iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSORLG00000007283.1	ENSORLT00000009138.1	ENSORLP00000009137.1
ENSORLG00000007283.1	ENSORLT00000009140.1	ENSORLP00000009139.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.50e-96	322.5	727	1051

Active Site

Position(s)	Description	Evidence
1020	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
            dlkk l+v f gEe++d+gG+t+ef+ ll+kel +p +g+f+y ++++  ++ ++        + ++F+++G+++g+a++++ ++d
   Q: 727  VDLKKPLKVIFDGEEAVDAGGLTKEFFLLLLKELMDPVYGMFTYYKESNLLWFSDKCFV-----EQNWFHLIGIICGLAIYNSTVVD 808
           589************************************************99888665.....579******************** PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           l+++ ++yk+ll+++ sled++e+ p+ ++sl+++++++ +d+e + + l+f ++ e++g t+++eL+pgGe+i V n+N++e+v+ 
   Q: 809  LHFPLALYKKLLDVSPSLEDFKELSPTEARSLQQLLDYEGRDVEGT-FLLNFAITRENYGMTEVKELVPGGESIAVDNTNRKEFVDS 894
           **************************************99999998.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           ++ y + ++++eq+ af++Gf +v+  e+lslF+++el  ++ G++++++e+l+k++ ykg+y++++p+++ Fwev++ef  e++k+
   Q: 895  YLRYVFSDSVDEQYSAFSSGFLKVCGGEILSLFQPSELMAMVVGNNNYNWEELEKNAVYKGEYSATHPTVRLFWEVFHEFPLEKKKQ 981
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           fL F+Tgs+r+P+ G+++l+   ++i+   a+++ lP ++TC+n+L++P+Y++keil+++L+ A+e+ +gF+l
   Q: 982  FLLFLTGSDRIPIHGMESLR---IIIQStTAEEHYLPVAHTCYNLLDMPRYQTKEILRRRLTQAVEQYEGFSL 1051
           ********************...7888857777**************************************97 PP

Organism

Oryzias latipes

Protein Sequence
(Fasta)

MLCWGNARDG QLGIGVEGNP VFEPRICHVF SGRGLKEVAC GGQHTLFLLQ DGSVYTCGSN 60
SCGQLGHDKA GNSPELVGAL DTQKITMVSC GRAHSVAVNE QGQVFVWGAG DGGQLGLETA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGTTGTGCT GGGGGAATGC CAGAGACGGG CAGTTGGGCA TTGGTGTGGA GGGGAATCCT 60
GTTTTTGAAC CAAGGATCTG TCATGTGTTC AGCGGCAGAG GGCTGAAAGA GGTTGCGTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001673	Ailuropoda melanoleuca	65.15	0.00e+00	1352.00
IUUC-Apl-003535	Anas platyrhynchos	65.15	0.00e+00	1356.00
IUUC-Aca-005223	Anolis carolinensis	64.27	0.00e+00	1345.00
IUUC-Ame-010816	Astyanax mexicanus	76.73	0.00e+00	1358.00
IUUC-Bta-013373	Bos taurus	65.25	0.00e+00	1362.00
IUUC-Bdi-014791	Brachypodium distachyon	38.00	3.00e-53	202.00
IUUC-Cel-018150	Caenorhabditis elegans	33.95	2.00e-155	543.00
IUUC-Cja-019609	Callithrix jacchus	65.15	0.00e+00	1351.00
IUUC-Cfa-021071	Canis familiaris	64.96	0.00e+00	1348.00
IUUC-Cpo-021548	Cavia porcellus	64.99	0.00e+00	1345.00
IUUC-Csa-023987	Chlorocebus sabaeus	65.25	0.00e+00	1352.00
IUUC-Cho-024325	Choloepus hoffmanni	72.23	0.00e+00	864.00
IUUC-Dre-027472	Danio rerio	78.27	0.00e+00	1661.00
IUUC-Dno-029241	Dasypus novemcinctus	64.81	0.00e+00	1339.00
IUUC-Dor-030672	Dipodomys ordii	54.97	0.00e+00	644.00
IUUC-Ete-032642	Echinops telfairi	62.97	0.00e+00	1254.00
IUUC-Eca-033646	Equus caballus	64.96	0.00e+00	1345.00
IUUC-Eeu-035098	Erinaceus europaeus	61.76	0.00e+00	812.00
IUUC-Fal-036952	Ficedula albicollis	65.72	0.00e+00	1361.00
IUUC-Gmo-039297	Gadus morhua	77.40	0.00e+00	1612.00
IUUC-Gga-040591	Gallus gallus	65.09	0.00e+00	1356.00
IUUC-Gac-041741	Gasterosteus aculeatus	84.64	0.00e+00	1826.00
IUUC-Ggo-044769	Gorilla gorilla	65.18	0.00e+00	1347.00
IUUC-Hsa-046066	Homo sapiens	65.15	0.00e+00	1349.00
IUUC-Itr-048311	Ictidomys tridecemlineatus	65.28	0.00e+00	1353.00
IUUC-Lch-050301	Latimeria chalumnae	66.29	0.00e+00	1427.00
IUUC-Loc-052803	Lepisosteus oculatus	74.70	0.00e+00	1630.00
IUUC-Laf-053364	Loxodonta africana	65.40	0.00e+00	1352.00
IUUC-Mcc-054930	Macaca mulatta	65.25	0.00e+00	1353.00
IUUC-Meu-056274	Macropus eugenii	52.64	2.00e-156	546.00
IUUC-Mga-059563	Meleagris gallopavo	65.15	0.00e+00	1357.00
IUUC-Mmr-060792	Microcebus murinus	64.33	0.00e+00	1326.00
IUUC-Mdo-062195	Monodelphis domestica	65.31	0.00e+00	1351.00
IUUC-Mmu-063855	Mus musculus	64.49	0.00e+00	1345.00
IUUC-Mpu-066308	Mustela putorius furo	65.15	0.00e+00	1353.00
IUUC-Mlu-066927	Myotis lucifugus	64.90	0.00e+00	1352.00
IUUC-Nle-070090	Nomascus leucogenys	65.15	0.00e+00	1351.00
IUUC-Opr-070891	Ochotona princeps	58.39	0.00e+00	1147.00
IUUC-Ont-072201	Oreochromis niloticus	84.99	0.00e+00	1811.00
IUUC-Ocu-074770	Oryctolagus cuniculus	65.25	0.00e+00	1351.00
IUUC-Oga-088831	Otolemur garnettii	64.77	0.00e+00	1339.00
IUUC-Oar-090449	Ovis aries	65.28	0.00e+00	1358.00
IUUC-Pan-092135	Papio anubis	65.28	0.00e+00	1352.00
IUUC-Psi-093832	Pelodiscus sinensis	64.23	0.00e+00	1368.00
IUUC-Pfo-097268	Poecilia formosa	86.45	0.00e+00	1864.00
IUUC-Pab-098249	Pongo abelii	65.15	0.00e+00	1350.00
IUUC-Pca-100855	Procavia capensis	58.15	0.00e+00	855.00
IUUC-Pva-102506	Pteropus vampyrus	58.81	0.00e+00	1150.00
IUUC-Rno-105242	Rattus norvegicus	64.77	0.00e+00	1389.00
IUUC-Sar-113612	Sorex araneus	71.50	5.00e-155	541.00
IUUC-Ssc-115473	Sus scrofa	65.25	0.00e+00	1355.00
IUUC-Tgu-116974	Taeniopygia guttata	65.47	0.00e+00	1339.00
IUUC-Tru-118077	Takifugu rubripes	82.02	0.00e+00	1759.00
IUUC-Tsy-119619	Tarsius syrichta	55.49	0.00e+00	1140.00
IUUC-Tni-120807	Tetraodon nigroviridis	82.70	0.00e+00	1774.00
IUUC-Tbe-127640	Tupaia belangeri	63.26	0.00e+00	1271.00
IUUC-Ttr-129172	Tursiops truncatus	64.96	0.00e+00	1342.00
IUUC-Xtr-132194	Xenopus tropicalis	57.84	0.00e+00	1117.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence