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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-064347
Ensembl Protein ID ENSMUSP00000110523.1
UniProt Accession Q61644; PACN1_MOUSE
Genbank Protein ID CAA59437.1; AAH14698.1
Protein Name Protein kinase C and casein kinase substrate in neurons protein 1; Syndapin-1
Genbank Nucleotide ID X85124; BC014698
Gene Name Pacsin1; Pacsin
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000040276.14 ENSMUST00000114873.7 ENSMUSP00000110523.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDHINTMentha
Protein 3D Structure
PDBMMDB
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 7.40e-15 55.8 386 441
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekl 62
           +v++lydy++q++deL++k+Gd ++ +  ee ++gW++g + ++g+ Gl P+n+ve +
   Q: 386  RVRALYDYDGQEQDELSFKAGDELTKL-GEEDEQGWCRG-RLDSGQLGLYPANYVEAI 441
           699************************.***********.59*************975 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission.
 Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission.
Protein Sequence
(Fasta)
MSGSYDEASE EITDSFWEVG NYKRTVKRID DGHRLCNDLM SCVQERAKIE KAYAQQLTDW 60
AKRWRQLIEK GPQYGSLERA WGAMMTEADK VSELHQEVKN SLLNEDLEKV KNWQKDAYHK 120
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Protein Fasta Sequence


>IUUC-Mmu-064347|UBD,SH3|Mus musculus
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Nucleotide Sequence
(Fasta)
GTCGCCATTG GCTCACGGAG AAGCCGCTCT AATCCGCGCC GCCTCCGCCC CCGCGCGGCG 60
CTGCGCTCGG CGGAGTCTCT GACCTTCCTC CTTCCCGCAG CCCCAGAGAG ACGCGCGGCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064347|UBD,SH3|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0965--Cell junction
KW-1003--Cell membrane
KW-0966--Cell projection
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0903--Direct protein sequencing
KW-0254--Endocytosis
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0770--Synapse
KW-0771--Synaptosome
Interpro

IPR027267--AH/BAR-dom
IPR031160--F_BAR
IPR001060--FCH_dom
IPR028518--PACSIN1
IPR001452--SH3_domain
PROSITE

PS51741--F_BAR
PS50002--SH3
Pfam

PF00611--FCH
PF14604--SH3_9
PRINTS

PR00452--SH3DOMAIN
SMART

SM00055--FCH
SM00326--SH3
Gene Ontology

GO:0043679--C:axon terminus
GO:0030054--C:cell junction
GO:0030137--C:COPI-coated vesicle
GO:0005737--C:cytoplasm
GO:0030659--C:cytoplasmic vesicle membrane
GO:0005829--C:cytosol
GO:0005768--C:endosome
GO:0043209--C:myelin sheath
GO:0032587--C:ruffle membrane
GO:0008092--F:cytoskeletal protein binding
GO:0005543--F:phospholipid binding
GO:0007015--P:actin filament organization
GO:0045806--P:negative regulation of endocytosis
GO:0048812--P:neuron projection morphogenesis
GO:0097320--P:plasma membrane tubulation
GO:0072657--P:protein localization to membrane
GO:0007165--P:signal transduction
GO:0048488--P:synaptic vesicle endocytosis
KEGG mmu:23969
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001861 Ailuropoda melanoleuca 86.07 0.00e+00 756.00
IUUC-Apl-003667 Anas platyrhynchos 84.04 0.00e+00 688.00
IUUC-Aca-005229 Anolis carolinensis 81.84 0.00e+00 716.00
IUUC-Ame-011410 Astyanax mexicanus 73.03 3.00e-177 614.00
IUUC-Bta-013509 Bos taurus 93.92 0.00e+00 742.00
IUUC-Cel-018168 Caenorhabditis elegans 28.72 1.00e-60 227.00
IUUC-Cja-019659 Callithrix jacchus 95.50 0.00e+00 809.00
IUUC-Cfa-020396 Canis familiaris 95.27 0.00e+00 783.00
IUUC-Cpo-022376 Cavia porcellus 96.17 0.00e+00 785.00
IUUC-Csa-023701 Chlorocebus sabaeus 95.27 0.00e+00 779.00
IUUC-Dre-027456 Danio rerio 74.22 0.00e+00 665.00
IUUC-Eca-033679 Equus caballus 89.04 0.00e+00 713.00
IUUC-Fca-036314 Felis catus 95.05 0.00e+00 781.00
IUUC-Fal-037300 Ficedula albicollis 83.41 0.00e+00 721.00
IUUC-Gmo-038571 Gadus morhua 67.92 6.00e-162 563.00
IUUC-Gga-040626 Gallus gallus 82.96 0.00e+00 682.00
IUUC-Gac-041445 Gasterosteus aculeatus 68.90 3.00e-166 578.00
IUUC-Ggo-045557 Gorilla gorilla 95.05 0.00e+00 778.00
IUUC-Hsa-045778 Homo sapiens 95.05 0.00e+00 778.00
IUUC-Itr-048856 Ictidomys tridecemlineatus 96.17 0.00e+00 786.00
IUUC-Lch-050070 Latimeria chalumnae 71.63 0.00e+00 672.00
IUUC-Loc-051764 Lepisosteus oculatus 78.25 0.00e+00 691.00
IUUC-Laf-054465 Loxodonta africana 95.51 0.00e+00 802.00
IUUC-Mcc-055324 Macaca mulatta 95.05 0.00e+00 779.00
IUUC-Meu-056348 Macropus eugenii 90.09 0.00e+00 740.00
IUUC-Mga-059285 Meleagris gallopavo 84.51 0.00e+00 671.00
IUUC-Mmr-061367 Microcebus murinus 96.85 0.00e+00 747.00
IUUC-Mdo-062432 Monodelphis domestica 58.39 2.00e-138 485.00
IUUC-Mpu-066864 Mustela putorius furo 94.82 0.00e+00 778.00
IUUC-Nle-070027 Nomascus leucogenys 95.75 0.00e+00 747.00
IUUC-Ont-072188 Oreochromis niloticus 71.75 0.00e+00 635.00
IUUC-Ocu-074297 Oryctolagus cuniculus 96.40 0.00e+00 756.00
IUUC-Ola-087188 Oryzias latipes 72.13 3.00e-162 564.00
IUUC-Oga-088856 Otolemur garnettii 95.95 0.00e+00 762.00
IUUC-Oar-090278 Ovis aries 86.26 0.00e+00 640.00
IUUC-Pan-092056 Papio anubis 95.27 0.00e+00 779.00
IUUC-Pfo-097528 Poecilia formosa 69.28 2.00e-156 545.00
IUUC-Pab-098202 Pongo abelii 95.05 0.00e+00 778.00
IUUC-Pca-100881 Procavia capensis 94.37 0.00e+00 773.00
IUUC-Pva-102181 Pteropus vampyrus 94.14 0.00e+00 773.00
IUUC-Rno-105295 Rattus norvegicus 95.46 0.00e+00 790.00
IUUC-Sha-107163 Sarcophilus harrisii 76.64 0.00e+00 651.00
IUUC-Ssc-115685 Sus scrofa 93.92 0.00e+00 773.00
IUUC-Tgu-116524 Taeniopygia guttata 77.13 0.00e+00 639.00
IUUC-Tru-118248 Takifugu rubripes 69.35 1.00e-153 535.00
IUUC-Tni-120717 Tetraodon nigroviridis 70.18 8.00e-158 550.00
IUUC-Ttr-129069 Tursiops truncatus 95.74 0.00e+00 750.00
IUUC-Xtr-132759 Xenopus tropicalis 73.02 0.00e+00 644.00
Created Date 25-Jun-2017

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