iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/SCF/F-box	1.90e-06	28.0	233	282

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/SCF/F-box

   S: 97   gpdaglldrlpeeilveilklldkeellraarvcrrwqelasqkalwktv 146
           ++  + ++rl++eil+ i+k l+k++llr+a vcrr+++++++++lw ++
   Q: 233  NSGINYFERLSDEILLDIFKWLPKKTLLRMATVCRRFNRCSRDETLWTRL 282
           45567899***************************************876 PP

Organism

Drosophila melanogaster

Protein Sequence
(Fasta)

MSSRKHRGSE NMENLCPVTR KRSTNKNHVS VVGALVSTTK SSHYEHPSSP SALTFEALEE 60
MGIGMLDSEE SSSSALSAIA LAVSATSDDN SNETTPCASV SRMAHQLQHT QRLSLGSTGD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGGTTCCATG CAAAAATAGC GCGAAGTTTT TGTGTTTACG GCGGTGAAAA AATAGATTTC 60
GTGTAAATAT GAGCAGTCGC AAGCACAGAG GCTCCGAAAA CATGGAAAAT TTGTGCCCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001810--F-box_dom
IPR032675--L_dom-like
IPR006553--Leu-rich_rpt_Cys-con_subtyp

PROSITE

PS50181--FBOX

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX
SM00367--LRR_CC

Gene Ontology

GO:0019005--C:SCF ubiquitin ligase complex
GO:0048749--P:compound eye development
GO:0007113--P:endomitotic cell cycle
GO:0000278--P:mitotic cell cycle
GO:0045787--P:positive regulation of cell cycle
GO:0016567--P:protein ubiquitination
GO:0031647--P:regulation of protein stability
GO:0031146--P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0035220--P:wing disc development

KEGG

dme:Dmel_CG9772

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002197	Ailuropoda melanoleuca	32.88	3.00e-54	204.00
IUUC-Apl-003453	Anas platyrhynchos	38.01	2.00e-57	215.00
IUUC-Aca-005185	Anolis carolinensis	34.46	1.00e-57	216.00
IUUC-Ame-010665	Astyanax mexicanus	35.67	5.00e-48	184.00
IUUC-Bta-013450	Bos taurus	34.59	1.00e-58	219.00
IUUC-Cel-018410	Caenorhabditis elegans	26.61	2.00e-32	132.00
IUUC-Cja-019834	Callithrix jacchus	33.14	4.00e-55	207.00
IUUC-Cfa-020401	Canis familiaris	34.02	7.00e-58	217.00
IUUC-Cpo-022183	Cavia porcellus	33.70	1.00e-58	219.00
IUUC-Cre-022616	Chlamydomonas reinhardtii	40.54	1.00e-03	37.70
IUUC-Csa-023418	Chlorocebus sabaeus	33.43	8.00e-57	213.00
IUUC-Cho-024412	Choloepus hoffmanni	35.16	4.00e-38	151.00
IUUC-Cin-025248	Ciona intestinalis	31.71	7.00e-49	187.00
IUUC-Csv-026189	Ciona savignyi	32.42	3.00e-46	178.00
IUUC-Dre-028032	Danio rerio	33.96	3.00e-51	195.00
IUUC-Dno-029222	Dasypus novemcinctus	33.43	9.00e-57	213.00
IUUC-Dor-030505	Dipodomys ordii	33.33	5.00e-38	151.00
IUUC-Ete-032234	Echinops telfairi	34.52	4.00e-25	108.00
IUUC-Eca-033944	Equus caballus	35.17	2.00e-59	222.00
IUUC-Eeu-035008	Erinaceus europaeus	35.52	3.00e-37	147.00
IUUC-Fca-035412	Felis catus	32.33	2.00e-57	215.00
IUUC-Fal-037337	Ficedula albicollis	37.06	4.00e-58	218.00
IUUC-Gmo-038934	Gadus morhua	34.98	2.00e-22	99.00
IUUC-Gga-041152	Gallus gallus	36.06	6.00e-66	244.00
IUUC-Gac-041819	Gasterosteus aculeatus	36.11	2.00e-50	192.00
IUUC-Ggo-045479	Gorilla gorilla	34.52	2.00e-43	169.00
IUUC-Hsa-046512	Homo sapiens	33.72	5.00e-57	214.00
IUUC-Itr-048515	Ictidomys tridecemlineatus	32.60	6.00e-57	213.00
IUUC-Lch-050115	Latimeria chalumnae	34.97	7.00e-60	223.00
IUUC-Loc-052554	Lepisosteus oculatus	35.28	1.00e-49	189.00
IUUC-Laf-053563	Loxodonta africana	33.43	5.00e-58	217.00
IUUC-Mcc-055143	Macaca mulatta	33.43	5.00e-57	214.00
IUUC-Meu-056593	Macropus eugenii	28.87	9.00e-21	93.60
IUUC-Mga-060084	Meleagris gallopavo	34.47	8.00e-39	152.00
IUUC-Mmr-060660	Microcebus murinus	34.01	3.00e-58	218.00
IUUC-Mdo-062363	Monodelphis domestica	35.47	5.00e-52	197.00
IUUC-Mmu-063287	Mus musculus	34.02	3.00e-57	214.00
IUUC-Mpu-065791	Mustela putorius furo	32.88	2.00e-58	218.00
IUUC-Mlu-067714	Myotis lucifugus	33.14	2.00e-54	205.00
IUUC-Nle-069823	Nomascus leucogenys	33.43	1.00e-56	213.00
IUUC-Opr-071046	Ochotona princeps	28.33	1.00e-11	63.50
IUUC-Ont-071820	Oreochromis niloticus	33.55	1.00e-31	129.00
IUUC-Ocu-074868	Oryctolagus cuniculus	32.05	4.00e-56	211.00
IUUC-Ola-086608	Oryzias latipes	35.43	1.00e-41	162.00
IUUC-Oga-089044	Otolemur garnettii	34.01	5.00e-57	214.00
IUUC-Oar-089650	Ovis aries	34.59	1.00e-58	219.00
IUUC-Ptr-090743	Pan troglodytes	33.72	5.00e-57	214.00
IUUC-Pan-092501	Papio anubis	33.43	6.00e-57	213.00
IUUC-Psi-094032	Pelodiscus sinensis	35.88	2.00e-63	235.00
IUUC-Pfo-097279	Poecilia formosa	36.92	9.00e-36	143.00
IUUC-Pab-097821	Pongo abelii	34.16	6.00e-43	167.00
IUUC-Pca-100100	Procavia capensis	33.45	5.00e-43	167.00
IUUC-Pva-103181	Pteropus vampyrus	33.81	6.00e-39	154.00
IUUC-Rno-105091	Rattus norvegicus	33.42	4.00e-58	218.00
IUUC-Sha-107226	Sarcophilus harrisii	34.07	1.00e-52	199.00
IUUC-Ssc-115665	Sus scrofa	32.88	9.00e-58	216.00
IUUC-Tgu-116982	Taeniopygia guttata	37.94	1.00e-58	219.00
IUUC-Tru-118276	Takifugu rubripes	31.82	3.00e-35	142.00
IUUC-Tsy-119074	Tarsius syrichta	34.53	3.00e-43	168.00
IUUC-Tni-120702	Tetraodon nigroviridis	33.33	4.00e-25	107.00
IUUC-Tbe-127990	Tupaia belangeri	31.20	6.00e-32	130.00
IUUC-Ttr-128661	Tursiops truncatus	32.06	9.00e-32	130.00
IUUC-Xtr-132166	Xenopus tropicalis	35.38	1.00e-54	206.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence