iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000017442.1	ENSONIT00000022016.1	ENSONIP00000021997.1
ENSONIG00000017442.1	ENSONIT00000022017.1	ENSONIP00000021998.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-85	288.3	723	1052

Active Site

Position(s)	Description	Evidence
1021	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
            dlkk l+v f gEe++d+gGvt+ef+ ll+kel +p +g+f++ ++++  ++ ++        + ++F+++G+++g+a+++  ++d
   Q: 723  VDLKKPLKVIFDGEEAVDAGGVTKEFFLLLLKELMDPVYGMFTHYKESNLLWFSDKCFV-----EQNWFHLIGIICGLAIYNATVVD 804
           589*****************************************999999999888665.....579******************** PP
   S: 90   lplsksfyklllgk..klsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNk...e 171
           l+++ ++yk+ll++     l++  ++ ++  +sl+++++++ sd+ee+ + l+f ++ e++g t+++eL+pgGe++ V ++N+   +
   Q: 805  LHFPLALYKKLLEVspMRGLQNSRKLTQHSLRSLQQLLDYEGSDVEET-FLLNFAITRENYGMTEVKELIPGGESVAVDKNNRgfiQ 890
           *************9633457********************99999997.*******************************9986667 PP
   S: 172  eYvklvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefss 258
            +v+  +++  ++++ eq+ af++Gf +v+  e+lslF+++el  ++ G++++++e+++k++ ykg+yt+++p+++ Fwev++ef  
   Q: 891  HFVSCFCSLAWHNSVGEQYSAFSAGFLKVCGGEILSLFQPSELMAMVVGNNNYNWEEMEKNAVYKGEYTATHPTVRLFWEVFHEFPL 977
           9999*********************************************************************************** PP
   S: 259  eerkafLqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           e++k+fL F+Tgs+r+P+ G+++l+   ++i+   a+++ lP ++TC+n+L++P+Y++ke l+++L+ A+e+ +gF+l
   Q: 978  EKKKQFLLFLTGSDRIPIHGMESLR---IIIQStTAEEHYLPVAHTCYNLLDMPRYQTKEMLRRRLTQAVEQYEGFSL 1052
           *************************...7888857777**************************************97 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MLCWGNAKDG QLGIGVEKNP VFEPRNCHVF SGRGLKEVGC GGQHSVFLMH DGSVYTCGSN 60
SCGQLGHDKA GISPEVVGAL DTQKITMVSC GRGHSMAVNE QGQLFAWGAG DGGQLGLGTT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCTGATGAC GTATGCAGCT GTGGCACTTC CTCGTTTGTT TTCTGGGCTG ATGAACCGAA 60
ACCAGTCGCC CAAATTCAGA ATGCATCTGT CAAGGTAAAC ACAGTGTTTT AATTTTGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001673	Ailuropoda melanoleuca	64.08	0.00e+00	1328.00
IUUC-Apl-003535	Anas platyrhynchos	64.53	0.00e+00	1338.00
IUUC-Aca-005223	Anolis carolinensis	63.89	0.00e+00	1328.00
IUUC-Ame-010816	Astyanax mexicanus	77.50	0.00e+00	1374.00
IUUC-Bta-013373	Bos taurus	64.33	0.00e+00	1338.00
IUUC-Bdi-014791	Brachypodium distachyon	37.58	3.00e-55	209.00
IUUC-Cja-019609	Callithrix jacchus	64.08	0.00e+00	1327.00
IUUC-Cfa-021071	Canis familiaris	63.89	0.00e+00	1325.00
IUUC-Cpo-021548	Cavia porcellus	63.99	0.00e+00	1327.00
IUUC-Csa-023987	Chlorocebus sabaeus	64.18	0.00e+00	1329.00
IUUC-Cho-024325	Choloepus hoffmanni	68.93	0.00e+00	839.00
IUUC-Dre-027472	Danio rerio	77.25	0.00e+00	1642.00
IUUC-Dno-029241	Dasypus novemcinctus	63.36	0.00e+00	1311.00
IUUC-Dor-030672	Dipodomys ordii	55.76	0.00e+00	654.00
IUUC-Ete-032642	Echinops telfairi	62.45	0.00e+00	1240.00
IUUC-Eca-033646	Equus caballus	63.80	0.00e+00	1322.00
IUUC-Eeu-035098	Erinaceus europaeus	60.03	0.00e+00	796.00
IUUC-Fal-036952	Ficedula albicollis	64.91	0.00e+00	1343.00
IUUC-Gmo-039297	Gadus morhua	77.06	0.00e+00	1608.00
IUUC-Gga-040591	Gallus gallus	64.09	0.00e+00	1330.00
IUUC-Gac-041741	Gasterosteus aculeatus	87.57	0.00e+00	1897.00
IUUC-Gma-043616	Glycine max	34.80	7.00e-52	198.00
IUUC-Ggo-044769	Gorilla gorilla	64.02	0.00e+00	1323.00
IUUC-Hsa-046066	Homo sapiens	63.99	0.00e+00	1325.00
IUUC-Itr-048311	Ictidomys tridecemlineatus	64.31	0.00e+00	1334.00
IUUC-Lch-050301	Latimeria chalumnae	65.56	0.00e+00	1421.00
IUUC-Loc-052803	Lepisosteus oculatus	74.20	0.00e+00	1638.00
IUUC-Laf-053364	Loxodonta africana	64.52	0.00e+00	1333.00
IUUC-Mcc-054930	Macaca mulatta	64.18	0.00e+00	1329.00
IUUC-Meu-056274	Macropus eugenii	53.66	3.00e-158	553.00
IUUC-Mtr-058277	Medicago truncatula	35.83	7.00e-51	194.00
IUUC-Mga-059563	Meleagris gallopavo	64.34	0.00e+00	1338.00
IUUC-Mmr-060792	Microcebus murinus	63.15	0.00e+00	1300.00
IUUC-Mdo-062195	Monodelphis domestica	65.00	0.00e+00	1348.00
IUUC-Mmu-063855	Mus musculus	63.42	0.00e+00	1316.00
IUUC-Mpu-066308	Mustela putorius furo	64.08	0.00e+00	1328.00
IUUC-Mlu-066927	Myotis lucifugus	63.89	0.00e+00	1326.00
IUUC-Nle-070090	Nomascus leucogenys	64.08	0.00e+00	1328.00
IUUC-Opr-070891	Ochotona princeps	56.76	0.00e+00	1116.00
IUUC-Ocu-074770	Oryctolagus cuniculus	64.18	0.00e+00	1329.00
IUUC-Oba-075262	Oryza barthii	35.67	2.00e-48	186.00
IUUC-Obr-076115	Oryza brachyantha	35.40	3.00e-47	182.00
IUUC-Ogl-077586	Oryza glaberrima	35.67	2.00e-48	186.00
IUUC-Ogu-078796	Oryza glumaepatula	35.67	2.00e-48	186.00
IUUC-Oin-079298	Oryza indica	35.67	2.00e-48	186.00
IUUC-Olo-080768	Oryza longistaminata	36.69	3.00e-55	209.00
IUUC-Ome-081908	Oryza meridionalis	35.40	2.00e-47	183.00
IUUC-Oni-082049	Oryza nivara	35.67	2.00e-48	186.00
IUUC-Opu-083608	Oryza punctata	35.65	2.00e-48	186.00
IUUC-Oru-084712	Oryza rufipogon	35.67	2.00e-48	186.00
IUUC-Osa-086078	Oryza sativa	35.67	2.00e-48	186.00
IUUC-Ola-086550	Oryzias latipes	84.99	0.00e+00	1843.00
IUUC-Oga-088831	Otolemur garnettii	63.71	0.00e+00	1316.00
IUUC-Oar-090449	Ovis aries	64.46	0.00e+00	1338.00
IUUC-Pan-092135	Papio anubis	64.12	0.00e+00	1329.00
IUUC-Psi-093832	Pelodiscus sinensis	63.46	0.00e+00	1343.00
IUUC-Pfo-097268	Poecilia formosa	88.82	0.00e+00	1929.00
IUUC-Pab-098249	Pongo abelii	63.89	0.00e+00	1326.00
IUUC-Pca-100855	Procavia capensis	58.50	0.00e+00	867.00
IUUC-Pva-102506	Pteropus vampyrus	58.79	0.00e+00	1146.00
IUUC-Rno-105242	Rattus norvegicus	63.61	0.00e+00	1362.00
IUUC-Sit-110415	Setaria italica	36.39	7.00e-56	211.00
IUUC-Sar-113612	Sorex araneus	69.82	4.00e-153	535.00
IUUC-Ssc-115473	Sus scrofa	64.46	0.00e+00	1335.00
IUUC-Tgu-116974	Taeniopygia guttata	65.00	0.00e+00	1326.00
IUUC-Tru-118077	Takifugu rubripes	83.43	0.00e+00	1785.00
IUUC-Tsy-119619	Tarsius syrichta	54.82	0.00e+00	1123.00
IUUC-Tni-120807	Tetraodon nigroviridis	84.01	0.00e+00	1801.00
IUUC-Tbe-127640	Tupaia belangeri	61.65	0.00e+00	1243.00
IUUC-Ttr-129172	Tursiops truncatus	64.18	0.00e+00	1323.00
IUUC-Xtr-132194	Xenopus tropicalis	56.24	0.00e+00	1090.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence