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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Hsa-046382
Ensembl Protein ID ENSP00000379612.2
UniProt Accession Q86VP1; A4D196; B4DKU7; E7ENV2; O60398; O95770; Q13311; Q9BQG5; Q9UI88; TAXB1_HUMAN
Genbank Protein ID AAA75595.2; AAG03025.1; CAB66521.1; AAF24016.1; CAG33337.1; BAG59309.1; BAG36949.1; CAG38587.1; AAC13359.2; AAD15412.1; EAL24213.1; EAW93901.1; EAW93904.1; AAH50358.1
Protein Name Tax1-binding protein 1; TRAF6-binding protein
Genbank Nucleotide ID U33821; AF268075; AL136586; AF090891; CR457056; AK296720; AK314292; CR533556; AC004549; AC005091; CH236948; CH471073; CH471073; BC050358
Gene Name TAX1BP1; T6BP; PRO0105
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000106052.13 ENST00000265393.10 ENSP00000265393.6
ENSG00000106052.13 ENST00000409980.5 ENSP00000386515.1
ENSG00000106052.13 ENST00000416801.6 ENSP00000391215.2
ENSG00000106052.13 ENST00000396319.6 ENSP00000379612.2
ENSG00000106052.13 ENST00000457186.2 ENSP00000412575.2
ENSG00000106052.13 ENST00000488564.2 ENSP00000477282.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetmiRTarBasemicroRNATRANSFAC
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Information
GWASdbOMIM
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
HPRDUniProtPHOSIDABioGRID
mUbiSiDa
DNA Methylation
TCGAICGC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
UBD/ZnF/UBZ UBZ 18239685
Classification
Family E-value Score Start End
UBD/ZnF/UBZ 2.30e-16 61.2 755 781
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/ZnF/UBZ
   S: 2    lvCPvCqkm....vdqtdfeeHlDeCl 24
           +vCP+C+++    +dq+ fe+H+++++
   Q: 755  KVCPMCSEQfppdYDQQVFERHVQTHF 781
           79************************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.
 Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.
Protein Sequence
(Fasta)
MTSFQEVPLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHPKDWV GIFKVGWSTA 60
RDYYTFLWSP MPEHYVEGST VNCVLAFQGY YLPNDDGEFY QFCYVTHKGE IRGASTPFQF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046382|UBD,UBZ|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ACATATCCTT TCTGGTGCTA TTGCAAGGTT TGTCAGGGTT TTACGGCAAC AGAAGACTAT 60
GATGAATTCG AATGGGACAC ATTTGCTTCT GTGGAGTTAC GATTCAAACT GAATGTCCAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046382|UBD,UBZ|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0053--Apoptosis
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR012852--CALCOCO1-like
Pfam

PF07888--CALCOCO1
Gene Ontology

GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0019900--F:kinase binding
GO:0046872--F:metal ion binding
GO:0006915--P:apoptotic process
GO:0043066--P:negative regulation of apoptotic process
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0032480--P:negative regulation of type I interferon production
GO:0010803--P:regulation of tumor necrosis factor-mediated signaling pathway
KEGG hsa:8887
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001679 Ailuropoda melanoleuca 88.74 0.00e+00 1444.00
IUUC-Apl-003483 Anas platyrhynchos 69.37 0.00e+00 974.00
IUUC-Aca-004388 Anolis carolinensis 67.69 0.00e+00 1025.00
IUUC-Ame-011597 Astyanax mexicanus 52.07 0.00e+00 753.00
IUUC-Bta-013302 Bos taurus 88.37 0.00e+00 1427.00
IUUC-Cja-019115 Callithrix jacchus 92.63 0.00e+00 1494.00
IUUC-Cfa-020964 Canis familiaris 89.85 0.00e+00 1454.00
IUUC-Cpo-021321 Cavia porcellus 85.78 0.00e+00 1369.00
IUUC-Csa-023834 Chlorocebus sabaeus 90.28 0.00e+00 1431.00
IUUC-Cho-024833 Choloepus hoffmanni 75.54 0.00e+00 1121.00
IUUC-Cin-025652 Ciona intestinalis 39.32 1.00e-33 136.00
IUUC-Csv-026309 Ciona savignyi 33.84 2.00e-39 156.00
IUUC-Cne-026777 Cryptococcus neoformans 28.85 4.40e-01 30.00
IUUC-Dre-028589 Danio rerio 50.72 0.00e+00 696.00
IUUC-Dno-030000 Dasypus novemcinctus 87.88 0.00e+00 1401.00
IUUC-Dor-030372 Dipodomys ordii 80.04 0.00e+00 863.00
IUUC-Ete-032476 Echinops telfairi 71.99 0.00e+00 815.00
IUUC-Eca-033369 Equus caballus 89.60 0.00e+00 1412.00
IUUC-Eeu-034551 Erinaceus europaeus 81.75 0.00e+00 1252.00
IUUC-Fca-036201 Felis catus 88.74 0.00e+00 1434.00
IUUC-Fal-036858 Ficedula albicollis 68.81 0.00e+00 1099.00
IUUC-Gmo-038559 Gadus morhua 49.21 0.00e+00 697.00
IUUC-Gga-040410 Gallus gallus 70.67 0.00e+00 1110.00
IUUC-Gac-041455 Gasterosteus aculeatus 49.28 0.00e+00 718.00
IUUC-Ggo-044630 Gorilla gorilla 92.27 0.00e+00 1481.00
IUUC-Itr-048080 Ictidomys tridecemlineatus 94.27 0.00e+00 978.00
IUUC-Lch-050570 Latimeria chalumnae 58.20 0.00e+00 870.00
IUUC-Loc-052138 Lepisosteus oculatus 53.38 0.00e+00 769.00
IUUC-Laf-053961 Loxodonta africana 86.71 0.00e+00 1401.00
IUUC-Mcc-055567 Macaca mulatta 95.20 0.00e+00 1538.00
IUUC-Meu-056498 Macropus eugenii 63.86 2.00e-134 473.00
IUUC-Mga-059976 Meleagris gallopavo 70.10 0.00e+00 1095.00
IUUC-Mmr-061120 Microcebus murinus 88.78 0.00e+00 1440.00
IUUC-Mdo-062786 Monodelphis domestica 75.94 0.00e+00 1191.00
IUUC-Mmu-064335 Mus musculus 84.44 0.00e+00 1368.00
IUUC-Mpu-065955 Mustela putorius furo 87.41 0.00e+00 1244.00
IUUC-Mlu-067346 Myotis lucifugus 87.15 0.00e+00 1407.00
IUUC-Nle-070020 Nomascus leucogenys 98.99 0.00e+00 1563.00
IUUC-Opr-070912 Ochotona princeps 85.39 0.00e+00 1350.00
IUUC-Ont-072077 Oreochromis niloticus 50.12 0.00e+00 701.00
IUUC-Oan-072766 Ornithorhynchus anatinus 74.61 0.00e+00 1180.00
IUUC-Ocu-073890 Oryctolagus cuniculus 86.78 0.00e+00 1384.00
IUUC-Ogl-077852 Oryza glaberrima 31.11 7.20e-02 31.20
IUUC-Ogu-079005 Oryza glumaepatula 31.11 9.20e-02 31.60
IUUC-Oni-082860 Oryza nivara 31.11 8.40e-01 30.40
IUUC-Ola-086797 Oryzias latipes 50.06 0.00e+00 716.00
IUUC-Oga-088654 Otolemur garnettii 88.37 0.00e+00 1399.00
IUUC-Oar-089818 Ovis aries 88.25 0.00e+00 1410.00
IUUC-Ptr-091003 Pan troglodytes 98.99 0.00e+00 1568.00
IUUC-Pan-092314 Papio anubis 95.08 0.00e+00 1532.00
IUUC-Psi-093572 Pelodiscus sinensis 71.74 0.00e+00 1090.00
IUUC-Pma-094507 Petromyzon marinus 64.29 7.00e-52 196.00
IUUC-Pfo-097213 Poecilia formosa 50.77 0.00e+00 723.00
IUUC-Pab-097686 Pongo abelii 91.14 0.00e+00 1447.00
IUUC-Pca-100726 Procavia capensis 60.66 0.00e+00 885.00
IUUC-Pva-102509 Pteropus vampyrus 74.81 0.00e+00 1083.00
IUUC-Rno-105535 Rattus norvegicus 84.05 0.00e+00 1333.00
IUUC-Sha-107520 Sarcophilus harrisii 76.46 0.00e+00 1177.00
IUUC-Sja-107809 Schizosaccharomyces japonicus 34.21 2.70e-01 30.40
IUUC-Ssl-108483 Sclerotinia sclerotiorum 28.16 9.00e-03 35.80
IUUC-Sar-113699 Sorex araneus 88.04 0.00e+00 1372.00
IUUC-Sre-115091 Sporisorium reilianum 31.82 8.20e-02 33.10
IUUC-Ssc-115399 Sus scrofa 81.79 3.00e-146 510.00
IUUC-Tgu-116486 Taeniopygia guttata 69.21 0.00e+00 1103.00
IUUC-Tru-118050 Takifugu rubripes 48.80 0.00e+00 668.00
IUUC-Tsy-118822 Tarsius syrichta 92.69 0.00e+00 1526.00
IUUC-Tni-120117 Tetraodon nigroviridis 47.24 0.00e+00 677.00
IUUC-Tre-122132 Trichoderma reesei 28.79 5.00e-03 37.40
IUUC-Tbe-127368 Tupaia belangeri 73.27 1.00e-148 520.00
IUUC-Ttr-128751 Tursiops truncatus 86.84 0.00e+00 910.00
IUUC-Vpa-130362 Vicugna pacos 89.67 0.00e+00 1161.00
IUUC-Xtr-132419 Xenopus tropicalis 59.66 0.00e+00 909.00
Created Date 25-Jun-2017

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