• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Cel-018187
Ensembl Protein ID B0205.3.1
UniProt Accession O61742; PSMD4_CAEEL
Genbank Protein ID CCD61298.1
Protein Name 26S proteasome non-ATPase regulatory subunit 4; 26S proteasome regulatory subunit rpn-10
Genbank Nucleotide ID BX284601
Gene Name rpn-10; B0205.3
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
WBGene00004466 B0205.3.1 B0205.3.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNAmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAMentha
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/Alpha-Helix/UIM 3.10e-06 26.9 273 290
UBD/Alpha-Helix/UIM 7.5e-06 14.2 217 233
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/Alpha-Helix/UIM
   S: 1    dEdeeLqlAlalSlqEee 18
           +E+++L++Al+lS+qE +
   Q: 273  TEEQQLEWALRLSMQENA 290
           59**************75 PP
   

   UBD/Alpha-Helix/UIM
   S: 2    EdeeLqlAlalSlqEee 18
            d++L+lAl++S++Ee+
   Q: 217  NDPDLALALRVSMEEER 233
           699************97 PP
   
Organism Caenorhabditis elegans
Functional Description
(View)

Functional Description


     Binds and presumably selects ubiquitin-conjugates for destruction (By similarity). Required for protein degradation and ubiquitin-proteasome system (UBS) function and regulates proteasomal subunit expression (PubMed:20453865, PubMed:22105480, PubMed:26828939). Involvement in UBS might be cell type specific (PubMed:20453865). Regulator of the autophagy-lysosome pathway that may confer resistance to autophagy by regulating the expression of autophagy-related proteins such as lgg-1, and by regulating lysosome formation, possibly by modulating elt-2 activity (PubMed:26828939). Required for fertility, sperm production, and sex determination through regulation of tra-2 protein (PubMed:17050737). Plays a role in the elimination of paternal mitochondria in fertilized eggs (PubMed:22105480).
 Binds and presumably selects ubiquitin-conjugates for destruction (By similarity). Required for protein degradation and ubiquitin-proteasome system (UBS) function and regulates proteasomal subunit expression (PubMed:20453865, PubMed:22105480, PubMed:26828939). Involvement in UBS might be cell type specific (PubMed:20453865). Regulator of the autophagy-lysosome pathway that may confer resistance to autophagy by regulating the expression of autophagy-related proteins such as lgg-1, and by regulating lysosome formation, possibly by modulating elt-2 activity (PubMed:26828939). Required for fertility, sperm production, and sex determination through regulation of tra-2 protein (PubMed:17050737). Plays a role in the elimination of paternal mitochondria in fertilized eggs (PubMed:22105480).
Protein Sequence
(Fasta)
MVQESTMICV DNSEYMRNGD FQPTRLQSQQ DAVNLVTQCK LRANPENAVG ILSMANSVQV 60
LSSLSTEQGR LMMKNHSIEP FGKCNFIAGI KIAHLALKHR QNRNHKMRVV LFIGSPLEEI 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Cel-018187|UBD,UIM|Caenorhabditis elegans
Please wait for a moment...
Nucleotide Sequence
(Fasta)
AATTTTATTT CTCACATTCT ACAGAGTTCA TACAAAGGTG CTCAACACAT TTCCAAAATG 60
GTTCAAGAAA GTACTATGAT TTGGTGAGTT TTTCTTGAAT AATACGAACA ATGGCAATAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Cel-018187|UBD,UIM|Caenorhabditis elegans
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0539--Nucleus
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR027040--Proteasome_su_Rpn10
IPR003903--UIM_dom
IPR002035--VWF_A
PROSITE

PS50330--UIM
Pfam

PF02809--UIM
PF13519--VWA_2
SMART

SM00726--UIM
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0008540--C:proteasome regulatory particle, base subcomplex
GO:0031593--F:polyubiquitin binding
GO:0043248--P:proteasome assembly
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0007283--P:spermatogenesis
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG cel:CELE_B0205.3
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001241 Ailuropoda melanoleuca 47.04 2.00e-69 254.00
IUUC-Atr-002938 Amborella trichopoda 43.04 5.00e-41 160.00
IUUC-Apl-003881 Anas platyrhynchos 53.27 9.00e-57 211.00
IUUC-Aca-004397 Anolis carolinensis 56.33 2.00e-65 240.00
IUUC-Aly-005564 Arabidopsis lyrata 42.62 5.00e-36 143.00
IUUC-Ath-007436 Arabidopsis thaliana 42.62 7.00e-36 143.00
IUUC-Ago-007858 Ashbya gossypii 41.38 4.00e-38 150.00
IUUC-Acl-008094 Aspergillus clavatus 37.50 4.00e-33 133.00
IUUC-Afl-008689 Aspergillus flavus 41.38 7.00e-33 132.00
IUUC-Afu-008959 Aspergillus fumigatus 38.70 2.00e-34 137.00
IUUC-Ani-009344 Aspergillus nidulans 35.38 5.00e-21 93.20
IUUC-Ang-009602 Aspergillus niger 37.50 2.00e-32 131.00
IUUC-Aor-009906 Aspergillus oryzae 38.54 1.00e-19 88.60
IUUC-Ate-010267 Aspergillus terreus 34.93 7.00e-25 106.00
IUUC-Ame-011018 Astyanax mexicanus 46.57 5.00e-71 259.00
IUUC-Bgr-012200 Blumeria graminis 40.66 1.00e-34 139.00
IUUC-Bta-013066 Bos taurus 46.31 1.00e-68 251.00
IUUC-Bci-013904 Botrytis cinerea 37.60 1.00e-35 142.00
IUUC-Bdi-014537 Brachypodium distachyon 40.93 4.00e-35 140.00
IUUC-Bol-016027 Brassica oleracea 41.88 3.00e-35 140.00
IUUC-Bra-018039 Brassica rapa 42.62 7.00e-36 143.00
IUUC-Cja-019738 Callithrix jacchus 56.77 1.00e-65 242.00
IUUC-Cfa-020362 Canis familiaris 47.04 2.00e-69 254.00
IUUC-Cpo-021297 Cavia porcellus 45.77 5.00e-64 238.00
IUUC-Cre-022783 Chlamydomonas reinhardtii 43.62 7.00e-36 142.00
IUUC-Cho-024800 Choloepus hoffmanni 54.55 6.00e-22 96.70
IUUC-Cin-025469 Ciona intestinalis 45.25 5.00e-55 206.00
IUUC-Csv-026297 Ciona savignyi 41.43 2.00e-57 214.00
IUUC-Cgl-026657 Colletotrichum gloeosporioides 36.71 1.00e-30 125.00
IUUC-Cne-027027 Cryptococcus neoformans 40.34 4.00e-38 150.00
IUUC-Cme-027212 Cyanidioschyzon merolae 35.25 2.00e-30 125.00
IUUC-Dre-027759 Danio rerio 47.43 1.00e-71 261.00
IUUC-Dno-029528 Dasypus novemcinctus 56.77 1.00e-65 242.00
IUUC-Dor-030255 Dipodomys ordii 55.91 4.00e-61 227.00
IUUC-Dse-031464 Dothistroma septosporum 40.34 2.00e-30 124.00
IUUC-Dme-032000 Drosophila melanogaster 52.84 2.00e-59 221.00
IUUC-Ete-032762 Echinops telfairi 56.33 3.00e-65 241.00
IUUC-Eca-034399 Equus caballus 45.95 3.00e-64 239.00
IUUC-Eeu-035072 Erinaceus europaeus 52.05 5.00e-39 153.00
IUUC-Fca-035993 Felis catus 55.00 5.00e-60 223.00
IUUC-Fal-037623 Ficedula albicollis 58.39 3.00e-41 160.00
IUUC-Fox-037746 Fusarium oxysporum 39.41 3.00e-35 140.00
IUUC-Fso-038431 Fusarium solani 43.04 7.00e-37 145.00
IUUC-Gmo-038712 Gadus morhua 45.77 1.00e-63 236.00
IUUC-Ggr-039821 Gaeumannomyces graminis 36.27 2.00e-30 124.00
IUUC-Gga-040288 Gallus gallus 44.16 3.00e-66 244.00
IUUC-Gac-041309 Gasterosteus aculeatus 57.73 3.00e-61 228.00
IUUC-Gma-044042 Glycine max 40.95 5.00e-41 160.00
IUUC-Ggo-044628 Gorilla gorilla 56.77 1.00e-65 242.00
IUUC-Hsa-045850 Homo sapiens 46.76 1.00e-69 255.00
IUUC-Hvu-047715 Hordeum vulgare 41.91 3.00e-37 147.00
IUUC-Itr-048388 Ictidomys tridecemlineatus 56.05 3.00e-63 234.00
IUUC-Kpa-049158 Komagataella pastoris 40.91 9.00e-38 149.00
IUUC-Lch-050472 Latimeria chalumnae 45.35 1.00e-62 233.00
IUUC-Lpe-051233 Leersia perrieri 39.24 5.00e-31 129.00
IUUC-Loc-052437 Lepisosteus oculatus 42.27 3.00e-39 155.00
IUUC-Lma-053295 Leptosphaeria maculans 42.92 6.00e-36 142.00
IUUC-Laf-053504 Loxodonta africana 56.77 9.00e-66 242.00
IUUC-Mcc-054877 Macaca mulatta 56.77 1.00e-65 242.00
IUUC-Meu-056114 Macropus eugenii 45.38 2.00e-68 251.00
IUUC-Mor-057212 Magnaporthe oryzae 37.45 2.00e-28 118.00
IUUC-Mpo-057587 Magnaporthe poae 36.27 2.00e-30 124.00
IUUC-Mtr-058520 Medicago truncatula 38.49 2.00e-33 135.00
IUUC-Mla-059105 Melampsora laricipopulina 32.14 9.00e-15 72.80
IUUC-Mga-059537 Meleagris gallopavo 46.02 7.00e-69 252.00
IUUC-Mvi-060277 Microbotryum violaceum 33.07 3.00e-34 137.00
IUUC-Mmr-061736 Microcebus murinus 45.45 1.00e-66 245.00
IUUC-Mdo-062403 Monodelphis domestica 44.80 2.00e-63 236.00
IUUC-Mmu-063937 Mus musculus 56.77 1.00e-65 241.00
IUUC-Mac-065456 Musa acuminata 40.69 1.00e-38 152.00
IUUC-Mpu-065901 Mustela putorius furo 46.48 1.00e-68 252.00
IUUC-Mlu-067994 Myotis lucifugus 46.76 1.00e-69 255.00
IUUC-Nfi-068540 Neosartorya fischeri 38.70 2.00e-34 137.00
IUUC-Ncr-068760 Neurospora crassa 41.00 2.00e-36 144.00
IUUC-Nle-069463 Nomascus leucogenys 56.77 1.00e-65 241.00
IUUC-Opr-070298 Ochotona princeps 56.77 9.00e-66 242.00
IUUC-Ont-072030 Oreochromis niloticus 47.14 3.00e-68 251.00
IUUC-Ocu-074141 Oryctolagus cuniculus 56.77 9.00e-66 242.00
IUUC-Oba-075955 Oryza barthii 39.66 1.00e-32 132.00
IUUC-Obr-076545 Oryza brachyantha 38.98 1.00e-31 129.00
IUUC-Ogl-077252 Oryza glaberrima 38.96 1.00e-30 125.00
IUUC-Ogu-078986 Oryza glumaepatula 39.66 1.00e-32 132.00
IUUC-Oin-080166 Oryza indica 38.56 1.00e-31 129.00
IUUC-Olo-080390 Oryza longistaminata 39.22 6.00e-30 125.00
IUUC-Ome-082015 Oryza meridionalis 39.66 1.00e-32 132.00
IUUC-Oni-082397 Oryza nivara 39.66 1.00e-32 132.00
IUUC-Opu-083674 Oryza punctata 39.66 1.00e-32 132.00
IUUC-Oru-085199 Oryza rufipogon 39.66 1.00e-32 132.00
IUUC-Osa-085911 Oryza sativa 39.66 1.00e-32 132.00
IUUC-Ola-086325 Oryzias latipes 43.98 6.00e-62 231.00
IUUC-Olu-087857 Ostreococcus lucimarinus 44.65 9.00e-35 139.00
IUUC-Oga-088882 Otolemur garnettii 45.66 5.00e-64 236.00
IUUC-Oar-089311 Ovis aries 46.31 1.00e-68 251.00
IUUC-Ptr-090931 Pan troglodytes 46.76 1.00e-69 255.00
IUUC-Pan-092286 Papio anubis 46.76 2.00e-69 254.00
IUUC-Psi-093908 Pelodiscus sinensis 45.56 6.00e-65 239.00
IUUC-Pma-094737 Petromyzon marinus 54.87 2.00e-58 218.00
IUUC-Pno-094807 Phaeosphaeria nodorum 42.80 6.00e-40 156.00
IUUC-Ppa-095749 Physcomitrella patens 40.33 1.00e-37 149.00
IUUC-Pfo-096593 Poecilia formosa 47.47 2.00e-67 248.00
IUUC-Pab-097708 Pongo abelii 45.95 5.00e-65 239.00
IUUC-Pop-099138 Populus trichocarpa 43.64 5.00e-42 163.00
IUUC-Pca-100722 Procavia capensis 53.33 4.00e-27 114.00
IUUC-Ppe-101877 Prunus persica 41.91 1.00e-43 169.00
IUUC-Pva-103185 Pteropus vampyrus 46.09 1.00e-68 252.00
IUUC-Pgr-103361 Puccinia graminis 34.85 6.00e-24 103.00
IUUC-Ptt-103848 Puccinia triticina 35.25 8.00e-12 62.80
IUUC-Pte-104114 Pyrenophora teres 41.81 8.00e-36 142.00
IUUC-Pyt-104662 Pyrenophora triticirepentis 42.68 2.00e-38 151.00
IUUC-Rno-104906 Rattus norvegicus 56.77 1.00e-65 241.00
IUUC-Sce-106427 Saccharomyces cerevisiae 37.50 1.00e-32 131.00
IUUC-Sha-106574 Sarcophilus harrisii 46.24 5.00e-68 249.00
IUUC-Sja-107706 Schizosaccharomyces japonicus 39.55 6.00e-36 142.00
IUUC-Spo-108378 Schizosaccharomyces pombe 38.84 1.00e-31 128.00
IUUC-Smo-109108 Selaginella moellendorffii 41.87 6.00e-38 150.00
IUUC-Sit-110284 Setaria italica 41.08 9.00e-35 139.00
IUUC-Sly-111246 Solanum lycopersicum 41.25 2.00e-38 152.00
IUUC-Stu-112695 Solanum tuberosum 41.25 2.00e-38 152.00
IUUC-Sar-113015 Sorex araneus 58.58 2.00e-52 197.00
IUUC-Sbi-114495 Sorghum bicolor 41.08 8.00e-35 139.00
IUUC-Sre-114891 Sporisorium reilianum 42.74 9.00e-41 159.00
IUUC-Ssc-116142 Sus scrofa 46.76 1.00e-69 255.00
IUUC-Tgu-116946 Taeniopygia guttata 38.64 2.00e-38 151.00
IUUC-Tru-118224 Takifugu rubripes 45.94 9.00e-67 245.00
IUUC-Tsy-119004 Tarsius syrichta 52.05 5.00e-39 153.00
IUUC-Tni-120074 Tetraodon nigroviridis 46.48 9.00e-71 259.00
IUUC-Tca-121251 Theobroma cacao 41.67 8.00e-37 146.00
IUUC-Tre-122168 Trichoderma reesei 45.80 1.00e-41 162.00
IUUC-Tvi-122655 Trichoderma virens 43.59 1.00e-33 135.00
IUUC-Tae-124568 Triticum aestivum 41.91 5.00e-37 147.00
IUUC-Tur-126420 Triticum urartu 41.91 6.00e-37 147.00
IUUC-Tme-126937 Tuber melanosporum 40.83 2.00e-38 150.00
IUUC-Tbe-128080 Tupaia belangeri 55.46 1.00e-63 235.00
IUUC-Ttr-128811 Tursiops truncatus 56.77 1.00e-65 242.00
IUUC-Uma-129436 Ustilago maydis 42.74 9.00e-41 159.00
IUUC-Vda-129920 Verticillium dahliae 40.33 1.00e-32 132.00
IUUC-Vpa-130762 Vicugna pacos 61.82 2.00e-41 161.00
IUUC-Vvi-130840 Vitis vinifera 39.50 1.00e-39 155.00
IUUC-Xtr-131967 Xenopus tropicalis 40.61 3.00e-30 124.00
IUUC-Xma-133989 Xiphophorus maculatus 47.14 3.00e-69 254.00
IUUC-Yli-134643 Yarrowia lipolytica 42.32 8.00e-41 159.00
IUUC-Zma-135632 Zea mays 41.08 2.00e-36 145.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved