iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Cel-018346

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Probable ubiquitin carboxyl-terminal hydrolase K02C4.3; Deubiquitinating enzyme; Ubiquitin thioesterase; Ubiquitin-specific-processing protease

Genbank Nucleotide ID

Z47811

Gene Name

K02C4.3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
WBGene00010502	K02C4.3	K02C4.3

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.80e-37	127.9	168	761

Active Site

Position(s)	Description	Evidence
177	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
707	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle......kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs....gyeqqDa 92
           tGl N gNtC++N++ Q+L++ip++r+ l +      +++  +n + ++++++ell+ ++ lf+el+ s+ k+++   l++++ k++++ +       qqDa
   Q: 168  TGLYNSGNTCWLNCLSQVLYSIPKFRSILYHcaplswHEQPITNVKIENQQHAELLMLFRGLFAELQFSEMKYIEVGPLINMVDKLSKSSKgpstIGTQQDA 269
           7******************************8887762222233333378999**************9999999999999999999888776666899**** PP
   S: 93   qEflaflldqleeelkk....eknkpkeeeeeedkselsde....................................aeekkkkknkslisdlFqgqlksqi 154
            E+l+ ++d l+++++     + n + ++ ++e++   sd+                                      + ++k+ +s+ + lF+ + k +i
   Q: 270  TEMLTLIFDWLQRAFDAalhaQLNPEFSNVSDEENLVISDStttapnsdiigappgynaanlslpssshvdpkstlnPMYVNEKEPSSTPTSLFGTRSK-TI 370
           ***************665544444444444444444444448888888999999999999888888887777766653344444444455555544333.22 PP
   S: 155  kclecdnvssreepfldlslpvpgkeetkke....................slqdcLesftkeeelegenkyycekck........................ 212
            +      +++ ++    s ++pg++ ++++                    s++++++s   +e++ ++  ++ ++                          
   Q: 371  EV------NESMDTEAATSSNLPGNSVENHPnpaapevddnkkafcdklkeSFNNIFSSVCYTESVAEDGTVSVKSNVrncpqffqlqvtygnlhdaleaat 466
           22......2333333444445555554444466667777777777776666555555555556666655444333333333444444444444444444444 PP
   S: 213  .....kkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts.....peekqke.............................. 274
                +++ +  +   + lP v+ + L+Rfsf++  + ++k+++k++fp+ + +++++             +                              
   Q: 467  fdhglGNTASHVRNLYDPLPAVIFFGLSRFSFNS--NIESKLHDKFTFPKIIFMDRYLKCnkeqlV-----Qlrshrelcrdslsevraklsglrrypqgng 561
           444444444677778899************9977..6999************9*998777334440.....3556666666666666666666666666666 PP
   S: 275  ...................................................................................................... 274
                                                                                                                 
   Q: 562  evrledsfqtvwqavsnfrefvtfylkvsqktffsredahentafvgpltpstyqsssdncsskfvkdggklfptftegffpgkaafietlqnmlealktee 663
           666666666666666666666666666666666666666667777777777777777777777788888888888888888888888888888888888888 PP
   S: 275  ........................kkkYeLiavvvHsGslssGHYvayvknekgk....WllfdDskVtevkeeevleetg.......staYvlfYkr 337
                                   ++kYeL+a++vHsG+++ GHY++y  +++ +    W +++D++   v++ +v++++         +aY+l+Y r
   Q: 664  rdclaeearlqevidqtyevpelqQHKYELHAIIVHSGEANRGHYWTYKLKKSIDgleeWEKLNDQNADRVDWPKVESDSFgtgsrdaPSAYMLMYVR 761
           888888888888999999999999************************99965556778*******************8779**************87 PP

Organism

Caenorhabditis elegans

Protein Sequence
(Fasta)

MVEENETGTP GTSRTVTFHD GRKLTDAEHF VFFKVKEVIA DKVAEAEILE SIRKRSECKP 60
TDEQFISDII NELFYSGEPP KGRKSERFIG PLFDPEKAST ASGPMDCTDV VSYDSTHPNI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGATGGTTGA AGAAAATGAG ACAGGGACGC CGGGAACAAG TCGAACTGTG ACATTTCACG 60
ACGGAAGAAA ATTAACTGAC GCGGAACACT TTGTATTTTT CAAAGTTAAA GAAGTTATTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001340	Ailuropoda melanoleuca	27.66	5.00e-29	122.00
IUUC-Apl-004030	Anas platyrhynchos	26.87	4.00e-27	115.00
IUUC-Aca-004741	Anolis carolinensis	46.67	1.00e-15	77.80
IUUC-Ago-007865	Ashbya gossypii	30.53	5.00e-07	49.30
IUUC-Ame-010624	Astyanax mexicanus	27.11	9.00e-26	110.00
IUUC-Bgr-011993	Blumeria graminis	38.00	9.00e-07	48.50
IUUC-Bta-013166	Bos taurus	26.90	2.00e-27	117.00
IUUC-Cja-019150	Callithrix jacchus	35.15	7.00e-18	85.50
IUUC-Cfa-020649	Canis familiaris	27.41	2.00e-28	120.00
IUUC-Cpo-021807	Cavia porcellus	27.78	2.00e-28	120.00
IUUC-Csa-023388	Chlorocebus sabaeus	26.88	1.00e-27	117.00
IUUC-Cho-024343	Choloepus hoffmanni	38.14	7.00e-17	81.60
IUUC-Cin-025302	Ciona intestinalis	26.36	4.00e-20	91.70
IUUC-Csv-025911	Ciona savignyi	28.57	6.00e-11	61.60
IUUC-Dre-028016	Danio rerio	27.60	4.00e-25	109.00
IUUC-Dno-029495	Dasypus novemcinctus	26.77	3.00e-27	116.00
IUUC-Dor-030955	Dipodomys ordii	29.94	2.00e-26	113.00
IUUC-Ete-032828	Echinops telfairi	28.61	1.00e-21	97.80
IUUC-Eca-034300	Equus caballus	40.21	5.00e-14	72.40
IUUC-Eeu-034458	Erinaceus europaeus	29.06	4.00e-24	105.00
IUUC-Fca-035876	Felis catus	27.41	2.00e-29	123.00
IUUC-Fal-036762	Ficedula albicollis	26.87	1.00e-27	116.00
IUUC-Gmo-039593	Gadus morhua	32.14	4.00e-13	69.30
IUUC-Gga-040878	Gallus gallus	27.83	5.00e-28	119.00
IUUC-Gac-042473	Gasterosteus aculeatus	27.18	2.00e-25	110.00
IUUC-Ggo-044939	Gorilla gorilla	34.55	3.00e-18	86.70
IUUC-Hsa-046204	Homo sapiens	35.15	9.00e-18	84.70
IUUC-Itr-048276	Ictidomys tridecemlineatus	32.56	6.00e-15	74.70
IUUC-Kpa-049349	Komagataella pastoris	26.96	1.00e-06	48.10
IUUC-Lch-049572	Latimeria chalumnae	36.00	1.00e-18	87.80
IUUC-Loc-052070	Lepisosteus oculatus	27.01	5.00e-29	122.00
IUUC-Laf-054426	Loxodonta africana	27.20	1.00e-28	120.00
IUUC-Mcc-055858	Macaca mulatta	26.88	1.00e-27	117.00
IUUC-Meu-056416	Macropus eugenii	33.53	2.00e-14	73.90
IUUC-Mla-058944	Melampsora laricipopulina	23.47	5.00e-06	46.20
IUUC-Mga-060011	Meleagris gallopavo	28.81	3.00e-27	116.00
IUUC-Mmr-060987	Microcebus murinus	34.55	3.00e-18	86.30
IUUC-Mdo-061955	Monodelphis domestica	29.51	3.00e-25	110.00
IUUC-Mmu-064245	Mus musculus	35.10	5.00e-18	85.50
IUUC-Mpu-066304	Mustela putorius furo	33.54	2.00e-18	87.00
IUUC-Mlu-067139	Myotis lucifugus	27.34	4.00e-28	119.00
IUUC-Nle-069075	Nomascus leucogenys	35.15	8.00e-18	84.70
IUUC-Opr-070214	Ochotona princeps	40.40	6.00e-14	72.00
IUUC-Ont-072386	Oreochromis niloticus	32.86	2.00e-14	73.60
IUUC-Oan-073054	Ornithorhynchus anatinus	36.02	3.00e-19	90.10
IUUC-Ocu-074102	Oryctolagus cuniculus	27.46	6.00e-28	118.00
IUUC-Oga-088939	Otolemur garnettii	28.10	1.00e-29	124.00
IUUC-Oar-090266	Ovis aries	26.90	1.00e-28	120.00
IUUC-Ptr-090546	Pan troglodytes	35.15	8.00e-18	84.70
IUUC-Pan-092311	Papio anubis	26.88	1.00e-27	117.00
IUUC-Psi-093422	Pelodiscus sinensis	28.64	4.00e-28	119.00
IUUC-Pfo-096466	Poecilia formosa	26.03	1.00e-25	110.00
IUUC-Pab-097608	Pongo abelii	35.15	6.00e-18	85.10
IUUC-Pca-100718	Procavia capensis	29.26	3.00e-31	129.00
IUUC-Pva-103150	Pteropus vampyrus	28.10	5.00e-27	115.00
IUUC-Rno-105727	Rattus norvegicus	34.97	4.00e-18	85.90
IUUC-Sce-106441	Saccharomyces cerevisiae	27.35	2.00e-07	50.80
IUUC-Sha-107051	Sarcophilus harrisii	28.18	1.00e-28	120.00
IUUC-Spo-108381	Schizosaccharomyces pombe	33.33	7.00e-08	52.00
IUUC-Sar-113097	Sorex araneus	27.85	2.00e-29	123.00
IUUC-Sre-115145	Sporisorium reilianum	22.40	2.00e-06	47.40
IUUC-Ssc-115877	Sus scrofa	32.93	7.00e-18	85.10
IUUC-Tgu-117473	Taeniopygia guttata	26.87	4.00e-27	115.00
IUUC-Tru-117807	Takifugu rubripes	27.25	4.00e-27	115.00
IUUC-Tsy-119471	Tarsius syrichta	27.30	2.00e-21	96.70
IUUC-Tni-119983	Tetraodon nigroviridis	27.23	3.00e-29	123.00
IUUC-Tbe-127549	Tupaia belangeri	26.26	8.00e-24	104.00
IUUC-Ttr-128887	Tursiops truncatus	30.03	7.00e-26	111.00
IUUC-Vda-129742	Verticillium dahliae	37.50	3.00e-07	50.40
IUUC-Vpa-130500	Vicugna pacos	32.93	3.00e-17	83.20
IUUC-Xtr-132896	Xenopus tropicalis	28.07	1.00e-28	121.00
IUUC-Xma-133995	Xiphophorus maculatus	26.97	2.00e-23	103.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence