iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Eca-033957

UUCD1 version

UUC-EqC-01044

Ensembl Protein ID

ENSECAP00000007221.1

UniProt Accession

F6YCB2; F6YCB2_HORSE

Protein Name

Ubiquitinyl hydrolase 1

Gene Name

USP27X

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSECAG00000009308.1	ENSECAT00000009480.1	ENSECAP00000007221.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-90	304.0	179	521

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L+++p lr+++l+ ++++++    ++p+ +l++++ +lf+el++++ +   p +ll+ ++  a+++ gy+qq
   Q: 179  GLINLGNTCFMNCIVQALTHTPILRDFFLS-DRHRCEM---PSPELCLVCEMSSLFRELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQ 263
           9*****************************.9999987...589********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgk 179
           Da+Efl   ld l++++k                  +  +  +++++ +++i+++F g ++s+++c++c+ vs++ +p +d+sl++pg+
   Q: 264  DAHEFLIAALDVLHRHCKG----------------DDAGKAANNPNHCNCIIDQIFTGGMQSDVTCQACHGVSTTIDPCWDISLDLPGS 336
           *****************22................22335678899999***************************************9 PP
   S: 180  eetkke...................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksreki 249
            ++  +                   +l+dcL+ ft++e+l ++ k++c +c+++qe++k+l+++klP v ++h+kRf  +++ k+r+ki
   Q: 337  CTSFWPmspgressvngeshipgitTLTDCLRRFTRPEHLGSSAKIKCGSCQSYQESTKQLTMNKLPVVACFHFKRF--EHSAKQRRKI 423
           98766699*********************************************************************..55667999** PP
   S: 250  nkkvefpleLdlspfctspeekqke............kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleet 326
           +++++fpleLd++pf++s++e+  +            ++kY+L+avv+H+G+l+sGHY+++++++k++W+++dD  +t+ + ++vl   
   Q: 424  TTYISFPLELDMTPFMASSKESRMNgqlqlptnsgndENKYSLFAVVNHQGTLESGHYTSFIRHHKDQWFKCDDAVITKASIKDVLD-- 510
           ******************5544444566666666666**************************************************.. PP
   S: 327  gstaYvlfYkrr 338
            s++Y+lfY+++
   Q: 511  -SEGYLLFYHKQ 521
           .********985 PP

Organism

Equus caballus

Protein Sequence
(Fasta)

RYRRGPGGGC LDVDFTVGPP GCSHVNSFKV GENWRQELRV IYQCFVWCGT PETRKSKAKS 60
CICHVCGTHL NRLHSCLSCV FFGCFTEKHI HEHAETKQHN LAVDLYYGGI YCFMCKDYVY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGTACCGGC GCGGCCCTGG GGGCGGATGC CTGGATGTGG ATTTCACTGT GGGTCCACCA 60
GGCTGTTCCC ACGTGAACAG CTTTAAGGTG GGAGAGAACT GGAGGCAGGA ACTGCGGGTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0061578--F:Lys63-specific deubiquitinase activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0043065--P:positive regulation of apoptotic process
GO:0050821--P:protein stabilization
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002084	Ailuropoda melanoleuca	98.10	0.00e+00	1080.00
IUUC-Aly-006565	Arabidopsis lyrata	36.59	2.00e-74	273.00
IUUC-Ath-007536	Arabidopsis thaliana	34.01	1.00e-75	277.00
IUUC-Bra-016962	Brassica rapa	36.92	4.00e-74	272.00
IUUC-Cja-019954	Callithrix jacchus	88.30	0.00e+00	946.00
IUUC-Cfa-020956	Canis familiaris	96.82	0.00e+00	1014.00
IUUC-Cpo-022014	Cavia porcellus	97.52	0.00e+00	1071.00
IUUC-Dno-029905	Dasypus novemcinctus	95.07	0.00e+00	842.00
IUUC-Dor-030832	Dipodomys ordii	97.41	5.00e-112	397.00
IUUC-Fca-035768	Felis catus	97.91	0.00e+00	1079.00
IUUC-Ggr-040044	Gaeumannomyces graminis	31.60	4.00e-57	215.00
IUUC-Ggo-044925	Gorilla gorilla	97.53	0.00e+00	1075.00
IUUC-Laf-053947	Loxodonta africana	96.37	0.00e+00	1061.00
IUUC-Mtr-057769	Medicago truncatula	36.52	2.00e-83	303.00
IUUC-Mvi-060530	Microbotryum violaceum	32.95	5.00e-58	218.00
IUUC-Mpu-066433	Mustela putorius furo	97.70	0.00e+00	1066.00
IUUC-Mlu-067330	Myotis lucifugus	96.58	0.00e+00	1064.00
IUUC-Nle-069084	Nomascus leucogenys	96.01	0.00e+00	851.00
IUUC-Ocu-074951	Oryctolagus cuniculus	95.19	0.00e+00	1042.00
IUUC-Oga-088771	Otolemur garnettii	96.56	0.00e+00	1051.00
IUUC-Oar-089610	Ovis aries	96.62	0.00e+00	1013.00
IUUC-Pan-092253	Papio anubis	96.62	0.00e+00	1012.00
IUUC-Pab-098324	Pongo abelii	97.53	0.00e+00	1075.00
IUUC-Pop-099558	Populus trichocarpa	35.34	8.00e-88	317.00
IUUC-Pca-100329	Procavia capensis	96.39	0.00e+00	1063.00
IUUC-Ppe-102020	Prunus persica	36.44	6.00e-92	331.00
IUUC-Pva-102721	Pteropus vampyrus	92.88	0.00e+00	991.00
IUUC-Smo-109310	Selaginella moellendorffii	35.82	1.00e-85	310.00
IUUC-Sly-111077	Solanum lycopersicum	37.27	5.00e-82	298.00
IUUC-Stu-112203	Solanum tuberosum	39.49	6.00e-76	277.00
IUUC-Sar-113174	Sorex araneus	91.46	0.00e+00	944.00
IUUC-Sre-115195	Sporisorium reilianum	26.92	1.00e-52	201.00
IUUC-Ssc-115315	Sus scrofa	97.32	0.00e+00	1059.00
IUUC-Tvi-122599	Trichoderma virens	30.89	3.00e-55	209.00
IUUC-Ttr-129006	Tursiops truncatus	97.87	0.00e+00	1057.00
IUUC-Vvi-131477	Vitis vinifera	36.74	2.00e-77	283.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence