iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Cfa-021202

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AAEX03012419

Gene Name

KEAP1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCAFG00000017784.3	ENSCAFT00000028191.3	ENSCAFP00000026217.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	7.30e-17	61.8	77	148
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	7.00e-09	34.9	181	211

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvv....g.geeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklden 68
           +Dv+l+v    +   +f ahk+vLa+sS+vF+a+f+++l+e+   + v i+++ p+v++ l++F Yt ++++ 
   Q: 77   CDVTLQVkyedApAAQFMAHKVVLASSSPVFKAMFTNGLREQG-MEVVSIEGIHPKVMERLIEFAYTASISMG 148
           8******66652699**************************98.***********************998875 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           ++N++gi  fA++ +c +L+++a+++i  hF
   Q: 181  PSNAIGIANFAEQIGCAELHQRAREYIYMHF 211
           89****************************9 PP

Organism

Canis familiaris

Protein Sequence
(Fasta)

MQPEPGPSGA GARTRFLPLR SQRPEGAGDT VMYASTECKA EVTPSQHGNR TFSYTLEDHT 60
KQAFGIMNEL RLSQQLCDVT LQVKYEDAPA AQFMAHKVVL ASSSPVFKAM FTNGLREQGM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCAGCCGG AACCTGGGCC TAGCGGGGCT GGGGCCCGCA CTCGATTCCT TCCCCTGAGG 60
TCACAGCGCC CCGAGGGGGC AGGGGACACG GTGATGTACG CCTCCACCGA GTGCAAAGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR030563--KEAP1
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0005884--C:actin filament
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005815--C:microtubule organizing center
GO:0030496--C:midbody
GO:0005654--C:nucleoplasm
GO:0008134--F:transcription factor binding
GO:0071353--P:cellular response to interleukin-4
GO:0042994--P:cytoplasmic sequestering of transcription factor
GO:0001701--P:in utero embryonic development
GO:0043433--P:negative regulation of sequence-specific DNA binding transcription factor activity
GO:0010499--P:proteasomal ubiquitin-independent protein catabolic process
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0045604--P:regulation of epidermal cell differentiation

KEGG

cfa:476713

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001377	Ailuropoda melanoleuca	99.04	0.00e+00	1298.00
IUUC-Aca-005389	Anolis carolinensis	86.34	0.00e+00	1088.00
IUUC-Ame-010749	Astyanax mexicanus	78.74	0.00e+00	970.00
IUUC-Bta-013505	Bos taurus	98.40	0.00e+00	1291.00
IUUC-Cja-018823	Callithrix jacchus	96.96	0.00e+00	1270.00
IUUC-Cpo-021830	Cavia porcellus	96.12	0.00e+00	842.00
IUUC-Csa-023728	Chlorocebus sabaeus	97.28	0.00e+00	1273.00
IUUC-Cin-025195	Ciona intestinalis	55.52	0.00e+00	682.00
IUUC-Csv-026155	Ciona savignyi	53.94	0.00e+00	631.00
IUUC-Dre-027388	Danio rerio	77.59	0.00e+00	954.00
IUUC-Dno-029066	Dasypus novemcinctus	86.08	0.00e+00	1099.00
IUUC-Dor-030674	Dipodomys ordii	94.89	0.00e+00	832.00
IUUC-Dme-032165	Drosophila melanogaster	49.55	4.00e-161	561.00
IUUC-Ete-032255	Echinops telfairi	93.41	2.00e-98	352.00
IUUC-Eca-034381	Equus caballus	94.42	0.00e+00	1217.00
IUUC-Eeu-034791	Erinaceus europaeus	92.36	0.00e+00	818.00
IUUC-Fca-036067	Felis catus	98.72	0.00e+00	1295.00
IUUC-Gmo-039691	Gadus morhua	77.21	0.00e+00	949.00
IUUC-Gga-040266	Gallus gallus	79.87	0.00e+00	1003.00
IUUC-Gac-041866	Gasterosteus aculeatus	77.46	0.00e+00	957.00
IUUC-Ggo-044719	Gorilla gorilla	97.60	0.00e+00	1276.00
IUUC-Hsa-046255	Homo sapiens	97.60	0.00e+00	1276.00
IUUC-Itr-048457	Ictidomys tridecemlineatus	97.28	0.00e+00	1272.00
IUUC-Lch-049646	Latimeria chalumnae	83.39	0.00e+00	1047.00
IUUC-Loc-052296	Lepisosteus oculatus	56.97	0.00e+00	644.00
IUUC-Laf-054579	Loxodonta africana	97.12	0.00e+00	1273.00
IUUC-Mcc-055315	Macaca mulatta	97.28	0.00e+00	1273.00
IUUC-Meu-056288	Macropus eugenii	88.78	0.00e+00	1135.00
IUUC-Mmr-061639	Microcebus murinus	97.60	0.00e+00	1284.00
IUUC-Mdo-062072	Monodelphis domestica	94.71	0.00e+00	1233.00
IUUC-Mmu-063622	Mus musculus	94.23	0.00e+00	1240.00
IUUC-Mpu-066737	Mustela putorius furo	96.47	0.00e+00	1256.00
IUUC-Mlu-068173	Myotis lucifugus	98.24	0.00e+00	1288.00
IUUC-Nle-069336	Nomascus leucogenys	57.55	0.00e+00	629.00
IUUC-Opr-070432	Ochotona princeps	97.33	0.00e+00	1230.00
IUUC-Ont-072160	Oreochromis niloticus	77.65	0.00e+00	953.00
IUUC-Oan-072691	Ornithorhynchus anatinus	81.18	0.00e+00	986.00
IUUC-Ocu-073798	Oryctolagus cuniculus	96.63	0.00e+00	1273.00
IUUC-Ola-086367	Oryzias latipes	74.87	0.00e+00	918.00
IUUC-Oga-088231	Otolemur garnettii	97.76	0.00e+00	1282.00
IUUC-Oar-089227	Ovis aries	97.12	0.00e+00	1265.00
IUUC-Ptr-091460	Pan troglodytes	97.60	0.00e+00	1276.00
IUUC-Pan-092713	Papio anubis	97.28	0.00e+00	1273.00
IUUC-Pfo-096468	Poecilia formosa	78.44	0.00e+00	959.00
IUUC-Pab-098357	Pongo abelii	97.76	0.00e+00	1280.00
IUUC-Pca-100837	Procavia capensis	95.99	0.00e+00	1253.00
IUUC-Pva-103249	Pteropus vampyrus	95.99	0.00e+00	1229.00
IUUC-Rno-106086	Rattus norvegicus	93.75	0.00e+00	1227.00
IUUC-Sha-107245	Sarcophilus harrisii	94.23	0.00e+00	1228.00
IUUC-Sar-112985	Sorex araneus	95.99	0.00e+00	1261.00
IUUC-Ssc-115756	Sus scrofa	99.04	0.00e+00	1297.00
IUUC-Tgu-116838	Taeniopygia guttata	53.66	4.00e-118	417.00
IUUC-Tru-117644	Takifugu rubripes	76.78	0.00e+00	972.00
IUUC-Tni-120245	Tetraodon nigroviridis	78.02	0.00e+00	961.00
IUUC-Tbe-127472	Tupaia belangeri	97.96	2.00e-148	519.00
IUUC-Ttr-128953	Tursiops truncatus	98.04	0.00e+00	726.00
IUUC-Vpa-130683	Vicugna pacos	95.61	0.00e+00	1120.00
IUUC-Xtr-132827	Xenopus tropicalis	76.11	0.00e+00	951.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence