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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045960
UUCD1 version UUC-HoS-00023
Ensembl Protein ID ENSP00000376628.3
UniProt Accession O43567; A6NC87; B3KR12; Q05D66; Q6IBJ9; RNF13_HUMAN
Genbank Protein ID AAC03769.1; AAC28641.1; BAG36109.1; BAG52202.1; BAG52224.1; CAG33085.1; EAW78858.1; EAW78859.1; EAW78860.1; EAW78861.1; EAW78862.1; EAW78863.1; AAH09803.1; AAH09781.1; AAH17878.1
Protein Name E3 ubiquitin-protein ligase RNF13; RING finger protein 13; RING-type E3 ubiquitin transferase RNF13
Genbank Nucleotide ID AF037204; AF070558; AK313304; AK090638; AK090771; CR456804; AC069216; CH471052; CH471052; CH471052; CH471052; CH471052; BC009803; BC009781; BC017878
Gene Name RNF13; RZF
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000082996.19 ENST00000392894.7 ENSP00000376628.3
ENSG00000082996.19 ENST00000474348.5 ENSP00000420124.1
ENSG00000082996.19 ENST00000467996.1 ENSP00000419809.1
ENSG00000082996.19 ENST00000490631.5 ENSP00000417294.1
ENSG00000082996.19 ENST00000361785.10 ENSP00000355268.6
ENSG00000082996.19 ENST00000468289.1 ENSP00000420510.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
AREsitecircBasecircRNADbCircNet
miRTarBasemicroRNATRANSFACTargetScan
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
BioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 21078126; 21078127; 20230530
Classification
Family E-value Score Start End
E3 activity/RING/RING 1.30e-08 36.8 240 282
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiCl++++dg  +++lpC H++h +C+  w     +++++ +CP+C+
   Q: 240  CAICLDEYEDGdkLRILPCSHAYHCKCVDPW-----LTKTKKTCPVCK 282
           ********66666******************.....899********7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation.
 E3 ubiquitin-protein ligase that may play a role in controlling cell proliferation.
Protein Sequence
(Fasta)
MLLSIGMLML SATQVYTILT VQLFAFLNLL PVEADILAYN FENASQTFDD LPARFGYRLP 60
AEGLKGFLIN SKPENACEPI VPPPVKDNSS GTFIVLIRRL DCNFDIKVLN AQRAGYKAAI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045960|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTCTTTAGTA GGTCGGGTGA GTGTAGTGTG CAGGGAAGAG ACGCGTCAGC GCCAGGGCCA 60
GGCCCGCCCG GGGGCAGCCC GGCAGCCGAA TCTTGGGCTA CTCTGTCCCA ACAGCCGGAG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045960|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0967--Endosome
KW-0325--Glycoprotein
KW-0333--Golgi apparatus
KW-0458--Lysosome
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003137--PA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF02225--PA
PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005829--C:cytosol
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0016021--C:integral component of membrane
GO:0043231--C:intracellular membrane-bounded organelle
GO:0031902--C:late endosome membrane
GO:0005765--C:lysosomal membrane
GO:0005637--C:nuclear inner membrane
GO:0005654--C:nucleoplasm
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0051865--P:protein autoubiquitination
KEGG hsa:11342
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000889 Aegilops tauschii 27.68 7.00e-18 85.50
IUUC-Aml-001909 Ailuropoda melanoleuca 97.38 0.00e+00 646.00
IUUC-Atr-003055 Amborella trichopoda 31.45 7.00e-32 131.00
IUUC-Apl-004022 Anas platyrhynchos 91.08 2.00e-173 602.00
IUUC-Aca-004641 Anolis carolinensis 87.24 7.00e-168 583.00
IUUC-Aly-006519 Arabidopsis lyrata 32.68 2.00e-32 132.00
IUUC-Ani-009169 Aspergillus nidulans 37.84 8.00e-13 68.60
IUUC-Ame-010635 Astyanax mexicanus 72.50 8.00e-141 493.00
IUUC-Bgr-012131 Blumeria graminis 50.00 2.00e-12 68.20
IUUC-Bta-012593 Bos taurus 97.90 0.00e+00 692.00
IUUC-Bci-013936 Botrytis cinerea 35.14 6.00e-13 69.30
IUUC-Bdi-014479 Brachypodium distachyon 32.02 9.00e-28 117.00
IUUC-Bol-015396 Brassica oleracea 34.14 1.00e-22 100.00
IUUC-Bra-017689 Brassica rapa 32.74 6.00e-33 135.00
IUUC-Cel-018181 Caenorhabditis elegans 32.16 5.00e-29 122.00
IUUC-Cja-019353 Callithrix jacchus 99.21 0.00e+00 653.00
IUUC-Cfa-020234 Canis familiaris 97.64 0.00e+00 646.00
IUUC-Cpo-021602 Cavia porcellus 95.04 2.00e-158 551.00
IUUC-Cre-022983 Chlamydomonas reinhardtii 37.93 1.00e-10 61.20
IUUC-Csa-023201 Chlorocebus sabaeus 99.74 0.00e+00 656.00
IUUC-Cho-024954 Choloepus hoffmanni 81.36 3.00e-148 517.00
IUUC-Cin-025554 Ciona intestinalis 42.12 4.00e-61 228.00
IUUC-Csv-025959 Ciona savignyi 44.06 1.00e-51 197.00
IUUC-Dre-028744 Danio rerio 77.54 2.00e-136 478.00
IUUC-Dno-029675 Dasypus novemcinctus 96.33 0.00e+00 637.00
IUUC-Dor-030791 Dipodomys ordii 78.22 3.00e-135 474.00
IUUC-Dse-031406 Dothistroma septosporum 43.33 2.00e-12 68.20
IUUC-Dme-031765 Drosophila melanogaster 39.72 1.00e-50 194.00
IUUC-Ete-032577 Echinops telfairi 85.53 7.00e-139 486.00
IUUC-Eca-034148 Equus caballus 96.33 0.00e+00 639.00
IUUC-Eeu-034552 Erinaceus europaeus 94.75 7.00e-178 616.00
IUUC-Fca-036021 Felis catus 97.38 0.00e+00 643.00
IUUC-Fal-037621 Ficedula albicollis 90.03 1.00e-170 592.00
IUUC-Fox-038011 Fusarium oxysporum 35.79 3.00e-13 70.10
IUUC-Gmo-039485 Gadus morhua 77.74 4.00e-134 471.00
IUUC-Gga-041166 Gallus gallus 91.08 2.00e-174 604.00
IUUC-Gac-042124 Gasterosteus aculeatus 75.94 5.00e-129 454.00
IUUC-Ggo-045344 Gorilla gorilla 100.00 0.00e+00 658.00
IUUC-Hvu-047136 Hordeum vulgare 34.52 6.00e-29 122.00
IUUC-Itr-048327 Ictidomys tridecemlineatus 95.54 0.00e+00 635.00
IUUC-Lch-050635 Latimeria chalumnae 82.50 2.00e-135 474.00
IUUC-Lpe-051192 Leersia perrieri 34.78 3.00e-29 123.00
IUUC-Loc-052869 Lepisosteus oculatus 79.20 1.00e-140 493.00
IUUC-Laf-054477 Loxodonta africana 95.01 0.00e+00 636.00
IUUC-Mcc-055232 Macaca mulatta 99.74 0.00e+00 656.00
IUUC-Meu-056237 Macropus eugenii 82.35 1.00e-116 412.00
IUUC-Mpo-057522 Magnaporthe poae 44.44 4.00e-13 69.70
IUUC-Mtr-058129 Medicago truncatula 32.68 3.00e-28 119.00
IUUC-Mla-059171 Melampsora laricipopulina 42.59 2.00e-10 60.80
IUUC-Mga-059780 Meleagris gallopavo 91.08 4.00e-174 603.00
IUUC-Mvi-060468 Microbotryum violaceum 46.00 5.00e-12 66.60
IUUC-Mmr-061384 Microcebus murinus 96.76 2.00e-179 621.00
IUUC-Mdo-062781 Monodelphis domestica 92.67 5.00e-180 623.00
IUUC-Mmu-063727 Mus musculus 93.44 1.00e-172 598.00
IUUC-Mac-065216 Musa acuminata 34.38 7.00e-30 125.00
IUUC-Mpu-066497 Mustela putorius furo 97.90 0.00e+00 646.00
IUUC-Mlu-067654 Myotis lucifugus 95.71 3.00e-115 407.00
IUUC-Nle-069368 Nomascus leucogenys 100.00 0.00e+00 658.00
IUUC-Opr-070934 Ochotona princeps 67.98 4.00e-111 394.00
IUUC-Ont-071868 Oreochromis niloticus 75.55 1.00e-128 452.00
IUUC-Oan-072733 Ornithorhynchus anatinus 87.19 6.00e-105 373.00
IUUC-Ocu-074083 Oryctolagus cuniculus 96.59 0.00e+00 640.00
IUUC-Oba-075841 Oryza barthii 33.33 2.00e-27 117.00
IUUC-Obr-076703 Oryza brachyantha 35.57 5.00e-30 125.00
IUUC-Ogl-077861 Oryza glaberrima 35.57 3.00e-30 126.00
IUUC-Ogu-078205 Oryza glumaepatula 34.78 4.00e-28 119.00
IUUC-Oin-080138 Oryza indica 32.56 4.00e-28 119.00
IUUC-Olo-081024 Oryza longistaminata 35.18 3.00e-29 124.00
IUUC-Ome-081844 Oryza meridionalis 35.57 4.00e-30 125.00
IUUC-Oni-082382 Oryza nivara 32.81 8.00e-30 125.00
IUUC-Opu-083162 Oryza punctata 36.36 3.00e-30 126.00
IUUC-Oru-085122 Oryza rufipogon 33.12 4.00e-28 119.00
IUUC-Osa-086175 Oryza sativa 35.57 3.00e-30 126.00
IUUC-Ola-086440 Oryzias latipes 74.01 5.00e-116 410.00
IUUC-Oga-088291 Otolemur garnettii 91.91 4.00e-168 583.00
IUUC-Oar-089911 Ovis aries 97.64 0.00e+00 690.00
IUUC-Ptr-091166 Pan troglodytes 100.00 0.00e+00 658.00
IUUC-Pan-092154 Papio anubis 99.74 0.00e+00 656.00
IUUC-Psi-093062 Pelodiscus sinensis 91.34 4.00e-170 590.00
IUUC-Pma-094545 Petromyzon marinus 73.21 8.00e-26 107.00
IUUC-Ppa-095928 Physcomitrella patens 34.47 4.00e-31 128.00
IUUC-Pfo-097232 Poecilia formosa 77.43 2.00e-132 465.00
IUUC-Pab-097909 Pongo abelii 99.74 0.00e+00 659.00
IUUC-Pop-099688 Populus trichocarpa 31.70 2.00e-22 99.80
IUUC-Pca-100724 Procavia capensis 79.13 4.00e-138 484.00
IUUC-Ppe-101605 Prunus persica 31.41 4.00e-28 118.00
IUUC-Pva-102624 Pteropus vampyrus 91.08 2.00e-165 575.00
IUUC-Pgr-103420 Puccinia graminis 55.32 3.00e-12 67.80
IUUC-Ptt-103943 Puccinia triticina 44.44 9.00e-11 62.00
IUUC-Rno-105109 Rattus norvegicus 91.60 7.00e-165 573.00
IUUC-Sha-107563 Sarcophilus harrisii 92.41 2.00e-175 607.00
IUUC-Spo-108083 Schizosaccharomyces pombe 26.61 1.00e-14 74.30
IUUC-Ssl-108601 Sclerotinia sclerotiorum 41.07 9.00e-13 68.20
IUUC-Smo-109274 Selaginella moellendorffii 36.08 3.00e-32 132.00
IUUC-Sit-110628 Setaria italica 33.55 2.00e-31 130.00
IUUC-Sly-110842 Solanum lycopersicum 29.39 4.00e-28 119.00
IUUC-Sre-114989 Sporisorium reilianum 43.14 1.00e-12 68.90
IUUC-Ssc-116043 Sus scrofa 97.64 0.00e+00 643.00
IUUC-Tgu-116908 Taeniopygia guttata 89.79 2.00e-171 594.00
IUUC-Tru-118219 Takifugu rubripes 75.47 1.00e-131 462.00
IUUC-Tsy-119333 Tarsius syrichta 97.90 0.00e+00 639.00
IUUC-Tni-120332 Tetraodon nigroviridis 71.49 1.00e-88 319.00
IUUC-Tca-121333 Theobroma cacao 33.08 1.00e-27 117.00
IUUC-Tae-125320 Triticum aestivum 31.16 1.00e-29 123.00
IUUC-Tur-126455 Triticum urartu 32.61 1.00e-26 114.00
IUUC-Tbe-127859 Tupaia belangeri 85.79 7.00e-167 579.00
IUUC-Ttr-129219 Tursiops truncatus 87.14 2.00e-157 548.00
IUUC-Uma-129559 Ustilago maydis 52.08 2.00e-12 67.80
IUUC-Vda-129899 Verticillium dahliae 43.40 9.00e-13 68.60
IUUC-Vpa-130314 Vicugna pacos 95.01 9.00e-176 609.00
IUUC-Vvi-131355 Vitis vinifera 33.46 5.00e-29 122.00
IUUC-Xtr-132114 Xenopus tropicalis 75.56 3.00e-131 461.00
IUUC-Xma-133474 Xiphophorus maculatus 77.43 2.00e-132 465.00
IUUC-Yli-134442 Yarrowia lipolytica 44.68 4.00e-12 65.90
Created Date 25-Jun-2017

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