iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Tgu-117515

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABQF01008702

Gene Name

HECW1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000001817.1	ENSTGUT00000001896.1	ENSTGUP00000001878.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.60e-122	409.0	1272	1604

Active Site

Position(s)	Description	Evidence
1572	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++lls+el+np++glf+ys+nd++t+q++p s +  ++hl++F+f Gr+lg+al ++ lld
   Q: 1272 ELQRNKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSAFV-ENHLEWFRFSGRILGLALIHQYLLD 1357
           567899****************************************************985.6************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+ +++l+dle +d+e+++sl+++k+n   +i+++ ldltf+v+ee++g+++e+eLk+gG+n+ Vt++Nk+eY+++
   Q: 1358 AFFTRPFYKALLRLPCDLSDLEYLDEEFHQSLQWMKDN---NITDI-LDLTFTVNEEVFGQVTERELKSGGANTAVTEKNKKEYIER 1440
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+ea+ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++ + +i+wFw ++e+f++e+r +
   Q: 1441 MVKWRVERGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGTAEIDLNDWRNNTEYRGGYHDGHIVIRWFWAAVERFNNEQRLR 1527
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+     r+f+i+k+++ ++lP+++TCfn+L+LP+Y+s++ l+ekLl+A+eet+ F+l+
   Q: 1528 LLQFVTGTSSVPYEGFAALRgsngLRRFCIEKWGKITSLPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGLE 1604
           ************************999***********************************************985 PP

Organism

Taeniopygia guttata

Protein Sequence
(Fasta)

CKYYPFFFSS QNLYQNRFLG LAAMASPSRN SQNRRRCKEP LRYSYNPDQF HNMDIRNNSH 60
ETVTIPRSTS DTDLVTSDSR STLMVSSSYY SIGHSQDLVI YWDIKEEVDA GDWIGMYLID 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TGTAAATACT ATCCTTTCTT TTTTTCTTCA CAGAATCTGT ACCAAAACAG GTTCCTGGGC 60
CTGGCAGCCA TGGCATCTCC ATCTAGGAAC TCACAAAATC GGCGCCGGTG CAAAGAGCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005829--C:cytosol
GO:0004842--F:ubiquitin-protein transferase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001636	Ailuropoda melanoleuca	81.62	0.00e+00	1687.00
IUUC-Apl-003299	Anas platyrhynchos	95.17	0.00e+00	2904.00
IUUC-Aca-005024	Anolis carolinensis	87.85	0.00e+00	2668.00
IUUC-Bta-012604	Bos taurus	78.85	0.00e+00	2384.00
IUUC-Cja-019880	Callithrix jacchus	75.93	0.00e+00	2007.00
IUUC-Cfa-021216	Canis familiaris	82.62	0.00e+00	1714.00
IUUC-Cpo-021466	Cavia porcellus	92.31	0.00e+00	1647.00
IUUC-Csa-023080	Chlorocebus sabaeus	81.60	0.00e+00	2415.00
IUUC-Cho-024740	Choloepus hoffmanni	90.87	0.00e+00	1124.00
IUUC-Dre-028750	Danio rerio	73.65	0.00e+00	1571.00
IUUC-Dno-030019	Dasypus novemcinctus	80.71	0.00e+00	2405.00
IUUC-Dor-031030	Dipodomys ordii	71.84	0.00e+00	1112.00
IUUC-Ete-032352	Echinops telfairi	92.53	0.00e+00	1243.00
IUUC-Eca-033948	Equus caballus	82.55	0.00e+00	1712.00
IUUC-Eeu-034474	Erinaceus europaeus	68.35	0.00e+00	818.00
IUUC-Fca-036148	Felis catus	85.09	0.00e+00	1724.00
IUUC-Fal-036957	Ficedula albicollis	97.58	0.00e+00	2962.00
IUUC-Gmo-038714	Gadus morhua	68.63	0.00e+00	1021.00
IUUC-Gga-041194	Gallus gallus	94.96	0.00e+00	2935.00
IUUC-Gac-041366	Gasterosteus aculeatus	76.88	0.00e+00	1367.00
IUUC-Ggo-045442	Gorilla gorilla	69.20	0.00e+00	1796.00
IUUC-Hsa-045730	Homo sapiens	81.73	0.00e+00	2416.00
IUUC-Itr-048439	Ictidomys tridecemlineatus	81.28	0.00e+00	2434.00
IUUC-Lch-050185	Latimeria chalumnae	73.69	0.00e+00	2059.00
IUUC-Loc-052744	Lepisosteus oculatus	82.34	0.00e+00	1631.00
IUUC-Mcc-055487	Macaca mulatta	81.86	0.00e+00	2424.00
IUUC-Meu-056751	Macropus eugenii	91.34	0.00e+00	728.00
IUUC-Mga-059545	Meleagris gallopavo	95.12	0.00e+00	2908.00
IUUC-Mmr-061078	Microcebus murinus	81.50	0.00e+00	1686.00
IUUC-Mdo-062176	Monodelphis domestica	83.86	0.00e+00	1706.00
IUUC-Mmu-063513	Mus musculus	79.67	0.00e+00	2330.00
IUUC-Mpu-065786	Mustela putorius furo	85.36	0.00e+00	1753.00
IUUC-Mlu-067780	Myotis lucifugus	76.96	0.00e+00	1539.00
IUUC-Nle-069213	Nomascus leucogenys	81.82	0.00e+00	2387.00
IUUC-Opr-070208	Ochotona princeps	93.82	0.00e+00	1449.00
IUUC-Ont-072132	Oreochromis niloticus	76.70	0.00e+00	1363.00
IUUC-Oan-072807	Ornithorhynchus anatinus	88.28	0.00e+00	1789.00
IUUC-Ocu-074745	Oryctolagus cuniculus	85.23	0.00e+00	1731.00
IUUC-Ola-086981	Oryzias latipes	73.00	0.00e+00	1490.00
IUUC-Oga-087965	Otolemur garnettii	82.85	0.00e+00	1713.00
IUUC-Oar-089749	Ovis aries	81.98	0.00e+00	1724.00
IUUC-Ptr-091243	Pan troglodytes	81.75	0.00e+00	2414.00
IUUC-Pan-092201	Papio anubis	81.20	0.00e+00	2407.00
IUUC-Psi-093511	Pelodiscus sinensis	89.64	0.00e+00	2664.00
IUUC-Pfo-097001	Poecilia formosa	65.94	0.00e+00	1597.00
IUUC-Pab-098728	Pongo abelii	79.62	0.00e+00	2305.00
IUUC-Pca-100129	Procavia capensis	77.90	0.00e+00	1204.00
IUUC-Pva-102250	Pteropus vampyrus	70.23	0.00e+00	1939.00
IUUC-Rno-105031	Rattus norvegicus	78.92	0.00e+00	2333.00
IUUC-Tru-117914	Takifugu rubripes	75.73	0.00e+00	1382.00
IUUC-Tsy-119379	Tarsius syrichta	78.03	0.00e+00	782.00
IUUC-Tni-120178	Tetraodon nigroviridis	76.00	0.00e+00	1403.00
IUUC-Tbe-127762	Tupaia belangeri	81.23	0.00e+00	1617.00
IUUC-Ttr-128806	Tursiops truncatus	87.70	0.00e+00	1631.00
IUUC-Xtr-132903	Xenopus tropicalis	78.82	0.00e+00	1976.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence