iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073030

UUCD1 version

UUC-OrA-00861

Ensembl Protein ID

ENSOANP00000010547.2

UniProt Accession

F6Q5U3; F6Q5U3_ORNAN

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP44

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000006614.2	ENSOANT00000010549.2	ENSOANP00000010547.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.50e-62	210.8	268	578

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...kkkeklneenp............................................ 42
           tGl+NlgNtCYmNSvLQ+Ls++  +r+++l+   ++++      +                                            
   Q: 268  TGLRNLGNTCYMNSVLQVLSHLLIFRQCFLKldlNQTQ------Ellataasgktrssckhpsvsdsvipmqenpekvtgsplsrrpsl 350
           7******************************5552223......223345578888888888999999999999999999999999999 PP
   S: 43   ......................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkk 109
                                 +++  +l+++l++lf+ +w++k+  vsp ++l++++++ + f+gy+qqDaqEfl+ lld+++ el  
   Q: 351  ssglsggasksrnmeliqprepSSKYISLCHELHTLFQVMWSGKWALVSPFAMLHSVWRLIPAFRGYAQQDAQEFLCELLDKVQHEL-- 437
           999999999998888888888777777************************************************************.. PP
   S: 110  eknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke........slqdc 190
                  e+++++  +l  ++++k  k+  ++++++F+gql sq++cl+cdn+s++ epf+dlsl++p++ +++ +         ++++
   Q: 438  -------EATGTRYPALIPSSQRKLIKRVLNVVNTIFHGQLLSQVTCLACDNKSNTVEPFWDLSLEFPERYHCNGKemvsqypcLVTEM 519
           .......67888888999999************************************************99998889999********* PP
   S: 191  Lesftkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsf 239
           L++ft++e leg+  y c++c+ k++           a+k+l++ +lP+vL lhLkRf+ 
   Q: 520  LAKFTETEALEGRI-YACDQCNTKRRkfsskpvilteAQKQLMVCRLPQVLRLHLKRFRL 578
           ***********965.*******999999999999999*********************54 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MDKCKHVGRL RLAQDHSILN PQKWHCVDCN TTESVWACLS CSHVACGRYI EEHALKHFQE 60
SSHPVALEVN ELYVFCYLCD DYVLNDNATG DLKLLRSTLS AIKSQNYDCT TRSGRILRSM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGTACAGATG AAAGCTTATG TATTCACCTC TTTCATTTGT GTTTTCAGAG CCGAGCGTTA 60
TGGAGGGGAA ACTCACTTGG ATTATGTTTC TCAGCTGGAC TGCATAAATA TTAACAATGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:1904667--P:negative regulation of ubiquitin protein ligase activity
GO:0016579--P:protein deubiquitination
GO:0090231--P:regulation of spindle checkpoint
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	78.66	0.00e+00	900.00
IUUC-Apl-003673	Anas platyrhynchos	85.03	0.00e+00	926.00
IUUC-Aca-004434	Anolis carolinensis	79.73	0.00e+00	899.00
IUUC-Ame-010986	Astyanax mexicanus	67.67	0.00e+00	734.00
IUUC-Bta-012774	Bos taurus	77.89	0.00e+00	879.00
IUUC-Cja-019619	Callithrix jacchus	77.49	0.00e+00	867.00
IUUC-Cfa-020957	Canis familiaris	77.80	0.00e+00	905.00
IUUC-Csa-023177	Chlorocebus sabaeus	78.35	0.00e+00	875.00
IUUC-Cho-024877	Choloepus hoffmanni	76.83	0.00e+00	714.00
IUUC-Csv-025814	Ciona savignyi	41.90	3.00e-113	401.00
IUUC-Dre-027878	Danio rerio	68.15	0.00e+00	710.00
IUUC-Dno-029832	Dasypus novemcinctus	78.49	0.00e+00	906.00
IUUC-Ete-032627	Echinops telfairi	75.95	0.00e+00	872.00
IUUC-Eca-033863	Equus caballus	75.91	0.00e+00	849.00
IUUC-Eeu-035225	Erinaceus europaeus	76.17	0.00e+00	858.00
IUUC-Fca-036288	Felis catus	77.28	0.00e+00	885.00
IUUC-Fal-037207	Ficedula albicollis	83.65	0.00e+00	904.00
IUUC-Gga-040457	Gallus gallus	83.82	0.00e+00	887.00
IUUC-Gac-042595	Gasterosteus aculeatus	53.80	1.00e-159	556.00
IUUC-Ggo-044926	Gorilla gorilla	78.18	0.00e+00	872.00
IUUC-Hsa-046079	Homo sapiens	78.18	0.00e+00	872.00
IUUC-Itr-048737	Ictidomys tridecemlineatus	77.49	0.00e+00	889.00
IUUC-Lch-050260	Latimeria chalumnae	77.70	0.00e+00	799.00
IUUC-Laf-054491	Loxodonta africana	77.11	0.00e+00	862.00
IUUC-Mcc-055694	Macaca mulatta	78.52	0.00e+00	878.00
IUUC-Meu-055971	Macropus eugenii	52.95	7.00e-119	420.00
IUUC-Mga-059523	Meleagris gallopavo	83.65	0.00e+00	905.00
IUUC-Mmr-060885	Microcebus murinus	79.73	0.00e+00	912.00
IUUC-Mdo-063018	Monodelphis domestica	88.81	0.00e+00	961.00
IUUC-Mmu-064012	Mus musculus	69.69	0.00e+00	749.00
IUUC-Mpu-066207	Mustela putorius furo	78.49	0.00e+00	911.00
IUUC-Mlu-066929	Myotis lucifugus	74.70	0.00e+00	868.00
IUUC-Nle-069313	Nomascus leucogenys	68.14	0.00e+00	714.00
IUUC-Opr-070375	Ochotona princeps	76.88	0.00e+00	791.00
IUUC-Ont-071637	Oreochromis niloticus	66.89	0.00e+00	726.00
IUUC-Ocu-074836	Oryctolagus cuniculus	75.26	0.00e+00	836.00
IUUC-Oga-088367	Otolemur garnettii	79.04	0.00e+00	883.00
IUUC-Oar-089953	Ovis aries	78.28	0.00e+00	900.00
IUUC-Ptr-090980	Pan troglodytes	78.18	0.00e+00	873.00
IUUC-Pan-092748	Papio anubis	78.83	0.00e+00	883.00
IUUC-Psi-094078	Pelodiscus sinensis	86.14	0.00e+00	941.00
IUUC-Pma-094155	Petromyzon marinus	72.91	3.00e-82	297.00
IUUC-Pfo-096413	Poecilia formosa	53.59	1.00e-162	566.00
IUUC-Pab-098514	Pongo abelii	79.21	0.00e+00	885.00
IUUC-Pca-100449	Procavia capensis	62.00	0.00e+00	652.00
IUUC-Pva-102984	Pteropus vampyrus	77.97	0.00e+00	910.00
IUUC-Rno-106019	Rattus norvegicus	69.68	0.00e+00	787.00
IUUC-Sha-106965	Sarcophilus harrisii	88.47	0.00e+00	966.00
IUUC-Ssc-115299	Sus scrofa	77.97	0.00e+00	906.00
IUUC-Tgu-117160	Taeniopygia guttata	82.84	0.00e+00	911.00
IUUC-Tru-118156	Takifugu rubripes	64.06	0.00e+00	719.00
IUUC-Tni-119733	Tetraodon nigroviridis	64.85	0.00e+00	726.00
IUUC-Tbe-128084	Tupaia belangeri	73.16	0.00e+00	849.00
IUUC-Ttr-128928	Tursiops truncatus	79.00	0.00e+00	909.00
IUUC-Vpa-130706	Vicugna pacos	79.69	0.00e+00	909.00
IUUC-Xtr-132061	Xenopus tropicalis	78.74	0.00e+00	888.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence