iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.50e-97	326.7	726	1049

Active Site

Position(s)	Description	Evidence
1018	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           dlkk l+v f gEeg+d+gGvt+ef+ ll+kel np +g+f+y ++++  ++ +         + ++F+++G+ +g+a++++ ++dl
   Q: 726  DLKKPLKVIFDGEEGVDAGGVTKEFFLLLLKELLNPIYGMFTYYQDSNLLWFSDTCFV-----EHNWFHLIGITCGLAIYNSTVVDL 807
           899******************************************9999999776554.....579********************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklv 177
           +++ ++yk+ll++k sledl+e+ p+  +sl+e++++  +diee+ ++l+f+v  e++g +++++L+pgG+++ V ++N++e+v+++
   Q: 808  HFPLALYKKLLNVKPSLEDLKELSPTEGRSLQELLDYPGEDIEET-FCLNFTVCRESYGVIEQKKLIPGGDRVAVCKDNRQEFVDAY 893
           *******************************************98.***************************************** PP
   S: 178  veyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkaf 264
           v+y+++ +++e ++af++Gf +v+  ++l+lF++ el+ ++ G++++++e+l++++ ykg+y++++p+++ Fwe+++ef  e++k+f
   Q: 894  VNYIFQISVHEWYTAFSSGFLKVCGGKVLELFQPAELRAMMVGNSNYNWEELEETAVYKGDYSSTHPTVKLFWETFHEFPLEKKKRF 980
           *************************************************************************************** PP
   S: 265  LqFvTgssrlPlgGfaelkprlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           L F+Tgs+r+P+ G+a+l+   +vi+  ++ +d lP ++TC+n+L+LP+Ysskei+k +L+ A ++ +gF+l
   Q: 981  LLFLTGSDRIPIYGMASLQ---IVIQStATGEDYLPVAHTCYNLLDLPKYSSKEIMKARLTQALDNYEGFSL 1049
           *******************...8888867888**************************************97 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MLCWGYWSLG QPGISSNLQG IVAEPQVCRF VSDRSIKEVA CGGNHSVFLL EDGEVYTCGV 60
NTKGQLGHER EGNKPEQIGA LADQHIIHVA CGESHSLALS DRGQLFSWGA GSDGQLGLMT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGGAAGTCGT TCTCCTAGCT CGATCTGCGG GAGTGCGGGG GGAAACTTCA TTATTACTGT 60
GACGCTGAAG GCCGGGGAGG CCCGAGCTGC CTGAGGGCTG CAGCCGCCGG GTCGGCGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

rno:362377

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001673	Ailuropoda melanoleuca	95.43	0.00e+00	2044.00
IUUC-Apl-003535	Anas platyrhynchos	86.76	0.00e+00	1858.00
IUUC-Aca-005223	Anolis carolinensis	84.76	0.00e+00	1819.00
IUUC-Ame-010816	Astyanax mexicanus	65.47	0.00e+00	1159.00
IUUC-Bta-013373	Bos taurus	94.95	0.00e+00	2044.00
IUUC-Cja-019609	Callithrix jacchus	95.33	0.00e+00	2046.00
IUUC-Cfa-021071	Canis familiaris	95.24	0.00e+00	2040.00
IUUC-Cpo-021548	Cavia porcellus	94.48	0.00e+00	2029.00
IUUC-Csa-023987	Chlorocebus sabaeus	95.81	0.00e+00	2052.00
IUUC-Cho-024325	Choloepus hoffmanni	94.59	0.00e+00	1176.00
IUUC-Dre-027472	Danio rerio	65.78	0.00e+00	1391.00
IUUC-Dno-029241	Dasypus novemcinctus	93.63	0.00e+00	2011.00
IUUC-Dor-030672	Dipodomys ordii	89.32	0.00e+00	1104.00
IUUC-Ete-032642	Echinops telfairi	89.62	0.00e+00	1865.00
IUUC-Eca-033646	Equus caballus	95.05	0.00e+00	2039.00
IUUC-Eeu-035098	Erinaceus europaeus	82.34	0.00e+00	1348.00
IUUC-Fal-036952	Ficedula albicollis	86.38	0.00e+00	1853.00
IUUC-Gmo-039297	Gadus morhua	63.71	0.00e+00	1316.00
IUUC-Gga-040591	Gallus gallus	85.82	0.00e+00	1835.00
IUUC-Gac-041741	Gasterosteus aculeatus	64.61	0.00e+00	1380.00
IUUC-Ggo-044769	Gorilla gorilla	95.53	0.00e+00	2045.00
IUUC-Hsa-046066	Homo sapiens	95.62	0.00e+00	2049.00
IUUC-Itr-048311	Ictidomys tridecemlineatus	95.34	0.00e+00	2043.00
IUUC-Lch-050301	Latimeria chalumnae	72.38	0.00e+00	1606.00
IUUC-Loc-052803	Lepisosteus oculatus	66.60	0.00e+00	1448.00
IUUC-Laf-053364	Loxodonta africana	94.76	0.00e+00	2033.00
IUUC-Mcc-054930	Macaca mulatta	95.81	0.00e+00	2051.00
IUUC-Meu-056274	Macropus eugenii	77.98	0.00e+00	857.00
IUUC-Mtr-058277	Medicago truncatula	37.58	2.00e-52	199.00
IUUC-Mga-059563	Meleagris gallopavo	86.38	0.00e+00	1852.00
IUUC-Mmr-060792	Microcebus murinus	93.52	0.00e+00	1994.00
IUUC-Mdo-062195	Monodelphis domestica	89.34	0.00e+00	1925.00
IUUC-Mmu-063855	Mus musculus	99.14	0.00e+00	2105.00
IUUC-Mpu-066308	Mustela putorius furo	95.43	0.00e+00	2047.00
IUUC-Mlu-066927	Myotis lucifugus	94.67	0.00e+00	2028.00
IUUC-Nle-070090	Nomascus leucogenys	95.62	0.00e+00	2049.00
IUUC-Opr-070891	Ochotona princeps	83.24	0.00e+00	1734.00
IUUC-Ont-072201	Oreochromis niloticus	63.61	0.00e+00	1335.00
IUUC-Ocu-074770	Oryctolagus cuniculus	94.95	0.00e+00	2041.00
IUUC-Ola-086550	Oryzias latipes	64.77	0.00e+00	1389.00
IUUC-Olu-087836	Ostreococcus lucimarinus	33.53	8.00e-41	160.00
IUUC-Oga-088831	Otolemur garnettii	95.05	0.00e+00	2033.00
IUUC-Oar-090449	Ovis aries	95.05	0.00e+00	2040.00
IUUC-Pan-092135	Papio anubis	95.72	0.00e+00	2047.00
IUUC-Psi-093832	Pelodiscus sinensis	84.59	0.00e+00	1860.00
IUUC-Pfo-097268	Poecilia formosa	65.62	0.00e+00	1392.00
IUUC-Pab-098249	Pongo abelii	95.33	0.00e+00	2043.00
IUUC-Pca-100855	Procavia capensis	90.44	0.00e+00	1386.00
IUUC-Pva-102506	Pteropus vampyrus	86.68	0.00e+00	1793.00
IUUC-Sha-107186	Sarcophilus harrisii	87.36	0.00e+00	1176.00
IUUC-Sar-113612	Sorex araneus	93.86	0.00e+00	734.00
IUUC-Ssc-115473	Sus scrofa	94.57	0.00e+00	2030.00
IUUC-Tgu-116974	Taeniopygia guttata	86.39	0.00e+00	1832.00
IUUC-Tru-118077	Takifugu rubripes	63.55	0.00e+00	1320.00
IUUC-Tsy-119619	Tarsius syrichta	84.10	0.00e+00	1811.00
IUUC-Tni-120807	Tetraodon nigroviridis	63.46	0.00e+00	1337.00
IUUC-Tbe-127640	Tupaia belangeri	91.14	0.00e+00	1904.00
IUUC-Ttr-129172	Tursiops truncatus	94.86	0.00e+00	2028.00
IUUC-Vpa-130442	Vicugna pacos	80.89	0.00e+00	1681.00
IUUC-Xtr-132194	Xenopus tropicalis	69.90	0.00e+00	1427.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence