iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004504

UUCD1 version

UUC-AnC-00523

Ensembl Protein ID

ENSACAP00000004120.1

UniProt Accession

G1KCN4; G1KCN4_ANOCA

Protein Name

Uncharacterized protein

Gene Name

SOCS5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000004259.1	ENSACAT00000004217.1	ENSACAP00000004120.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.40e-14	53.7	471	516

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 5    wllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            l r+ p+SLq++CR +I+r++ ++++   d+LPLP++L+d+L++++y+
   Q: 471  SLNRTFPFSLQYICRAVICRYTSYDGI---DCLPLPSMLQDFLKEYHYK 516
           577899*********************...****************985 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MGKVGKMWNS FKYRCQNLFN NESGNRNENL DVNSNNSSVR DKSVFVLDPV DQRSSSPLRD 60
VSLQLSLNPS KASSKKLQNC AAEIPQIVEI SIEKESDLGA ATGARLARRD SYSRHAPWGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGTAAAG TTGGGAAGAT GTGGAATAGC TTTAAATACA GATGCCAGAA TCTCTTCAAT 60
AACGAAAGTG GAAACAGAAA TGAAAATTTA GATGTGAACT CCAATAATTC ATCTGTTAGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR022252--SOCS4/SOCS5_dom
IPR028420--SOCS5
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0071404--P:cellular response to low-density lipoprotein particle stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0050728--P:negative regulation of inflammatory response
GO:0032715--P:negative regulation of interleukin-6 production
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0071638--P:negative regulation of monocyte chemotactic protein-1 production
GO:0006469--P:negative regulation of protein kinase activity
GO:0045629--P:negative regulation of T-helper 2 cell differentiation
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045627--P:positive regulation of T-helper 1 cell differentiation
GO:0016567--P:protein ubiquitination
GO:0097699--P:vascular endothelial cell response to fluid shear stress

KEGG

acs:100567705

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000371	Aegilops tauschii	32.65	2.40e-01	28.50
IUUC-Apl-003815	Anas platyrhynchos	86.01	0.00e+00	924.00
IUUC-Ame-010677	Astyanax mexicanus	62.63	7.00e-178	616.00
IUUC-Bta-012338	Bos taurus	85.45	0.00e+00	899.00
IUUC-Cja-019828	Callithrix jacchus	84.89	0.00e+00	885.00
IUUC-Cfa-020369	Canis familiaris	84.89	0.00e+00	900.00
IUUC-Cpo-021397	Cavia porcellus	83.58	0.00e+00	908.00
IUUC-Csa-023856	Chlorocebus sabaeus	85.45	0.00e+00	901.00
IUUC-Dre-028262	Danio rerio	61.96	4.00e-168	584.00
IUUC-Dno-029019	Dasypus novemcinctus	84.89	0.00e+00	919.00
IUUC-Dme-031965	Drosophila melanogaster	68.02	2.00e-69	256.00
IUUC-Eca-033867	Equus caballus	84.89	0.00e+00	919.00
IUUC-Fca-035806	Felis catus	84.70	0.00e+00	903.00
IUUC-Fal-037117	Ficedula albicollis	85.63	0.00e+00	915.00
IUUC-Gmo-039066	Gadus morhua	82.38	2.00e-104	372.00
IUUC-Gga-040876	Gallus gallus	85.26	0.00e+00	899.00
IUUC-Gac-042149	Gasterosteus aculeatus	65.43	0.00e+00	626.00
IUUC-Ggo-045169	Gorilla gorilla	84.14	0.00e+00	894.00
IUUC-Hsa-045805	Homo sapiens	85.07	0.00e+00	900.00
IUUC-Hvu-047122	Hordeum vulgare	38.89	1.90e-01	29.30
IUUC-Itr-049048	Ictidomys tridecemlineatus	84.70	0.00e+00	919.00
IUUC-Lch-049686	Latimeria chalumnae	77.86	0.00e+00	805.00
IUUC-Loc-051745	Lepisosteus oculatus	69.84	0.00e+00	692.00
IUUC-Laf-054124	Loxodonta africana	85.10	0.00e+00	910.00
IUUC-Mcc-055175	Macaca mulatta	85.45	0.00e+00	901.00
IUUC-Meu-056557	Macropus eugenii	85.34	0.00e+00	913.00
IUUC-Mga-059214	Meleagris gallopavo	86.01	0.00e+00	922.00
IUUC-Mvi-060418	Microbotryum violaceum	28.44	3.20e-02	31.60
IUUC-Mmr-060613	Microcebus murinus	71.08	0.00e+00	684.00
IUUC-Mdo-062788	Monodelphis domestica	85.34	0.00e+00	877.00
IUUC-Mmu-064333	Mus musculus	84.51	0.00e+00	898.00
IUUC-Mpu-066048	Mustela putorius furo	85.07	0.00e+00	898.00
IUUC-Mlu-067430	Myotis lucifugus	85.45	0.00e+00	889.00
IUUC-Nle-069086	Nomascus leucogenys	85.07	0.00e+00	922.00
IUUC-Opr-070312	Ochotona princeps	83.58	0.00e+00	898.00
IUUC-Ont-072299	Oreochromis niloticus	63.81	0.00e+00	634.00
IUUC-Ocu-074123	Oryctolagus cuniculus	82.46	0.00e+00	880.00
IUUC-Ola-086934	Oryzias latipes	66.11	0.00e+00	644.00
IUUC-Oga-088535	Otolemur garnettii	84.70	0.00e+00	917.00
IUUC-Oar-089875	Ovis aries	85.63	0.00e+00	904.00
IUUC-Ptr-090541	Pan troglodytes	85.07	0.00e+00	900.00
IUUC-Pan-092416	Papio anubis	85.45	0.00e+00	901.00
IUUC-Psi-092960	Pelodiscus sinensis	84.51	0.00e+00	908.00
IUUC-Pma-094222	Petromyzon marinus	51.85	6.00e-133	467.00
IUUC-Pfo-096930	Poecilia formosa	64.12	0.00e+00	641.00
IUUC-Pab-098659	Pongo abelii	85.26	0.00e+00	900.00
IUUC-Pop-098820	Populus trichocarpa	41.18	1.20e-01	30.80
IUUC-Pca-100222	Procavia capensis	84.17	0.00e+00	906.00
IUUC-Pva-102387	Pteropus vampyrus	84.51	0.00e+00	891.00
IUUC-Rno-105698	Rattus norvegicus	84.89	0.00e+00	897.00
IUUC-Sha-107234	Sarcophilus harrisii	84.60	0.00e+00	882.00
IUUC-Sar-113698	Sorex araneus	81.16	0.00e+00	822.00
IUUC-Ssc-115985	Sus scrofa	84.51	0.00e+00	920.00
IUUC-Tgu-116676	Taeniopygia guttata	86.57	0.00e+00	925.00
IUUC-Tru-118441	Takifugu rubripes	57.22	9.00e-148	516.00
IUUC-Tsy-119163	Tarsius syrichta	81.34	0.00e+00	872.00
IUUC-Tni-120436	Tetraodon nigroviridis	64.75	0.00e+00	629.00
IUUC-Tbe-127353	Tupaia belangeri	85.07	0.00e+00	898.00
IUUC-Ttr-128907	Tursiops truncatus	85.07	0.00e+00	885.00
IUUC-Vpa-130140	Vicugna pacos	85.45	0.00e+00	899.00
IUUC-Xtr-132817	Xenopus tropicalis	75.84	0.00e+00	815.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence