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Tag Content
UUCD2 ID IUUC-Dre-027435
UUCD1 version UUC-DaR-01290
Ensembl Protein ID ENSDARP00000070818.4
UniProt Accession Q8JFV5; Q8JFV5_DANRE
Genbank Protein ID CAD32862.1
Protein Name HECT domain-containing 1; Novel protein with HECT-domain (Ubiquitin-transferase)
Genbank Nucleotide ID BX324186
Gene Name hectd1; OTTDARP00000001496; dZ142B24.4-001
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000054213.7 ENSDART00000076344.5 ENSDARP00000070818.4
ENSDARG00000054213.7 ENSDART00000152000.1 ENSDARP00000126492.1
ENSDARG00000054213.7 ENSDART00000152057.1 ENSDARP00000126451.1
ENSDARG00000054213.7 ENSDART00000164981.1 ENSDARP00000133558.1
ENSDARG00000054213.7 ENSDART00000076340.4 ENSDARP00000070814.3
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/HECT 4.10e-119 398.8 2118 2576
Active Site
Position(s) Description Evidence
2545 Glycyl thioester intermediate {ECO:0000256|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysen..dketlqpnpdsglknp..................... 65
           ++d+k++levef+gEeg++l G+t+ef+al+++e+q+++lg++l++++  d+e++q++   glk+p                     
   Q: 2118 HADRKSVLEVEFQGEEGTGL-GPTLEFYALVAAEFQRTSLGIWLCDDDfpDDESRQVDLGGGLKPPgyyvqrscglfpapfpqdsde 2203
           6899****************.******************************************988********************* PP
   S: 66   ..ehlklFeflGrllgkalqdgrlldlplsksfykll.................................................. 100
             + +klF flG++l+k++qd+rl+dlp+s++f+kll                                                  
   Q: 2204 leRITKLFLFLGIFLAKCIQDNRLVDLPISQPFFKLLcmgdiksnmskllyqtrgesdchfseiqseasteegqdtysvgsfdedsk 2290
           *************************************99999999999999999999999999999988888888888888777777 PP
   S: 101  ...............lgkklsledleevdpelykslkeikena........es..........................dieelgld 138
                           +  l++ed+e v+p+++ +lke+k++         ++                           +e+lgl+
   Q: 2291 sefildppkpkppawYHGILTWEDFELVNPHRALFLKELKALSvkrrqilgNKslsedekntrlqdlmlknpmgsgpplCVEDLGLN 2377
           7777666666655555557*********************99866655555116667777889999999999999***9******** PP
   S: 139  ltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeid 225
           ++f++s+++ g  +++ Lkp+Ge+++Vt++N+eeYv+l++++++++gi++q+eafreGfn+v+p+e+ls+F+++e+++++cG+   +
   Q: 2378 FQFCPSSKVHGFSSVD-LKPNGEDEMVTMDNAEEYVELMFDFCMHTGIQKQMEAFREGFNKVFPMEKLSSFSHKEVQMILCGN---Q 2460
           ******9988888777.******************************************************************...5 PP
   S: 226  vedlkket..ky...kggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfn 306
           ++++++e+  +y   k gyt+dsp++ +F++vl+++ss+erkafLqF+Tg+s+lP+gG+a+l+prl+++rk da+d+++Ps+nTC++
   Q: 2461 SPSWTAEDivNYtepKLGYTRDSPGFLRFVRVLCGMSSDERKAFLQFTTGCSTLPPGGLANLHPRLTIVRKvDATDASYPSVNTCVH 2547
           555555555544555************************************************************************ PP
   S: 307  yLkLPeYsskeilkekLlyAieetkgFels 336
           yLkLPeYss+ei++e+Ll+A++e kgF+l+
   Q: 2548 YLKLPEYSSEEIMRERLLAATME-KGFHLN 2576
           ***********************.****86 PP
   
Organism Danio rerio
Protein Sequence
(Fasta)
MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP RTFLPALCKI 60
FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK ALCNRLVVVE LNNRTSRDLA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dre-027435|E3,HECT|Danio rerio
Please wait for a moment...
Nucleotide Sequence
(Fasta)
TACAATTTCG CAATATAGGT GAATGAATGT CTGATCTGTT TTTTTGTCGA CCTCGATGAA 60
GGCGAGGTGT TTTAGCACCC CCTGTCGCTG AGCCGCATCG CTGCGTGTTT CTGACCGCTG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dre-027435|E3,HECT|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0040--ANK repeat
KW-0181--Complete proteome
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
Interpro

IPR002110--Ankyrin_rpt
IPR020683--Ankyrin_rpt-contain_dom
IPR011989--ARM-like
IPR016024--ARM-type_fold
IPR008979--Galactose-bd-like
IPR000569--HECT_dom
IPR010606--Mib_Herc2
IPR012919--SUN_dom
PROSITE

PS50297--ANK_REP_REGION
PS50088--ANK_REPEAT
PS50237--HECT
PS51416--MIB_HERC2
Pfam

PF12796--Ank_2
PF00632--HECT
PF06701--MIB_HERC2
PF07738--Sad1_UNC
SMART

SM00248--ANK
SM00119--HECTc
Gene Ontology

GO:0046872--F:metal ion binding
GO:0004842--F:ubiquitin-protein transferase activity
KEGG dre:100002034
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001987 Ailuropoda melanoleuca 87.03 0.00e+00 4108.00
IUUC-Apl-003493 Anas platyrhynchos 87.54 0.00e+00 4125.00
IUUC-Aca-004521 Anolis carolinensis 88.02 0.00e+00 4116.00
IUUC-Ame-011258 Astyanax mexicanus 93.70 0.00e+00 4282.00
IUUC-Bta-012835 Bos taurus 86.91 0.00e+00 4113.00
IUUC-Cel-018153 Caenorhabditis elegans 52.24 2.00e-168 588.00
IUUC-Cja-019174 Callithrix jacchus 86.11 0.00e+00 4032.00
IUUC-Cfa-021115 Canis familiaris 86.88 0.00e+00 4065.00
IUUC-Cpo-022382 Cavia porcellus 83.19 0.00e+00 3869.00
IUUC-Csa-023230 Chlorocebus sabaeus 86.95 0.00e+00 4108.00
IUUC-Cho-024711 Choloepus hoffmanni 84.63 0.00e+00 1478.00
IUUC-Cin-025342 Ciona intestinalis 52.59 0.00e+00 1359.00
IUUC-Csv-026031 Ciona savignyi 51.79 0.00e+00 1391.00
IUUC-Dno-029954 Dasypus novemcinctus 87.03 0.00e+00 4082.00
IUUC-Dor-030734 Dipodomys ordii 90.76 0.00e+00 1372.00
IUUC-Dme-031739 Drosophila melanogaster 60.66 0.00e+00 1633.00
IUUC-Ete-033192 Echinops telfairi 86.76 0.00e+00 1142.00
IUUC-Eca-033434 Equus caballus 86.60 0.00e+00 4080.00
IUUC-Eeu-035031 Erinaceus europaeus 79.03 0.00e+00 1033.00
IUUC-Fca-035998 Felis catus 85.54 0.00e+00 4000.00
IUUC-Fal-037468 Ficedula albicollis 87.78 0.00e+00 4083.00
IUUC-Gmo-038495 Gadus morhua 92.57 0.00e+00 1385.00
IUUC-Gga-040736 Gallus gallus 88.55 0.00e+00 4091.00
IUUC-Gac-041777 Gasterosteus aculeatus 94.34 0.00e+00 2461.00
IUUC-Ggo-044677 Gorilla gorilla 82.88 0.00e+00 3843.00
IUUC-Hsa-045879 Homo sapiens 86.95 0.00e+00 4108.00
IUUC-Itr-048664 Ictidomys tridecemlineatus 86.88 0.00e+00 4110.00
IUUC-Lch-050444 Latimeria chalumnae 89.25 0.00e+00 2561.00
IUUC-Loc-051986 Lepisosteus oculatus 89.72 0.00e+00 4234.00
IUUC-Laf-054230 Loxodonta africana 86.45 0.00e+00 4049.00
IUUC-Mcc-054787 Macaca mulatta 86.95 0.00e+00 4108.00
IUUC-Meu-056502 Macropus eugenii 81.68 0.00e+00 1221.00
IUUC-Mga-059409 Meleagris gallopavo 95.21 0.00e+00 1899.00
IUUC-Mmr-061667 Microcebus murinus 86.59 0.00e+00 4076.00
IUUC-Mdo-061960 Monodelphis domestica 87.57 0.00e+00 4108.00
IUUC-Mmu-063941 Mus musculus 86.38 0.00e+00 4071.00
IUUC-Mpu-065939 Mustela putorius furo 87.07 0.00e+00 4113.00
IUUC-Mlu-068112 Myotis lucifugus 86.99 0.00e+00 4084.00
IUUC-Nle-069001 Nomascus leucogenys 86.91 0.00e+00 4105.00
IUUC-Opr-071222 Ochotona princeps 90.37 0.00e+00 2033.00
IUUC-Ont-072101 Oreochromis niloticus 88.81 0.00e+00 4147.00
IUUC-Oan-072814 Ornithorhynchus anatinus 87.37 0.00e+00 4095.00
IUUC-Ocu-074011 Oryctolagus cuniculus 86.91 0.00e+00 4108.00
IUUC-Ola-086412 Oryzias latipes 94.41 0.00e+00 2463.00
IUUC-Oar-089668 Ovis aries 86.91 0.00e+00 4106.00
IUUC-Ptr-090517 Pan troglodytes 86.62 0.00e+00 4070.00
IUUC-Pan-091849 Papio anubis 84.51 0.00e+00 3942.00
IUUC-Psi-093390 Pelodiscus sinensis 86.63 0.00e+00 3991.00
IUUC-Pma-094628 Petromyzon marinus 82.46 0.00e+00 1539.00
IUUC-Ppa-095264 Physcomitrella patens 33.02 4.00e-81 296.00
IUUC-Pfo-097075 Poecilia formosa 95.29 0.00e+00 2516.00
IUUC-Pab-098176 Pongo abelii 86.95 0.00e+00 4108.00
IUUC-Pca-101123 Procavia capensis 75.41 0.00e+00 2003.00
IUUC-Pva-103008 Pteropus vampyrus 95.67 0.00e+00 1545.00
IUUC-Rno-105885 Rattus norvegicus 86.80 0.00e+00 4104.00
IUUC-Sha-107048 Sarcophilus harrisii 87.43 0.00e+00 4116.00
IUUC-Sar-113071 Sorex araneus 89.78 0.00e+00 1231.00
IUUC-Ssc-115963 Sus scrofa 86.22 0.00e+00 4105.00
IUUC-Tgu-117167 Taeniopygia guttata 80.98 0.00e+00 2298.00
IUUC-Tru-118626 Takifugu rubripes 95.20 0.00e+00 2530.00
IUUC-Tsy-119504 Tarsius syrichta 86.38 0.00e+00 2079.00
IUUC-Tni-119877 Tetraodon nigroviridis 94.64 0.00e+00 2474.00
IUUC-Tbe-127602 Tupaia belangeri 87.12 0.00e+00 1011.00
IUUC-Ttr-128394 Tursiops truncatus 81.38 0.00e+00 2628.00
IUUC-Vpa-130280 Vicugna pacos 85.88 0.00e+00 3881.00
IUUC-Xtr-131787 Xenopus tropicalis 80.05 0.00e+00 3769.00
Created Date 25-Jun-2017

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