iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mpu-066322

Ensembl Protein ID

ENSMPUP00000002554.1

UniProt Accession

M3XU04; M3XU04_MUSPF

Genbank Protein ID

ENSMPUP00000002554

Protein Name

Nitric oxide synthase-interacting protein

Genbank Nucleotide ID

AEYP01068230

Gene Name

NOSIP

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMPUG00000002583.1	ENSMPUT00000002607.1	ENSMPUP00000002554.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/U-box	4.10e-15	55.6	105	144

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlpsGitydrssIekwlasggk 41
           v ++ +C +sl++ +dPvv+p+G+ y+r++I +++ +++k
   Q: 105  VKDFDCCCLSLQPCHDPVVTPDGYLYEREAILEYILHQKK 144
           567789*****************************98887 PP

Organism

Mustela putorius furo

Functional Description
(View)

Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.

Protein Sequence
(Fasta)

MEEPGPKGTE NCGVLGEKRT RVALTGTFRL LLPFPEGGKE ERRIYQVRRG AQLKKQRRNE 60
ESFVRMTRHG KNCTAGAVYT YHEKKKDTAA SGYGTQNIRL SRDAVKDFDC CCLSLQPCHD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGGAAC CCGGGCCTAA GGGGACTGAG AACTGTGGAG TCCTGGGAGA GAAGAGGACT 60
AGAGGCAAGG GTTCCTGAGT CCAGGGAAGG TGGATGGGCG GGGAGGGGGG GGTGTCTGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-1185--Reference proteome

Interpro

IPR016818--Nitric_oxide_synth-interacting
IPR031790--Znf-NOSIP
IPR013083--Znf_RING/FYVE/PHD

Pfam

PF15906--zf-NOSIP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0003723--F:RNA binding
GO:0051001--P:negative regulation of nitric-oxide synthase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000769	Aegilops tauschii	46.51	2.00e-16	80.90
IUUC-Aml-002069	Ailuropoda melanoleuca	93.35	7.00e-167	579.00
IUUC-Atr-002661	Amborella trichopoda	32.76	1.00e-31	130.00
IUUC-Aca-004630	Anolis carolinensis	75.25	1.00e-136	478.00
IUUC-Aly-006316	Arabidopsis lyrata	31.07	8.00e-32	130.00
IUUC-Ath-007000	Arabidopsis thaliana	30.42	9.00e-31	127.00
IUUC-Acl-008175	Aspergillus clavatus	33.63	7.00e-06	45.10
IUUC-Afl-008440	Aspergillus flavus	33.91	7.00e-06	45.10
IUUC-Afu-009012	Aspergillus fumigatus	34.78	2.00e-06	47.00
IUUC-Ani-009153	Aspergillus nidulans	33.33	2.00e-03	36.60
IUUC-Ang-009556	Aspergillus niger	34.78	4.00e-06	45.80
IUUC-Aor-009892	Aspergillus oryzae	33.91	8.00e-06	44.70
IUUC-Ate-010473	Aspergillus terreus	30.43	2.00e-04	41.60
IUUC-Ame-011874	Astyanax mexicanus	64.10	2.00e-110	392.00
IUUC-Bgr-012090	Blumeria graminis	26.15	4.00e-06	45.40
IUUC-Bta-012956	Bos taurus	97.04	4.00e-173	599.00
IUUC-Bci-013897	Botrytis cinerea	42.50	1.00e-09	57.40
IUUC-Bdi-014968	Brachypodium distachyon	30.72	5.00e-35	141.00
IUUC-Bol-015578	Brassica oleracea	31.37	2.00e-35	142.00
IUUC-Bra-017234	Brassica rapa	31.37	2.00e-35	142.00
IUUC-Cel-018637	Caenorhabditis elegans	41.72	6.00e-58	217.00
IUUC-Cja-019632	Callithrix jacchus	93.40	6.00e-168	582.00
IUUC-Cfa-020192	Canis familiaris	94.98	3.00e-179	621.00
IUUC-Cpo-021939	Cavia porcellus	90.10	7.00e-157	546.00
IUUC-Cre-023005	Chlamydomonas reinhardtii	34.54	3.00e-43	169.00
IUUC-Csa-023802	Chlorocebus sabaeus	92.48	1.00e-173	602.00
IUUC-Cho-024637	Choloepus hoffmanni	79.72	5.00e-87	313.00
IUUC-Cin-025180	Ciona intestinalis	52.13	1.00e-86	312.00
IUUC-Csv-026206	Ciona savignyi	54.42	1.00e-43	168.00
IUUC-Cgl-026696	Colletotrichum gloeosporioides	26.85	2.00e-13	70.10
IUUC-Cne-026827	Cryptococcus neoformans	36.36	1.00e-06	47.40
IUUC-Cme-027146	Cyanidioschyzon merolae	25.64	8.70e-02	32.00
IUUC-Dre-028092	Danio rerio	65.58	1.00e-117	415.00
IUUC-Dno-029501	Dasypus novemcinctus	88.56	4.00e-144	504.00
IUUC-Dor-030542	Dipodomys ordii	91.75	2.00e-165	574.00
IUUC-Dse-031188	Dothistroma septosporum	25.99	7.00e-08	51.60
IUUC-Dme-031734	Drosophila melanogaster	48.54	9.00e-79	286.00
IUUC-Eca-033577	Equus caballus	96.04	2.00e-172	597.00
IUUC-Fca-035761	Felis catus	96.70	7.00e-173	599.00
IUUC-Fox-037703	Fusarium oxysporum	27.33	1.00e-07	50.40
IUUC-Fso-038208	Fusarium solani	26.74	7.00e-13	68.20
IUUC-Gmo-038523	Gadus morhua	61.14	2.00e-62	231.00
IUUC-Ggr-040087	Gaeumannomyces graminis	41.03	8.00e-10	57.80
IUUC-Gac-042621	Gasterosteus aculeatus	60.38	2.00e-109	388.00
IUUC-Gma-042698	Glycine max	31.51	2.00e-33	135.00
IUUC-Ggo-045357	Gorilla gorilla	93.73	5.00e-168	583.00
IUUC-Hsa-046195	Homo sapiens	93.73	5.00e-168	583.00
IUUC-Hvu-047174	Hordeum vulgare	31.63	6.00e-36	144.00
IUUC-Itr-048487	Ictidomys tridecemlineatus	94.06	3.00e-163	567.00
IUUC-Lch-050569	Latimeria chalumnae	67.52	3.00e-115	407.00
IUUC-Lpe-050992	Leersia perrieri	35.92	2.00e-24	107.00
IUUC-Loc-052522	Lepisosteus oculatus	70.30	2.00e-117	415.00
IUUC-Lma-053254	Leptosphaeria maculans	39.24	2.00e-09	56.60
IUUC-Laf-053397	Loxodonta africana	96.70	7.00e-174	602.00
IUUC-Mcc-054681	Macaca mulatta	88.34	6.00e-175	606.00
IUUC-Meu-056723	Macropus eugenii	83.83	3.00e-152	530.00
IUUC-Mor-056961	Magnaporthe oryzae	24.03	2.00e-11	63.20
IUUC-Mpo-057359	Magnaporthe poae	25.84	1.00e-06	46.60
IUUC-Mtr-058063	Medicago truncatula	32.43	4.00e-35	141.00
IUUC-Mla-059004	Melampsora laricipopulina	29.07	6.00e-25	108.00
IUUC-Mvi-060460	Microbotryum violaceum	28.87	5.00e-26	111.00
IUUC-Mmr-060847	Microcebus murinus	95.38	2.00e-170	591.00
IUUC-Mdo-062480	Monodelphis domestica	85.15	3.00e-154	537.00
IUUC-Mmu-063809	Mus musculus	91.42	1.00e-162	565.00
IUUC-Mac-064870	Musa acuminata	31.51	1.00e-34	139.00
IUUC-Mlu-067556	Myotis lucifugus	92.76	2.00e-160	557.00
IUUC-Nfi-068440	Neosartorya fischeri	34.78	2.00e-06	47.00
IUUC-Ncr-068898	Neurospora crassa	38.46	1.00e-07	50.80
IUUC-Nle-070049	Nomascus leucogenys	93.06	6.00e-174	602.00
IUUC-Opr-070972	Ochotona princeps	89.84	1.00e-156	545.00
IUUC-Ont-071682	Oreochromis niloticus	65.03	3.00e-116	410.00
IUUC-Oan-073296	Ornithorhynchus anatinus	82.89	4.00e-33	133.00
IUUC-Ocu-074218	Oryctolagus cuniculus	89.72	1.00e-131	462.00
IUUC-Oba-075284	Oryza barthii	32.42	6.00e-35	140.00
IUUC-Obr-076651	Oryza brachyantha	32.20	2.00e-37	149.00
IUUC-Ogl-077899	Oryza glaberrima	32.42	6.00e-35	140.00
IUUC-Ogu-078477	Oryza glumaepatula	32.54	2.00e-35	142.00
IUUC-Oin-080011	Oryza indica	32.42	7.00e-35	140.00
IUUC-Olo-080545	Oryza longistaminata	31.40	9.00e-28	117.00
IUUC-Ome-081543	Oryza meridionalis	32.42	7.00e-35	140.00
IUUC-Oni-082955	Oryza nivara	32.42	7.00e-35	140.00
IUUC-Opu-083565	Oryza punctata	31.85	6.00e-35	140.00
IUUC-Oru-084474	Oryza rufipogon	32.42	7.00e-35	140.00
IUUC-Osa-085913	Oryza sativa	32.42	7.00e-35	140.00
IUUC-Ola-086851	Oryzias latipes	66.67	3.00e-121	427.00
IUUC-Olu-087724	Ostreococcus lucimarinus	33.01	2.00e-12	66.20
IUUC-Oga-087970	Otolemur garnettii	93.42	1.00e-166	578.00
IUUC-Oar-089756	Ovis aries	93.44	3.00e-161	560.00
IUUC-Ptr-091485	Pan troglodytes	92.41	2.00e-164	571.00
IUUC-Pan-091832	Papio anubis	94.06	2.00e-168	584.00
IUUC-Pma-094551	Petromyzon marinus	63.19	6.00e-109	386.00
IUUC-Pno-094830	Phaeosphaeria nodorum	26.84	4.00e-09	55.50
IUUC-Ppa-095255	Physcomitrella patens	30.20	6.00e-33	134.00
IUUC-Pfo-096373	Poecilia formosa	65.36	3.00e-117	414.00
IUUC-Pab-098247	Pongo abelii	92.79	2.00e-174	605.00
IUUC-Pop-099186	Populus trichocarpa	31.53	1.00e-32	133.00
IUUC-Pca-100677	Procavia capensis	90.97	2.00e-139	488.00
IUUC-Ppe-101403	Prunus persica	30.74	2.00e-32	132.00
IUUC-Pva-103000	Pteropus vampyrus	95.71	1.00e-171	595.00
IUUC-Pgr-103663	Puccinia graminis	30.77	1.00e-31	130.00
IUUC-Ptt-103712	Puccinia triticina	40.00	7.00e-09	54.30
IUUC-Pte-104287	Pyrenophora teres	26.41	3.00e-17	82.40
IUUC-Pyt-104579	Pyrenophora triticirepentis	25.09	1.00e-12	67.00
IUUC-Rno-106069	Rattus norvegicus	91.75	3.00e-163	567.00
IUUC-Sha-106553	Sarcophilus harrisii	84.16	1.00e-153	535.00
IUUC-Smo-108874	Selaginella moellendorffii	32.89	6.00e-40	157.00
IUUC-Sit-110307	Setaria italica	31.85	3.00e-34	138.00
IUUC-Sly-111094	Solanum lycopersicum	33.11	1.00e-33	137.00
IUUC-Stu-112363	Solanum tuberosum	31.67	1.00e-33	137.00
IUUC-Sar-113480	Sorex araneus	93.73	6.00e-158	549.00
IUUC-Sbi-113939	Sorghum bicolor	32.42	9.00e-35	140.00
IUUC-Ssc-115644	Sus scrofa	97.36	1.00e-174	605.00
IUUC-Tru-118781	Takifugu rubripes	65.26	3.00e-120	424.00
IUUC-Tni-119672	Tetraodon nigroviridis	73.56	2.00e-34	136.00
IUUC-Tca-121795	Theobroma cacao	32.20	2.00e-36	145.00
IUUC-Tre-122037	Trichoderma reesei	36.36	5.00e-08	52.00
IUUC-Tvi-122524	Trichoderma virens	27.15	6.00e-17	81.60
IUUC-Tae-122828	Triticum aestivum	31.97	4.00e-36	144.00
IUUC-Tur-126387	Triticum urartu	31.66	2.00e-29	123.00
IUUC-Tme-127111	Tuber melanosporum	40.00	3.00e-09	56.20
IUUC-Ttr-128227	Tursiops truncatus	97.03	2.00e-173	600.00
IUUC-Vda-129924	Verticillium dahliae	27.16	2.00e-15	76.30
IUUC-Vpa-130802	Vicugna pacos	97.75	2.00e-45	176.00
IUUC-Vvi-131105	Vitis vinifera	32.88	9.00e-35	140.00
IUUC-Xtr-132830	Xenopus tropicalis	65.83	9.00e-123	432.00
IUUC-Xma-133618	Xiphophorus maculatus	66.45	1.00e-111	395.00
IUUC-Zma-135389	Zea mays	31.51	1.00e-33	136.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence