iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	miRNAMap	RAID2
Protein-protein Interaction
IID	PINA	HINT
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/Other	E3 activity/Other	20098713; 19107218

Reviewed

Classification

Family	Identity	E-value	Score	Source Orthology
E3 activity/Other	87.01	0.00e+00	807.00	IUUC-Hsa-046374

Organism

Mus musculus

Functional Description
(View)

Interacts with SUV39H1 and HIPK2. Interacts with CSNK2B (By similarity). Component of a PRC1-like complex. Interacts with histone H3-K9Me3. Interacts with CHTOP.

Protein Sequence
(Fasta)

MELPAVGEHV FAVESIEKKR IRKGRVEYLV KWRGWSPKYN TWEPEENILD PRLLIAFQNR 60
ERQEQLMGYR KRGPKPKPLV VQVPTFARRS NVLTGLQDSS ADNRAKLELG TQGKGQGHQY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCGAGCGA GCGCGAGCTG AGAGCCGGCG GGTGCAGGCA GCGGCGGCGG CGGCGGCGGC 60
CAGGCTGTTG AGGGGCGAGT GGCGGCGGCG GGGGCCGGGC GCGTGGCGAG GTCCACGCGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0156--Chromatin regulator
KW-0181--Complete proteome
KW-1017--Isopeptide bond
KW-0436--Ligase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0678--Repressor
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR033773--CBX7_C
IPR000953--Chromo/chromo_shadow_dom
IPR017984--Chromo_dom_subgr
IPR023780--Chromo_domain
IPR016197--Chromodomain-like
IPR023779--Chromodomain_CS

PROSITE

PS00598--CHROMO_1
PS50013--CHROMO_2

Pfam

PF17218--CBX7_C
PF00385--Chromo

PRINTS

PR00504--CHROMODOMAIN

SMART

SM00298--CHROMO

Gene Ontology

GO:0016604--C:nuclear body
GO:0016607--C:nuclear speck
GO:0005654--C:nucleoplasm
GO:0005634--C:nucleus
GO:0031519--C:PcG protein complex
GO:0035102--C:PRC1 complex
GO:0003682--F:chromatin binding
GO:0019899--F:enzyme binding
GO:0016874--F:ligase activity
GO:0035064--F:methylated histone binding
GO:0051219--F:phosphoprotein binding
GO:0003727--F:single-stranded RNA binding
GO:0032183--F:SUMO binding
GO:0019789--F:SUMO transferase activity
GO:0044212--F:transcription regulatory region DNA binding
GO:0016569--P:covalent chromatin modification
GO:0000122--P:negative regulation of transcription from RNA polymerase II promoter
GO:0045892--P:negative regulation of transcription, DNA-templated
GO:0016925--P:protein sumoylation
GO:0006351--P:transcription, DNA-templated

KEGG

mmu:12418

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001747	Ailuropoda melanoleuca	86.62	0.00e+00	723.00
IUUC-Atr-003112	Amborella trichopoda	52.94	5.00e-11	62.40
IUUC-Apl-003876	Anas platyrhynchos	64.49	1.00e-75	275.00
IUUC-Aca-004445	Anolis carolinensis	48.54	4.00e-111	395.00
IUUC-Aly-006366	Arabidopsis lyrata	53.33	1.00e-11	64.30
IUUC-Ath-006608	Arabidopsis thaliana	53.33	1.00e-11	64.30
IUUC-Ame-010980	Astyanax mexicanus	44.95	1.00e-102	367.00
IUUC-Bta-013216	Bos taurus	72.78	0.00e+00	631.00
IUUC-Bdi-014604	Brachypodium distachyon	39.74	2.00e-12	66.60
IUUC-Bol-015449	Brassica oleracea	55.56	3.00e-12	66.60
IUUC-Bra-017229	Brassica rapa	55.56	2.00e-12	67.00
IUUC-Cja-018821	Callithrix jacchus	85.58	0.00e+00	791.00
IUUC-Cfa-020457	Canis familiaris	87.32	0.00e+00	650.00
IUUC-Cpo-021550	Cavia porcellus	82.42	0.00e+00	796.00
IUUC-Csa-024090	Chlorocebus sabaeus	87.54	0.00e+00	816.00
IUUC-Dre-027769	Danio rerio	57.00	2.00e-69	256.00
IUUC-Dno-028987	Dasypus novemcinctus	85.20	2.00e-127	448.00
IUUC-Eca-033419	Equus caballus	82.17	4.00e-98	350.00
IUUC-Fca-035513	Felis catus	89.11	0.00e+00	761.00
IUUC-Gmo-038639	Gadus morhua	40.78	3.00e-84	306.00
IUUC-Gga-040221	Gallus gallus	60.14	2.00e-162	565.00
IUUC-Gac-042105	Gasterosteus aculeatus	41.58	3.00e-93	335.00
IUUC-Ggo-044433	Gorilla gorilla	80.98	0.00e+00	712.00
IUUC-Hsa-046374	Homo sapiens	86.65	0.00e+00	783.00
IUUC-Hvu-047395	Hordeum vulgare	42.86	4.00e-09	55.80
IUUC-Itr-048523	Ictidomys tridecemlineatus	89.75	0.00e+00	850.00
IUUC-Lch-050606	Latimeria chalumnae	50.95	2.00e-137	483.00
IUUC-Loc-052513	Lepisosteus oculatus	74.60	4.00e-71	260.00
IUUC-Laf-053583	Loxodonta africana	70.83	1.00e-100	358.00
IUUC-Mcc-055070	Macaca mulatta	86.29	0.00e+00	679.00
IUUC-Meu-055954	Macropus eugenii	78.53	8.00e-125	439.00
IUUC-Mga-059417	Meleagris gallopavo	54.36	2.00e-110	392.00
IUUC-Mmr-060774	Microcebus murinus	87.61	0.00e+00	805.00
IUUC-Mdo-062825	Monodelphis domestica	75.95	0.00e+00	707.00
IUUC-Mpu-066193	Mustela putorius furo	88.78	0.00e+00	735.00
IUUC-Mlu-067939	Myotis lucifugus	85.82	0.00e+00	729.00
IUUC-Nle-069889	Nomascus leucogenys	95.71	3.00e-35	141.00
IUUC-Ont-071531	Oreochromis niloticus	42.65	5.00e-96	344.00
IUUC-Ocu-074528	Oryctolagus cuniculus	78.89	4.00e-139	487.00
IUUC-Oba-075909	Oryza barthii	37.93	7.00e-12	65.10
IUUC-Obr-076678	Oryza brachyantha	36.59	2.00e-11	63.50
IUUC-Ogl-077833	Oryza glaberrima	37.93	9.00e-12	64.70
IUUC-Ogu-078599	Oryza glumaepatula	37.93	8.00e-12	64.70
IUUC-Oni-082564	Oryza nivara	37.93	8.00e-12	65.10
IUUC-Opu-083875	Oryza punctata	37.93	8.00e-12	64.70
IUUC-Oru-084465	Oryza rufipogon	37.93	8.00e-12	65.10
IUUC-Osa-085995	Oryza sativa	37.93	8.00e-12	64.70
IUUC-Ola-086942	Oryzias latipes	43.99	5.00e-95	341.00
IUUC-Oga-088509	Otolemur garnettii	88.22	0.00e+00	863.00
IUUC-Oar-089503	Ovis aries	88.74	0.00e+00	746.00
IUUC-Ptr-091416	Pan troglodytes	86.65	0.00e+00	783.00
IUUC-Pan-092459	Papio anubis	87.57	0.00e+00	817.00
IUUC-Psi-093173	Pelodiscus sinensis	55.58	2.00e-113	402.00
IUUC-Pfo-096252	Poecilia formosa	43.50	2.00e-98	352.00
IUUC-Pab-097991	Pongo abelii	84.68	0.00e+00	643.00
IUUC-Pca-100744	Procavia capensis	77.76	0.00e+00	744.00
IUUC-Pte-104285	Pyrenophora teres	45.71	3.00e-03	35.00
IUUC-Rno-105878	Rattus norvegicus	98.56	7.00e-112	397.00
IUUC-Sha-107505	Sarcophilus harrisii	76.61	4.00e-162	564.00
IUUC-Sit-110439	Setaria italica	53.33	2.00e-11	63.50
IUUC-Sly-111669	Solanum lycopersicum	44.64	6.00e-12	65.90
IUUC-Stu-112251	Solanum tuberosum	39.44	2.00e-12	67.40
IUUC-Ssc-115965	Sus scrofa	89.49	0.00e+00	822.00
IUUC-Tgu-117367	Taeniopygia guttata	52.62	8.00e-128	450.00
IUUC-Tru-118234	Takifugu rubripes	41.40	1.00e-87	317.00
IUUC-Tni-120129	Tetraodon nigroviridis	42.05	6.00e-76	278.00
IUUC-Tae-124603	Triticum aestivum	44.29	2.00e-09	56.60
IUUC-Ttr-128982	Tursiops truncatus	83.85	0.00e+00	704.00
IUUC-Vvi-131282	Vitis vinifera	46.81	5.00e-11	62.40
IUUC-Xtr-132586	Xenopus tropicalis	56.50	8.00e-103	367.00
IUUC-Xma-133102	Xiphophorus maculatus	42.73	4.00e-93	335.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence