iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-049062

Ensembl Protein ID

ENSSTOP00000012796.2

UniProt Accession

I3MMM4; I3MMM4_ICTTR

Genbank Protein ID

ENSSTOP00000012796

Protein Name

Inhibitor of growth protein

Genbank Nucleotide ID

AGTP01057184

Gene Name

ING2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000014291.2	ENSSTOT00000014288.2	ENSSTOP00000012796.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	1.30e-09	38.1	213	259

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCr 52
           ++C +C + + +e  ++ C++  C  ewfH+ C++l+    +p+ + w+CpkCr
   Q: 213  TYC-LCNQVSYGE--MIGCDNeqCPiEWFHFSCVSLT---YKPKGK-WYCPKCR 259
           69*.*******99..*****999*99***********...888886.******8 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MLGQQQQQLY SSAALLTGER SRLLTCYVQD YLECVESLPH DMQRNVSVLR ELDNKYQETL 60
KEIDDVYEKY KKEDDSNQKK RLQQHLQRAL INSQELGDEK IQIVTQMLEL VENRARQMEL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GATGTTAGGG CAGCAGCAGC AGCAACTGTA CTCGTCGGCC GCGCTCCTGA CCGGGGAGCG 60
GAGCCGGCTC CTCACCTGCT ACGTGCAGGA CTACCTTGAG TGTGTAGAGT CACTGCCCCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028639--ING2
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM01408--ING
SM00249--PHD

Gene Ontology

GO:0016602--C:CCAAT-binding factor complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0005886--C:plasma membrane
GO:0016580--C:Sin3 complex
GO:0003682--F:chromatin binding
GO:0003677--F:DNA binding
GO:0035091--F:phosphatidylinositol binding
GO:0008270--F:zinc ion binding
GO:0016569--P:covalent chromatin modification
GO:0030317--P:flagellated sperm motility
GO:0048133--P:male germ-line stem cell asymmetric division
GO:0007141--P:male meiosis I
GO:2001234--P:negative regulation of apoptotic signaling pathway
GO:0008285--P:negative regulation of cell proliferation
GO:0031065--P:positive regulation of histone deacetylation
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0030511--P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:2000772--P:regulation of cellular senescence
GO:0072520--P:seminiferous tubule development
GO:0007286--P:spermatid development

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002213	Ailuropoda melanoleuca	98.21	1.00e-121	428.00
IUUC-Apl-003705	Anas platyrhynchos	88.34	3.00e-91	327.00
IUUC-Aca-004990	Anolis carolinensis	80.31	1.00e-96	346.00
IUUC-Ame-011426	Astyanax mexicanus	70.07	4.00e-83	300.00
IUUC-Bta-012721	Bos taurus	97.88	4.00e-121	426.00
IUUC-Cja-018960	Callithrix jacchus	97.73	4.00e-106	377.00
IUUC-Cfa-020869	Canis familiaris	97.86	5.00e-121	426.00
IUUC-Cpo-021414	Cavia porcellus	97.50	6.00e-121	426.00
IUUC-Csa-023304	Chlorocebus sabaeus	97.86	2.00e-112	397.00
IUUC-Dre-028562	Danio rerio	68.27	1.00e-87	315.00
IUUC-Dno-029945	Dasypus novemcinctus	97.73	2.00e-115	407.00
IUUC-Dor-030141	Dipodomys ordii	97.14	5.00e-119	419.00
IUUC-Ete-032709	Echinops telfairi	95.05	3.00e-127	447.00
IUUC-Eca-033432	Equus caballus	98.53	5.00e-120	423.00
IUUC-Eeu-035285	Erinaceus europaeus	98.54	3.00e-91	327.00
IUUC-Fca-036467	Felis catus	98.48	2.00e-115	408.00
IUUC-Fal-036700	Ficedula albicollis	87.11	1.00e-90	325.00
IUUC-Gmo-038748	Gadus morhua	62.68	3.00e-85	307.00
IUUC-Gga-040175	Gallus gallus	87.89	4.00e-91	327.00
IUUC-Gac-041403	Gasterosteus aculeatus	64.23	1.00e-89	322.00
IUUC-Hsa-045837	Homo sapiens	97.86	2.00e-112	397.00
IUUC-Lch-049965	Latimeria chalumnae	80.53	5.00e-100	356.00
IUUC-Laf-053353	Loxodonta africana	96.00	5.00e-100	356.00
IUUC-Mcc-055155	Macaca mulatta	97.70	2.00e-72	264.00
IUUC-Meu-056470	Macropus eugenii	92.52	3.00e-110	390.00
IUUC-Mga-059570	Meleagris gallopavo	87.89	2.00e-90	324.00
IUUC-Mmr-061385	Microcebus murinus	98.21	6.00e-113	399.00
IUUC-Mdo-062144	Monodelphis domestica	92.58	9.00e-112	395.00
IUUC-Mmu-063215	Mus musculus	97.15	4.00e-120	423.00
IUUC-Mpu-065749	Mustela putorius furo	97.49	3.00e-99	353.00
IUUC-Nle-069968	Nomascus leucogenys	97.37	4.00e-81	293.00
IUUC-Ont-071524	Oreochromis niloticus	65.93	1.00e-86	312.00
IUUC-Ocu-074870	Oryctolagus cuniculus	98.23	2.00e-121	428.00
IUUC-Oga-088336	Otolemur garnettii	96.82	8.00e-111	392.00
IUUC-Oar-090136	Ovis aries	98.52	2.00e-119	421.00
IUUC-Ptr-091348	Pan troglodytes	97.89	7.00e-82	296.00
IUUC-Pan-092819	Papio anubis	97.86	2.00e-112	397.00
IUUC-Pfo-096633	Poecilia formosa	63.79	1.00e-80	292.00
IUUC-Pab-098346	Pongo abelii	98.21	6.00e-113	399.00
IUUC-Pca-100278	Procavia capensis	95.67	5.00e-117	413.00
IUUC-Pva-103190	Pteropus vampyrus	98.86	3.00e-116	410.00
IUUC-Rno-104940	Rattus norvegicus	97.35	1.00e-114	405.00
IUUC-Sha-107533	Sarcophilus harrisii	90.81	1.00e-112	399.00
IUUC-Sar-113630	Sorex araneus	96.10	8.00e-90	322.00
IUUC-Ssc-115734	Sus scrofa	98.86	4.00e-116	410.00
IUUC-Tgu-117034	Taeniopygia guttata	87.56	4.00e-91	326.00
IUUC-Tru-118168	Takifugu rubripes	60.34	3.00e-81	294.00
IUUC-Tsy-119494	Tarsius syrichta	98.42	2.00e-82	297.00
IUUC-Tni-120100	Tetraodon nigroviridis	61.25	8.00e-78	283.00
IUUC-Ttr-128442	Tursiops truncatus	99.02	1.00e-91	328.00
IUUC-Vpa-130063	Vicugna pacos	97.86	5.00e-121	426.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence