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Tag Content
UUCD2 ID IUUC-Sha-107216
UUCD1 version UUC-SaH-00367
Ensembl Protein ID ENSSHAP00000009664.1
UniProt Accession G3W2K9; G3W2K9_SARHA
Genbank Protein ID ENSSHAP00000009664
Protein Name Uncharacterized protein
Genbank Nucleotide ID AEFK01076593
Gene Name SMURF1
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSSHAG00000008364.1 ENSSHAT00000009749.1 ENSSHAP00000009664.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 5.90e-128 427.1 420 755
Active Site
Position(s) Description Evidence
724 Glycyl thioester intermediate {ECO:0000256|PIRSR:PIRSR001569-1,
ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkkrl+v+f+gEegld+gGv+re+l+ll++e+ np++glf+ys ++ ++lq+npds + np+hl++F+f+Gr++g+a+++g++++ 
   Q: 420  PKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSSI-NPDHLSYFHFVGRIMGLAVFHGHYING 507
           689*********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+dle+vdpel+ksl +i+en   di+   ld tf+v+++ +g + ++eLkp+G+n+pVt+eNk+eYv+l+v+
   Q: 508  GFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILEN---DITPV-LDHTFCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVN 592
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfne+ip++ll+ F+++elel+i G ++id++d+k++t+ k+ +++ds+ ++wFw+++e f++e r+++LqFv
   Q: 593  WRFMRGIEAQFLALQKGFNELIPQHLLKPFDQKELELIIGGLDKIDLNDWKSNTRLKH-CMADSNIVKWFWQAVETFDEERRARLLQFV 680
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk.......prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgs r+Pl+Gf++l+       prlf+i+  da++d+lP+++TCfn++++P+Y+s+e+l+ekLl+A+eet gF +
   Q: 681  TGSTRVPLQGFKALQgstgaagPRLFTIHLiDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETCGFAV 755
           ******************************99999**************************************76 PP
   
Organism Sarcophilus harrisii
Protein Sequence
(Fasta)
FAKKITRRNV SFYFFSLTVL CAKNLAKKDF FRLPDPFAKI VVDGSGQCHS TDTVKNTLDP 60
KWNQHYDLYV GKTDSITISV WNHKKIHKKQ GAGFLGCVRL LSNAISRLKD TGYQRLDLCK 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Sha-107216|E3,HECT|Sarcophilus harrisii
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TTTGCAAAGA AAATAACAAG AAGAAATGTT TCTTTTTATT TTTTTTCTCT TACAGAAAAG 60
TAGAATAAAA GTCTTAATGA AATCTCTTTC ACAAGTGCTA ACTCTTTTTT TTTCTTATTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Sha-107216|E3,HECT|Sarcophilus harrisii
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom
PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2
Pfam

PF00168--C2
PF00632--HECT
PF00397--WW
SMART

SM00239--C2
SM00119--HECTc
SM00456--WW
Gene Ontology

GO:0070062--C:extracellular exosome
GO:0005739--C:mitochondrion
GO:0005886--C:plasma membrane
GO:0061630--F:ubiquitin protein ligase activity
GO:0030509--P:BMP signaling pathway
GO:0061736--P:engulfment of target by autophagosome
GO:0030279--P:negative regulation of ossification
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:2000060--P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0006611--P:protein export from nucleus
GO:0034394--P:protein localization to cell surface
GO:0000209--P:protein polyubiquitination
GO:0071211--P:protein targeting to vacuole involved in autophagy
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0061753--P:substrate localization to autophagosome
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001459 Ailuropoda melanoleuca 88.39 0.00e+00 1394.00
IUUC-Apl-004155 Anas platyrhynchos 95.70 0.00e+00 1464.00
IUUC-Aca-005238 Anolis carolinensis 93.54 0.00e+00 1433.00
IUUC-Ame-010901 Astyanax mexicanus 87.50 0.00e+00 1361.00
IUUC-Bta-013221 Bos taurus 88.60 0.00e+00 1333.00
IUUC-Cja-018985 Callithrix jacchus 94.81 0.00e+00 1477.00
IUUC-Cfa-020568 Canis familiaris 93.74 0.00e+00 1449.00
IUUC-Cpo-022531 Cavia porcellus 94.28 0.00e+00 1469.00
IUUC-Csa-024145 Chlorocebus sabaeus 93.75 0.00e+00 1452.00
IUUC-Cho-024963 Choloepus hoffmanni 76.76 0.00e+00 923.00
IUUC-Cin-025126 Ciona intestinalis 61.36 0.00e+00 915.00
IUUC-Csv-026339 Ciona savignyi 61.09 0.00e+00 929.00
IUUC-Dre-028341 Danio rerio 87.92 0.00e+00 1373.00
IUUC-Dno-029705 Dasypus novemcinctus 93.13 0.00e+00 1439.00
IUUC-Dme-031740 Drosophila melanogaster 71.11 1.00e-175 610.00
IUUC-Eca-034125 Equus caballus 95.26 0.00e+00 1464.00
IUUC-Fca-035905 Felis catus 92.92 0.00e+00 1431.00
IUUC-Fal-037336 Ficedula albicollis 93.31 0.00e+00 1424.00
IUUC-Gmo-039486 Gadus morhua 77.26 0.00e+00 858.00
IUUC-Gga-040218 Gallus gallus 95.09 0.00e+00 1474.00
IUUC-Gac-041707 Gasterosteus aculeatus 81.42 0.00e+00 1258.00
IUUC-Ggo-045408 Gorilla gorilla 88.93 0.00e+00 1360.00
IUUC-Hsa-045878 Homo sapiens 94.95 0.00e+00 1478.00
IUUC-Itr-048317 Ictidomys tridecemlineatus 95.13 0.00e+00 1457.00
IUUC-Loc-052628 Lepisosteus oculatus 82.55 0.00e+00 1345.00
IUUC-Laf-053644 Loxodonta africana 88.82 0.00e+00 1375.00
IUUC-Mcc-055479 Macaca mulatta 86.17 0.00e+00 1302.00
IUUC-Mga-059723 Meleagris gallopavo 90.61 0.00e+00 1404.00
IUUC-Mdo-063005 Monodelphis domestica 95.74 0.00e+00 1485.00
IUUC-Mmu-063634 Mus musculus 93.35 0.00e+00 1432.00
IUUC-Mpu-065898 Mustela putorius furo 93.94 0.00e+00 1433.00
IUUC-Mlu-067584 Myotis lucifugus 94.49 0.00e+00 1458.00
IUUC-Nle-069033 Nomascus leucogenys 95.67 0.00e+00 1468.00
IUUC-Ont-072265 Oreochromis niloticus 83.18 0.00e+00 1289.00
IUUC-Oan-073621 Ornithorhynchus anatinus 90.13 0.00e+00 1436.00
IUUC-Ocu-073960 Oryctolagus cuniculus 93.93 0.00e+00 1430.00
IUUC-Oga-088579 Otolemur garnettii 94.95 0.00e+00 1477.00
IUUC-Oar-090396 Ovis aries 92.49 0.00e+00 1362.00
IUUC-Ptr-091624 Pan troglodytes 94.95 0.00e+00 1478.00
IUUC-Pan-092479 Papio anubis 94.67 0.00e+00 1467.00
IUUC-Psi-094074 Pelodiscus sinensis 95.02 0.00e+00 1141.00
IUUC-Pfo-097203 Poecilia formosa 81.45 0.00e+00 1266.00
IUUC-Pab-097540 Pongo abelii 94.58 0.00e+00 1407.00
IUUC-Pca-100379 Procavia capensis 72.73 0.00e+00 644.00
IUUC-Rno-105396 Rattus norvegicus 93.35 0.00e+00 1434.00
IUUC-Ssc-116413 Sus scrofa 93.00 0.00e+00 1399.00
IUUC-Tgu-116723 Taeniopygia guttata 93.60 0.00e+00 1428.00
IUUC-Tru-117843 Takifugu rubripes 79.20 0.00e+00 1244.00
IUUC-Tsy-119455 Tarsius syrichta 94.62 0.00e+00 1368.00
IUUC-Tni-120037 Tetraodon nigroviridis 81.07 0.00e+00 1218.00
IUUC-Tbe-127879 Tupaia belangeri 81.30 0.00e+00 1192.00
IUUC-Ttr-128423 Tursiops truncatus 93.77 0.00e+00 1383.00
IUUC-Xtr-132237 Xenopus tropicalis 87.58 0.00e+00 1377.00
Created Date 25-Jun-2017

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