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Tag Content
UUCD2 ID IUUC-Cja-019580
UUCD1 version UUC-CaJ-00685
Ensembl Protein ID ENSCJAP00000003623.1
UniProt Accession F7H9X2; TRIM2_CALJA
Genbank Protein ID ENSCJAP00000003623
Protein Name Tripartite motif-containing protein 2; E3 ubiquitin-protein ligase TRIM2; RING-type E3 ubiquitin transferase TRIM2
Genbank Nucleotide ID ACFV01002178
Gene Name TRIM2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSCJAG00000002004.2 ENSCJAT00000003816.1 ENSCJAP00000003623.1
Status Unreviewed
Classification
Family E-Value Score Start End
E3 activity/RING/RING 2.60e-08 35.2 23 64
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCle++k+ p+vlpC H+f++ Clq++       s + +CP+Cr
   Q: 23   CSICLERYKN-PKVLPCLHTFCERCLQNY---IPAHSLTLSCPVCR 64
           **********.******************...44578999*****8 PP
   
Organism Callithrix jacchus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase that mediates the ubiquitination of phosphorylated BCL2L11. Also mediates the UBE2D1-dependent ubiquitination of NEFL. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.
 E3 ubiquitin-protein ligase that mediates the ubiquitination of phosphorylated BCL2L11. Also mediates the UBE2D1-dependent ubiquitination of NEFL. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance.
Protein Sequence
(Fasta)
MASEGTNIPS PVVRQIDKQF LICSICLERY KNPKVLPCLH TFCERCLQNY IPAHSLTLSC 60
PVCRQTSILP EKGVAALQNN FFITNLMDVL QRTPGSNVEE SSILETVTAV AAGKPLSCPN 120
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Protein Fasta Sequence


>IUUC-Cja-019580|E3,RING|Callithrix jacchus
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Nucleotide Sequence
(Fasta)
AGCATTTTGA GTGAGCTTGC TGAAAATTAG GGGCTTTCAG CTGGCCGCCT GCTTGTCACC 60
TCTCGCTGCC TGAACGGCGG CTCTCAGAGC GCGTTTCGCG TCTTCTTAAT TACAGCGGCA 120
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Nucleotide Fasta Sequence


>IUUC-Cja-019580|E3,RING|Callithrix jacchus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR011042--6-blade_b-propeller_TolB-like
IPR003649--Bbox_C
IPR017868--Filamin/ABP280_repeat-like
IPR001298--Filamin/ABP280_rpt
IPR013783--Ig-like_fold
IPR014756--Ig_E-set
IPR001258--NHL_repeat
IPR013017--NHL_repeat_subgr
IPR027370--Znf-RING_LisH
IPR000315--Znf_B-box
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
PROSITE

PS50194--FILAMIN_REPEAT
PS51125--NHL
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2
Pfam

PF00630--Filamin
PF01436--NHL
PF00643--zf-B_box
PF13445--zf-RING_UBOX
SMART

SM00502--BBC
SM00336--BBOX
SM00557--IG_FLMN
SM00184--RING
Gene Ontology

GO:0005737--C:cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0043523--P:regulation of neuron apoptotic process
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002127 Ailuropoda melanoleuca 99.06 0.00e+00 1532.00
IUUC-Apl-003865 Anas platyrhynchos 96.51 0.00e+00 1500.00
IUUC-Aca-004825 Anolis carolinensis 95.14 0.00e+00 1308.00
IUUC-Ame-011612 Astyanax mexicanus 80.99 0.00e+00 1281.00
IUUC-Bta-012548 Bos taurus 98.52 0.00e+00 1528.00
IUUC-Cpo-022342 Cavia porcellus 96.10 0.00e+00 1480.00
IUUC-Csa-023735 Chlorocebus sabaeus 99.60 0.00e+00 1538.00
IUUC-Cho-025025 Choloepus hoffmanni 87.85 0.00e+00 812.00
IUUC-Csv-026112 Ciona savignyi 27.85 1.00e-83 304.00
IUUC-Dre-028599 Danio rerio 79.60 0.00e+00 1212.00
IUUC-Dno-029768 Dasypus novemcinctus 99.60 0.00e+00 1540.00
IUUC-Dor-030841 Dipodomys ordii 91.13 0.00e+00 1384.00
IUUC-Eca-033960 Equus caballus 98.92 0.00e+00 1530.00
IUUC-Eeu-035207 Erinaceus europaeus 89.34 0.00e+00 1170.00
IUUC-Fca-035695 Felis catus 99.06 0.00e+00 1533.00
IUUC-Fal-037000 Ficedula albicollis 96.77 0.00e+00 1506.00
IUUC-Gmo-038767 Gadus morhua 78.49 0.00e+00 1205.00
IUUC-Gga-041007 Gallus gallus 96.37 0.00e+00 1503.00
IUUC-Gac-042586 Gasterosteus aculeatus 84.41 0.00e+00 1332.00
IUUC-Ggo-045221 Gorilla gorilla 99.60 0.00e+00 1536.00
IUUC-Hsa-046365 Homo sapiens 99.60 0.00e+00 1537.00
IUUC-Lch-050198 Latimeria chalumnae 84.86 0.00e+00 1320.00
IUUC-Loc-052583 Lepisosteus oculatus 89.52 0.00e+00 1368.00
IUUC-Laf-054233 Loxodonta africana 98.79 0.00e+00 1531.00
IUUC-Mcc-055569 Macaca mulatta 99.86 0.00e+00 1442.00
IUUC-Mga-059355 Meleagris gallopavo 95.58 0.00e+00 1491.00
IUUC-Mmr-061171 Microcebus murinus 99.19 0.00e+00 1535.00
IUUC-Mdo-062885 Monodelphis domestica 97.85 0.00e+00 1518.00
IUUC-Mmu-063562 Mus musculus 99.19 0.00e+00 1531.00
IUUC-Mpu-066097 Mustela putorius furo 98.66 0.00e+00 1529.00
IUUC-Mlu-068044 Myotis lucifugus 99.19 0.00e+00 1533.00
IUUC-Nle-069532 Nomascus leucogenys 99.87 0.00e+00 1540.00
IUUC-Opr-070346 Ochotona princeps 98.39 0.00e+00 1519.00
IUUC-Ont-071572 Oreochromis niloticus 84.68 0.00e+00 1335.00
IUUC-Oan-072836 Ornithorhynchus anatinus 97.55 0.00e+00 1419.00
IUUC-Ocu-074750 Oryctolagus cuniculus 99.19 0.00e+00 1533.00
IUUC-Ola-087547 Oryzias latipes 82.39 0.00e+00 1308.00
IUUC-Oga-088484 Otolemur garnettii 99.19 0.00e+00 1535.00
IUUC-Oar-089231 Ovis aries 97.58 0.00e+00 1508.00
IUUC-Ptr-091007 Pan troglodytes 98.12 0.00e+00 1506.00
IUUC-Pan-092589 Papio anubis 99.87 0.00e+00 1540.00
IUUC-Psi-093880 Pelodiscus sinensis 96.77 0.00e+00 1506.00
IUUC-Pma-094132 Petromyzon marinus 86.19 3.00e-132 464.00
IUUC-Pfo-096688 Poecilia formosa 80.84 0.00e+00 1163.00
IUUC-Pab-098260 Pongo abelii 99.73 0.00e+00 1539.00
IUUC-Pca-100644 Procavia capensis 99.16 0.00e+00 975.00
IUUC-Pva-102141 Pteropus vampyrus 99.19 0.00e+00 1534.00
IUUC-Rno-105358 Rattus norvegicus 96.11 0.00e+00 1468.00
IUUC-Sha-106703 Sarcophilus harrisii 97.86 0.00e+00 1512.00
IUUC-Sar-113100 Sorex araneus 98.74 0.00e+00 972.00
IUUC-Ssc-116118 Sus scrofa 98.79 0.00e+00 1527.00
IUUC-Tgu-117257 Taeniopygia guttata 96.64 0.00e+00 1502.00
IUUC-Tru-118683 Takifugu rubripes 82.62 0.00e+00 1303.00
IUUC-Tni-120534 Tetraodon nigroviridis 82.39 0.00e+00 1286.00
IUUC-Tbe-127438 Tupaia belangeri 91.00 0.00e+00 936.00
IUUC-Ttr-128897 Tursiops truncatus 97.72 0.00e+00 1511.00
IUUC-Vpa-130582 Vicugna pacos 99.25 5.00e-160 558.00
Created Date 25-Jun-2017

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