iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012960

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

E3 UFM1-protein ligase 1

Genbank Nucleotide ID

BC126563

Gene Name

UFL1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000020410.4	ENSBTAT00000027202.4	ENSBTAP00000027202.4

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
E3 activity/Other	91.81	0.00e+00	1444.00	IUUC-Hsa-046823
ULD/UDP/UBQ/UBQ_Other	91.81	0.00e+00	1444.00	IUUC-Hsa-046823
E3 activity/Other	89.55	0.00e+00	1388.00	IUUC-Mmu-064248

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Bos taurus

Functional Description
(View)

E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling. May also through TRIP4 ufmylation play a role in nuclear receptors-mediated transcription. May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress.

Protein Sequence
(Fasta)

MADAWEEIRR LAADFQRAQF AEATQRLSER NCIEIVNKLI AQKQLEVVHT LDGKEYITPA 60
QISKEMRDEL HVRGGRVNIV DLQQAINVDL THIENRIGDI VKSEKHVQLV LGQLIDENYL 120

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Nucleotide Sequence
(Fasta)

GGCTGGGCGA ATAGGGCCGA GATGGCGGAC GCCTGGGAAG AGATTAGGCG TTTGGCGGCA 60
GATTTTCAGC GGGCGCAGTT CGCAGAAGCC ACGCAAAGGT GCCTGACCCT CCCTCTCCGT 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0256--Endoplasmic reticulum
KW-0436--Ligase
KW-0488--Methylation
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0043--Tumor suppressor
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway

Interpro

IPR018611--E3_UFM1_ligase_1

Pfam

PF09743--DUF2042

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005789--C:endoplasmic reticulum membrane
GO:0043005--C:neuron projection
GO:0043234--C:protein complex
GO:0016874--F:ligase activity
GO:0071568--F:UFM1 transferase activity
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0031397--P:negative regulation of protein ubiquitination
GO:0001649--P:osteoblast differentiation
GO:0060252--P:positive regulation of glial cell proliferation
GO:1990592--P:protein K69-linked ufmylation
GO:0071569--P:protein ufmylation
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway
GO:0032434--P:regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0032880--P:regulation of protein localization
GO:0034976--P:response to endoplasmic reticulum stress
GO:1902065--P:response to L-glutamate

KEGG

bta:515894

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000068	Aegilops tauschii	30.83	5.00e-43	169.00
IUUC-Aml-001894	Ailuropoda melanoleuca	93.69	0.00e+00	1424.00
IUUC-Atr-003137	Amborella trichopoda	33.42	6.00e-55	207.00
IUUC-Apl-003993	Anas platyrhynchos	74.37	0.00e+00	1078.00
IUUC-Aca-004941	Anolis carolinensis	74.61	0.00e+00	842.00
IUUC-Aly-006023	Arabidopsis lyrata	28.50	2.00e-48	187.00
IUUC-Ath-007249	Arabidopsis thaliana	28.76	1.00e-48	188.00
IUUC-Ame-011084	Astyanax mexicanus	72.27	9.00e-136	476.00
IUUC-Bdi-014730	Brachypodium distachyon	32.07	6.00e-50	192.00
IUUC-Bol-016306	Brassica oleracea	28.96	2.00e-46	181.00
IUUC-Bra-016735	Brassica rapa	29.23	1.00e-46	181.00
IUUC-Cel-018267	Caenorhabditis elegans	29.36	2.00e-37	150.00
IUUC-Cja-019432	Callithrix jacchus	92.32	0.00e+00	1406.00
IUUC-Cfa-020879	Canis familiaris	92.80	0.00e+00	1380.00
IUUC-Cpo-021915	Cavia porcellus	84.94	0.00e+00	1272.00
IUUC-Cre-022838	Chlamydomonas reinhardtii	42.97	6.00e-23	99.80
IUUC-Csa-023667	Chlorocebus sabaeus	93.07	0.00e+00	1418.00
IUUC-Cin-025254	Ciona intestinalis	41.18	6.00e-180	624.00
IUUC-Csv-026110	Ciona savignyi	42.76	2.00e-176	612.00
IUUC-Cme-027205	Cyanidioschyzon merolae	30.00	3.20e-01	29.60
IUUC-Dre-028832	Danio rerio	70.27	9.00e-176	610.00
IUUC-Dno-029396	Dasypus novemcinctus	86.08	0.00e+00	1255.00
IUUC-Dor-030872	Dipodomys ordii	75.34	3.00e-161	561.00
IUUC-Dme-031860	Drosophila melanogaster	40.61	4.00e-91	329.00
IUUC-Ete-032382	Echinops telfairi	86.52	0.00e+00	1268.00
IUUC-Eca-034175	Equus caballus	88.44	0.00e+00	1362.00
IUUC-Eeu-035073	Erinaceus europaeus	76.98	8.00e-168	583.00
IUUC-Fca-035655	Felis catus	90.17	0.00e+00	1358.00
IUUC-Fal-037594	Ficedula albicollis	73.09	0.00e+00	905.00
IUUC-Fso-038403	Fusarium solani	37.84	2.10e-02	31.20
IUUC-Gmo-038897	Gadus morhua	61.10	0.00e+00	812.00
IUUC-Gga-040147	Gallus gallus	74.84	0.00e+00	1096.00
IUUC-Gac-042365	Gasterosteus aculeatus	61.46	0.00e+00	945.00
IUUC-Gma-044359	Glycine max	32.30	2.00e-41	164.00
IUUC-Ggo-045085	Gorilla gorilla	92.82	0.00e+00	1396.00
IUUC-Hsa-046823	Homo sapiens	93.07	0.00e+00	1400.00
IUUC-Hvu-047672	Hordeum vulgare	29.80	2.00e-21	97.80
IUUC-Itr-048558	Ictidomys tridecemlineatus	91.81	0.00e+00	1373.00
IUUC-Lch-050099	Latimeria chalumnae	71.14	0.00e+00	1087.00
IUUC-Lpe-051353	Leersia perrieri	32.53	3.00e-52	200.00
IUUC-Loc-052237	Lepisosteus oculatus	74.26	0.00e+00	639.00
IUUC-Laf-053535	Loxodonta africana	88.32	0.00e+00	1311.00
IUUC-Mcc-054991	Macaca mulatta	91.81	0.00e+00	1417.00
IUUC-Meu-055924	Macropus eugenii	78.93	1.00e-97	350.00
IUUC-Mtr-058527	Medicago truncatula	33.33	4.00e-41	162.00
IUUC-Mga-059514	Meleagris gallopavo	71.48	0.00e+00	1092.00
IUUC-Mmr-061625	Microcebus murinus	92.95	0.00e+00	1410.00
IUUC-Mdo-062551	Monodelphis domestica	83.75	0.00e+00	1263.00
IUUC-Mmu-064248	Mus musculus	87.78	0.00e+00	1332.00
IUUC-Mac-065571	Musa acuminata	34.24	4.00e-57	216.00
IUUC-Mpu-065883	Mustela putorius furo	94.32	0.00e+00	1421.00
IUUC-Mlu-067468	Myotis lucifugus	91.92	0.00e+00	1395.00
IUUC-Nle-069831	Nomascus leucogenys	93.07	0.00e+00	1422.00
IUUC-Opr-071153	Ochotona princeps	68.10	0.00e+00	814.00
IUUC-Ont-072677	Oreochromis niloticus	63.08	0.00e+00	968.00
IUUC-Oan-073682	Ornithorhynchus anatinus	75.50	0.00e+00	1062.00
IUUC-Ocu-074268	Oryctolagus cuniculus	92.32	0.00e+00	1408.00
IUUC-Oba-075467	Oryza barthii	28.64	1.00e-71	264.00
IUUC-Obr-076760	Oryza brachyantha	30.34	8.00e-22	99.40
IUUC-Ogl-077088	Oryza glaberrima	28.75	6.00e-72	265.00
IUUC-Ogu-078509	Oryza glumaepatula	28.55	7.00e-73	268.00
IUUC-Oin-079276	Oryza indica	29.07	4.00e-74	273.00
IUUC-Olo-080814	Oryza longistaminata	28.64	1.00e-71	265.00
IUUC-Ome-081647	Oryza meridionalis	32.28	6.00e-51	196.00
IUUC-Oni-082954	Oryza nivara	28.52	4.00e-71	262.00
IUUC-Opu-083580	Oryza punctata	28.11	3.00e-64	239.00
IUUC-Oru-084627	Oryza rufipogon	29.07	4.00e-74	273.00
IUUC-Osa-086096	Oryza sativa	29.07	4.00e-74	273.00
IUUC-Ola-087322	Oryzias latipes	61.78	0.00e+00	957.00
IUUC-Olu-087693	Ostreococcus lucimarinus	25.60	2.00e-19	91.30
IUUC-Oga-088769	Otolemur garnettii	88.93	0.00e+00	1337.00
IUUC-Oar-090007	Ovis aries	97.60	0.00e+00	1471.00
IUUC-Ptr-090760	Pan troglodytes	92.82	0.00e+00	1397.00
IUUC-Pan-092162	Papio anubis	93.20	0.00e+00	1419.00
IUUC-Psi-093045	Pelodiscus sinensis	76.39	0.00e+00	1102.00
IUUC-Ppa-095424	Physcomitrella patens	35.26	1.00e-58	221.00
IUUC-Pfo-096108	Poecilia formosa	69.51	1.00e-176	613.00
IUUC-Pab-098057	Pongo abelii	90.18	0.00e+00	1362.00
IUUC-Pop-099790	Populus trichocarpa	32.29	6.00e-54	205.00
IUUC-Pca-100307	Procavia capensis	85.89	0.00e+00	1300.00
IUUC-Ppe-102029	Prunus persica	30.85	6.00e-52	199.00
IUUC-Pva-102386	Pteropus vampyrus	90.50	0.00e+00	865.00
IUUC-Rno-105550	Rattus norvegicus	88.04	0.00e+00	1304.00
IUUC-Sha-107442	Sarcophilus harrisii	84.63	0.00e+00	1269.00
IUUC-Smo-109447	Selaginella moellendorffii	33.16	1.00e-54	207.00
IUUC-Sit-110568	Setaria italica	32.25	4.00e-50	193.00
IUUC-Sly-111028	Solanum lycopersicum	31.36	6.00e-50	192.00
IUUC-Stu-112317	Solanum tuberosum	30.85	4.00e-48	186.00
IUUC-Sar-113662	Sorex araneus	84.53	0.00e+00	1256.00
IUUC-Sbi-114636	Sorghum bicolor	32.62	1.00e-51	197.00
IUUC-Ssc-116423	Sus scrofa	93.94	0.00e+00	1427.00
IUUC-Tgu-116977	Taeniopygia guttata	73.93	0.00e+00	1090.00
IUUC-Tru-118314	Takifugu rubripes	68.55	8.00e-174	603.00
IUUC-Tsy-119391	Tarsius syrichta	88.41	0.00e+00	1326.00
IUUC-Tni-120594	Tetraodon nigroviridis	60.18	0.00e+00	900.00
IUUC-Tca-121351	Theobroma cacao	30.07	5.00e-55	209.00
IUUC-Tae-122849	Triticum aestivum	29.80	4.00e-22	100.00
IUUC-Tur-126308	Triticum urartu	29.80	5.00e-22	99.80
IUUC-Tbe-127999	Tupaia belangeri	90.14	0.00e+00	1256.00
IUUC-Ttr-129189	Tursiops truncatus	87.63	0.00e+00	1308.00
IUUC-Vpa-130734	Vicugna pacos	89.14	0.00e+00	1330.00
IUUC-Vvi-131695	Vitis vinifera	30.92	2.00e-50	194.00
IUUC-Xtr-132004	Xenopus tropicalis	63.49	0.00e+00	946.00
IUUC-Xma-134108	Xiphophorus maculatus	61.88	0.00e+00	823.00
IUUC-Zma-135513	Zea mays	32.52	2.00e-50	194.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence