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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-064333
UUCD1 version UUC-MuM-00268
Ensembl Protein ID ENSMUSP00000038591.6
UniProt Accession O54928; Q7TSK1; SOCS5_MOUSE
Genbank Protein ID AAB96648.1; AAY21058.1; EDL38623.1; AAH53015.1
Protein Name Suppressor of cytokine signaling 5; Cytokine-inducible SH2-containing protein 5
Genbank Nucleotide ID AF033187; AY902348; CH466537; BC053015
Gene Name Socs5; Cish5
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000037104.8 ENSMUST00000041369.6 ENSMUSP00000038591.6
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
Protein 3D Structure
PDB
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box 7.70e-16 58.8 473 520
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box
   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
            + l r+ p+SLq++CR +I+rc++++++   d+LPLP++L+d+L++++y+
   Q: 473  TISLNRTFPFSLQYICRAVICRCTTYDGI---DGLPLPSMLQDFLKEYHYK 520
           6778999**********************...****************985 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.
 SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling.
Protein Sequence
(Fasta)
MDKVGKMWNN LKYRCQNLFS HEGGSRNENV EMNPNRCPSV KEKSISLGEA APQQESSPLR 60
ENVALQLGLS PSKTFSRRNQ NCAAEIPQVV EISIEKDSDS GATPGTRLAR RDSYSRHAPW 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-064333|E3,SOCS|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CGCCGGCCCG GCAGGAGCGG AGGACGGGAC GCGCGGGCGG TCGCGCTCGC CCTGTCGCTG 60
ACTGCGCTGC CCCGGCCCAT CCTTGCCTGG CCGCAGGTGC CCTGGATGAG GCCGCCGCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-064333|E3,SOCS|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0341--Growth regulation
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway
Interpro

IPR000980--SH2
IPR022252--SOCS4/SOCS5_dom
IPR028420--SOCS5
IPR001496--SOCS_box
PROSITE

PS50001--SH2
PS50225--SOCS
Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box
SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005154--F:epidermal growth factor receptor binding
GO:0019210--F:kinase inhibitor activity
GO:0004860--F:protein kinase inhibitor activity
GO:0030971--F:receptor tyrosine kinase binding
GO:0016049--P:cell growth
GO:0071404--P:cellular response to low-density lipoprotein particle stimulus
GO:0019221--P:cytokine-mediated signaling pathway
GO:0007173--P:epidermal growth factor receptor signaling pathway
GO:0007259--P:JAK-STAT cascade
GO:1904988--P:negative regulation of endothelial cell activation
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0050728--P:negative regulation of inflammatory response
GO:0032715--P:negative regulation of interleukin-6 production
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0071638--P:negative regulation of monocyte chemotactic protein-1 production
GO:0006469--P:negative regulation of protein kinase activity
GO:0009968--P:negative regulation of signal transduction
GO:0045629--P:negative regulation of T-helper 2 cell differentiation
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0045627--P:positive regulation of T-helper 1 cell differentiation
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth
GO:0097699--P:vascular endothelial cell response to fluid shear stress
KEGG mmu:56468
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000371 Aegilops tauschii 36.73 1.40e-02 32.70
IUUC-Apl-003815 Anas platyrhynchos 90.11 0.00e+00 995.00
IUUC-Aca-004504 Anolis carolinensis 84.51 0.00e+00 873.00
IUUC-Ame-010677 Astyanax mexicanus 63.57 0.00e+00 641.00
IUUC-Bta-012338 Bos taurus 94.96 0.00e+00 1022.00
IUUC-Cja-019828 Callithrix jacchus 94.96 0.00e+00 1004.00
IUUC-Cfa-020369 Canis familiaris 93.84 0.00e+00 1014.00
IUUC-Cpo-021397 Cavia porcellus 92.91 0.00e+00 1025.00
IUUC-Csa-023856 Chlorocebus sabaeus 94.40 0.00e+00 1016.00
IUUC-Dre-028262 Danio rerio 64.36 3.00e-173 601.00
IUUC-Dno-029019 Dasypus novemcinctus 94.40 0.00e+00 1040.00
IUUC-Dme-031965 Drosophila melanogaster 68.02 9.00e-70 258.00
IUUC-Eca-033867 Equus caballus 94.22 0.00e+00 1037.00
IUUC-Fca-035806 Felis catus 94.03 0.00e+00 1014.00
IUUC-Fal-037117 Ficedula albicollis 89.55 0.00e+00 984.00
IUUC-Fso-038185 Fusarium solani 31.25 4.20e-01 28.50
IUUC-Gmo-039066 Gadus morhua 84.91 6.00e-109 387.00
IUUC-Gga-040876 Gallus gallus 89.18 0.00e+00 967.00
IUUC-Gac-042149 Gasterosteus aculeatus 67.59 0.00e+00 652.00
IUUC-Ggo-045169 Gorilla gorilla 93.28 0.00e+00 1009.00
IUUC-Hsa-045805 Homo sapiens 94.40 0.00e+00 1018.00
IUUC-Hvu-047122 Hordeum vulgare 39.02 1.80e-02 33.10
IUUC-Itr-049048 Ictidomys tridecemlineatus 94.40 0.00e+00 1037.00
IUUC-Lch-049686 Latimeria chalumnae 78.66 0.00e+00 837.00
IUUC-Lpe-051639 Leersia perrieri 30.77 4.00e-01 30.00
IUUC-Loc-051745 Lepisosteus oculatus 73.32 0.00e+00 717.00
IUUC-Laf-054124 Loxodonta africana 92.18 0.00e+00 1007.00
IUUC-Mcc-055175 Macaca mulatta 94.40 0.00e+00 1016.00
IUUC-Meu-056557 Macropus eugenii 90.54 0.00e+00 999.00
IUUC-Mga-059214 Meleagris gallopavo 88.62 0.00e+00 981.00
IUUC-Mmr-060613 Microcebus murinus 79.48 0.00e+00 792.00
IUUC-Mdo-062788 Monodelphis domestica 90.54 0.00e+00 964.00
IUUC-Mpu-066048 Mustela putorius furo 94.78 0.00e+00 1020.00
IUUC-Mlu-067430 Myotis lucifugus 94.40 0.00e+00 995.00
IUUC-Nle-069086 Nomascus leucogenys 94.40 0.00e+00 1038.00
IUUC-Opr-070312 Ochotona princeps 91.60 0.00e+00 984.00
IUUC-Ont-072299 Oreochromis niloticus 65.90 0.00e+00 651.00
IUUC-Ocu-074123 Oryctolagus cuniculus 89.74 0.00e+00 956.00
IUUC-Ola-086934 Oryzias latipes 69.06 0.00e+00 675.00
IUUC-Oga-088535 Otolemur garnettii 94.40 0.00e+00 1038.00
IUUC-Oar-089875 Ovis aries 94.96 0.00e+00 1024.00
IUUC-Ptr-090541 Pan troglodytes 94.40 0.00e+00 1018.00
IUUC-Pan-092416 Papio anubis 94.40 0.00e+00 1016.00
IUUC-Psi-092960 Pelodiscus sinensis 87.50 0.00e+00 971.00
IUUC-Pma-094222 Petromyzon marinus 52.77 2.00e-139 489.00
IUUC-Pfo-096930 Poecilia formosa 65.43 0.00e+00 664.00
IUUC-Pab-098659 Pongo abelii 94.59 0.00e+00 1019.00
IUUC-Pca-100222 Procavia capensis 90.88 0.00e+00 994.00
IUUC-Pva-102387 Pteropus vampyrus 93.84 0.00e+00 1010.00
IUUC-Rno-105698 Rattus norvegicus 97.57 0.00e+00 1046.00
IUUC-Sha-107234 Sarcophilus harrisii 88.68 0.00e+00 959.00
IUUC-Sar-113698 Sorex araneus 87.50 0.00e+00 896.00
IUUC-Ssc-115985 Sus scrofa 94.40 0.00e+00 1038.00
IUUC-Tgu-116676 Taeniopygia guttata 89.55 0.00e+00 986.00
IUUC-Tru-118441 Takifugu rubripes 60.26 9.00e-155 540.00
IUUC-Tsy-119163 Tarsius syrichta 89.18 0.00e+00 976.00
IUUC-Tni-120436 Tetraodon nigroviridis 67.65 0.00e+00 655.00
IUUC-Tae-124846 Triticum aestivum 36.73 3.00e-02 31.60
IUUC-Tbe-127353 Tupaia belangeri 94.59 0.00e+00 1019.00
IUUC-Ttr-128907 Tursiops truncatus 94.96 0.00e+00 1006.00
IUUC-Vpa-130140 Vicugna pacos 94.59 0.00e+00 1020.00
IUUC-Xtr-132817 Xenopus tropicalis 79.14 0.00e+00 866.00
Created Date 25-Jun-2017

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