iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069099

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Histone deacetylase

Genbank Nucleotide ID

ADFV01115277

Gene Name

HDAC4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000013474.2	ENSNLET00000017164.2	ENSNLEP00000016326.2

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	95.68	0.00e+00	1259.00	IUUC-Hsa-046925

Active Site

Position(s)	Description	Evidence
802	N/A	{ECO:0000256\|PIRSR:PIRSR037911-1}

Organism

Nomascus leucogenys

Functional Description
(View)

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events.

Protein Sequence
(Fasta)

MSSQSHPDGL SGRDQPVELL NPARVNHMPS TVDVATALPL QVAPSAVPMD LRLDHQFSLP 60
VAEPALREQQ LQQELLALKQ KQQIQRQILI AEFQRQHEQL SRQHEAQLHE HIKQQQEMLA 120

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Nucleotide Sequence
(Fasta)

CTACGCCTCC GTGCGCACGC AGCACCACGT GACCCACCAC CAGTACCCAA GATGGACGCC 60
GCGGCGAGGC CTGGCCGGCT CCCCGCCTCA GCCTGCATCC CATTGTGTGC CCTCTAAGCG 120

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Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc

Interpro

IPR033660--HDAC4
IPR000286--His_deacetylse
IPR023801--His_deacetylse_dom
IPR024643--Hist_deacetylase_Gln_rich_N
IPR017320--Histone_deAcase_II_euk

Pfam

PF12203--HDAC4_Gln
PF00850--Hist_deacetyl

Gene Ontology

GO:0005829--C:cytosol
GO:0000118--C:histone deacetylase complex
GO:0017053--C:transcriptional repressor complex
GO:0001047--F:core promoter binding
GO:0032041--F:NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0030955--F:potassium ion binding
GO:0043565--F:sequence-specific DNA binding
GO:0008270--F:zinc ion binding
GO:0006338--P:chromatin remodeling
GO:0070933--P:histone H4 deacetylation
GO:0010832--P:negative regulation of myotube differentiation
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0034983--P:peptidyl-lysine deacetylation
GO:0008284--P:positive regulation of cell proliferation
GO:0033235--P:positive regulation of protein sumoylation
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0040029--P:regulation of gene expression, epigenetic
GO:0043393--P:regulation of protein binding
GO:0070555--P:response to interleukin-1
GO:0006351--P:transcription, DNA-templated

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002279	Ailuropoda melanoleuca	89.93	0.00e+00	1163.00
IUUC-Apl-003250	Anas platyrhynchos	83.12	0.00e+00	1010.00
IUUC-Aca-004668	Anolis carolinensis	78.79	0.00e+00	1085.00
IUUC-Bta-013215	Bos taurus	89.01	0.00e+00	1177.00
IUUC-Cja-019816	Callithrix jacchus	94.44	0.00e+00	1268.00
IUUC-Cfa-020861	Canis familiaris	91.23	0.00e+00	1224.00
IUUC-Cpo-021562	Cavia porcellus	89.38	0.00e+00	1203.00
IUUC-Csa-023612	Chlorocebus sabaeus	94.85	0.00e+00	1244.00
IUUC-Dre-028284	Danio rerio	73.70	2.00e-154	540.00
IUUC-Dno-029951	Dasypus novemcinctus	88.51	0.00e+00	1069.00
IUUC-Dor-030362	Dipodomys ordii	84.58	0.00e+00	1032.00
IUUC-Fca-036187	Felis catus	90.28	0.00e+00	1142.00
IUUC-Gmo-038473	Gadus morhua	62.72	4.00e-121	429.00
IUUC-Gga-040501	Gallus gallus	86.96	0.00e+00	1098.00
IUUC-Gac-042335	Gasterosteus aculeatus	64.19	4.00e-123	436.00
IUUC-Ggo-045380	Gorilla gorilla	96.05	0.00e+00	1295.00
IUUC-Hsa-046925	Homo sapiens	95.68	0.00e+00	1246.00
IUUC-Itr-048036	Ictidomys tridecemlineatus	90.55	0.00e+00	1120.00
IUUC-Lch-050325	Latimeria chalumnae	80.10	0.00e+00	1016.00
IUUC-Loc-052231	Lepisosteus oculatus	75.66	0.00e+00	928.00
IUUC-Laf-054490	Loxodonta africana	80.33	0.00e+00	1061.00
IUUC-Mcc-055265	Macaca mulatta	94.97	0.00e+00	1249.00
IUUC-Meu-056676	Macropus eugenii	77.89	4.00e-109	389.00
IUUC-Mmr-061633	Microcebus murinus	82.59	0.00e+00	1032.00
IUUC-Mmu-063089	Mus musculus	90.25	0.00e+00	1120.00
IUUC-Mpu-065887	Mustela putorius furo	88.89	0.00e+00	1164.00
IUUC-Mlu-067470	Myotis lucifugus	90.78	0.00e+00	1171.00
IUUC-Ont-071613	Oreochromis niloticus	70.88	1.00e-131	464.00
IUUC-Oan-073275	Ornithorhynchus anatinus	84.81	0.00e+00	1089.00
IUUC-Ola-087031	Oryzias latipes	59.66	0.00e+00	679.00
IUUC-Oga-088201	Otolemur garnettii	83.45	0.00e+00	968.00
IUUC-Oar-089997	Ovis aries	78.90	0.00e+00	850.00
IUUC-Ptr-091116	Pan troglodytes	95.93	0.00e+00	1290.00
IUUC-Pan-092132	Papio anubis	91.88	1.00e-177	616.00
IUUC-Psi-093734	Pelodiscus sinensis	84.91	0.00e+00	1016.00
IUUC-Pma-094347	Petromyzon marinus	67.72	5.00e-70	259.00
IUUC-Pfo-096293	Poecilia formosa	67.01	1.00e-109	390.00
IUUC-Pab-098491	Pongo abelii	96.17	0.00e+00	1295.00
IUUC-Pca-101004	Procavia capensis	79.38	0.00e+00	852.00
IUUC-Pva-102961	Pteropus vampyrus	72.93	3.00e-172	598.00
IUUC-Rno-105005	Rattus norvegicus	90.00	0.00e+00	1092.00
IUUC-Sha-107646	Sarcophilus harrisii	70.90	6.00e-99	355.00
IUUC-Ssc-115428	Sus scrofa	89.37	0.00e+00	1070.00
IUUC-Tgu-116776	Taeniopygia guttata	86.79	0.00e+00	1091.00
IUUC-Tru-118180	Takifugu rubripes	68.09	7.00e-135	474.00
IUUC-Tsy-119468	Tarsius syrichta	89.57	1.00e-177	617.00
IUUC-Tni-120196	Tetraodon nigroviridis	61.95	3.00e-136	479.00
IUUC-Ttr-128360	Tursiops truncatus	74.85	1.00e-90	328.00
IUUC-Xtr-132956	Xenopus tropicalis	75.93	0.00e+00	914.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence