iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
RAID2
Protein-protein Interaction
IID
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RBR	1.90e-48	165.6	30	220

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RBR

   S: 1    CkvCllelsveeltvlleCehtfCkeClkqylelkikegqvteiscpaaecpek..leeseikellveeelykryekllleevveadaal 88
           Ck+Cl+e+s +++t l+eC+++fC+ Clkqy+ l i+eg+ + i+cp++ c ++  l+e+ei++ lv  + ++ y++l++e++v++d+ +
   Q: 30   CKLCLCEQSLDKMTILQECQCIFCTPCLKQYMVLSIREGCGSPITCPDMVCLNHgtLQEAEIAC-LVPVDEFQLYQRLKFEREVHMDPLR 118
           ***************************************************9988899******.699999******************* PP
   S: 89   kwcpapdCslvvllekea..eklevecekcgkefCveCkeewHeglsCkelkeklakteeekeeaeskelleanskkCpkCkvyiekneg 176
           +wcp +dC++v+ ++  +  + ++vec++c+ +fC++Ck++wHe++sC++ + ++ ++      a   + +++ +k+Cp C++yie+neg
   Q: 119  TWCPVADCQTVCHITAGDpgQPVSVECPSCHLKFCSCCKDAWHEESSCRDSQSAMPEHG-----ALFGTDADSPIKQCPVCRIYIERNEG 203
           ************99987777999999************************998877666.....899999******************** PP
   S: 177  CnhmtCakCkaefCwlC 193
           C++m+C++Ck++fCw+C
   Q: 204  CAQMMCKNCKHTFCWYC 220
           ***************** PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MDSVDGLQCL TMTAENPPSG DLIPAPLVTC KLCLCEQSLD KMTILQECQC IFCTPCLKQY 60
MVLSIREGCG SPITCPDMVC LNHGTLQEAE IACLVPVDEF QLYQRLKFER EVHMDPLRTW 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GGAGCGGGGT GCAAGGGCCG CAGGCCGCCG GAGAGAGCCC CAGGATGGTA GCTAGGAGAT 60
TGGAAAGCCT TTGATGCCAG AAGCCTCCGG CTGGAGCCGC TGACAACCCA GCCCTTGCCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR016150--Casein_kin_II_reg-sub_b-sht
IPR031127--E3_UB_ligase_RBR
IPR002867--IBR_dom
IPR001841--Znf_RING
IPR017907--Znf_RING_CS

PROSITE

PS00518--ZF_RING_1

Pfam

PF01485--IBR

SMART

SM00647--IBR
SM00184--RING

Gene Ontology

GO:0016021--C:integral component of membrane
GO:0031966--C:mitochondrial membrane
GO:0000151--C:ubiquitin ligase complex
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process

KEGG

rno:364681

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001257	Ailuropoda melanoleuca	86.47	3.00e-156	544.00
IUUC-Apl-004112	Anas platyrhynchos	79.78	3.00e-123	434.00
IUUC-Aca-004533	Anolis carolinensis	79.23	1.00e-131	462.00
IUUC-Bta-012641	Bos taurus	87.50	1.00e-155	542.00
IUUC-Cja-019626	Callithrix jacchus	76.49	2.00e-132	465.00
IUUC-Cfa-020702	Canis familiaris	86.14	2.00e-155	541.00
IUUC-Cpo-022147	Cavia porcellus	88.45	2.00e-157	547.00
IUUC-Csa-023473	Chlorocebus sabaeus	86.80	3.00e-156	544.00
IUUC-Cho-024298	Choloepus hoffmanni	84.05	1.00e-126	445.00
IUUC-Dre-028099	Danio rerio	62.41	2.00e-87	315.00
IUUC-Dno-029122	Dasypus novemcinctus	81.58	1.00e-142	499.00
IUUC-Dor-030669	Dipodomys ordii	89.70	2.00e-124	437.00
IUUC-Ete-033141	Echinops telfairi	74.59	2.00e-119	422.00
IUUC-Eca-034360	Equus caballus	87.79	1.00e-156	545.00
IUUC-Eeu-034538	Erinaceus europaeus	69.01	4.00e-80	290.00
IUUC-Fca-036055	Felis catus	85.15	4.00e-153	533.00
IUUC-Fal-037339	Ficedula albicollis	76.34	2.00e-125	441.00
IUUC-Gmo-038780	Gadus morhua	60.07	9.00e-84	303.00
IUUC-Gga-040256	Gallus gallus	78.52	1.00e-126	445.00
IUUC-Gac-042127	Gasterosteus aculeatus	60.85	7.00e-87	313.00
IUUC-Ggo-044867	Gorilla gorilla	88.12	1.00e-157	548.00
IUUC-Hsa-046928	Homo sapiens	87.79	3.00e-157	547.00
IUUC-Hvu-047484	Hordeum vulgare	29.35	7.00e-16	78.60
IUUC-Itr-048250	Ictidomys tridecemlineatus	89.64	5.00e-101	359.00
IUUC-Lch-050168	Latimeria chalumnae	71.86	5.00e-125	440.00
IUUC-Lpe-051649	Leersia perrieri	28.93	6.00e-16	79.70
IUUC-Loc-052150	Lepisosteus oculatus	60.14	1.00e-86	312.00
IUUC-Laf-053967	Loxodonta africana	88.45	6.00e-159	553.00
IUUC-Mcc-055898	Macaca mulatta	86.80	3.00e-156	544.00
IUUC-Meu-056628	Macropus eugenii	93.59	2.00e-42	165.00
IUUC-Mtr-057989	Medicago truncatula	27.45	7.00e-17	80.90
IUUC-Mga-059820	Meleagris gallopavo	77.41	8.00e-125	439.00
IUUC-Mmr-060680	Microcebus murinus	86.80	3.00e-154	537.00
IUUC-Mdo-062839	Monodelphis domestica	81.91	2.00e-146	511.00
IUUC-Mmu-063339	Mus musculus	98.01	1.00e-166	578.00
IUUC-Mac-065414	Musa acuminata	28.91	8.00e-18	84.30
IUUC-Mpu-065973	Mustela putorius furo	85.81	6.00e-155	540.00
IUUC-Mlu-067112	Myotis lucifugus	87.46	5.00e-147	513.00
IUUC-Nle-069795	Nomascus leucogenys	87.79	2.00e-157	548.00
IUUC-Opr-070390	Ochotona princeps	80.53	7.00e-137	479.00
IUUC-Ont-072329	Oreochromis niloticus	63.18	6.00e-88	317.00
IUUC-Oan-072980	Ornithorhynchus anatinus	80.43	1.00e-130	458.00
IUUC-Ocu-073845	Oryctolagus cuniculus	87.79	2.00e-156	544.00
IUUC-Ola-086872	Oryzias latipes	59.18	1.00e-81	295.00
IUUC-Oga-088954	Otolemur garnettii	87.79	2.00e-155	541.00
IUUC-Oar-089879	Ovis aries	87.50	1.00e-155	542.00
IUUC-Ptr-090685	Pan troglodytes	87.79	3.00e-157	547.00
IUUC-Pan-092086	Papio anubis	87.13	2.00e-156	544.00
IUUC-Psi-093481	Pelodiscus sinensis	78.88	5.00e-133	466.00
IUUC-Pfo-096065	Poecilia formosa	62.21	1.00e-88	319.00
IUUC-Pab-098031	Pongo abelii	87.79	1.00e-156	545.00
IUUC-Pca-100936	Procavia capensis	86.47	1.00e-153	535.00
IUUC-Pva-102864	Pteropus vampyrus	77.56	2.00e-133	468.00
IUUC-Sha-107425	Sarcophilus harrisii	82.24	6.00e-147	513.00
IUUC-Ssc-115458	Sus scrofa	85.34	9.00e-143	499.00
IUUC-Tgu-117226	Taeniopygia guttata	76.70	6.00e-127	446.00
IUUC-Tru-118362	Takifugu rubripes	63.91	7.00e-91	327.00
IUUC-Tsy-119255	Tarsius syrichta	88.12	3.00e-158	550.00
IUUC-Tni-120140	Tetraodon nigroviridis	59.93	3.00e-86	311.00
IUUC-Tae-124420	Triticum aestivum	30.46	4.00e-17	82.80
IUUC-Tbe-127306	Tupaia belangeri	87.79	6.00e-156	543.00
IUUC-Ttr-128923	Tursiops truncatus	86.51	4.00e-142	497.00
IUUC-Vpa-130148	Vicugna pacos	86.47	1.00e-154	538.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence