iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Oan-073565

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AAPN01106809

Gene Name

USP22

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOANG00000001270.3	ENSOANT00000002022.3	ENSOANP00000002021.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	9.10e-95	317.9	128	508

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqq 90
           Gl NlgNtC+mN+++Q+L+++p lr+++l+ +++k++ +   +p+ +l++++ +lf+e+++++++   p +ll+ +++ a+++ gyeqq
   Q: 128  GLINLGNTCFMNCIVQALTHTPLLRDFFLS-DRHKCEMQ---SPSSCLVCEMSTLFQEFYSGHRSPHIPYRLLHLVWTHARHLAGYEQQ 212
           9*****************************.99999975...78********************************************* PP
   S: 91   DaqEflaflldqleeelkkeknkpkeeeeeedkselsde.........................aeekkkkknkslisdlFqgqlksqi 154
           Da+Efl   ld l++++k    k++++ +    +++ +                          ++ +++++ +++i+++F g l+s++
   Q: 213  DAHEFLIAALDVLHRHCKVDIAKHQDNVR----NKTANVvlasmmpsavqgkprimnlagddngKKANNPNHCNCIIDQIFTGGLQSDV 297
           *****************552222222222....222222345568889**************888888899999*************** PP
   S: 155  kclecdnvssreepfldlslpvpgkeetkke....................slqdcLesftkeeelegenkyycekckkkqeaekklkl 223
           +c+ c+ vs++ +pf+d+sl++pg+++   +                    +l+dcL+ ft++e+l ++ k++c+ c+++qe++k+l++
   Q: 298  TCQVCHGVSTTIDPFWDISLDLPGSSTPFWPlspgsdgsvvngeshvsgttTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTM 386
           **************************87777********************************************************** PP
   S: 224  kklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts............peekqkekkkYeLiavvvHsGslssGHYvayvk 300
           kklP v ++hLkRf  +++ k r+ki+++v+fpleLd++pf++s            p+++ ++++kY+L+avv+H+G+l+sGHY+++++
   Q: 387  KKLPIVACFHLKRF--EHSAKLRRKITTYVSFPLELDMTPFMASskesrmngqyqqPTDSLNNDNKYSLFAVVNHQGTLESGHYTSFIR 473
           **************..5666899*********************5555555555554445555************************** PP
   S: 301  nekgkWllfdDskVtevkeeevleetgstaYvlfYkrr 338
           ++k++W+++dD  +t+ + ++vl    s++Y+lfY+++
   Q: 474  QHKDQWFKCDDAIITKASIKDVLD---SEGYLLFYHKQ 508
           ************************...********985 PP

Organism

Ornithorhynchus anatinus

Protein Sequence
(Fasta)

MCGAHLNRLH SCLYCVFFGC FTKKHIHEHA KTKRHNLAID LLYGGIYCFM CQDYIYDKDL 60
EQIAKEEQRK AWKLQAFTPT VVSHYQCTMT GIGEKYSTWE PTKRELELLR HNPKRRKITT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGGTTTAAG GTGGCTGGTG AAGCTGAAAT TGTTTTTCTC TGTTCCAGGC AAAGTCGTGC 60
ATCTGTCATA TGTGTGGTGC CCACCTGAAC AGACTCCACT CTTGCCTCTA CTGTGTCTTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

Gene Ontology

GO:0000124--C:SAGA complex
GO:0010485--F:H4 histone acetyltransferase activity
GO:0030374--F:ligand-dependent nuclear receptor transcription coactivator activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0016578--P:histone deubiquitination
GO:0016574--P:histone ubiquitination
GO:0045931--P:positive regulation of mitotic cell cycle
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000393	Aegilops tauschii	34.34	3.00e-60	226.00
IUUC-Aml-001343	Ailuropoda melanoleuca	84.99	0.00e+00	907.00
IUUC-Atr-002653	Amborella trichopoda	36.83	8.00e-91	327.00
IUUC-Apl-003433	Anas platyrhynchos	92.59	0.00e+00	984.00
IUUC-Aca-005347	Anolis carolinensis	89.02	0.00e+00	969.00
IUUC-Aly-006565	Arabidopsis lyrata	33.67	3.00e-67	249.00
IUUC-Ath-007536	Arabidopsis thaliana	33.87	2.00e-67	249.00
IUUC-Ago-007811	Ashbya gossypii	28.60	1.00e-48	187.00
IUUC-Acl-008124	Aspergillus clavatus	29.12	2.00e-53	202.00
IUUC-Afl-008464	Aspergillus flavus	29.55	2.00e-50	192.00
IUUC-Afu-008912	Aspergillus fumigatus	28.54	1.00e-50	193.00
IUUC-Ani-009168	Aspergillus nidulans	29.05	1.00e-52	200.00
IUUC-Ang-009694	Aspergillus niger	28.72	1.00e-51	196.00
IUUC-Aor-010035	Aspergillus oryzae	30.92	2.00e-34	138.00
IUUC-Ate-010382	Aspergillus terreus	29.76	7.00e-49	187.00
IUUC-Ame-011253	Astyanax mexicanus	76.02	0.00e+00	763.00
IUUC-Bgr-012150	Blumeria graminis	29.49	7.00e-46	177.00
IUUC-Bta-013303	Bos taurus	85.96	0.00e+00	915.00
IUUC-Bci-013604	Botrytis cinerea	30.28	7.00e-54	204.00
IUUC-Bdi-014171	Brachypodium distachyon	32.95	7.00e-73	267.00
IUUC-Bol-016509	Brassica oleracea	34.77	9.00e-71	261.00
IUUC-Bra-016962	Brassica rapa	33.59	5.00e-68	251.00
IUUC-Cja-019283	Callithrix jacchus	85.71	0.00e+00	845.00
IUUC-Cfa-021239	Canis familiaris	85.96	0.00e+00	917.00
IUUC-Cpo-022354	Cavia porcellus	86.35	0.00e+00	914.00
IUUC-Csa-023145	Chlorocebus sabaeus	86.55	0.00e+00	921.00
IUUC-Cho-024938	Choloepus hoffmanni	79.03	1.00e-56	213.00
IUUC-Cin-025109	Ciona intestinalis	53.87	1.00e-123	435.00
IUUC-Csv-026214	Ciona savignyi	52.24	4.00e-161	560.00
IUUC-Cgl-026457	Colletotrichum gloeosporioides	29.35	7.00e-50	191.00
IUUC-Cne-027085	Cryptococcus neoformans	29.71	2.00e-56	213.00
IUUC-Dre-027433	Danio rerio	86.35	0.00e+00	908.00
IUUC-Dno-030095	Dasypus novemcinctus	85.96	0.00e+00	919.00
IUUC-Dor-030832	Dipodomys ordii	86.08	2.00e-98	351.00
IUUC-Dse-031415	Dothistroma septosporum	29.71	1.00e-57	216.00
IUUC-Dme-032074	Drosophila melanogaster	50.58	1.00e-131	462.00
IUUC-Ete-033175	Echinops telfairi	98.34	3.00e-106	378.00
IUUC-Eca-033736	Equus caballus	85.58	0.00e+00	912.00
IUUC-Eeu-034814	Erinaceus europaeus	98.57	3.00e-123	434.00
IUUC-Fca-035861	Felis catus	86.16	0.00e+00	919.00
IUUC-Fal-037645	Ficedula albicollis	92.59	0.00e+00	985.00
IUUC-Fox-038046	Fusarium oxysporum	29.40	9.00e-51	193.00
IUUC-Fso-038321	Fusarium solani	30.08	2.00e-50	192.00
IUUC-Gmo-038474	Gadus morhua	84.68	6.00e-168	583.00
IUUC-Ggr-040044	Gaeumannomyces graminis	29.47	5.00e-51	194.00
IUUC-Gga-040624	Gallus gallus	92.59	0.00e+00	984.00
IUUC-Gac-042197	Gasterosteus aculeatus	81.32	0.00e+00	848.00
IUUC-Gma-042897	Glycine max	32.69	9.00e-78	283.00
IUUC-Ggo-044409	Gorilla gorilla	86.55	0.00e+00	923.00
IUUC-Hsa-046521	Homo sapiens	86.55	0.00e+00	923.00
IUUC-Hvu-047739	Hordeum vulgare	35.59	9.00e-66	243.00
IUUC-Itr-048375	Ictidomys tridecemlineatus	85.96	0.00e+00	915.00
IUUC-Kpa-049135	Komagataella pastoris	32.48	9.00e-63	233.00
IUUC-Lch-050537	Latimeria chalumnae	87.91	0.00e+00	931.00
IUUC-Lpe-050969	Leersia perrieri	36.12	1.00e-68	253.00
IUUC-Loc-052765	Lepisosteus oculatus	79.96	0.00e+00	832.00
IUUC-Lma-053105	Leptosphaeria maculans	31.91	7.00e-60	224.00
IUUC-Laf-053571	Loxodonta africana	86.74	0.00e+00	922.00
IUUC-Mcc-055166	Macaca mulatta	86.55	0.00e+00	921.00
IUUC-Mor-057103	Magnaporthe oryzae	29.35	3.00e-52	199.00
IUUC-Mpo-057621	Magnaporthe poae	29.86	7.00e-51	194.00
IUUC-Mtr-057894	Medicago truncatula	36.85	2.00e-80	292.00
IUUC-Mla-059185	Melampsora laricipopulina	30.56	5.00e-38	151.00
IUUC-Mga-059709	Meleagris gallopavo	92.59	0.00e+00	984.00
IUUC-Mvi-060530	Microbotryum violaceum	30.80	2.00e-54	205.00
IUUC-Mmr-060988	Microcebus murinus	86.55	0.00e+00	922.00
IUUC-Mdo-063065	Monodelphis domestica	89.67	0.00e+00	943.00
IUUC-Mmu-063829	Mus musculus	86.16	0.00e+00	918.00
IUUC-Mac-065419	Musa acuminata	36.54	1.00e-67	249.00
IUUC-Mpu-066687	Mustela putorius furo	85.60	0.00e+00	910.00
IUUC-Mlu-067330	Myotis lucifugus	76.41	0.00e+00	808.00
IUUC-Nfi-068423	Neosartorya fischeri	28.54	1.00e-50	193.00
IUUC-Ncr-068809	Neurospora crassa	28.71	2.00e-52	199.00
IUUC-Nle-069261	Nomascus leucogenys	82.46	0.00e+00	867.00
IUUC-Opr-070469	Ochotona princeps	70.11	0.00e+00	657.00
IUUC-Ont-071961	Oreochromis niloticus	83.63	0.00e+00	880.00
IUUC-Ocu-074435	Oryctolagus cuniculus	86.20	0.00e+00	891.00
IUUC-Oba-075688	Oryza barthii	33.77	9.00e-71	260.00
IUUC-Obr-076652	Oryza brachyantha	38.94	1.00e-69	256.00
IUUC-Ogl-077910	Oryza glaberrima	34.15	4.00e-75	275.00
IUUC-Ogu-078479	Oryza glumaepatula	34.15	4.00e-75	275.00
IUUC-Oin-079697	Oryza indica	37.25	4.00e-71	261.00
IUUC-Olo-080811	Oryza longistaminata	36.70	3.00e-48	184.00
IUUC-Ome-081706	Oryza meridionalis	33.40	1.00e-74	274.00
IUUC-Oni-083070	Oryza nivara	33.77	4.00e-75	275.00
IUUC-Opu-083605	Oryza punctata	37.47	1.00e-62	232.00
IUUC-Oru-084522	Oryza rufipogon	34.15	4.00e-75	275.00
IUUC-Osa-085351	Oryza sativa	37.22	3.00e-72	265.00
IUUC-Ola-086743	Oryzias latipes	78.85	0.00e+00	738.00
IUUC-Olu-087695	Ostreococcus lucimarinus	30.37	1.00e-48	186.00
IUUC-Oga-089131	Otolemur garnettii	86.38	0.00e+00	922.00
IUUC-Oar-089319	Ovis aries	85.96	0.00e+00	915.00
IUUC-Ptr-090783	Pan troglodytes	86.35	0.00e+00	922.00
IUUC-Pan-092927	Papio anubis	86.35	0.00e+00	920.00
IUUC-Psi-093670	Pelodiscus sinensis	92.59	0.00e+00	985.00
IUUC-Pma-094323	Petromyzon marinus	64.85	0.00e+00	683.00
IUUC-Pno-095141	Phaeosphaeria nodorum	29.98	1.00e-50	193.00
IUUC-Ppa-095413	Physcomitrella patens	33.62	1.00e-77	283.00
IUUC-Pfo-096462	Poecilia formosa	86.55	0.00e+00	910.00
IUUC-Pab-097612	Pongo abelii	86.55	0.00e+00	923.00
IUUC-Pop-099558	Populus trichocarpa	35.64	4.00e-80	291.00
IUUC-Pca-100329	Procavia capensis	76.61	0.00e+00	809.00
IUUC-Ppe-102020	Prunus persica	35.74	7.00e-84	304.00
IUUC-Pva-102721	Pteropus vampyrus	73.08	0.00e+00	749.00
IUUC-Pgr-103657	Puccinia graminis	30.46	6.00e-39	154.00
IUUC-Pte-104340	Pyrenophora teres	31.68	3.00e-53	202.00
IUUC-Pyt-104782	Pyrenophora triticirepentis	33.26	7.00e-61	227.00
IUUC-Rno-105247	Rattus norvegicus	86.16	0.00e+00	919.00
IUUC-Sce-106247	Saccharomyces cerevisiae	28.96	1.00e-48	186.00
IUUC-Sha-107538	Sarcophilus harrisii	97.24	3.00e-126	443.00
IUUC-Sja-107656	Schizosaccharomyces japonicus	31.98	8.00e-62	230.00
IUUC-Spo-108226	Schizosaccharomyces pombe	30.69	2.00e-55	209.00
IUUC-Ssl-108531	Sclerotinia sclerotiorum	30.00	1.00e-51	197.00
IUUC-Smo-109310	Selaginella moellendorffii	34.20	1.00e-81	296.00
IUUC-Sit-109716	Setaria italica	33.90	1.00e-74	273.00
IUUC-Sly-111077	Solanum lycopersicum	35.62	5.00e-73	268.00
IUUC-Stu-112203	Solanum tuberosum	36.17	1.00e-69	256.00
IUUC-Sar-113174	Sorex araneus	73.58	0.00e+00	725.00
IUUC-Sbi-114205	Sorghum bicolor	33.46	1.00e-75	276.00
IUUC-Sre-115195	Sporisorium reilianum	27.79	1.00e-57	217.00
IUUC-Ssc-115315	Sus scrofa	77.97	0.00e+00	830.00
IUUC-Tgu-116938	Taeniopygia guttata	89.67	0.00e+00	943.00
IUUC-Tru-117622	Takifugu rubripes	86.35	0.00e+00	914.00
IUUC-Tsy-119431	Tarsius syrichta	74.85	0.00e+00	765.00
IUUC-Tni-120119	Tetraodon nigroviridis	85.38	0.00e+00	902.00
IUUC-Tca-121716	Theobroma cacao	36.64	1.00e-84	306.00
IUUC-Tre-122139	Trichoderma reesei	29.74	1.00e-49	189.00
IUUC-Tvi-122599	Trichoderma virens	29.28	2.00e-50	192.00
IUUC-Tae-125608	Triticum aestivum	33.65	3.00e-83	301.00
IUUC-Tme-127115	Tuber melanosporum	35.27	1.00e-74	273.00
IUUC-Ttr-129006	Tursiops truncatus	76.74	0.00e+00	795.00
IUUC-Uma-129455	Ustilago maydis	33.58	8.00e-33	135.00
IUUC-Vda-129829	Verticillium dahliae	30.21	2.00e-31	129.00
IUUC-Vvi-131477	Vitis vinifera	34.99	2.00e-70	259.00
IUUC-Xtr-132444	Xenopus tropicalis	89.47	0.00e+00	957.00
IUUC-Xma-133514	Xiphophorus maculatus	86.55	0.00e+00	912.00
IUUC-Yli-134357	Yarrowia lipolytica	29.79	5.00e-49	188.00
IUUC-Zma-134945	Zea mays	33.46	8.00e-73	267.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence