iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	microRNA	TRANSFAC	RepTar
RAID2
Protein-protein Interaction
IID	PINA	HINT
Post-translational Modifications (PTMs)
dbPAF	PhosphositePlus	dbPTM	UniProt
PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/RING/RING	79.73	0.00e+00	798.00	IUUC-Hsa-045752

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2.

Protein Sequence
(Fasta)

MKRSEESTST QSPEEQTGTL HCWRCRKCIA SSGCFMTPLE TQVVEQDRHE SVDAQNTCHL 60
WHMNVDALPE WISCLLQKAQ WTVGKLNCPF CGARLGGFNF VSTPKCSCGQ LAAVHLCKSR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAAAGAA GCGAAGAGTC GACAAGTACG CAGAGCCCCG AGGAGCAAAC AGGCACCCTT 60
CATTGTTGGA GATGTAGAAA ATGCATTGCA AGTTCTGGTT GCTTCATGAC TCCTCTTGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0472--Membrane
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR033263--RNF180
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2

SMART

SM00184--RING

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0031227--C:intrinsic component of endoplasmic reticulum membrane
GO:0005635--C:nuclear envelope
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0030534--P:adult behavior
GO:0042415--P:norepinephrine metabolic process
GO:1901360--P:organic cyclic compound metabolic process
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0031398--P:positive regulation of protein ubiquitination
GO:0000209--P:protein polyubiquitination
GO:0050790--P:regulation of catalytic activity
GO:0042428--P:serotonin metabolic process

KEGG

mmu:71816

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002250	Ailuropoda melanoleuca	73.81	0.00e+00	763.00
IUUC-Apl-003598	Anas platyrhynchos	45.19	1.00e-108	386.00
IUUC-Aca-004364	Anolis carolinensis	43.18	3.00e-107	382.00
IUUC-Ame-011498	Astyanax mexicanus	54.84	2.00e-42	165.00
IUUC-Bta-012990	Bos taurus	72.92	0.00e+00	760.00
IUUC-Bci-013759	Botrytis cinerea	30.77	3.00e-04	40.00
IUUC-Cja-019420	Callithrix jacchus	78.98	0.00e+00	822.00
IUUC-Cfa-020028	Canis familiaris	73.24	0.00e+00	781.00
IUUC-Cpo-021698	Cavia porcellus	71.19	0.00e+00	689.00
IUUC-Csa-023637	Chlorocebus sabaeus	77.42	0.00e+00	808.00
IUUC-Cho-025073	Choloepus hoffmanni	65.01	7.00e-172	597.00
IUUC-Dre-027523	Danio rerio	56.93	1.00e-41	163.00
IUUC-Dno-030040	Dasypus novemcinctus	68.60	0.00e+00	645.00
IUUC-Dor-030405	Dipodomys ordii	75.66	0.00e+00	756.00
IUUC-Eca-033366	Equus caballus	76.89	0.00e+00	817.00
IUUC-Fca-035526	Felis catus	73.74	1.00e-168	585.00
IUUC-Fal-037590	Ficedula albicollis	41.97	8.00e-106	377.00
IUUC-Gmo-039484	Gadus morhua	50.86	7.00e-32	131.00
IUUC-Gga-040136	Gallus gallus	40.70	1.00e-111	397.00
IUUC-Gac-041811	Gasterosteus aculeatus	55.86	2.00e-33	137.00
IUUC-Ggo-044673	Gorilla gorilla	78.03	0.00e+00	823.00
IUUC-Hsa-045752	Homo sapiens	79.17	0.00e+00	831.00
IUUC-Itr-047971	Ictidomys tridecemlineatus	76.89	0.00e+00	815.00
IUUC-Lch-050309	Latimeria chalumnae	71.90	1.00e-49	191.00
IUUC-Loc-052203	Lepisosteus oculatus	39.75	8.00e-86	311.00
IUUC-Laf-053398	Loxodonta africana	72.54	0.00e+00	747.00
IUUC-Mcc-054745	Macaca mulatta	79.73	0.00e+00	837.00
IUUC-Mmr-060583	Microcebus murinus	77.27	0.00e+00	819.00
IUUC-Mdo-062873	Monodelphis domestica	58.60	7.00e-168	583.00
IUUC-Mac-065655	Musa acuminata	26.89	8.00e-07	47.80
IUUC-Mpu-066186	Mustela putorius furo	70.83	0.00e+00	757.00
IUUC-Mlu-068079	Myotis lucifugus	72.83	0.00e+00	743.00
IUUC-Nle-069164	Nomascus leucogenys	79.55	0.00e+00	838.00
IUUC-Opr-070362	Ochotona princeps	68.44	0.00e+00	663.00
IUUC-Oan-072729	Ornithorhynchus anatinus	34.92	1.00e-38	153.00
IUUC-Ocu-073894	Oryctolagus cuniculus	67.71	7.00e-180	623.00
IUUC-Oga-088485	Otolemur garnettii	77.08	0.00e+00	797.00
IUUC-Oar-089831	Ovis aries	71.54	0.00e+00	761.00
IUUC-Ptr-091570	Pan troglodytes	79.17	0.00e+00	833.00
IUUC-Psi-093962	Pelodiscus sinensis	47.66	2.00e-125	442.00
IUUC-Pfo-096369	Poecilia formosa	68.57	2.00e-41	162.00
IUUC-Pab-098224	Pongo abelii	65.09	0.00e+00	632.00
IUUC-Pca-100186	Procavia capensis	68.37	0.00e+00	646.00
IUUC-Pva-102511	Pteropus vampyrus	76.89	0.00e+00	819.00
IUUC-Rno-105170	Rattus norvegicus	87.69	0.00e+00	895.00
IUUC-Sha-107501	Sarcophilus harrisii	60.04	5.00e-157	547.00
IUUC-Ssc-115668	Sus scrofa	73.41	0.00e+00	796.00
IUUC-Tgu-117098	Taeniopygia guttata	44.26	4.00e-102	365.00
IUUC-Tru-118625	Takifugu rubripes	74.49	3.00e-43	167.00
IUUC-Tsy-118959	Tarsius syrichta	75.90	0.00e+00	788.00
IUUC-Tni-120324	Tetraodon nigroviridis	35.78	5.00e-25	109.00
IUUC-Tbe-127448	Tupaia belangeri	77.11	0.00e+00	677.00
IUUC-Ttr-128470	Tursiops truncatus	72.87	0.00e+00	724.00
IUUC-Vpa-130097	Vicugna pacos	75.52	0.00e+00	716.00
IUUC-Xtr-132848	Xenopus tropicalis	38.14	2.00e-86	313.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence