iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000027501.7	ENSDART00000097945.3	ENSDARP00000088718.3
ENSDARG00000027501.7	ENSDART00000030969.7	ENSDARP00000031659.6
ENSDARG00000027501.7	ENSDART00000165946.1	ENSDARP00000130112.1
ENSDARG00000027501.7	ENSDART00000006021.8	ENSDARP00000014964.7
ENSDARG00000027501.7	ENSDART00000122077.2	ENSDARP00000111054.1
ENSDARG00000027501.7	ENSDART00000111946.2	ENSDARP00000102925.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.10e-109	366.7	148	684

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw.kskkkavsprellkalkkeaeefsgye 88
           tG+kN+gN+CYmN++LQ+Lsn+p+l++++ +     ++   ++++k +l+ks+qkl++elw k++ ++v p++l++ +k ++++f+gy+
   Q: 148  TGMKNIGNSCYMNAALQALSNCPPLTQFFQD-----CSGLVRTDKKPALCKSYQKLISELWhKKRPSYVVPTTLFHGIKLVNPMFRGYA 231
           7******************************.....9999999******************99999*********************** PP
   S: 89   qqDaqEflaflldqleeelkk..............eknkpkeeeeeedkselsde.................................. 129
           qqD+qEfl++l+dql+eelk+                + +  ++ + d+s ++de                                  
   Q: 232  QQDTQEFLRCLMDQLHEELKEplfdcsggisevepDLSLDSCNLVDGDRSPSEDEflscdsgsgsergdgeraggeaelliqdecvavr 320
           *******************888888888887766644444445555555555555888889999999********************** PP
   S: 130  ......................................................................................... 129
                                                                                                    
   Q: 321  gtggisekerlkerrgeertremdedadvdtaaqdgqaeretetatpatavpapgntepdneasmhcpssrpcspahsvqelhsrlssn 409
           ***************************************************************************************** PP
   S: 130  .......................aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke.......... 185
                                   ++kk+++ +s+isd+F+g++ s ++cl+cd+vs++ e+f+dlslp+pgke+ +k+          
   Q: 410  pprssplrtgptytfkkaqmllsTKKKKQSRFRSVISDIFDGSILSLVQCLTCDRVSTTVETFQDLSLPIPGKEDLAKLhssihqsapv 498
           **********************9999************************************************99888********** PP
   S: 186  .......................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLk 235
                                                  +l+dcL++f++++el+g+n+y+ce+ckk+++ +k +k+ +lPe+L++hLk
   Q: 499  kagvctdgyaaqgwisyimdsirrfvvscipswfwgpmvTLEDCLAAFFAADELKGDNMYSCERCKKLRNGVKYCKVLRLPEILCIHLK 587
           ***************************************************************************************** PP
   S: 236  Rfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvkn.ekgkWllfdDskVtevkeeev 322
           Rf  ++e + + kin++v+fple Ldl+pf+++++ +q   ++Y+L++v++H+G+++sGHY+ay++n  +g+W++fdD++Vtev+e+ v
   Q: 588  RF--RHEVMYSFKINSHVSFPLEgLDLKPFLAKESPSQ--ITTYDLLSVICHHGTAGSGHYIAYCQNvINGQWYEFDDQYVTEVHETVV 672
           **..9999*************************88887..9**************************78999***************** PP
   S: 323  leetgstaYvlfYkr 337
           ++   ++aYvlfY++
   Q: 673  QN---AEAYVLFYRK 684
           **...********98 PP

Organism

Danio rerio

Protein Sequence
(Fasta)

MTDSGDLCPH LDSIGEVTKE ELIQKSKGTC QSCGVGGPNL WACLQCDCPY VGCGESYSDH 60
STIHAQAKKH NLTVNLTTFR VWCYVCEREV FLEPKPVTPV SSAHRCKPHD QDPVSQTTCY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTAAAGAACG AAATGCGCTC ATTGGCTGTG GTCAAAGCCG TGACGCACGC TTCTGCTGTA 60
TTCAGTATGG ATGCTGCTTA GTAGTAACGT TACACTGCTT CCCACCACTG TTACAAACAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF06337--DUSP
PF00443--UCH
PF02148--zf-UBP

SMART

SM00695--DUSP
SM00290--ZnF_UBP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002209	Ailuropoda melanoleuca	74.00	0.00e+00	1223.00
IUUC-Apl-003351	Anas platyrhynchos	76.20	0.00e+00	1261.00
IUUC-Aca-005077	Anolis carolinensis	68.83	0.00e+00	892.00
IUUC-Ame-011777	Astyanax mexicanus	80.00	0.00e+00	1453.00
IUUC-Bta-013063	Bos taurus	74.73	0.00e+00	1258.00
IUUC-Cja-019868	Callithrix jacchus	75.32	0.00e+00	1264.00
IUUC-Cfa-020761	Canis familiaris	75.00	0.00e+00	1254.00
IUUC-Cpo-022267	Cavia porcellus	73.22	0.00e+00	1204.00
IUUC-Csa-024251	Chlorocebus sabaeus	75.56	0.00e+00	1269.00
IUUC-Cho-024483	Choloepus hoffmanni	91.51	1.00e-118	421.00
IUUC-Dno-029423	Dasypus novemcinctus	75.00	0.00e+00	1257.00
IUUC-Dor-030877	Dipodomys ordii	76.92	0.00e+00	825.00
IUUC-Ete-032802	Echinops telfairi	60.28	5.00e-105	375.00
IUUC-Eca-034283	Equus caballus	73.80	0.00e+00	1232.00
IUUC-Eeu-034620	Erinaceus europaeus	70.89	0.00e+00	924.00
IUUC-Fca-036357	Felis catus	74.53	0.00e+00	1243.00
IUUC-Fal-037411	Ficedula albicollis	76.34	0.00e+00	1264.00
IUUC-Gga-041101	Gallus gallus	76.85	0.00e+00	1267.00
IUUC-Gac-041315	Gasterosteus aculeatus	71.47	0.00e+00	1286.00
IUUC-Ggo-045600	Gorilla gorilla	74.71	0.00e+00	1249.00
IUUC-Hsa-045825	Homo sapiens	75.03	0.00e+00	1261.00
IUUC-Itr-048549	Ictidomys tridecemlineatus	64.87	0.00e+00	1035.00
IUUC-Lch-050002	Latimeria chalumnae	72.27	0.00e+00	1142.00
IUUC-Loc-052574	Lepisosteus oculatus	80.80	0.00e+00	1348.00
IUUC-Laf-054428	Loxodonta africana	76.15	0.00e+00	1259.00
IUUC-Mcc-055736	Macaca mulatta	75.44	0.00e+00	1268.00
IUUC-Mga-059781	Meleagris gallopavo	76.60	0.00e+00	1267.00
IUUC-Mmr-061328	Microcebus murinus	86.97	0.00e+00	712.00
IUUC-Mdo-063048	Monodelphis domestica	76.76	0.00e+00	1231.00
IUUC-Mmu-064079	Mus musculus	74.12	0.00e+00	1240.00
IUUC-Mpu-066616	Mustela putorius furo	75.53	0.00e+00	1284.00
IUUC-Mlu-067294	Myotis lucifugus	73.82	0.00e+00	1226.00
IUUC-Nle-070015	Nomascus leucogenys	74.68	0.00e+00	1228.00
IUUC-Opr-070328	Ochotona princeps	74.71	0.00e+00	1247.00
IUUC-Ont-071464	Oreochromis niloticus	72.54	0.00e+00	1281.00
IUUC-Oan-073259	Ornithorhynchus anatinus	69.24	0.00e+00	1072.00
IUUC-Ocu-074630	Oryctolagus cuniculus	74.47	0.00e+00	1212.00
IUUC-Ola-087240	Oryzias latipes	78.06	0.00e+00	933.00
IUUC-Oga-088761	Otolemur garnettii	74.71	0.00e+00	1256.00
IUUC-Oar-089490	Ovis aries	71.06	0.00e+00	1137.00
IUUC-Ptr-091662	Pan troglodytes	75.03	0.00e+00	1259.00
IUUC-Pan-092199	Papio anubis	75.38	0.00e+00	1260.00
IUUC-Psi-093726	Pelodiscus sinensis	76.70	0.00e+00	1264.00
IUUC-Pma-094389	Petromyzon marinus	63.25	3.00e-101	361.00
IUUC-Pfo-096522	Poecilia formosa	77.01	0.00e+00	1015.00
IUUC-Pab-098632	Pongo abelii	75.00	0.00e+00	1266.00
IUUC-Pca-100614	Procavia capensis	68.42	0.00e+00	957.00
IUUC-Pva-102922	Pteropus vampyrus	67.57	0.00e+00	744.00
IUUC-Rno-105215	Rattus norvegicus	73.53	0.00e+00	1228.00
IUUC-Sce-106176	Saccharomyces cerevisiae	33.33	3.00e-26	114.00
IUUC-Sha-106601	Sarcophilus harrisii	74.17	0.00e+00	1217.00
IUUC-Ssc-115533	Sus scrofa	73.92	0.00e+00	1237.00
IUUC-Tgu-117364	Taeniopygia guttata	76.32	0.00e+00	1253.00
IUUC-Tru-117770	Takifugu rubripes	70.10	0.00e+00	1261.00
IUUC-Tni-120001	Tetraodon nigroviridis	69.97	0.00e+00	1228.00
IUUC-Ttr-128732	Tursiops truncatus	74.68	0.00e+00	1261.00
IUUC-Xtr-132157	Xenopus tropicalis	72.54	0.00e+00	1182.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence