iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Xma-133757

Ensembl Protein ID

ENSXMAP00000016062.1

UniProt Accession

M4ANL7; M4ANL7_XIPMA

Genbank Protein ID

ENSXMAP00000016062

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

AGAJ01002820

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSXMAG00000015992.1	ENSXMAT00000016086.1	ENSXMAP00000016062.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.20e-130	435.9	557	889

Active Site

Position(s)	Description	Evidence
858	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl++rl++ ++gEegld+gG++re+++lls+e+ np+++lf+y  +++++lq+np+s + np+hl +F+f+Gr++++al++g+++d+
   Q: 557  PYDLRRRLYIIMRGEEGLDYGGIAREWFFLLSHEVLNPMYCLFEYAGKNNYCLQINPASSI-NPDHLTYFRFIGRFIAMALYHGKFIDT 644
           6799********************************************************9.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk++l+kk +l+dle++dpe+y+s++++ken   ++ee+g++l f ++ eilg+++++ Lk+gGe++ Vt+eNkeeY++l+++
   Q: 645  GFTLPFYKRMLDKKPTLKDLESIDPEFYNSIMWVKEN---NLEECGVELYFAQDMEILGKVSSHPLKEGGEDELVTEENKEEYISLLTD 730
           ***********************************99...9************************************************ PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+++g++eq++af +Gfnev+ple+l++F+e+elel++cG++eid+ d++k++ y++ yt++s++i+wFw+v++e++se+r ++LqFv
   Q: 731  WRFTRGVEEQTKAFLDGFNEVVPLEWLRYFDEKELELMLCGMQEIDLADWQKNAIYRH-YTKNSKQIHWFWQVVKEMDSEKRIRLLQFV 818
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tg++rlP+gGf el     p++f+i + +++++lP+s+TCfn+L+LP+Y s e+l+ekLl+Aieet+gF++
   Q: 819  TGTCRLPVGGFTELIgsngPQKFCIDRVGKETWLPRSHTCFNRLDLPPYRSLEQLREKLLFAIEETEGFGQ 889
           *********************************************************************96 PP

Organism

Xiphophorus maculatus

Protein Sequence
(Fasta)

MAAASVTRPG SAQTPEKSQL ILKVVSAKPQ SPKLPNRHPR LSSFVEVTAD GLTSETKKTG 60
KRTGHLELQW NEDLTLNVTP QSHLDLKLWS CHTLRKELLG SATIDLLDTL RTHDGKMENV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCTGTGATG TCATGGCGGC TGCCAGCGTG ACCCGACCTG GCAGTGCCCA GACCCCCGAG 60
AAGTCTCAGT TGATCCTGAA AGGTAAAGAG CTAATTAGCA TGTAAAATGT TCTGCTTTGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0004842--F:ubiquitin-protein transferase activity
GO:0060021--P:palate development

KEGG

xma:102222753

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001575	Ailuropoda melanoleuca	73.38	0.00e+00	1295.00
IUUC-Apl-003912	Anas platyrhynchos	68.29	0.00e+00	1104.00
IUUC-Aca-004291	Anolis carolinensis	72.15	0.00e+00	1283.00
IUUC-Bta-013231	Bos taurus	90.30	0.00e+00	1108.00
IUUC-Cja-019455	Callithrix jacchus	71.15	0.00e+00	1293.00
IUUC-Cfa-021017	Canis familiaris	90.65	0.00e+00	1111.00
IUUC-Cpo-021988	Cavia porcellus	71.38	0.00e+00	1288.00
IUUC-Csa-023549	Chlorocebus sabaeus	71.33	0.00e+00	1293.00
IUUC-Dre-028513	Danio rerio	76.86	0.00e+00	1349.00
IUUC-Dno-028976	Dasypus novemcinctus	73.74	0.00e+00	1310.00
IUUC-Dor-030176	Dipodomys ordii	89.95	0.00e+00	1099.00
IUUC-Eca-033949	Equus caballus	73.30	0.00e+00	1290.00
IUUC-Eeu-034529	Erinaceus europaeus	87.78	0.00e+00	946.00
IUUC-Fca-036236	Felis catus	73.16	0.00e+00	1315.00
IUUC-Fal-036948	Ficedula albicollis	91.08	0.00e+00	1119.00
IUUC-Gmo-038842	Gadus morhua	92.95	0.00e+00	1100.00
IUUC-Gga-040617	Gallus gallus	72.33	0.00e+00	1280.00
IUUC-Gac-041338	Gasterosteus aculeatus	93.85	0.00e+00	1137.00
IUUC-Ggo-045278	Gorilla gorilla	71.55	0.00e+00	1298.00
IUUC-Hsa-046148	Homo sapiens	71.74	0.00e+00	1299.00
IUUC-Itr-047945	Ictidomys tridecemlineatus	90.11	0.00e+00	1036.00
IUUC-Lch-050663	Latimeria chalumnae	74.30	0.00e+00	1341.00
IUUC-Loc-052604	Lepisosteus oculatus	77.73	0.00e+00	1358.00
IUUC-Laf-053944	Loxodonta africana	73.74	0.00e+00	1307.00
IUUC-Mcc-055655	Macaca mulatta	71.08	0.00e+00	1296.00
IUUC-Meu-055953	Macropus eugenii	78.40	0.00e+00	955.00
IUUC-Mga-060190	Meleagris gallopavo	72.37	0.00e+00	1280.00
IUUC-Mmr-060896	Microcebus murinus	71.81	0.00e+00	1287.00
IUUC-Mdo-062536	Monodelphis domestica	72.56	0.00e+00	1313.00
IUUC-Mmu-064017	Mus musculus	72.27	0.00e+00	1302.00
IUUC-Mpu-066608	Mustela putorius furo	71.56	0.00e+00	1248.00
IUUC-Mlu-067623	Myotis lucifugus	70.07	0.00e+00	1241.00
IUUC-Nle-069496	Nomascus leucogenys	69.01	0.00e+00	1252.00
IUUC-Opr-071054	Ochotona princeps	89.77	0.00e+00	1096.00
IUUC-Ont-071279	Oreochromis niloticus	90.22	0.00e+00	1562.00
IUUC-Oan-073512	Ornithorhynchus anatinus	71.90	0.00e+00	1254.00
IUUC-Ocu-074271	Oryctolagus cuniculus	72.25	0.00e+00	1278.00
IUUC-Ola-087237	Oryzias latipes	81.28	0.00e+00	1431.00
IUUC-Oga-088164	Otolemur garnettii	73.43	0.00e+00	1302.00
IUUC-Oar-089698	Ovis aries	90.30	0.00e+00	1108.00
IUUC-Ptr-091306	Pan troglodytes	70.79	0.00e+00	1271.00
IUUC-Pan-092814	Papio anubis	68.55	0.00e+00	1222.00
IUUC-Pfo-096709	Poecilia formosa	94.54	0.00e+00	1596.00
IUUC-Pab-098494	Pongo abelii	72.49	0.00e+00	1273.00
IUUC-Pca-100596	Procavia capensis	65.28	0.00e+00	1104.00
IUUC-Pva-103154	Pteropus vampyrus	85.84	0.00e+00	1066.00
IUUC-Rno-104954	Rattus norvegicus	74.48	0.00e+00	1152.00
IUUC-Sha-106781	Sarcophilus harrisii	71.70	0.00e+00	1315.00
IUUC-Tgu-116530	Taeniopygia guttata	85.19	0.00e+00	1016.00
IUUC-Tru-118287	Takifugu rubripes	79.92	0.00e+00	1422.00
IUUC-Tni-120801	Tetraodon nigroviridis	79.72	0.00e+00	1377.00
IUUC-Tbe-127793	Tupaia belangeri	64.23	0.00e+00	1088.00
IUUC-Ttr-128275	Tursiops truncatus	90.30	0.00e+00	1110.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence