iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Bta-136411

Ensembl Protein ID

ENSBTAP00000013714.3

UniProt Accession

Q0IIH8; MINY3_BOVIN

Genbank Protein ID

BC122636

Protein Name

Ubiquitin carboxyl-terminal hydrolase MINDY-3;Deubiquitinating enzyme MINDY-3;Protein CARP

Genbank Nucleotide ID

AAI22637.1

Gene Name

MINDY3;CARP;FAM188A

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000010387.3	ENSBTAT00000013714.3	ENSBTAP00000013714.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
UBD/Alpha-Helix/MIU	97.53	0.00e+00	867.00	IUUC-Hsa-136747
DUB/MINDY	97.53	0.00e+00	867.00	IUUC-Hsa-136747

Active Site

Position(s)	Description	Evidence
51	Nucleophile	{ECO:0000250\|UniProtKB:Q8N5J2}
287	Proton acceptor	{ECO:0000250\|UniProtKB:Q8N5J2}

Organism

Bos taurus

Functional Description
(View)

Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.

Protein Sequence
(Fasta)

MSELTKELME LVWGTNSSPG LSDTIFCRWT QGFVFSESEG SALEQFEGGP CAVIAPVQAF 60
LLKKLLFSSE KSSWRDCPEE ERKELLCHTL CDILESAGCD NSGSYCLVSW LRGKTTEETA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTCAAGCTCG TTTACCGCCG CCGTCCCGCC ACTCTGGTCT CGGAAGCCGC CCCTTCCCCA 60
TGTGCCGGGG CAGGAGTCCT GAAAGCCAAG ACCAGCTCGC CGGCATCCCA TCATGTCCGA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0053--Apoptosis
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR025257--DUF4205
IPR011992--EF-hand-dom_pair

Pfam

PF13898--DUF4205

SMART

SM01174--DUF4205

Gene Ontology

GO:0031965--C:nuclear membrane
GO:0005654--C:nucleoplasm
GO:0016807--F:cysteine-type carboxypeptidase activity
GO:1990380--F:Lys48-specific deubiquitinase activity
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0006915--P:apoptotic process

KEGG

bta:538509

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-136377	Aegilops tauschii	30.56	2.00e-46	180.00
IUUC-Aml-136379	Ailuropoda melanoleuca	97.53	0.00e+00	865.00
IUUC-Atr-136383	Amborella trichopoda	30.84	1.00e-40	160.00
IUUC-Apl-136385	Anas platyrhynchos	86.34	0.00e+00	657.00
IUUC-Aca-136389	Anolis carolinensis	82.74	0.00e+00	766.00
IUUC-Aly-136394	Arabidopsis lyrata	29.98	2.00e-46	180.00
IUUC-Ath-136396	Arabidopsis thaliana	31.61	2.00e-47	183.00
IUUC-Ame-136407	Astyanax mexicanus	73.61	0.00e+00	702.00
IUUC-Bdi-136416	Brachypodium distachyon	29.82	2.00e-46	180.00
IUUC-Bol-136419	Brassica oleracea	31.75	7.00e-46	178.00
IUUC-Bra-136421	Brassica rapa	31.69	1.00e-45	177.00
IUUC-Cja-136424	Callithrix jacchus	96.63	0.00e+00	858.00
IUUC-Cfa-136428	Canis familiaris	94.20	0.00e+00	777.00
IUUC-Cpo-136432	Cavia porcellus	95.06	0.00e+00	849.00
IUUC-Csa-136438	Chlorocebus sabaeus	97.53	0.00e+00	866.00
IUUC-Cho-136444	Choloepus hoffmanni	90.91	8.00e-165	573.00
IUUC-Cin-136447	Ciona intestinalis	43.42	6.00e-98	350.00
IUUC-Csv-136448	Ciona savignyi	43.15	2.00e-96	346.00
IUUC-Dre-136452	Danio rerio	73.09	0.00e+00	654.00
IUUC-Dno-136456	Dasypus novemcinctus	95.06	0.00e+00	849.00
IUUC-Dor-136461	Dipodomys ordii	91.76	0.00e+00	661.00
IUUC-Dme-136466	Drosophila melanogaster	43.01	1.00e-110	393.00
IUUC-Ete-136467	Echinops telfairi	74.38	0.00e+00	650.00
IUUC-Eca-136471	Equus caballus	97.75	0.00e+00	869.00
IUUC-Eeu-136476	Erinaceus europaeus	90.56	0.00e+00	766.00
IUUC-Fca-136477	Felis catus	96.86	0.00e+00	861.00
IUUC-Fal-136481	Ficedula albicollis	85.31	0.00e+00	764.00
IUUC-Gmo-136486	Gadus morhua	69.57	5.00e-179	620.00
IUUC-Gga-136491	Gallus gallus	85.20	0.00e+00	793.00
IUUC-Gac-136495	Gasterosteus aculeatus	69.73	0.00e+00	637.00
IUUC-Gma-136499	Glycine max	30.02	5.00e-44	172.00
IUUC-Ggo-136502	Gorilla gorilla	89.04	0.00e+00	770.00
IUUC-Hsa-136747	Homo sapiens	97.53	0.00e+00	866.00
IUUC-Hvu-136508	Hordeum vulgare	33.70	1.00e-38	154.00
IUUC-Itr-136510	Ictidomys tridecemlineatus	94.81	6.00e-109	385.00
IUUC-Lch-136515	Latimeria chalumnae	77.51	0.00e+00	710.00
IUUC-Lpe-136518	Leersia perrieri	28.21	2.00e-41	163.00
IUUC-Loc-136521	Lepisosteus oculatus	75.72	0.00e+00	707.00
IUUC-Laf-136527	Loxodonta africana	96.40	0.00e+00	856.00
IUUC-Mcc-136530	Macaca mulatta	97.53	0.00e+00	866.00
IUUC-Meu-136534	Macropus eugenii	58.76	8.00e-90	323.00
IUUC-Mtr-136540	Medicago truncatula	29.30	1.00e-41	164.00
IUUC-Mga-136543	Meleagris gallopavo	85.20	0.00e+00	742.00
IUUC-Mmr-136547	Microcebus murinus	97.75	0.00e+00	870.00
IUUC-Mdo-136551	Monodelphis domestica	90.34	0.00e+00	847.00
IUUC-Mmu-136555	Mus musculus	94.38	0.00e+00	840.00
IUUC-Mac-136559	Musa acuminata	27.37	7.00e-40	158.00
IUUC-Mpu-136561	Mustela putorius furo	97.37	0.00e+00	654.00
IUUC-Mlu-136565	Myotis lucifugus	95.51	0.00e+00	852.00
IUUC-Nle-136572	Nomascus leucogenys	97.53	0.00e+00	866.00
IUUC-Opr-136576	Ochotona princeps	66.92	4.00e-137	481.00
IUUC-Ont-136579	Oreochromis niloticus	68.68	0.00e+00	629.00
IUUC-Oan-136582	Ornithorhynchus anatinus	86.97	0.00e+00	751.00
IUUC-Ocu-136585	Oryctolagus cuniculus	97.75	0.00e+00	868.00
IUUC-Oba-136589	Oryza barthii	27.55	3.00e-48	186.00
IUUC-Obr-136592	Oryza brachyantha	27.57	2.00e-46	180.00
IUUC-Ogl-136593	Oryza glaberrima	27.55	5.00e-48	185.00
IUUC-Ogu-136595	Oryza glumaepatula	27.55	7.00e-48	185.00
IUUC-Oin-136597	Oryza indica	28.03	9.00e-47	181.00
IUUC-Olo-136599	Oryza longistaminata	27.50	5.00e-48	185.00
IUUC-Oni-136602	Oryza nivara	27.55	5.00e-48	185.00
IUUC-Opu-136604	Oryza punctata	27.50	1.00e-47	184.00
IUUC-Oru-136606	Oryza rufipogon	27.55	5.00e-48	185.00
IUUC-Osa-136608	Oryza sativa	31.21	3.00e-33	135.00
IUUC-Ola-136610	Oryzias latipes	69.73	0.00e+00	654.00
IUUC-Oga-136614	Otolemur garnettii	95.75	0.00e+00	851.00
IUUC-Oar-136619	Ovis aries	99.78	0.00e+00	884.00
IUUC-Ptr-136623	Pan troglodytes	97.30	0.00e+00	865.00
IUUC-Pan-136627	Papio anubis	97.53	0.00e+00	866.00
IUUC-Psi-136631	Pelodiscus sinensis	86.82	0.00e+00	636.00
IUUC-Pma-136635	Petromyzon marinus	71.13	3.00e-47	180.00
IUUC-Pfo-136641	Poecilia formosa	66.23	0.00e+00	636.00
IUUC-Pab-136645	Pongo abelii	97.30	0.00e+00	863.00
IUUC-Pop-136650	Populus trichocarpa	30.43	3.00e-37	149.00
IUUC-Pca-136652	Procavia capensis	91.23	2.00e-121	429.00
IUUC-Ppe-136656	Prunus persica	29.19	4.00e-46	179.00
IUUC-Pva-136658	Pteropus vampyrus	88.09	0.00e+00	747.00
IUUC-Rno-136665	Rattus norvegicus	93.71	0.00e+00	841.00
IUUC-Sha-136671	Sarcophilus harrisii	90.11	0.00e+00	843.00
IUUC-Smo-136678	Selaginella moellendorffii	29.92	3.00e-44	173.00
IUUC-Sit-136680	Setaria italica	29.41	7.00e-37	147.00
IUUC-Sly-136683	Solanum lycopersicum	29.29	9.00e-44	171.00
IUUC-Sar-136685	Sorex araneus	87.37	0.00e+00	650.00
IUUC-Sbi-136688	Sorghum bicolor	30.05	2.00e-46	180.00
IUUC-Ssc-136691	Sus scrofa	97.75	0.00e+00	873.00
IUUC-Tgu-136694	Taeniopygia guttata	87.44	0.00e+00	756.00
IUUC-Tru-136698	Takifugu rubripes	67.53	0.00e+00	645.00
IUUC-Tsy-136703	Tarsius syrichta	91.91	0.00e+00	795.00
IUUC-Tni-136706	Tetraodon nigroviridis	70.25	0.00e+00	656.00
IUUC-Tca-136711	Theobroma cacao	30.43	6.00e-45	175.00
IUUC-Tae-136714	Triticum aestivum	30.64	7.00e-49	188.00
IUUC-Tur-136716	Triticum urartu	26.30	2.00e-30	127.00
IUUC-Tbe-136719	Tupaia belangeri	96.13	0.00e+00	789.00
IUUC-Ttr-136722	Tursiops truncatus	93.03	0.00e+00	824.00
IUUC-Vpa-136729	Vicugna pacos	97.09	0.00e+00	800.00
IUUC-Vvi-136732	Vitis vinifera	28.87	3.00e-46	180.00
IUUC-Xtr-136734	Xenopus tropicalis	72.30	0.00e+00	626.00
IUUC-Xma-136738	Xiphophorus maculatus	68.23	0.00e+00	644.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence