iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Oar-089718

Ensembl Protein ID

ENSOARP00000012691.1

UniProt Accession

W5PQG4; W5PQG4_SHEEP

Genbank Protein ID

ENSOARP00000012691

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AMGL01106866

Gene Name

USP45

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOARG00000011837.1	ENSOART00000012877.1	ENSOARP00000012691.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.90e-83	280.0	191	815

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle..kkkeklneenp.............kepkgellkslqklfeelwkskkkavsprell 74
           +G++NlgNtC++N+v+Q L++   l+el++e  ++  +l+                  ++ g+l+++l  +++++ +++++  sp+ l+
   Q: 191  KGITNLGNTCFFNAVMQNLAQSYILTELMNEikEHGTELKI--VpssdsqldplvveLSSPGPLTSALFLFLHSMKETERGPLSPKVLF 277
           59**************************9995533333333..2335556666666677777*************************** PP
   S: 75   kalkkeaee..fsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknk......slisdlFqgqlksqik 155
           ++l++ ++   f++++qqD+qE+l++lld++++e +k+ +  + +++++ ++++ d++ +kk k +       ++i+++F g+l+s+++
   Q: 278  NQLCQNHRApaFKSFQQQDSQELLHYLLDAVRTEETKRIQAGILKAFNNPTTKTADDETRKKVKAYGregvkmNFIDRIFIGELTSTVM 366
           ***99876555************************99788887777777777777774444444443455555**************** PP
   S: 156  clecdnvssreepfldlslpvpgkeetkke........................................................... 185
           c+ec n+s+ ++pf+d+slp+ +++ +k+                                                            
   Q: 367  CEECSNISTVKDPFIDISLPIIEERVSKPVllgriskygslqetdtgqysgtvtventhqprairkhssskdmnqlihgrkctrksged 455
           *************************98777*********************************************************** PP
   S: 186  ......................................................................................... 185
                                                                                                    
   Q: 456  kaaviyqkneslevnrdsslfasvmnteltltesptdgsekedslsessvdadseasesesapkqtlllrsrsgyythtnghphypskr 544
           ***************************************************************************************** PP
   S: 186  .............................................................................slqdcLesftke 197
                                                                                        s+q+cL +ft+ 
   Q: 545  epltregdhgdegvaeaiselhlsstiirardfdrenqplsvsnnlcfsedkhmvsqspqnafqtlsqsyittskecSVQSCLYQFTSM 633
           ***************************************************************************************** PP
   S: 198  eelegenkyycekckkkqe...................aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfcts 267
           e l g+nk+ ce+c++k++                   a+k+l ++ +P +LilhLkRf  ++++ s +k+n++v+fpl+Ldl+pfc+ 
   Q: 634  ELLMGNNKLLCENCTEKKQkyqkettsaekkaegvytnARKQLLISAVPAILILHLKRF--HQAGLSLRKVNRHVDFPLMLDLAPFCSA 720
           ***************99999999999999999999999*********************..9999************************ PP
   S: 268  peekqke..kkkYeLiavvvHsGslssGHYvayvkn..........................ekgkWllfdDskVtevkeeevleetgs 328
           +++++++  k+ Y L++vv HsGs+++GHY+ayvk                           +  +W++++D++V++v+e++ l+   +
   Q: 721  TCKNVSVggKVLYGLYGVVEHSGSMRGGHYTAYVKVrtpsrkllehitgkknvpglkeadseSASQWVHVSDTYVQVVPESRALS---A 806
           9999887889**************************999999999999999999998887766777*******************...* PP
   S: 329  taYvlfYkr 337
           +aY+lfY+r
   Q: 807  QAYLLFYER 815
           *******98 PP

Organism

Ovis aries

Protein Sequence
(Fasta)

MRVKQPSKAS PEKAKRSKRP PIPHDEDSSD DVAVGFTCQH ISHAVSVHHV KKAIAENLWS 60
VCLECLKERR FCDGQPILPP DIWLCLKCGF QGCGKNSEGQ HSLKHFKSWR AELHCIIINL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCGGGTGA AACAGCCATC CAAAGCTTCA CCTGAGAAAG CTAAGAGAAG TAAAAGGCCT 60
CCTATACCTC ACGATGAAGA CTCGTCAGAT GACGTTGCTG GTAAATTATG ATGTCTCGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002331	Ailuropoda melanoleuca	75.58	0.00e+00	1153.00
IUUC-Apl-003512	Anas platyrhynchos	68.69	0.00e+00	1089.00
IUUC-Aca-004284	Anolis carolinensis	62.08	0.00e+00	973.00
IUUC-Ame-010735	Astyanax mexicanus	48.24	2.00e-108	385.00
IUUC-Bta-012880	Bos taurus	97.31	0.00e+00	1546.00
IUUC-Cja-019144	Callithrix jacchus	81.17	0.00e+00	1338.00
IUUC-Cfa-020971	Canis familiaris	82.37	0.00e+00	751.00
IUUC-Cpo-022497	Cavia porcellus	79.60	0.00e+00	719.00
IUUC-Csa-023910	Chlorocebus sabaeus	81.19	0.00e+00	1233.00
IUUC-Cho-024358	Choloepus hoffmanni	80.41	1.00e-66	247.00
IUUC-Dre-028106	Danio rerio	53.18	0.00e+00	800.00
IUUC-Dno-029456	Dasypus novemcinctus	75.39	0.00e+00	714.00
IUUC-Dor-030438	Dipodomys ordii	64.43	0.00e+00	964.00
IUUC-Dme-031870	Drosophila melanogaster	47.90	6.00e-37	149.00
IUUC-Ete-032736	Echinops telfairi	65.95	0.00e+00	982.00
IUUC-Eca-034211	Equus caballus	85.73	0.00e+00	1402.00
IUUC-Eeu-034797	Erinaceus europaeus	78.79	3.00e-87	315.00
IUUC-Fca-035947	Felis catus	81.47	0.00e+00	1220.00
IUUC-Fal-037199	Ficedula albicollis	67.62	0.00e+00	942.00
IUUC-Gmo-039228	Gadus morhua	59.70	3.00e-137	482.00
IUUC-Gga-040823	Gallus gallus	66.34	5.00e-178	617.00
IUUC-Gac-042406	Gasterosteus aculeatus	52.58	0.00e+00	773.00
IUUC-Ggo-045402	Gorilla gorilla	82.00	0.00e+00	1320.00
IUUC-Hsa-046430	Homo sapiens	81.85	0.00e+00	1325.00
IUUC-Itr-048855	Ictidomys tridecemlineatus	82.25	0.00e+00	769.00
IUUC-Lch-049547	Latimeria chalumnae	59.66	0.00e+00	942.00
IUUC-Loc-052842	Lepisosteus oculatus	58.34	0.00e+00	902.00
IUUC-Laf-053988	Loxodonta africana	81.75	0.00e+00	1328.00
IUUC-Mcc-055491	Macaca mulatta	78.17	0.00e+00	1252.00
IUUC-Meu-056256	Macropus eugenii	65.62	0.00e+00	635.00
IUUC-Mla-059026	Melampsora laricipopulina	31.71	1.00e-17	85.10
IUUC-Mga-059833	Meleagris gallopavo	62.80	4.00e-179	620.00
IUUC-Mmr-060952	Microcebus murinus	80.49	0.00e+00	1280.00
IUUC-Mdo-062642	Monodelphis domestica	70.21	0.00e+00	1085.00
IUUC-Mmu-063945	Mus musculus	77.68	0.00e+00	1237.00
IUUC-Mpu-065944	Mustela putorius furo	79.24	0.00e+00	1228.00
IUUC-Mlu-067049	Myotis lucifugus	84.74	0.00e+00	1343.00
IUUC-Nle-069828	Nomascus leucogenys	81.56	0.00e+00	1317.00
IUUC-Opr-070672	Ochotona princeps	67.20	6.00e-136	478.00
IUUC-Ont-072121	Oreochromis niloticus	58.29	6.00e-135	474.00
IUUC-Oan-073656	Ornithorhynchus anatinus	65.58	0.00e+00	1050.00
IUUC-Ocu-074323	Oryctolagus cuniculus	78.29	0.00e+00	1228.00
IUUC-Ola-087238	Oryzias latipes	51.78	0.00e+00	792.00
IUUC-Oga-088379	Otolemur garnettii	75.48	0.00e+00	1208.00
IUUC-Ptr-091358	Pan troglodytes	82.10	0.00e+00	1326.00
IUUC-Pan-092023	Papio anubis	82.42	0.00e+00	1331.00
IUUC-Psi-093256	Pelodiscus sinensis	66.59	0.00e+00	1001.00
IUUC-Pfo-097285	Poecilia formosa	49.22	0.00e+00	705.00
IUUC-Pab-098539	Pongo abelii	81.66	0.00e+00	1321.00
IUUC-Pca-100610	Procavia capensis	67.62	0.00e+00	923.00
IUUC-Pva-102985	Pteropus vampyrus	90.59	0.00e+00	704.00
IUUC-Rno-105538	Rattus norvegicus	76.95	0.00e+00	1236.00
IUUC-Sha-107022	Sarcophilus harrisii	62.30	0.00e+00	976.00
IUUC-Sja-107712	Schizosaccharomyces japonicus	28.07	7.00e-21	95.90
IUUC-Spo-108149	Schizosaccharomyces pombe	30.39	4.00e-21	96.70
IUUC-Sar-113637	Sorex araneus	72.20	0.00e+00	1078.00
IUUC-Ssc-115870	Sus scrofa	87.42	0.00e+00	1440.00
IUUC-Tgu-116907	Taeniopygia guttata	67.56	0.00e+00	1076.00
IUUC-Tru-117835	Takifugu rubripes	51.58	2.00e-105	377.00
IUUC-Tsy-118869	Tarsius syrichta	80.33	0.00e+00	1129.00
IUUC-Tni-119716	Tetraodon nigroviridis	62.90	4.00e-92	332.00
IUUC-Tbe-128041	Tupaia belangeri	69.78	0.00e+00	919.00
IUUC-Ttr-128901	Tursiops truncatus	86.57	0.00e+00	1399.00
IUUC-Vpa-130331	Vicugna pacos	87.97	0.00e+00	1318.00
IUUC-Xtr-131794	Xenopus tropicalis	52.13	0.00e+00	775.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence