iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tgu-117489

Ensembl Protein ID

ENSTGUP00000009655.1

UniProt Accession

H0ZGE3; H0ZGE3_TAEGU

Genbank Protein ID

ENSTGUP00000009655

Protein Name

E3 ubiquitin-protein ligase parkin

Genbank Nucleotide ID

ABQF01014832

Gene Name

PARK2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTGUG00000009367.1	ENSTGUT00000009759.1	ENSTGUP00000009655.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UBQ/UBQ_PIM	1.20e-22	79.4	1	73

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UBQ/UBQ_PIM

   S: 3    ltvktlkgkefelevseddtveelKekiakesgvppeqqkLIyaGkiLkDdttLselgikdgsvvhlvvkksk 75
           ++v++++++ f++ev +d+++ +lKe++a+++gvp++q+++I+aG++L++d tL+++++ ++s+vh+v +++k
   Q: 1    VFVRFNSSHGFPVEVGSDSSILQLKEAVAQRQGVPADQLRVIFAGRELSNDLTLQNCDLAQQSIVHIVESPQK 73
           789**99999**********************************************************99987 PP

Organism

Taeniopygia guttata

Functional Description
(View)

Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins.

Protein Sequence
(Fasta)

VFVRFNSSHG FPVEVGSDSS ILQLKEAVAQ RQGVPADQLR VIFAGRELSN DLTLQNCDLA 60
QQSIVHIVES PQKNSQDKEK TEYSCVGGVP KALKREPESL TRIDLSTSIL PSVSAGLAVI 120

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Nucleotide Sequence
(Fasta)

GTGTTTGTCA GGTTCAACTC CAGCCATGGC TTCCCCGTGG AGGTTGGTTC AGATTCCAGC 60
ATCCTCCAGT TGAAAGAGGC AGTTGCCCAG CGACAGGGAG TTCCAGCTGA CCAGCTGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR003977--Parkin
IPR029071--Ubiquitin-rel_dom
IPR000626--Ubiquitin_dom

PROSITE

PS50053--UBIQUITIN_2

Pfam

PF01485--IBR
PF00240--ubiquitin

PRINTS

PR01475--PARKIN

SMART

SM00647--IBR
SM00213--UBQ

Gene Ontology

GO:0016235--C:aggresome
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005794--C:Golgi apparatus
GO:0071797--C:LUBAC complex
GO:0005739--C:mitochondrion
GO:0099073--C:mitochondrion-derived vesicle
GO:0043005--C:neuron projection
GO:0005634--C:nucleus
GO:1990452--C:Parkin-FBXW7-Cul1 ubiquitin ligase complex
GO:0048471--C:perinuclear region of cytoplasm
GO:0098793--C:presynapse
GO:0043234--C:protein complex
GO:0046872--F:metal ion binding
GO:0000976--F:transcription regulatory region sequence-specific DNA binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008344--P:adult locomotory behavior
GO:0070842--P:aggresome assembly
GO:0097237--P:cellular response to toxic substance
GO:0042417--P:dopamine metabolic process
GO:0051583--P:dopamine uptake involved in synaptic transmission
GO:0010994--P:free ubiquitin chain polymerization
GO:0007612--P:learning
GO:0000423--P:macromitophagy
GO:0099074--P:mitochondrion to lysosome transport
GO:0044828--P:negative regulation by host of viral genome replication
GO:0032232--P:negative regulation of actin filament bundle assembly
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:1903382--P:negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903542--P:negative regulation of exosomal secretion
GO:0033132--P:negative regulation of glucokinase activity
GO:0046676--P:negative regulation of insulin secretion
GO:1905366--P:negative regulation of intralumenal vesicle formation
GO:1902254--P:negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1903377--P:negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1902283--P:negative regulation of primary amine oxidase activity
GO:0001933--P:negative regulation of protein phosphorylation
GO:2000378--P:negative regulation of reactive oxygen species metabolic process
GO:0090201--P:negative regulation of release of cytochrome c from mitochondria
GO:1904049--P:negative regulation of spontaneous neurotransmitter secretion
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0042415--P:norepinephrine metabolic process
GO:0061734--P:parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
GO:1903861--P:positive regulation of dendrite extension
GO:0043388--P:positive regulation of DNA binding
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0010636--P:positive regulation of mitochondrial fusion
GO:0051582--P:positive regulation of neurotransmitter uptake
GO:1903378--P:positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032092--P:positive regulation of protein binding
GO:1902530--P:positive regulation of protein linear polyubiquitination
GO:1905477--P:positive regulation of protein localization to membrane
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:1903265--P:positive regulation of tumor necrosis factor-mediated signaling pathway
GO:0043161--P:proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0031648--P:protein destabilization
GO:0070979--P:protein K11-linked ubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0085020--P:protein K6-linked ubiquitination
GO:0070534--P:protein K63-linked ubiquitination
GO:0070585--P:protein localization to mitochondrion
GO:0006513--P:protein monoubiquitination
GO:0050821--P:protein stabilization
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0042053--P:regulation of dopamine metabolic process
GO:0051881--P:regulation of mitochondrial membrane potential
GO:0034976--P:response to endoplasmic reticulum stress
GO:0001964--P:startle response
GO:0035249--P:synaptic transmission, glutamatergic

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001814	Ailuropoda melanoleuca	71.18	2.00e-118	417.00
IUUC-Apl-003304	Anas platyrhynchos	92.07	0.00e+00	635.00
IUUC-Aca-004908	Anolis carolinensis	75.93	4.00e-49	185.00
IUUC-Ame-011856	Astyanax mexicanus	65.80	0.00e+00	632.00
IUUC-Bta-013014	Bos taurus	71.00	2.00e-169	588.00
IUUC-Cel-018687	Caenorhabditis elegans	28.12	3.00e-42	165.00
IUUC-Cja-019274	Callithrix jacchus	68.75	5.00e-115	406.00
IUUC-Cfa-020461	Canis familiaris	69.20	2.00e-116	411.00
IUUC-Cpo-022251	Cavia porcellus	70.83	2.00e-118	417.00
IUUC-Csa-023112	Chlorocebus sabaeus	68.40	2.00e-108	384.00
IUUC-Cho-024504	Choloepus hoffmanni	54.01	3.00e-133	468.00
IUUC-Cgl-026479	Colletotrichum gloeosporioides	49.02	1.00e-10	60.80
IUUC-Dre-028202	Danio rerio	65.52	5.00e-172	597.00
IUUC-Dno-028946	Dasypus novemcinctus	83.33	2.00e-39	152.00
IUUC-Dor-030508	Dipodomys ordii	61.84	5.00e-120	423.00
IUUC-Dme-031980	Drosophila melanogaster	42.49	2.00e-104	372.00
IUUC-Ete-032281	Echinops telfairi	58.19	2.00e-73	269.00
IUUC-Eca-033228	Equus caballus	71.09	3.00e-118	417.00
IUUC-Fal-037507	Ficedula albicollis	95.67	0.00e+00	912.00
IUUC-Gmo-038744	Gadus morhua	59.65	7.00e-94	337.00
IUUC-Ggr-039963	Gaeumannomyces graminis	47.06	6.00e-09	55.10
IUUC-Gga-040353	Gallus gallus	86.83	0.00e+00	809.00
IUUC-Gac-042519	Gasterosteus aculeatus	50.64	5.00e-135	473.00
IUUC-Hsa-046016	Homo sapiens	72.94	0.00e+00	691.00
IUUC-Itr-048744	Ictidomys tridecemlineatus	71.55	0.00e+00	662.00
IUUC-Loc-052389	Lepisosteus oculatus	66.09	1.00e-174	605.00
IUUC-Laf-053412	Loxodonta africana	50.53	2.00e-17	79.70
IUUC-Mcc-054933	Macaca mulatta	72.73	0.00e+00	688.00
IUUC-Meu-055963	Macropus eugenii	59.95	3.00e-133	468.00
IUUC-Mpo-057509	Magnaporthe poae	41.18	3.00e-11	62.00
IUUC-Mga-059626	Meleagris gallopavo	86.67	2.00e-35	139.00
IUUC-Mmr-061566	Microcebus murinus	79.45	4.00e-89	319.00
IUUC-Mdo-061952	Monodelphis domestica	87.93	9.00e-30	120.00
IUUC-Mmu-063561	Mus musculus	70.56	0.00e+00	689.00
IUUC-Mpu-065799	Mustela putorius furo	69.55	1.00e-115	408.00
IUUC-Mlu-068134	Myotis lucifugus	68.89	2.00e-138	484.00
IUUC-Nle-070078	Nomascus leucogenys	68.23	1.00e-118	419.00
IUUC-Opr-070541	Ochotona princeps	69.63	0.00e+00	634.00
IUUC-Ont-071743	Oreochromis niloticus	51.41	1.00e-137	482.00
IUUC-Oan-073700	Ornithorhynchus anatinus	81.48	1.00e-22	96.70
IUUC-Ola-086426	Oryzias latipes	61.49	1.00e-63	234.00
IUUC-Oga-088867	Otolemur garnettii	71.86	0.00e+00	674.00
IUUC-Oar-089365	Ovis aries	70.25	8.00e-149	519.00
IUUC-Ptr-091371	Pan troglodytes	72.94	0.00e+00	688.00
IUUC-Pan-092443	Papio anubis	69.10	3.00e-115	407.00
IUUC-Psi-093851	Pelodiscus sinensis	78.06	3.00e-109	387.00
IUUC-Pfo-097194	Poecilia formosa	51.95	1.00e-130	459.00
IUUC-Pab-097999	Pongo abelii	59.89	1.00e-110	392.00
IUUC-Pca-100410	Procavia capensis	67.76	3.00e-168	584.00
IUUC-Pva-102300	Pteropus vampyrus	65.08	5.00e-167	580.00
IUUC-Rno-105556	Rattus norvegicus	66.67	9.00e-112	395.00
IUUC-Sha-106992	Sarcophilus harrisii	85.19	1.00e-23	100.00
IUUC-Ssl-108406	Sclerotinia sclerotiorum	50.00	3.00e-09	55.80
IUUC-Sar-113121	Sorex araneus	83.62	1.00e-56	213.00
IUUC-Ssc-116435	Sus scrofa	68.49	3.00e-113	400.00
IUUC-Tru-117927	Takifugu rubripes	51.53	4.00e-142	497.00
IUUC-Tsy-119372	Tarsius syrichta	77.30	1.00e-149	522.00
IUUC-Tni-120043	Tetraodon nigroviridis	50.31	3.00e-127	447.00
IUUC-Tre-122176	Trichoderma reesei	24.65	2.00e-09	57.40
IUUC-Tvi-122588	Trichoderma virens	23.10	1.00e-10	61.20
IUUC-Tbe-127539	Tupaia belangeri	64.86	3.00e-168	583.00
IUUC-Ttr-129149	Tursiops truncatus	69.26	0.00e+00	681.00
IUUC-Vpa-130439	Vicugna pacos	53.66	3.00e-137	481.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence