iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-007271

Ensembl Protein ID

AT2G17200.1

UniProt Accession

Q9SII8; Q94C51; DSK2B_ARATH

Genbank Protein ID

AAD25138.1; AEC06597.1; AAK59681.1; AAN13037.1

Protein Name

Ubiquitin domain-containing protein DSK2b

Genbank Nucleotide ID

AC007127; CP002685; AY035177; AY142486

Gene Name

DSK2B; At2g17200; T23A1.6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT2G17200	AT2G17200.1	AT2G17200.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
PINA	HINT	Mentha
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/UBA	UBA	21764993
ULD/UDP/UBQ/UBQ_PIM	UBQ_PIM	20059542; 21764993

Classification

Family	E-value	Score	Start	End
UBD/Alpha-Helix/UBA	1.80e-11	44.7	511	546
ULD/UDP/UBQ/UBQ_PIM	1.20e-24	86.9	19	92

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 5    dkleqlveMGF.dreealqaLraannnleaAveyLl 39
            +l+ql+eMGF dr e+++aL+a+n+n++aAve+Ll
   Q: 511  TQLQQLQEMGFyDRAENIRALLATNGNVNAAVERLL 546
           68*********************************9 PP

ULD/UDP/UBQ/UBQ_PIM

   S: 2    kltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
            +++++++g++f ++ s d+tve++Ke++a++s+vp++qq+LIy+G+iLkDd+tL ++g++ ++++h+v   ++
   Q: 19   AVNIRCSNGTKFSVKTSLDSTVESFKELVAQSSDVPANQQRLIYKGRILKDDQTLLSYGLQADHTIHMVRGSAP 92
           699******************************************************************87665 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Binds and presumably selects ubiquitin-conjugates for destruction. Prefers multiubiquitin chains rather than single ubiquitins, with a binding affinity for 'Lys-48'-linked ubiquitin chains. Acts as a ubiquitin receptor that associates with the 26S proteasomal docking subunit RPN10 for the indirect recognition of ubiquitinated substrates of ubiquitin/26S proteasome-mediated proteolysis (UPP).

Protein Sequence
(Fasta)

MGGEGDSSQP QSGEGEAVAV NIRCSNGTKF SVKTSLDSTV ESFKELVAQS SDVPANQQRL 60
IYKGRILKDD QTLLSYGLQA DHTIHMVRGS APSSAPPPAP AASQTTAPSV TRGVGSDNSS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCTCTTCGAT CCATTTCGTC AAGCAATCTA CCGAACCGAC TCAGAGCTTT TGAGTCTTCT 60
AAATCTCTAT CGAATTTTTC TAGGGTTAGG GCTCCTGATC GATTTCGCGA GCTCTGCGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR006636--STI1_HS-bd
IPR015940--UBA
IPR009060--UBA-like
IPR015496--Ubiquilin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50030--UBA
PS50053--UBIQUITIN_2

Pfam

PF00627--UBA
PF00240--ubiquitin

SMART

SM00727--STI1
SM00165--UBA
SM00213--UBQ

Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0031593--F:polyubiquitin binding

KEGG

ath:AT2G17200

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000864	Aegilops tauschii	77.37	6.00e-59	221.00
IUUC-Aml-001461	Ailuropoda melanoleuca	39.26	1.00e-43	170.00
IUUC-Atr-002470	Amborella trichopoda	56.58	1.00e-105	376.00
IUUC-Apl-003241	Anas platyrhynchos	40.59	4.00e-43	168.00
IUUC-Aly-005736	Arabidopsis lyrata	90.68	0.00e+00	791.00
IUUC-Bci-013628	Botrytis cinerea	26.82	2.00e-11	63.20
IUUC-Bdi-014506	Brachypodium distachyon	59.55	9.00e-109	386.00
IUUC-Bol-015326	Brassica oleracea	81.83	0.00e+00	682.00
IUUC-Bra-017098	Brassica rapa	85.38	0.00e+00	687.00
IUUC-Cel-018631	Caenorhabditis elegans	34.69	2.00e-46	179.00
IUUC-Cpo-022388	Cavia porcellus	35.45	4.00e-52	198.00
IUUC-Cin-025136	Ciona intestinalis	50.31	2.00e-41	163.00
IUUC-Dno-029892	Dasypus novemcinctus	53.72	2.00e-35	143.00
IUUC-Dor-030519	Dipodomys ordii	34.47	1.00e-49	190.00
IUUC-Dme-032013	Drosophila melanogaster	36.39	1.00e-40	160.00
IUUC-Eeu-034727	Erinaceus europaeus	53.28	2.00e-35	143.00
IUUC-Fca-036179	Felis catus	39.26	8.00e-44	171.00
IUUC-Gga-041264	Gallus gallus	41.25	4.00e-44	171.00
IUUC-Gma-043430	Glycine max	55.86	9.00e-101	360.00
IUUC-Ggo-044680	Gorilla gorilla	53.72	2.00e-35	143.00
IUUC-Hsa-046554	Homo sapiens	53.72	1.00e-35	143.00
IUUC-Hvu-047533	Hordeum vulgare	61.80	1.00e-40	159.00
IUUC-Itr-048337	Ictidomys tridecemlineatus	36.30	7.00e-52	197.00
IUUC-Lch-050192	Latimeria chalumnae	38.78	7.00e-45	174.00
IUUC-Lpe-050974	Leersia perrieri	54.45	1.00e-118	419.00
IUUC-Loc-052846	Lepisosteus oculatus	54.14	3.00e-39	155.00
IUUC-Laf-054278	Loxodonta africana	34.32	1.00e-48	187.00
IUUC-Mcc-054765	Macaca mulatta	53.72	2.00e-35	143.00
IUUC-Meu-056414	Macropus eugenii	48.24	8.00e-42	164.00
IUUC-Mpo-057467	Magnaporthe poae	55.56	8.00e-10	55.10
IUUC-Mtr-058674	Medicago truncatula	56.19	6.00e-102	363.00
IUUC-Mga-059894	Meleagris gallopavo	35.52	6.00e-46	177.00
IUUC-Mdo-062728	Monodelphis domestica	48.24	3.00e-42	166.00
IUUC-Mac-065458	Musa acuminata	56.04	5.00e-135	473.00
IUUC-Mpu-066282	Mustela putorius furo	38.93	1.00e-43	170.00
IUUC-Mlu-068158	Myotis lucifugus	39.13	2.00e-43	169.00
IUUC-Opr-071098	Ochotona princeps	40.34	3.00e-44	172.00
IUUC-Oba-075114	Oryza barthii	61.54	3.00e-87	315.00
IUUC-Obr-076444	Oryza brachyantha	70.25	1.00e-52	200.00
IUUC-Ogl-077319	Oryza glaberrima	57.11	6.00e-100	357.00
IUUC-Ogu-078074	Oryza glumaepatula	54.70	8.00e-101	360.00
IUUC-Oin-079142	Oryza indica	56.86	3.00e-99	355.00
IUUC-Olo-080565	Oryza longistaminata	54.83	9.00e-101	360.00
IUUC-Ome-081155	Oryza meridionalis	59.12	2.00e-81	295.00
IUUC-Oni-082272	Oryza nivara	56.86	3.00e-99	355.00
IUUC-Opu-083339	Oryza punctata	59.65	1.00e-77	283.00
IUUC-Oru-085257	Oryza rufipogon	56.86	3.00e-99	355.00
IUUC-Osa-086257	Oryza sativa	57.11	5.00e-100	357.00
IUUC-Olu-087597	Ostreococcus lucimarinus	33.51	1.00e-37	150.00
IUUC-Oga-088495	Otolemur garnettii	38.93	1.00e-43	170.00
IUUC-Ptr-091312	Pan troglodytes	53.72	2.00e-35	143.00
IUUC-Pan-092351	Papio anubis	53.72	2.00e-35	143.00
IUUC-Psi-093261	Pelodiscus sinensis	31.16	5.00e-37	148.00
IUUC-Pma-094727	Petromyzon marinus	36.84	1.00e-13	70.90
IUUC-Ppa-095193	Physcomitrella patens	72.87	3.00e-54	205.00
IUUC-Pab-097627	Pongo abelii	53.72	2.00e-35	143.00
IUUC-Pop-099549	Populus trichocarpa	60.84	3.00e-157	548.00
IUUC-Pca-100194	Procavia capensis	38.65	2.00e-32	133.00
IUUC-Ppe-101901	Prunus persica	65.61	6.00e-163	566.00
IUUC-Pva-102513	Pteropus vampyrus	47.34	1.00e-39	157.00
IUUC-Pgr-103261	Puccinia graminis	28.99	3.00e-14	72.00
IUUC-Rno-104908	Rattus norvegicus	33.93	2.00e-59	222.00
IUUC-Sha-107327	Sarcophilus harrisii	40.10	1.00e-34	140.00
IUUC-Ssl-108425	Sclerotinia sclerotiorum	55.81	4.00e-09	54.70
IUUC-Smo-108910	Selaginella moellendorffii	53.20	5.00e-91	327.00
IUUC-Sit-110766	Setaria italica	57.67	1.00e-96	346.00
IUUC-Sly-111240	Solanum lycopersicum	64.46	4.00e-83	301.00
IUUC-Stu-112263	Solanum tuberosum	65.81	1.00e-89	322.00
IUUC-Sbi-114273	Sorghum bicolor	61.76	7.00e-88	317.00
IUUC-Tgu-116930	Taeniopygia guttata	35.64	2.00e-36	146.00
IUUC-Tsy-119596	Tarsius syrichta	56.64	2.00e-36	146.00
IUUC-Tre-122085	Trichoderma reesei	58.33	1.00e-10	60.10
IUUC-Tae-125801	Triticum aestivum	78.10	2.00e-59	222.00
IUUC-Tme-127116	Tuber melanosporum	30.12	7.00e-18	84.30
IUUC-Tbe-127379	Tupaia belangeri	48.82	2.00e-40	159.00
IUUC-Ttr-128630	Tursiops truncatus	38.93	1.00e-43	170.00
IUUC-Vda-129991	Verticillium dahliae	30.21	3.00e-14	72.40
IUUC-Vpa-130546	Vicugna pacos	56.48	1.00e-32	133.00
IUUC-Vvi-131599	Vitis vinifera	60.28	3.00e-146	511.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence