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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063452
Ensembl Protein ID ENSMUSP00000030895.5
UniProt Accession Q9JM98; Q8BQ21; WRP73_MOUSE
Genbank Protein ID BAA92311.1; BAC34722.1; BAE33920.1; BAE35741.1; CAM18777.1; EDL14958.1
Protein Name WD repeat-containing protein WRAP73; WD repeat-containing protein 8; WD repeat-containing protein antisense to TP73 gene
Genbank Nucleotide ID AB034911; AK051688; AK156969; AK160331; AL806525; CH466594
Gene Name Wrap73; Dd57; Wdr8
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000029029.14 ENSMUST00000030895.11 ENSMUSP00000030895.5
ENSMUSG00000029029.14 ENSMUST00000146734.1 ENSMUSP00000118548.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
microRNATRANSFACRepTarmiRNAMap
RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 3.50e-06 28.3 372 403
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtclaf.sd.tllvsGsdDgtikvWDlr 31
           H ++v+++++ +  ++l+ +++  ++++W++ 
   Q: 372  HMSPVRSFQWdPQqPRLAICTGGSKVYLWSPA 403
           99********966688888888899****965 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles (By similarity).
 The SSX2IP:WRAP73 complex is proposed to act as regulator of spindle anchoring at the mitotic centrosome. Required for the centrosomal localization of SSX2IP and normal mitotic bipolar spindle morphology. Required for the targeting of centriole satellite proteins to centrosomes such as of PCM1, SSX2IP, CEP290 and PIBF1/CEP90. Required for ciliogenesis and involved in the removal of the CEP97:CCP110 complex from the mother centriole. Involved in ciliary vesicle formation at the mother centriole and required for the docking of vesicles to the basal body during ciliogenesis; may promote docking of RAB8A- and ARL13B-containing vesicles (By similarity).
Protein Sequence
(Fasta)
MNFSESFKLS GLLCRFSPDG KYLASCVQYR LVIRDVTTLQ ILQLYTCLDQ IQHIEWSADS 60
LFILCAMYRR GLVQVWSLEQ PEWHCKIDEG SAGLVASCWS PDGRHILNTT EFHLRITVWS 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063452|E3,WD_repeat|Mus musculus
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Nucleotide Sequence
(Fasta)
GTACTTCCGG CCGCTGCCTG GGGCGGTTGC GGGAGGTACT TCGGAGCCGG GCTGGCCCGG 60
GCTGGCCGTG GCCATGAACT TCTCGGAGTC ATTCAAGCTC TCGGGCCTGC TCTGCAGGTT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063452|E3,WD_repeat|Mus musculus
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Sequence Source Ensembl
Keyword

KW-0970--Cilium biogenesis/degradation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR023302--Pept_S9A_N
IPR011044--Quino_amine_DH_bsu
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
Pfam

PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005813--C:centrosome
GO:0036064--C:ciliary basal body
GO:0005737--C:cytoplasm
GO:0030030--P:cell projection organization
GO:0090307--P:mitotic spindle assembly
GO:1902857--P:positive regulation of non-motile cilium assembly
KEGG mmu:59002
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001962 Ailuropoda melanoleuca 89.40 0.00e+00 831.00
IUUC-Ame-011800 Astyanax mexicanus 70.09 0.00e+00 685.00
IUUC-Bta-012871 Bos taurus 87.06 0.00e+00 833.00
IUUC-Cja-019673 Callithrix jacchus 86.90 0.00e+00 813.00
IUUC-Cfa-020819 Canis familiaris 88.96 0.00e+00 860.00
IUUC-Cpo-021547 Cavia porcellus 86.85 0.00e+00 820.00
IUUC-Csa-023788 Chlorocebus sabaeus 88.65 0.00e+00 831.00
IUUC-Cin-025531 Ciona intestinalis 52.46 4.00e-144 504.00
IUUC-Dre-027827 Danio rerio 68.58 0.00e+00 669.00
IUUC-Dno-029109 Dasypus novemcinctus 84.51 0.00e+00 770.00
IUUC-Dor-030894 Dipodomys ordii 87.34 0.00e+00 847.00
IUUC-Eca-033543 Equus caballus 90.36 0.00e+00 857.00
IUUC-Eeu-034534 Erinaceus europaeus 79.56 0.00e+00 741.00
IUUC-Fca-035577 Felis catus 84.11 0.00e+00 797.00
IUUC-Ggo-044595 Gorilla gorilla 88.86 0.00e+00 858.00
IUUC-Hsa-045848 Homo sapiens 88.65 0.00e+00 857.00
IUUC-Itr-048797 Ictidomys tridecemlineatus 90.37 0.00e+00 845.00
IUUC-Mpu-065795 Mustela putorius furo 89.18 0.00e+00 823.00
IUUC-Mlu-067626 Myotis lucifugus 83.04 0.00e+00 783.00
IUUC-Nle-069334 Nomascus leucogenys 84.50 0.00e+00 804.00
IUUC-Opr-071133 Ochotona princeps 81.47 1.00e-130 459.00
IUUC-Ogu-078740 Oryza glumaepatula 46.34 3.00e-116 413.00
IUUC-Oar-090219 Ovis aries 74.74 0.00e+00 718.00
IUUC-Ptr-090500 Pan troglodytes 88.86 0.00e+00 858.00
IUUC-Pan-092844 Papio anubis 88.21 0.00e+00 827.00
IUUC-Pfo-097218 Poecilia formosa 71.46 0.00e+00 686.00
IUUC-Pab-097585 Pongo abelii 88.86 0.00e+00 856.00
IUUC-Tni-120612 Tetraodon nigroviridis 66.59 0.00e+00 671.00
IUUC-Tbe-127387 Tupaia belangeri 89.08 0.00e+00 859.00
IUUC-Ttr-129229 Tursiops truncatus 84.87 0.00e+00 811.00
Created Date 25-Jun-2017

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