iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Itr-047978

Ensembl Protein ID

ENSSTOP00000008871.2

UniProt Accession

I3MEF6; I3MEF6_ICTTR

Genbank Protein ID

ENSSTOP00000008871

Protein Name

Inhibitor of growth protein

Genbank Nucleotide ID

AGTP01097477

Gene Name

ING4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSTOG00000009890.2	ENSSTOT00000009892.2	ENSSTOP00000008871.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	7.00e-10	38.9	197	244

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 2    kvClvCgeggedekslveCek..Cr.ewfHpaClklsveeelpnsekwiCpkCrs 53
           ++C +C++ + +e  ++ C++  C+ ewfH+aC++l+   ++p+ + w+Cp+C++
   Q: 197  TYC-LCHQVSYGE--MIGCDNpdCSiEWFHFACVGLT---TKPRGK-WFCPRCSQ 244
           69*.*******99..********999***********...899996.******97 PP

Organism

Ictidomys tridecemlineatus

Protein Sequence
(Fasta)

MAAGMYLEHY LDSIENLPFE LQRNFQLMRD LDQRTEDLKA EIDKLATEYM SSARNLSSEE 60
KLALLRQIQE AYGKCKEFGD DKVQLAMQTY EMVDKHIRRL DTDLARFEAD LKEKQIESSD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTTTGTTTT GCTTCAAGAT GGCTGCGGGG ATGTATTTGG AACATTATCT GGACAGTAAG 60
AGCAGTCTGG AGGAGGGGGT CAGGGGTCAT AGAGTGGTGG GGGGATCAGG GCTGAGAGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR028647--ING4
IPR028651--ING_fam
IPR024610--ING_N_histone_binding
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF12998--ING

SMART

SM01408--ING
SM00249--PHD

Gene Ontology

GO:0000123--C:histone acetyltransferase complex
GO:0003713--F:transcription coactivator activity
GO:0008270--F:zinc ion binding
GO:0006915--P:apoptotic process
GO:0007050--P:cell cycle arrest
GO:0006978--P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0006260--P:DNA replication
GO:0043966--P:histone H3 acetylation
GO:0043983--P:histone H4-K12 acetylation
GO:0043981--P:histone H4-K5 acetylation
GO:0043982--P:histone H4-K8 acetylation
GO:0008285--P:negative regulation of cell proliferation
GO:0045926--P:negative regulation of growth
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0043065--P:positive regulation of apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001338	Ailuropoda melanoleuca	98.39	5.00e-127	446.00
IUUC-Atr-002906	Amborella trichopoda	31.08	7.00e-29	120.00
IUUC-Apl-004097	Anas platyrhynchos	92.74	4.00e-118	416.00
IUUC-Aca-004593	Anolis carolinensis	95.98	7.00e-124	436.00
IUUC-Ame-011133	Astyanax mexicanus	80.48	1.00e-116	411.00
IUUC-Bta-012699	Bos taurus	97.99	4.00e-127	446.00
IUUC-Bdi-014504	Brachypodium distachyon	35.46	7.00e-39	153.00
IUUC-Bol-015245	Brassica oleracea	31.33	5.00e-30	124.00
IUUC-Bra-017027	Brassica rapa	31.73	1.00e-30	125.00
IUUC-Cja-019988	Callithrix jacchus	98.80	2.00e-120	424.00
IUUC-Cfa-021282	Canis familiaris	98.80	2.00e-120	424.00
IUUC-Cpo-022011	Cavia porcellus	99.60	8.00e-131	458.00
IUUC-Cre-022920	Chlamydomonas reinhardtii	31.23	8.00e-29	120.00
IUUC-Csa-023203	Chlorocebus sabaeus	98.80	2.00e-120	424.00
IUUC-Cin-025479	Ciona intestinalis	60.92	6.00e-79	286.00
IUUC-Csv-026288	Ciona savignyi	55.06	2.00e-74	271.00
IUUC-Dre-028264	Danio rerio	80.08	5.00e-115	406.00
IUUC-Dno-029766	Dasypus novemcinctus	95.97	7.00e-114	402.00
IUUC-Dor-031136	Dipodomys ordii	84.75	3.00e-99	353.00
IUUC-Dme-032200	Drosophila melanogaster	74.19	1.00e-40	159.00
IUUC-Eca-033565	Equus caballus	99.60	5.00e-131	459.00
IUUC-Eeu-034948	Erinaceus europaeus	78.54	5.00e-99	353.00
IUUC-Fca-036368	Felis catus	99.20	6.00e-121	426.00
IUUC-Fal-037120	Ficedula albicollis	92.34	8.00e-117	412.00
IUUC-Gmo-038982	Gadus morhua	81.60	5.00e-116	409.00
IUUC-Gga-040771	Gallus gallus	95.98	7.00e-124	436.00
IUUC-Gac-042184	Gasterosteus aculeatus	80.89	4.00e-112	396.00
IUUC-Gma-044339	Glycine max	29.37	9.00e-34	136.00
IUUC-Ggo-045559	Gorilla gorilla	98.80	2.00e-120	424.00
IUUC-Hsa-046852	Homo sapiens	98.80	2.00e-120	424.00
IUUC-Hvu-047046	Hordeum vulgare	35.71	5.00e-38	150.00
IUUC-Kpa-049229	Komagataella pastoris	59.18	1.00e-16	79.30
IUUC-Lpe-050822	Leersia perrieri	34.66	6.00e-38	150.00
IUUC-Loc-052725	Lepisosteus oculatus	66.27	3.00e-81	294.00
IUUC-Laf-054057	Loxodonta africana	99.20	6.00e-121	426.00
IUUC-Mcc-055212	Macaca mulatta	92.43	1.00e-114	405.00
IUUC-Meu-056511	Macropus eugenii	97.88	7.00e-121	425.00
IUUC-Mtr-058288	Medicago truncatula	31.48	2.00e-32	132.00
IUUC-Mga-059967	Meleagris gallopavo	93.52	1.00e-117	415.00
IUUC-Mmr-060843	Microcebus murinus	97.19	7.00e-127	445.00
IUUC-Mdo-062357	Monodelphis domestica	97.99	2.00e-129	454.00
IUUC-Mmu-064093	Mus musculus	99.60	8.00e-131	458.00
IUUC-Mac-064625	Musa acuminata	34.36	9.00e-37	146.00
IUUC-Mpu-066923	Mustela putorius furo	87.55	6.00e-98	349.00
IUUC-Mlu-067754	Myotis lucifugus	91.67	5.00e-119	419.00
IUUC-Nle-069062	Nomascus leucogenys	98.80	2.00e-120	424.00
IUUC-Opr-070207	Ochotona princeps	91.95	3.00e-111	394.00
IUUC-Ont-072446	Oreochromis niloticus	82.00	1.00e-114	405.00
IUUC-Oan-073652	Ornithorhynchus anatinus	65.40	7.00e-82	296.00
IUUC-Ocu-074235	Oryctolagus cuniculus	98.80	2.00e-120	424.00
IUUC-Obr-076266	Oryza brachyantha	35.06	7.00e-37	146.00
IUUC-Ogl-077118	Oryza glaberrima	33.20	2.00e-36	145.00
IUUC-Oin-079049	Oryza indica	33.72	4.00e-35	140.00
IUUC-Ome-081291	Oryza meridionalis	33.59	8.00e-37	146.00
IUUC-Oni-082218	Oryza nivara	33.72	4.00e-35	140.00
IUUC-Opu-084171	Oryza punctata	34.13	6.00e-36	144.00
IUUC-Osa-085563	Oryza sativa	33.59	8.00e-37	146.00
IUUC-Ola-086429	Oryzias latipes	77.20	7.00e-106	375.00
IUUC-Olu-087851	Ostreococcus lucimarinus	33.95	4.00e-20	90.90
IUUC-Oga-089123	Otolemur garnettii	99.20	6.00e-121	426.00
IUUC-Oar-089524	Ovis aries	97.99	4.00e-127	446.00
IUUC-Ptr-090908	Pan troglodytes	98.39	6.00e-120	422.00
IUUC-Pan-092837	Papio anubis	97.99	1.00e-126	444.00
IUUC-Psi-093828	Pelodiscus sinensis	95.71	2.00e-113	400.00
IUUC-Ppa-096009	Physcomitrella patens	33.59	1.00e-34	139.00
IUUC-Pfo-096617	Poecilia formosa	81.60	1.00e-114	405.00
IUUC-Pab-097978	Pongo abelii	98.31	6.00e-110	389.00
IUUC-Pop-099415	Populus trichocarpa	73.68	1.00e-26	112.00
IUUC-Pca-100475	Procavia capensis	66.67	3.00e-85	307.00
IUUC-Ppe-101441	Prunus persica	33.59	5.00e-37	147.00
IUUC-Pva-102325	Pteropus vampyrus	99.60	5.00e-131	459.00
IUUC-Rno-105178	Rattus norvegicus	97.99	7.00e-137	479.00
IUUC-Sha-106773	Sarcophilus harrisii	97.99	1.00e-129	455.00
IUUC-Smo-109441	Selaginella moellendorffii	30.86	5.00e-35	140.00
IUUC-Sit-109827	Setaria italica	34.26	2.00e-36	145.00
IUUC-Sly-111750	Solanum lycopersicum	34.13	2.00e-35	141.00
IUUC-Stu-112250	Solanum tuberosum	34.13	2.00e-35	141.00
IUUC-Sbi-114826	Sorghum bicolor	35.86	3.00e-37	147.00
IUUC-Sre-115124	Sporisorium reilianum	58.21	2.00e-22	100.00
IUUC-Ssc-115797	Sus scrofa	92.28	4.00e-105	373.00
IUUC-Tgu-117270	Taeniopygia guttata	95.98	7.00e-124	436.00
IUUC-Tru-118253	Takifugu rubripes	80.88	4.00e-115	406.00
IUUC-Tni-120024	Tetraodon nigroviridis	58.23	2.00e-70	258.00
IUUC-Tca-121597	Theobroma cacao	69.84	3.00e-28	118.00
IUUC-Tae-123043	Triticum aestivum	35.14	2.00e-37	148.00
IUUC-Tbe-127558	Tupaia belangeri	98.39	5.00e-127	446.00
IUUC-Ttr-128300	Tursiops truncatus	100.00	1.00e-65	242.00
IUUC-Uma-129581	Ustilago maydis	57.63	3.00e-21	97.10
IUUC-Vvi-131487	Vitis vinifera	65.08	2.00e-26	112.00
IUUC-Xtr-132189	Xenopus tropicalis	69.08	1.00e-89	322.00
IUUC-Xma-133297	Xiphophorus maculatus	63.45	6.00e-84	303.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence