iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-003394

Ensembl Protein ID

ENSAPLP00000009627.1

UniProt Accession

U3IQV4; U3IQV4_ANAPL

Genbank Protein ID

ENSAPLP00000009627

Protein Name

Tyrosine-protein kinase

Genbank Nucleotide ID

ADON01109768

Gene Name

FRK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000009906.1	ENSAPLT00000010323.1	ENSAPLP00000009627.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.30e-10	40.7	56	119

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvk........elegkrGlfPenFve 60
           k+ + +l++yea ++++L++++G++++v+  +   egW+++            ++ +G +P+n+++
   Q: 56   KKNFVALFSYEARTEEDLSFQAGEKLEVL--DASHEGWWYARLllppgsvsPGRKLQGYIPANYIA 119
           78899************************..88899*****9899999988888999*******96 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

MGNICRKYCT CLKPYIPCLF SVKEHEKEDK IGQTFPNLAV ILTDNQRNEE AKESEKKNFV 60
ALFSYEARTE EDLSFQAGEK LEVLDASHEG WWYARLLLPP GSVSPGRKLQ GYIPANYIAA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGAAACA TCTGTCGGAA GTACTGCACC TGTTTGAAGC CCTATATCCC TTGCTTATTC 60
TCAGTGAAGG AACATGAAAA GGAAGACAAA ATTGGCCAAA CTTTTCCCAA CCTTGCTGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0005654--C:nucleoplasm
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aca-004553	Anolis carolinensis	63.06	0.00e+00	693.00
IUUC-Bra-017825	Brassica rapa	29.52	1.00e-19	91.70
IUUC-Cja-019885	Callithrix jacchus	67.96	0.00e+00	727.00
IUUC-Cre-022669	Chlamydomonas reinhardtii	28.94	1.00e-19	90.50
IUUC-Dre-028274	Danio rerio	54.35	4.00e-160	557.00
IUUC-Dno-029689	Dasypus novemcinctus	68.55	0.00e+00	718.00
IUUC-Dme-031976	Drosophila melanogaster	59.96	3.00e-164	570.00
IUUC-Eeu-034770	Erinaceus europaeus	55.70	2.00e-145	508.00
IUUC-Fal-036892	Ficedula albicollis	73.09	0.00e+00	779.00
IUUC-Gga-041072	Gallus gallus	77.46	0.00e+00	818.00
IUUC-Hvu-047855	Hordeum vulgare	29.01	4.00e-22	99.40
IUUC-Loc-052913	Lepisosteus oculatus	59.10	3.00e-173	600.00
IUUC-Mga-059456	Meleagris gallopavo	79.53	0.00e+00	822.00
IUUC-Mmr-061480	Microcebus murinus	66.73	0.00e+00	696.00
IUUC-Mlu-067167	Myotis lucifugus	68.29	0.00e+00	704.00
IUUC-Nle-069786	Nomascus leucogenys	67.38	0.00e+00	723.00
IUUC-Ont-072417	Oreochromis niloticus	56.40	8.00e-171	593.00
IUUC-Obr-076765	Oryza brachyantha	26.88	8.00e-21	95.50
IUUC-Ola-086419	Oryzias latipes	61.23	2.00e-165	575.00
IUUC-Pan-092732	Papio anubis	67.57	0.00e+00	723.00
IUUC-Psi-093899	Pelodiscus sinensis	70.97	0.00e+00	741.00
IUUC-Pma-094230	Petromyzon marinus	57.68	6.00e-156	543.00
IUUC-Pfo-096035	Poecilia formosa	59.87	2.00e-164	572.00
IUUC-Rno-105269	Rattus norvegicus	67.50	0.00e+00	711.00
IUUC-Sit-109712	Setaria italica	27.41	1.00e-20	94.70
IUUC-Tgu-116491	Taeniopygia guttata	77.83	0.00e+00	743.00
IUUC-Tru-117795	Takifugu rubripes	56.62	4.00e-153	534.00
IUUC-Tni-120512	Tetraodon nigroviridis	57.14	1.00e-172	598.00
IUUC-Tae-123706	Triticum aestivum	29.70	5.00e-22	99.80
IUUC-Tur-126022	Triticum urartu	29.70	5.00e-22	99.80
IUUC-Ttr-128817	Tursiops truncatus	66.41	0.00e+00	703.00
IUUC-Vpa-130389	Vicugna pacos	62.72	0.00e+00	654.00
IUUC-Xtr-132360	Xenopus tropicalis	57.06	5.00e-178	617.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence