iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-005358

UUCD1 version

UUC-AnC-00397

Ensembl Protein ID

ENSACAP00000000604.3

UniProt Accession

H9G425; H9G425_ANOCA

Protein Name

Uncharacterized protein

Gene Name

SMURF2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000000474.3	ENSACAT00000000624.3	ENSACAP00000000604.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.10e-131	439.1	421	753

Active Site

Position(s)	Description	Evidence
722	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dl krl+++f+gEegld+gGv+re+l+lls+e+ np++glf+ys +d +tlq+npds + npehl++F+f+Gr++g+a+++g+++d 
   Q: 421  PKDLWKRLMIKFRGEEGLDYGGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAV-NPEHLSYFHFVGRIMGMAVFHGHYIDG 508
           678999*****************************************************98.89************************* PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvve 179
            ++ +fyk+llgk+++l+d+e vdp+l++sl +i+en   di+   ld tf+v+++ +ge+ ++eLkp+G++ipVt++Nk+eYv+l+v+
   Q: 509  GFTLPFYKQLLGKPITLDDMELVDPDLHNSLVWILEN---DITGV-LDHTFCVEHNAYGEIIQHELKPNGKSIPVTEDNKKEYVRLYVN 593
           ***********************************99...9***8.******************************************* PP
   S: 180  yrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFv 268
           +r+ +gi+ q+ a+++Gfnevip++ll+ F+e+elel+icG  +idv+d+k++t+ k+ +t+ds+ ++wFw+++e f++e r+++LqFv
   Q: 594  WRFLRGIEAQFLALQKGFNEVIPQHLLKTFDEKELELIICGLGKIDVNDWKANTRLKH-CTPDSNIVKWFWKAVELFDEERRARLLQFV 681
           ********************************************************99.****************************** PP
   S: 269  TgssrlPlgGfaelk....prlfvirk.dasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           Tgssr+Pl+Gf++l+    prlf+i++ das+++lP+++TCfn++++P+Y+s+e+l+ekLl+Aieet gF +
   Q: 682  TGSSRVPLQGFKALQgaagPRLFTIHQiDASTNNLPKAHTCFNRIDIPPYESYEKLYEKLLTAIEETCGFAV 753
           **********************************************************************76 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MSNPGARRNG PVKLRLTVLC AKNLVKKDFF RLPDPFAKVV VDGSGQCHST DTVKNTLDPK 60
WNQHYDLYIG KSDSITISVW NHKKIHKKQG AGFLGCVRLL SNAINRLKDT GYQRLDLCKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGCACTTA GAGGGTTGAA AAAATCAGGG TCTTCGTGGA GAAGGCCCCT TTCACACAGT 60
TCAGGACCCC ATGGCAGTTC AGGCAGGGCC AAAGTGAGTC AGTTCTCCAG TGCAGACAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0016607--C:nuclear speck
GO:0000151--C:ubiquitin ligase complex
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030512--P:negative regulation of transforming growth factor beta receptor signaling pathway
GO:1901165--P:positive regulation of trophoblast cell migration
GO:0030579--P:ubiquitin-dependent SMAD protein catabolic process

KEGG

acs:100552537

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001305	Ailuropoda melanoleuca	96.90	0.00e+00	1472.00
IUUC-Apl-003513	Anas platyrhynchos	97.83	0.00e+00	1493.00
IUUC-Ame-011320	Astyanax mexicanus	88.51	0.00e+00	1405.00
IUUC-Bta-013399	Bos taurus	97.15	0.00e+00	1467.00
IUUC-Cja-019355	Callithrix jacchus	96.90	0.00e+00	1472.00
IUUC-Cpo-022200	Cavia porcellus	97.29	0.00e+00	1474.00
IUUC-Cho-024804	Choloepus hoffmanni	98.06	0.00e+00	637.00
IUUC-Cin-025126	Ciona intestinalis	65.41	0.00e+00	976.00
IUUC-Csv-026339	Ciona savignyi	64.53	0.00e+00	1007.00
IUUC-Dre-027650	Danio rerio	91.24	0.00e+00	1448.00
IUUC-Dno-029534	Dasypus novemcinctus	97.21	0.00e+00	1503.00
IUUC-Dme-031740	Drosophila melanogaster	72.16	2.00e-173	603.00
IUUC-Ete-032715	Echinops telfairi	91.85	0.00e+00	1382.00
IUUC-Eca-033580	Equus caballus	97.29	0.00e+00	1474.00
IUUC-Eeu-034945	Erinaceus europaeus	95.16	0.00e+00	1365.00
IUUC-Fal-037275	Ficedula albicollis	97.98	0.00e+00	1486.00
IUUC-Gga-041060	Gallus gallus	95.23	0.00e+00	1449.00
IUUC-Gac-041983	Gasterosteus aculeatus	91.10	0.00e+00	1414.00
IUUC-Hsa-046726	Homo sapiens	97.21	0.00e+00	1502.00
IUUC-Lch-050026	Latimeria chalumnae	96.68	0.00e+00	1478.00
IUUC-Loc-051760	Lepisosteus oculatus	88.13	0.00e+00	1390.00
IUUC-Laf-053753	Loxodonta africana	97.43	0.00e+00	1472.00
IUUC-Mcc-054815	Macaca mulatta	96.95	0.00e+00	1498.00
IUUC-Meu-056436	Macropus eugenii	76.13	0.00e+00	1098.00
IUUC-Mpo-057442	Magnaporthe poae	38.14	1.00e-145	510.00
IUUC-Mmr-060806	Microcebus murinus	97.02	0.00e+00	1472.00
IUUC-Mdo-062805	Monodelphis domestica	96.42	0.00e+00	1486.00
IUUC-Mmu-064034	Mus musculus	96.95	0.00e+00	1498.00
IUUC-Mpu-066762	Mustela putorius furo	96.90	0.00e+00	1473.00
IUUC-Mlu-066981	Myotis lucifugus	97.15	0.00e+00	1469.00
IUUC-Nle-069804	Nomascus leucogenys	97.20	0.00e+00	1495.00
IUUC-Opr-070591	Ochotona princeps	91.03	0.00e+00	1370.00
IUUC-Ont-072243	Oreochromis niloticus	90.08	0.00e+00	1431.00
IUUC-Oan-072699	Ornithorhynchus anatinus	94.56	0.00e+00	1496.00
IUUC-Ocu-074913	Oryctolagus cuniculus	97.21	0.00e+00	1503.00
IUUC-Ola-086597	Oryzias latipes	85.18	0.00e+00	1294.00
IUUC-Oga-089116	Otolemur garnettii	93.77	0.00e+00	1411.00
IUUC-Oar-089366	Ovis aries	96.89	0.00e+00	1468.00
IUUC-Ptr-091382	Pan troglodytes	97.21	0.00e+00	1502.00
IUUC-Psi-093298	Pelodiscus sinensis	97.02	0.00e+00	1464.00
IUUC-Pma-094354	Petromyzon marinus	73.13	0.00e+00	1129.00
IUUC-Pfo-096071	Poecilia formosa	90.53	0.00e+00	1437.00
IUUC-Pab-098682	Pongo abelii	97.21	0.00e+00	1500.00
IUUC-Pca-100516	Procavia capensis	89.24	0.00e+00	631.00
IUUC-Pva-102754	Pteropus vampyrus	95.38	0.00e+00	1435.00
IUUC-Rno-105600	Rattus norvegicus	97.35	0.00e+00	1274.00
IUUC-Sha-107144	Sarcophilus harrisii	96.51	0.00e+00	1350.00
IUUC-Spo-108171	Schizosaccharomyces pombe	39.95	5.00e-163	567.00
IUUC-Sar-113122	Sorex araneus	86.01	0.00e+00	1255.00
IUUC-Tgu-117112	Taeniopygia guttata	98.14	0.00e+00	1513.00
IUUC-Tru-118497	Takifugu rubripes	90.53	0.00e+00	1383.00
IUUC-Tni-120781	Tetraodon nigroviridis	90.85	0.00e+00	1192.00
IUUC-Tme-126897	Tuber melanosporum	39.13	9.00e-154	536.00
IUUC-Tbe-127371	Tupaia belangeri	86.64	0.00e+00	1198.00
IUUC-Ttr-129305	Tursiops truncatus	89.47	0.00e+00	1265.00
IUUC-Vpa-130591	Vicugna pacos	87.23	0.00e+00	1276.00
IUUC-Xtr-132979	Xenopus tropicalis	78.07	0.00e+00	1113.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence