 92.29 0.00e+00 1399.00
IUUC-Ocu-073960 Oryctolagus cuniculus 88.63 0.00e+00 1364.00
IUUC-Oga-088579 Otolemur garnettii 88.10 0.00e+00 1381.00
IUUC-Oar-090396 Ovis aries 89.55 0.00e+00 1320.00
IUUC-Ptr-091624 Pan troglodytes 88.10 0.00e+00 1383.00
IUUC-Pan-092479 Papio anubis 88.64 0.00e+00 1385.00
IUUC-Pfo-097203 Poecilia formosa 79.05 0.00e+00 1223.00
IUUC-Pab-097540 Pongo abelii 87.45 0.00e+00 1312.00
IUUC-Pca-100379 Procavia capensis 71.86 2.00e-175 609.00
IUUC-Pva-102456 Pteropus vampyrus 78.85 0.00e+00 1172.00
IUUC-Rno-105396 Rattus norvegicus 90.67 0.00e+00 1387.00
IUUC-Sha-107216 Sarcophilus harrisii 88.48 0.00e+00 1372.00
IUUC-Ssc-116413 Sus scrofa 92.47 0.00e+00 1359.00
IUUC-Tgu-116723 Taeniopygia guttata 87.24 0.00e+00 1351.00
IUUC-Tru-117843 Takifugu rubripes 79.67 0.00e+00 1221.00
IUUC-Tsy-119455 Tarsius syrichta 87.43 0.00e+00 1303.00
IUUC-Tni-120829 Tetraodon nigroviridis 79.13 0.00e+00 1184.00
IUUC-Tbe-127879 Tupaia belangeri 76.46 0.00e+00 1117.00
IUUC-Ttr-128423 Tursiops truncatus 88.85 0.00e+00 1322.00
IUUC-Xtr-132237 Xenopus tropicalis 82.40 0.00e+00 1287.00
Created Date 25-Jun-2017

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